Ligand: YK2

Total number of chains: 2
Active chains: 1
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 100.0% 7EJVB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC DYRK2 DYRK2_HUMAN 7EJVA Q92630 151 537 601.0 YK2:60501 Type1 Active DFGin 6.9004 15.4242 BLAminus -121.6, -175.71 52.95, 74.47 -89.12, 21.12 283.92, 70.74 -60.92, -24.61 in-in in 8.9819 Saltbr-in 3.1299 HRD-in -72.41, -42.76 75.36, 0.64 in-in-in SNCiii in-in ActLoopNT-in 2.7545 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.92, 162.27 APE9-dihe-na 76.47, 145.84 APE8-dihe-in -66.78, 142.47 APE8-rot-in 275.38 APE67-dihe-in -56.79, -30.59 -58.46, -46.41 APE12-dist-in 12.9176 APE11-dist-in 11.2975 APE10-dist-in 6.969 APE9-dist-in 3.3038 None PTR382 PTR382 XRAY 2.5 0.202 0.246 A 387.0 385.0 2 25 25 0 [[222, 535]] 1.0 7ejv CMGC_DYRK2_HUMAN CMGC 1e-98 336.2 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
CMGC DYRK2 DYRK2_HUMAN 7EJVB Q92630 153 543 601.0 YK2:60501 Type1 Inactive DFGin 7.1548 15.7755 BLAminus -119.43, -178.81 52.81, 76.66 -89.1, 19.14 283.4, 73.64 -64.56, -23.63 in-out in 8.918 Saltbr-out 3.6232 HRD-in -70.75, -42.53 75.19, 1.74 out-in-in SNCoii in-in ActLoopNT-in 2.8738 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.05, 163.39 APE9-dihe-na 74.33, 145.19 APE8-dihe-in -65.87, 144.25 APE8-rot-in 282.1 APE67-dihe-in -56.42, -28.58 -55.11, -50.7 APE12-dist-in 13.0281 APE11-dist-in 11.7681 APE10-dist-in 7.5692 APE9-dist-in 3.367 None PTR382 PTR382 XRAY 2.5 0.202 0.246 B 391.0 391.0 0 25 25 0 [[222, 535]] 1.0 7ejv CMGC_DYRK2_HUMAN CMGC 1.1e-98 336.2 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2

Ligand: YK2

Total number of chains: 2
Active chains: 1
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 100.0% 7EJVB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC DYRK2 DYRK2_HUMAN 7EJVA Q92630 151 537 601.0 YK2:60501 Type1 Active DFGin 6.9004 15.4242 BLAminus -121.6, -175.71 52.95, 74.47 -89.12, 21.12 283.92, 70.74 -60.92, -24.61 in-in in 8.9819 Saltbr-in 3.1299 HRD-in -72.41, -42.76 75.36, 0.64 in-in-in SNCiii in-in ActLoopNT-in 2.7545 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.92, 162.27 APE9-dihe-na 76.47, 145.84 APE8-dihe-in -66.78, 142.47 APE8-rot-in 275.38 APE67-dihe-in -56.79, -30.59 -58.46, -46.41 APE12-dist-in 12.9176 APE11-dist-in 11.2975 APE10-dist-in 6.969 APE9-dist-in 3.3038 None PTR382 PTR382 XRAY 2.5 0.202 0.246 A 387.0 385.0 2 25 25 0 [[222, 535]] 1.0 7ejv Homo sapiens CMGC_DYRK2_HUMAN CMGC 1e-98 336.2 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
CMGC DYRK2 DYRK2_HUMAN 7EJVB Q92630 153 543 601.0 YK2:60501 Type1 Inactive DFGin 7.1548 15.7755 BLAminus -119.43, -178.81 52.81, 76.66 -89.1, 19.14 283.4, 73.64 -64.56, -23.63 in-out in 8.918 Saltbr-out 3.6232 HRD-in -70.75, -42.53 75.19, 1.74 out-in-in SNCoii in-in ActLoopNT-in 2.8738 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.05, 163.39 APE9-dihe-na 74.33, 145.19 APE8-dihe-in -65.87, 144.25 APE8-rot-in 282.1 APE67-dihe-in -56.42, -28.58 -55.11, -50.7 APE12-dist-in 13.0281 APE11-dist-in 11.7681 APE10-dist-in 7.5692 APE9-dist-in 3.367 None PTR382 PTR382 XRAY 2.5 0.202 0.246 B 391.0 391.0 0 25 25 0 [[222, 535]] 1.0 7ejv Homo sapiens CMGC_DYRK2_HUMAN CMGC 1.1e-98 336.2 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2

Ligand: YK2

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name