| Group | Gene | SwissprotID | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TYR | EGFR | EGFR_HUMAN | 2GS7A | P00533 | 703 | 1012 | 1210.0 | ANP:60301 | ATPlike | Inactive | DFGin | 5.3734 | 16.6335 | BLBtrans | -99.51, 171.1 | 60.81, 33.31 | -69.51, 142.46 | 163.35, 73.66 | 92.75, -41.51 | out-out | out | 14.0894 | Saltbr-out | 13.0754 | HRD-in | -69.91, -45.27 | 73.69, -18.97 | out-out-out | SNCooo | out-out | ActLoopNT-out | 6.362 | ActLoopCT-out | TYR | APEdihe_niiai | APEdist_aaao | APE10-dihe-none | 999.0, 134.47 | APE9-dihe-in | -142.48, 136.32 | APE8-dihe-in | -67.69, 63.71 | APE8-rot-na | 37.05 | APE67-dihe-in | -69.28, 11.68 | -49.57, -49.09 | APE12-dist-na | 999.0 | APE11-dist-na | 999.0 | APE10-dist-na | 13.0118 | APE9-dist-out | 8.2 | V948R | None | None | XRAY | 2.6 | 0.258 | 0.298 | A | 330.0 | 281.0 | 4 | 30 | 26 | 4 | [[712, 970]] | 1.0 | 2gs7 | TYR_EGFR_HUMAN | TYR | 8.1e-88 | 300.1 | 3.0 | 259.0 | 257.0 | 854 | 855 | 856 | 858 | 860 | 745 | 762 | 766 | 834 | 836 | 835 | 837.0 | 896 | 884 | 879 | 878 | 877 | 876 | 875 | 874 | 873 | 791 | Epidermal growth factor receptor |
| TYR | EGFR | EGFR_HUMAN | 2GS7B | P00533 | 701 | 1016 | 1210.0 | ANP:60302 | ATPlike | Inactive | DFGin | 5.284 | 16.3489 | BLBtrans | -104.25, 165.26 | 71.85, 26.96 | -61.96, 139.7 | 163.92, 72.26 | 85.01, -32.88 | out-out | out | 13.995 | Saltbr-out | 14.3086 | HRD-in | -67.25, -42.1 | 68.95, -3.07 | out-out-none | SNCoon | out-none | ActLoopNT-out | 6.4734 | ActLoopCT-none | TYR | APEdihe_niiai | APEdist_aaai | APE10-dihe-none | 999.0, 151.84 | APE9-dihe-in | -148.05, 134.8 | APE8-dihe-in | -62.95, 72.83 | APE8-rot-na | 33.79 | APE67-dihe-in | -67.93, 1.22 | -55.72, -45.91 | APE12-dist-na | 999.0 | APE11-dist-na | 999.0 | APE10-dist-na | 13.1301 | APE9-dist-in | 7.9025 | V948R | None | None | XRAY | 2.6 | 0.258 | 0.298 | B | 330.0 | 288.0 | 3 | 30 | 27 | 3 | [[712, 970]] | 1.0 | 2gs7 | TYR_EGFR_HUMAN | TYR | 8.1e-88 | 300.1 | 3.0 | 259.0 | 257.0 | 854 | 855 | 856 | 858 | 860 | 745 | 762 | 766 | 834 | 836 | 835 | 837.0 | 896 | 884 | 879 | 878 | 877 | 876 | 875 | 874 | 873 | 791 | Epidermal growth factor receptor |
| Group | Gene | SwissprotID | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Species | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TYR | EGFR | EGFR_HUMAN | 2GS7A | P00533 | 703 | 1012 | 1210.0 | ANP:60301 | ATPlike | Inactive | DFGin | 5.3734 | 16.6335 | BLBtrans | -99.51, 171.1 | 60.81, 33.31 | -69.51, 142.46 | 163.35, 73.66 | 92.75, -41.51 | out-out | out | 14.0894 | Saltbr-out | 13.0754 | HRD-in | -69.91, -45.27 | 73.69, -18.97 | out-out-out | SNCooo | out-out | ActLoopNT-out | 6.362 | ActLoopCT-out | TYR | APEdihe_niiai | APEdist_aaao | APE10-dihe-none | 999.0, 134.47 | APE9-dihe-in | -142.48, 136.32 | APE8-dihe-in | -67.69, 63.71 | APE8-rot-na | 37.05 | APE67-dihe-in | -69.28, 11.68 | -49.57, -49.09 | APE12-dist-na | 999.0 | APE11-dist-na | 999.0 | APE10-dist-na | 13.0118 | APE9-dist-out | 8.2 | V948R | None | None | XRAY | 2.6 | 0.258 | 0.298 | A | 330.0 | 281.0 | 4 | 30 | 26 | 4 | [[712, 970]] | 1.0 | 2gs7 | Homo sapiens | TYR_EGFR_HUMAN | TYR | 8.1e-88 | 300.1 | 3.0 | 259.0 | 257.0 | 854 | 855 | 856 | 858 | 860 | 745 | 762 | 766 | 834 | 836 | 835 | 837.0 | 896 | 884 | 879 | 878 | 877 | 876 | 875 | 874 | 873 | 791 | Epidermal growth factor receptor |
| TYR | EGFR | EGFR_HUMAN | 2GS7B | P00533 | 701 | 1016 | 1210.0 | ANP:60302 | ATPlike | Inactive | DFGin | 5.284 | 16.3489 | BLBtrans | -104.25, 165.26 | 71.85, 26.96 | -61.96, 139.7 | 163.92, 72.26 | 85.01, -32.88 | out-out | out | 13.995 | Saltbr-out | 14.3086 | HRD-in | -67.25, -42.1 | 68.95, -3.07 | out-out-none | SNCoon | out-none | ActLoopNT-out | 6.4734 | ActLoopCT-none | TYR | APEdihe_niiai | APEdist_aaai | APE10-dihe-none | 999.0, 151.84 | APE9-dihe-in | -148.05, 134.8 | APE8-dihe-in | -62.95, 72.83 | APE8-rot-na | 33.79 | APE67-dihe-in | -67.93, 1.22 | -55.72, -45.91 | APE12-dist-na | 999.0 | APE11-dist-na | 999.0 | APE10-dist-na | 13.1301 | APE9-dist-in | 7.9025 | V948R | None | None | XRAY | 2.6 | 0.258 | 0.298 | B | 330.0 | 288.0 | 3 | 30 | 27 | 3 | [[712, 970]] | 1.0 | 2gs7 | Homo sapiens | TYR_EGFR_HUMAN | TYR | 8.1e-88 | 300.1 | 3.0 | 259.0 | 257.0 | 854 | 855 | 856 | 858 | 860 | 745 | 762 | 766 | 834 | 836 | 835 | 837.0 | 896 | 884 | 879 | 878 | 877 | 876 | 875 | 874 | 873 | 791 | Epidermal growth factor receptor |
| Spatial label | Dihedral label | Number of Chains | Percent | Representative |
|---|
| Group | Gene | SwissprotID | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Species | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
|---|