PDB: 2HZ4 — TYR ABL1_HUMAN

Total number of chains: 3
Active chains: 2
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 100.0% 2HZ4A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR ABL1 ABL1_HUMAN 2HZ4A P00519 234 500 1130.0 4ST:501 Allosteric Inactive DFGin 6.8992 13.3144 BLAminus -141.07, -179.05 61.44, 74.68 -93.23, 11.06 298.48, 103.02 -47.37, -45.58 in-out in 8.0434 Saltbr-out 4.199 HRD-in -73.48, -44.6 66.11, 2.51 out-in-in SNCoii in-in ActLoopNT-in 3.1356 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -110.55, 127.23 APE9-dihe-in -112.0, 154.72 APE8-dihe-in -73.75, 92.13 APE8-rot-na 28.06 APE67-dihe-in -62.73, -9.15 -43.63, -56.72 APE12-dist-na 15.4332 APE11-dist-na 10.6082 APE10-dist-na 12.4721 APE9-dist-in 7.4233 None None None XRAY 2.8 0.22 0.285 A 273.0 262.0 5 29 29 0 [[242, 495]] 1.0 2hz4 TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 2HZ4C P00519 234 500 1130.0 4ST:501 Allosteric Active DFGin 7.1088 13.5166 BLAminus -106.9, 179.4 68.82, 76.0 -90.83, 7.94 295.39, 93.15 -43.83, -23.1 in-in in 7.8776 Saltbr-in 2.737 HRD-in -90.54, -43.68 68.76, 3.22 in-in-in SNCiii in-in ActLoopNT-in 2.9997 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -120.98, 153.91 APE9-dihe-in -143.05, 161.74 APE8-dihe-in -62.63, 109.18 APE8-rot-na 10.02 APE67-dihe-in -54.86, -29.12 -56.69, -54.75 APE12-dist-na 14.9509 APE11-dist-na 10.1567 APE10-dist-na 13.1342 APE9-dist-in 7.4103 None None None XRAY 2.8 0.22 0.285 C 273.0 259.0 8 29 29 0 [[242, 495]] 1.0 2hz4 TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 2HZ4B P00519 233 498 1130.0 4ST:501 Type1 Active DFGin 6.7811 12.9056 BLAminus -136.29, 178.03 62.62, 92.29 -99.12, 17.06 306.64, 102.22 -49.71, -38.7 in-in in 8.1144 Saltbr-in 2.713 HRD-in -96.51, -47.12 66.31, -5.28 in-in-in SNCiii in-in ActLoopNT-in 3.1047 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -93.77, 139.94 APE9-dihe-in -124.12, 153.4 APE8-dihe-in -60.98, 117.48 APE8-rot-na 25.18 APE67-dihe-in -77.16, -10.29 -56.55, -40.66 APE12-dist-na 14.7332 APE11-dist-na 10.0035 APE10-dist-na 12.9963 APE9-dist-in 7.1286 None None None XRAY 2.8 0.22 0.285 B 273.0 261.0 5 29 29 0 [[242, 495]] 1.0 2hz4 TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1

PDB: 2HZ4 — TYR ABL1_HUMAN

Total number of chains: 3
Active chains: 2
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 100.0% 2HZ4A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR ABL1 ABL1_HUMAN 2HZ4A P00519 234 500 1130.0 4ST:501 Allosteric Inactive DFGin 6.8992 13.3144 BLAminus -141.07, -179.05 61.44, 74.68 -93.23, 11.06 298.48, 103.02 -47.37, -45.58 in-out in 8.0434 Saltbr-out 4.199 HRD-in -73.48, -44.6 66.11, 2.51 out-in-in SNCoii in-in ActLoopNT-in 3.1356 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -110.55, 127.23 APE9-dihe-in -112.0, 154.72 APE8-dihe-in -73.75, 92.13 APE8-rot-na 28.06 APE67-dihe-in -62.73, -9.15 -43.63, -56.72 APE12-dist-na 15.4332 APE11-dist-na 10.6082 APE10-dist-na 12.4721 APE9-dist-in 7.4233 None None None XRAY 2.8 0.22 0.285 A 273.0 262.0 5 29 29 0 [[242, 495]] 1.0 2hz4 Homo sapiens TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 2HZ4C P00519 234 500 1130.0 4ST:501 Allosteric Active DFGin 7.1088 13.5166 BLAminus -106.9, 179.4 68.82, 76.0 -90.83, 7.94 295.39, 93.15 -43.83, -23.1 in-in in 7.8776 Saltbr-in 2.737 HRD-in -90.54, -43.68 68.76, 3.22 in-in-in SNCiii in-in ActLoopNT-in 2.9997 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -120.98, 153.91 APE9-dihe-in -143.05, 161.74 APE8-dihe-in -62.63, 109.18 APE8-rot-na 10.02 APE67-dihe-in -54.86, -29.12 -56.69, -54.75 APE12-dist-na 14.9509 APE11-dist-na 10.1567 APE10-dist-na 13.1342 APE9-dist-in 7.4103 None None None XRAY 2.8 0.22 0.285 C 273.0 259.0 8 29 29 0 [[242, 495]] 1.0 2hz4 Homo sapiens TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 2HZ4B P00519 233 498 1130.0 4ST:501 Type1 Active DFGin 6.7811 12.9056 BLAminus -136.29, 178.03 62.62, 92.29 -99.12, 17.06 306.64, 102.22 -49.71, -38.7 in-in in 8.1144 Saltbr-in 2.713 HRD-in -96.51, -47.12 66.31, -5.28 in-in-in SNCiii in-in ActLoopNT-in 3.1047 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -93.77, 139.94 APE9-dihe-in -124.12, 153.4 APE8-dihe-in -60.98, 117.48 APE8-rot-na 25.18 APE67-dihe-in -77.16, -10.29 -56.55, -40.66 APE12-dist-na 14.7332 APE11-dist-na 10.0035 APE10-dist-na 12.9963 APE9-dist-in 7.1286 None None None XRAY 2.8 0.22 0.285 B 273.0 261.0 5 29 29 0 [[242, 495]] 1.0 2hz4 Homo sapiens TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1

PDB: 2HZ4 — TYR ABL1_HUMAN

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name