Ligand: ZC3

Total number of chains: 4
Active chains: 2
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 5A4LA
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC DYRK1A DYR1A_HUMAN 5A4LA Q13627 134 480 763.0 ZC3:1481 Type1 Active DFGin 7.234 14.766 BLAminus -122.38, 174.21 65.08, 93.49 -114.73, 26.8 284.64, 84.62 -79.93, -25.42 in-in in 8.428 Saltbr-in 3.23 HRD-in -65.21, -42.7 75.91, 6.95 in-in-in SNCiii in-in ActLoopNT-in 3.107 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -114.23, 163.1 APE9-dihe-na 70.58, 145.07 APE8-dihe-in -65.43, 141.62 APE8-rot-in 280.27 APE67-dihe-in -60.3, -30.26 -54.35, -42.8 APE12-dist-in 13.568 APE11-dist-in 11.426 APE10-dist-in 7.797 APE9-dist-in 3.088 None PTR321 PTR321 XRAY 2.73 0.224 0.267 A 368 342 5 0 0 0 [[159, 479]] 1.0 5a4l CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 5A4LB Q13627 133 480 763.0 ZC3:1481 Type1 Inactive DFGin 7.225 15.318 BLAminus -122.33, 174.38 63.37, 78.82 -100.66, 29.63 272.85, 85.35 -76.48, -46.67 in-in in 8.833 Saltbr-in 2.811 HRD-in -57.78, -46.91 78.18, -18.11 in-in-out SNCiio in-out ActLoopNT-in 3.43 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -127.68, 167.12 APE9-dihe-na 66.14, 152.91 APE8-dihe-in -68.52, 139.01 APE8-rot-in 283.99 APE67-dihe-in -47.52, -39.04 -51.76, -60.03 APE12-dist-in 13.532 APE11-dist-in 11.715 APE10-dist-out 8.072 APE9-dist-in 3.289 None PTR321 PTR321 XRAY 2.73 0.224 0.267 B 368 340 8 0 0 0 [[159, 479]] 1.0 5a4l CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 5A4LC Q13627 135 479 763.0 ZC3:1480 Type1 Inactive DFGin 7.006 14.913 BLAminus -127.3, 155.33 73.19, 93.96 -111.33, 27.03 285.01, 85.59 -87.36, -7.31 in-in in 8.652 Saltbr-in 2.868 HRD-in -55.97, -40.82 79.57, -27.3 in-out-out SNCioo out-out ActLoopNT-out 3.704 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -124.41, 154.1 APE9-dihe-na 82.43, 157.05 APE8-dihe-in -75.01, 149.63 APE8-rot-in 309.36 APE67-dihe-in -58.73, -24.55 -56.34, -55.91 APE12-dist-in 13.808 APE11-dist-in 12.046 APE10-dist-out 8.197 APE9-dist-in 3.158 None PTR321 PTR321 XRAY 2.73 0.224 0.267 C 368 333 12 0 0 0 [[159, 479]] 1.0 5a4l CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 5A4LD Q13627 134 479 763.0 ZC3:1480 Type1 Active DFGin 7.353 14.577 BLAminus -132.96, 164.11 69.89, 87.22 -105.39, 34.74 291.55, 76.59 -80.25, -34.64 in-in in 8.659 Saltbr-in 2.941 HRD-in -58.1, -45.98 75.95, 3.48 in-in-in SNCiii in-in ActLoopNT-in 3.239 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.1, 161.63 APE9-dihe-na 71.86, 145.21 APE8-dihe-in -54.07, 139.5 APE8-rot-in 266.11 APE67-dihe-in -50.1, -38.91 -55.61, -48.8 APE12-dist-in 13.859 APE11-dist-in 11.794 APE10-dist-in 7.849 APE9-dist-in 3.338 None PTR321 PTR321 XRAY 2.73 0.224 0.267 D 368 335 11 0 0 0 [[159, 479]] 1.0 5a4l CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A

Ligand: ZC3

Total number of chains: 4
Active chains: 2
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 5A4LA
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC DYRK1A DYR1A_HUMAN 5A4LA Q13627 134 480 763.0 ZC3:1481 Type1 Active DFGin 7.234 14.766 BLAminus -122.38, 174.21 65.08, 93.49 -114.73, 26.8 284.64, 84.62 -79.93, -25.42 in-in in 8.428 Saltbr-in 3.23 HRD-in -65.21, -42.7 75.91, 6.95 in-in-in SNCiii in-in ActLoopNT-in 3.107 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -114.23, 163.1 APE9-dihe-na 70.58, 145.07 APE8-dihe-in -65.43, 141.62 APE8-rot-in 280.27 APE67-dihe-in -60.3, -30.26 -54.35, -42.8 APE12-dist-in 13.568 APE11-dist-in 11.426 APE10-dist-in 7.797 APE9-dist-in 3.088 None PTR321 PTR321 XRAY 2.73 0.224 0.267 A 368 342 5 0 0 0 [[159, 479]] 1.0 5a4l Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 5A4LB Q13627 133 480 763.0 ZC3:1481 Type1 Inactive DFGin 7.225 15.318 BLAminus -122.33, 174.38 63.37, 78.82 -100.66, 29.63 272.85, 85.35 -76.48, -46.67 in-in in 8.833 Saltbr-in 2.811 HRD-in -57.78, -46.91 78.18, -18.11 in-in-out SNCiio in-out ActLoopNT-in 3.43 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -127.68, 167.12 APE9-dihe-na 66.14, 152.91 APE8-dihe-in -68.52, 139.01 APE8-rot-in 283.99 APE67-dihe-in -47.52, -39.04 -51.76, -60.03 APE12-dist-in 13.532 APE11-dist-in 11.715 APE10-dist-out 8.072 APE9-dist-in 3.289 None PTR321 PTR321 XRAY 2.73 0.224 0.267 B 368 340 8 0 0 0 [[159, 479]] 1.0 5a4l Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 5A4LC Q13627 135 479 763.0 ZC3:1480 Type1 Inactive DFGin 7.006 14.913 BLAminus -127.3, 155.33 73.19, 93.96 -111.33, 27.03 285.01, 85.59 -87.36, -7.31 in-in in 8.652 Saltbr-in 2.868 HRD-in -55.97, -40.82 79.57, -27.3 in-out-out SNCioo out-out ActLoopNT-out 3.704 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -124.41, 154.1 APE9-dihe-na 82.43, 157.05 APE8-dihe-in -75.01, 149.63 APE8-rot-in 309.36 APE67-dihe-in -58.73, -24.55 -56.34, -55.91 APE12-dist-in 13.808 APE11-dist-in 12.046 APE10-dist-out 8.197 APE9-dist-in 3.158 None PTR321 PTR321 XRAY 2.73 0.224 0.267 C 368 333 12 0 0 0 [[159, 479]] 1.0 5a4l Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 5A4LD Q13627 134 479 763.0 ZC3:1480 Type1 Active DFGin 7.353 14.577 BLAminus -132.96, 164.11 69.89, 87.22 -105.39, 34.74 291.55, 76.59 -80.25, -34.64 in-in in 8.659 Saltbr-in 2.941 HRD-in -58.1, -45.98 75.95, 3.48 in-in-in SNCiii in-in ActLoopNT-in 3.239 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.1, 161.63 APE9-dihe-na 71.86, 145.21 APE8-dihe-in -54.07, 139.5 APE8-rot-in 266.11 APE67-dihe-in -50.1, -38.91 -55.61, -48.8 APE12-dist-in 13.859 APE11-dist-in 11.794 APE10-dist-in 7.849 APE9-dist-in 3.338 None PTR321 PTR321 XRAY 2.73 0.224 0.267 D 368 335 11 0 0 0 [[159, 479]] 1.0 5a4l Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A

Ligand: ZC3

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name