Ligand: YOX

Total number of chains: 4
Active chains: 3
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 8R8EA
All chains - renumbered by
Uniprot PDB Alignment

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Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC DYRK1A DYR1A_HUMAN 8R8EA Q13627 135 481 763.0 YOX:501 Type1 Inactive DFGin 7.024 14.505 BLAminus -129.01, 171.95 62.59, 74.26 -89.71, 28.71 287.29, 75.01 -75.72, -10.22 in-in in 8.616 Saltbr-in 2.892 HRD-in -63.02, -47.54 76.3, -2.75 in-in-out SNCiio in-out ActLoopNT-in 2.91 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -143.31, 169.2 APE9-dihe-na 75.21, 146.05 APE8-dihe-in -69.06, 139.75 APE8-rot-out 193.55 APE67-dihe-in -59.48, -26.23 -55.55, -45.75 APE12-dist-in 12.641 APE11-dist-in 11.084 APE10-dist-in 6.734 APE9-dist-in 3.115 None PTR321 PTR321 XRAY 2.22 0.2 0.234 A 361 347 0 0 0 0 [[159, 479]] 1.0 8r8e CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 8R8EB Q13627 135 481 763.0 YOX:502 Type1 Active DFGin 7.069 14.684 BLAminus -127.98, 172.63 62.79, 73.8 -88.81, 28.19 285.67, 76.47 -75.54, -11.12 in-in in 8.71 Saltbr-in 2.951 HRD-in -62.54, -47.06 75.87, -2.9 in-in-in SNCiii in-in ActLoopNT-in 2.845 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.14, 171.54 APE9-dihe-na 74.42, 146.08 APE8-dihe-in -67.71, 141.78 APE8-rot-in 282.59 APE67-dihe-in -59.51, -26.74 -54.99, -45.67 APE12-dist-in 12.585 APE11-dist-in 11.047 APE10-dist-in 6.756 APE9-dist-in 3.113 None PTR321 PTR321 XRAY 2.22 0.2 0.234 B 361 347 0 0 0 0 [[159, 479]] 1.0 8r8e CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 8R8EC Q13627 136 481 763.0 YOX:502 Type1 Active DFGin 7.188 14.623 BLAminus -130.04, 167.44 62.25, 73.8 -89.0, 26.94 285.37, 75.31 -74.67, -11.09 in-in in 8.643 Saltbr-in 2.589 HRD-in -61.57, -46.23 75.55, -3.28 in-in-in SNCiii in-in ActLoopNT-in 2.85 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.37, 171.41 APE9-dihe-na 75.31, 148.56 APE8-dihe-in -65.26, 141.68 APE8-rot-in 281.12 APE67-dihe-in -59.77, -26.63 -54.67, -46.17 APE12-dist-in 12.705 APE11-dist-in 11.607 APE10-dist-in 7.189 APE9-dist-in 3.167 None PTR321 PTR321 XRAY 2.22 0.2 0.234 C 361 346 0 0 0 0 [[159, 479]] 1.0 8r8e CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 8R8ED Q13627 135 480 763.0 YOX:501 Type1 Active DFGin 7.027 14.622 BLAminus -127.82, 174.49 61.5, 72.32 -89.25, 27.64 284.65, 74.88 -76.43, -9.3 in-in in 8.69 Saltbr-in 2.92 HRD-in -62.74, -44.79 74.53, -3.37 in-in-in SNCiii in-in ActLoopNT-in 2.679 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.28, 171.24 APE9-dihe-na 73.58, 146.12 APE8-dihe-in -67.75, 140.76 APE8-rot-in 279.97 APE67-dihe-in -58.05, -26.12 -56.64, -45.76 APE12-dist-in 12.399 APE11-dist-in 11.386 APE10-dist-in 6.834 APE9-dist-in 3.119 None None None XRAY 2.22 0.2 0.234 D 361 346 0 0 0 0 [[159, 479]] 1.0 8r8e CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A

Ligand: YOX

Total number of chains: 4
Active chains: 3
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 8R8EA
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC DYRK1A DYR1A_HUMAN 8R8EA Q13627 135 481 763.0 YOX:501 Type1 Inactive DFGin 7.024 14.505 BLAminus -129.01, 171.95 62.59, 74.26 -89.71, 28.71 287.29, 75.01 -75.72, -10.22 in-in in 8.616 Saltbr-in 2.892 HRD-in -63.02, -47.54 76.3, -2.75 in-in-out SNCiio in-out ActLoopNT-in 2.91 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -143.31, 169.2 APE9-dihe-na 75.21, 146.05 APE8-dihe-in -69.06, 139.75 APE8-rot-out 193.55 APE67-dihe-in -59.48, -26.23 -55.55, -45.75 APE12-dist-in 12.641 APE11-dist-in 11.084 APE10-dist-in 6.734 APE9-dist-in 3.115 None PTR321 PTR321 XRAY 2.22 0.2 0.234 A 361 347 0 0 0 0 [[159, 479]] 1.0 8r8e Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 8R8EB Q13627 135 481 763.0 YOX:502 Type1 Active DFGin 7.069 14.684 BLAminus -127.98, 172.63 62.79, 73.8 -88.81, 28.19 285.67, 76.47 -75.54, -11.12 in-in in 8.71 Saltbr-in 2.951 HRD-in -62.54, -47.06 75.87, -2.9 in-in-in SNCiii in-in ActLoopNT-in 2.845 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.14, 171.54 APE9-dihe-na 74.42, 146.08 APE8-dihe-in -67.71, 141.78 APE8-rot-in 282.59 APE67-dihe-in -59.51, -26.74 -54.99, -45.67 APE12-dist-in 12.585 APE11-dist-in 11.047 APE10-dist-in 6.756 APE9-dist-in 3.113 None PTR321 PTR321 XRAY 2.22 0.2 0.234 B 361 347 0 0 0 0 [[159, 479]] 1.0 8r8e Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 8R8EC Q13627 136 481 763.0 YOX:502 Type1 Active DFGin 7.188 14.623 BLAminus -130.04, 167.44 62.25, 73.8 -89.0, 26.94 285.37, 75.31 -74.67, -11.09 in-in in 8.643 Saltbr-in 2.589 HRD-in -61.57, -46.23 75.55, -3.28 in-in-in SNCiii in-in ActLoopNT-in 2.85 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.37, 171.41 APE9-dihe-na 75.31, 148.56 APE8-dihe-in -65.26, 141.68 APE8-rot-in 281.12 APE67-dihe-in -59.77, -26.63 -54.67, -46.17 APE12-dist-in 12.705 APE11-dist-in 11.607 APE10-dist-in 7.189 APE9-dist-in 3.167 None PTR321 PTR321 XRAY 2.22 0.2 0.234 C 361 346 0 0 0 0 [[159, 479]] 1.0 8r8e Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 8R8ED Q13627 135 480 763.0 YOX:501 Type1 Active DFGin 7.027 14.622 BLAminus -127.82, 174.49 61.5, 72.32 -89.25, 27.64 284.65, 74.88 -76.43, -9.3 in-in in 8.69 Saltbr-in 2.92 HRD-in -62.74, -44.79 74.53, -3.37 in-in-in SNCiii in-in ActLoopNT-in 2.679 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.28, 171.24 APE9-dihe-na 73.58, 146.12 APE8-dihe-in -67.75, 140.76 APE8-rot-in 279.97 APE67-dihe-in -58.05, -26.12 -56.64, -45.76 APE12-dist-in 12.399 APE11-dist-in 11.386 APE10-dist-in 6.834 APE9-dist-in 3.119 None None None XRAY 2.22 0.2 0.234 D 361 346 0 0 0 0 [[159, 479]] 1.0 8r8e Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A

Ligand: YOX

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name