PDB: 4E4M — TYR JAK2_HUMAN

Total number of chains: 4
Active chains: 4
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 4E4MA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR JAK2-2 JAK2_HUMAN 4E4MA O60674 835 1132 1132.0 0NH:1201 Type1 Active DFGin 6.1804 13.8385 BLAminus -126.63, -156.25 24.74, 86.17 -92.72, 21.67 300.1, 90.36 -63.44, -19.58 in-in in 8.4137 Saltbr-in 2.7781 HRD-in -66.9, -48.08 75.55, -2.59 in-in-in SNCiii in-in ActLoopNT-in 2.6764 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -81.21, 124.91 APE9-dihe-in -103.01, 150.72 APE8-dihe-in -78.71, 77.02 APE8-rot-na 32.56 APE67-dihe-in -75.65, -0.18 -64.92, -29.56 APE12-dist-na 13.6695 APE11-dist-na 12.9145 APE10-dist-na 12.8148 APE9-dist-in 7.815 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.25 0.193 0.25 A 302.0 298.0 0 31 31 0 [[545, 807], [849, 1125]] 2.0 4e4m TYR_JAK2-2_HUMAN TYR 2.7e-87 298.3 1.0 260.0 260.0 993 994 995 997 999 882 898 902 973 975 974 976.0 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
TYR JAK2-2 JAK2_HUMAN 4E4MB O60674 835 1132 1132.0 0NH:1201 Type1 Active DFGin 6.3725 14.2034 BLAminus -118.84, -161.19 49.92, 72.51 -97.78, 25.28 298.31, 88.24 -69.84, -19.78 in-in in 8.441 Saltbr-in 2.7441 HRD-in -61.1, -46.48 75.69, -8.22 in-in-in SNCiii in-in ActLoopNT-in 2.8272 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -85.14, 74.01 APE9-dihe-in -58.89, 145.08 APE8-dihe-in -79.55, 72.25 APE8-rot-na 32.4 APE67-dihe-in -77.95, -3.75 -58.02, -29.09 APE12-dist-na 14.0442 APE11-dist-na 12.1561 APE10-dist-na 12.903 APE9-dist-in 7.9215 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.25 0.193 0.25 B 302.0 298.0 0 31 31 0 [[545, 807], [849, 1125]] 2.0 4e4m TYR_JAK2-2_HUMAN TYR 2.7e-87 298.3 1.0 260.0 260.0 993 994 995 997 999 882 898 902 973 975 974 976.0 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
TYR JAK2-2 JAK2_HUMAN 4E4MD O60674 835 1132 1132.0 0NH:1201 Type1 Active DFGin 6.3044 14.1312 BLAminus -117.3, -162.8 35.37, 82.7 -96.62, 19.05 298.07, 93.7 -70.19, -12.95 in-in in 8.4961 Saltbr-in 3.2274 HRD-in -71.15, -48.12 79.59, -3.5 in-in-in SNCiii in-in ActLoopNT-in 2.7926 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -85.18, 63.68 APE9-dihe-in -53.04, 143.19 APE8-dihe-in -78.69, 70.09 APE8-rot-na 32.31 APE67-dihe-in -79.35, -2.96 -56.35, -30.0 APE12-dist-na 14.2879 APE11-dist-na 12.1109 APE10-dist-na 12.7228 APE9-dist-in 7.8231 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.25 0.193 0.25 D 302.0 298.0 0 31 31 0 [[545, 807], [849, 1125]] 2.0 4e4m TYR_JAK2-2_HUMAN TYR 2.7e-87 298.3 1.0 260.0 260.0 993 994 995 997 999 882 898 902 973 975 974 976.0 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
TYR JAK2-2 JAK2_HUMAN 4E4ME O60674 835 1132 1132.0 0NH:1201 Type1 Active DFGin 6.1504 13.9693 BLAminus -129.52, -159.3 35.39, 81.53 -94.01, 23.95 298.27, 88.38 -61.49, -26.33 in-in in 8.438 Saltbr-in 2.7197 HRD-in -66.9, -47.68 77.51, -1.6 in-in-in SNCiii in-in ActLoopNT-in 2.7508 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -67.74, 130.71 APE9-dihe-in -111.94, 154.92 APE8-dihe-in -81.89, 77.11 APE8-rot-na 32.96 APE67-dihe-in -74.64, -3.77 -64.87, -30.41 APE12-dist-na 13.7245 APE11-dist-na 13.0291 APE10-dist-na 12.6587 APE9-dist-in 7.8739 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.25 0.193 0.25 E 302.0 298.0 0 31 31 0 [[545, 807], [849, 1125]] 2.0 4e4m TYR_JAK2-2_HUMAN TYR 2.7e-87 298.3 1.0 260.0 260.0 993 994 995 997 999 882 898 902 973 975 974 976.0 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2

PDB: 4E4M — TYR JAK2_HUMAN

Total number of chains: 4
Active chains: 4
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 4E4MA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR JAK2-2 JAK2_HUMAN 4E4MA O60674 835 1132 1132.0 0NH:1201 Type1 Active DFGin 6.1804 13.8385 BLAminus -126.63, -156.25 24.74, 86.17 -92.72, 21.67 300.1, 90.36 -63.44, -19.58 in-in in 8.4137 Saltbr-in 2.7781 HRD-in -66.9, -48.08 75.55, -2.59 in-in-in SNCiii in-in ActLoopNT-in 2.6764 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -81.21, 124.91 APE9-dihe-in -103.01, 150.72 APE8-dihe-in -78.71, 77.02 APE8-rot-na 32.56 APE67-dihe-in -75.65, -0.18 -64.92, -29.56 APE12-dist-na 13.6695 APE11-dist-na 12.9145 APE10-dist-na 12.8148 APE9-dist-in 7.815 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.25 0.193 0.25 A 302.0 298.0 0 31 31 0 [[545, 807], [849, 1125]] 2.0 4e4m Homo sapiens TYR_JAK2-2_HUMAN TYR 2.7e-87 298.3 1.0 260.0 260.0 993 994 995 997 999 882 898 902 973 975 974 976.0 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
TYR JAK2-2 JAK2_HUMAN 4E4MB O60674 835 1132 1132.0 0NH:1201 Type1 Active DFGin 6.3725 14.2034 BLAminus -118.84, -161.19 49.92, 72.51 -97.78, 25.28 298.31, 88.24 -69.84, -19.78 in-in in 8.441 Saltbr-in 2.7441 HRD-in -61.1, -46.48 75.69, -8.22 in-in-in SNCiii in-in ActLoopNT-in 2.8272 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -85.14, 74.01 APE9-dihe-in -58.89, 145.08 APE8-dihe-in -79.55, 72.25 APE8-rot-na 32.4 APE67-dihe-in -77.95, -3.75 -58.02, -29.09 APE12-dist-na 14.0442 APE11-dist-na 12.1561 APE10-dist-na 12.903 APE9-dist-in 7.9215 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.25 0.193 0.25 B 302.0 298.0 0 31 31 0 [[545, 807], [849, 1125]] 2.0 4e4m Homo sapiens TYR_JAK2-2_HUMAN TYR 2.7e-87 298.3 1.0 260.0 260.0 993 994 995 997 999 882 898 902 973 975 974 976.0 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
TYR JAK2-2 JAK2_HUMAN 4E4MD O60674 835 1132 1132.0 0NH:1201 Type1 Active DFGin 6.3044 14.1312 BLAminus -117.3, -162.8 35.37, 82.7 -96.62, 19.05 298.07, 93.7 -70.19, -12.95 in-in in 8.4961 Saltbr-in 3.2274 HRD-in -71.15, -48.12 79.59, -3.5 in-in-in SNCiii in-in ActLoopNT-in 2.7926 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -85.18, 63.68 APE9-dihe-in -53.04, 143.19 APE8-dihe-in -78.69, 70.09 APE8-rot-na 32.31 APE67-dihe-in -79.35, -2.96 -56.35, -30.0 APE12-dist-na 14.2879 APE11-dist-na 12.1109 APE10-dist-na 12.7228 APE9-dist-in 7.8231 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.25 0.193 0.25 D 302.0 298.0 0 31 31 0 [[545, 807], [849, 1125]] 2.0 4e4m Homo sapiens TYR_JAK2-2_HUMAN TYR 2.7e-87 298.3 1.0 260.0 260.0 993 994 995 997 999 882 898 902 973 975 974 976.0 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
TYR JAK2-2 JAK2_HUMAN 4E4ME O60674 835 1132 1132.0 0NH:1201 Type1 Active DFGin 6.1504 13.9693 BLAminus -129.52, -159.3 35.39, 81.53 -94.01, 23.95 298.27, 88.38 -61.49, -26.33 in-in in 8.438 Saltbr-in 2.7197 HRD-in -66.9, -47.68 77.51, -1.6 in-in-in SNCiii in-in ActLoopNT-in 2.7508 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -67.74, 130.71 APE9-dihe-in -111.94, 154.92 APE8-dihe-in -81.89, 77.11 APE8-rot-na 32.96 APE67-dihe-in -74.64, -3.77 -64.87, -30.41 APE12-dist-na 13.7245 APE11-dist-na 13.0291 APE10-dist-na 12.6587 APE9-dist-in 7.8739 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.25 0.193 0.25 E 302.0 298.0 0 31 31 0 [[545, 807], [849, 1125]] 2.0 4e4m Homo sapiens TYR_JAK2-2_HUMAN TYR 2.7e-87 298.3 1.0 260.0 260.0 993 994 995 997 999 882 898 902 973 975 974 976.0 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2

PDB: 4E4M — TYR JAK2_HUMAN

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name