Ligand: ZD6 (Vandetanib, Caprelsa)

Total number of chains: 1
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 1 100.0% 2IVUA
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR RET RET_HUMAN 2IVUA P07949 703 1012 1114.0 ZD6:63015 Type1 Inactive DFGin 6.687 14.139 BLAminus -133.73, 176.39 56.91, 72.42 -92.01, 6.48 287.74, 90.54 -52.61, -36.06 in-in in 7.509 Saltbr-in 2.697 HRD-in -80.4, -42.15 76.28, -31.91 in-in-out SNCiio in-out ActLoopNT-in 3.004 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -102.14, 16.52 APE9-dihe-in -91.09, 137.53 APE8-dihe-in -54.45, 140.76 APE8-rot-na 328.3 APE67-dihe-in -85.5, -4.86 -63.16, -25.73 APE12-dist-na 13.614 APE11-dist-na 9.285 APE10-dist-na 7.821 APE9-dist-in 5.522 None PTR905 PTR905 XRAY 2.5 0.193 0.248 A 314 286 23 0 0 0 [[724, 1007]] 1.0 2ivu TYR_RET_HUMAN TYR 4.1e-101 343.6 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret

Ligand: ZD6 (Vandetanib, Caprelsa)

Total number of chains: 1
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 1 100.0% 2IVUA
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR RET RET_HUMAN 2IVUA P07949 703 1012 1114.0 ZD6:63015 Type1 Inactive DFGin 6.687 14.139 BLAminus -133.73, 176.39 56.91, 72.42 -92.01, 6.48 287.74, 90.54 -52.61, -36.06 in-in in 7.509 Saltbr-in 2.697 HRD-in -80.4, -42.15 76.28, -31.91 in-in-out SNCiio in-out ActLoopNT-in 3.004 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -102.14, 16.52 APE9-dihe-in -91.09, 137.53 APE8-dihe-in -54.45, 140.76 APE8-rot-na 328.3 APE67-dihe-in -85.5, -4.86 -63.16, -25.73 APE12-dist-na 13.614 APE11-dist-na 9.285 APE10-dist-na 7.821 APE9-dist-in 5.522 None PTR905 PTR905 XRAY 2.5 0.193 0.248 A 314 286 23 0 0 0 [[724, 1007]] 1.0 2ivu Homo sapiens TYR_RET_HUMAN TYR 4.1e-101 343.6 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret

Ligand: ZD6 (Vandetanib, Caprelsa)

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name