Ligand: V25

Total number of chains: 4
Active chains: 2
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 6QTYA
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CLK1 CLK1_HUMAN 6QTYA P49759 149 481 484.0 V25:501 Type1 Active DFGin 7.189 13.828 BLAminus -129.69, 172.83 71.11, 83.55 -99.13, 16.45 297.38, 96.6 -71.94, -15.11 in-in in 8.324 Saltbr-in 2.651 HRD-in -69.24, -51.3 77.68, -14.79 in-in-in SNCiii in-in ActLoopNT-in 2.904 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.16, 166.1 APE9-dihe-na 76.64, 158.21 APE8-dihe-in -87.0, 137.14 APE8-rot-in 293.42 APE67-dihe-in -62.6, -10.5 -44.79, -53.3 APE12-dist-in 12.981 APE11-dist-in 11.463 APE10-dist-in 7.478 APE9-dist-in 3.088 None None None XRAY 1.65 0.139 0.203 A 337 333 0 0 0 0 [[161, 477]] 1.0 6qty CMGC_CLK1_HUMAN CMGC 1.9e-93 318.9 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CMGC CLK1 CLK1_HUMAN 2VAGA P49759 148 481 484.0 V25:61482 Type1 Inactive DFGin 7.108 14.026 BLAminus -129.43, 175.64 66.18, 85.97 -104.96, 23.22 293.24, 95.17 -73.67, -15.41 in-in in 8.37 Saltbr-in 2.627 HRD-in -71.48, -53.18 82.14, -13.71 in-in-out SNCiio in-out ActLoopNT-in 2.844 ActLoopCT-out nonTYR APEdihe_aaino APEdist_oioo APE10-dihe-na -88.11, 138.68 APE9-dihe-na -83.4, -165.24 APE8-dihe-in -49.62, 134.22 APE8-rot-none 999.0 APE67-dihe-out -47.82, -50.26 -151.88, 142.32 APE12-dist-out 14.065 APE11-dist-in 12.864 APE10-dist-out 9.777 APE9-dist-out 8.618 None SEP341,TPO342 SEP341,TPO342 XRAY 1.8 0.182 0.225 A 339 331 3 0 0 0 [[161, 477]] 1.0 2vag CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CMGC CLK1 CLK1_HUMAN 6TW2E P49759 148 484 484.0 V25:62301 Type1 Inactive DFGin 7.105 14.057 BLAminus -132.08, 175.35 68.1, 86.44 -104.28, 22.11 293.58, 88.16 -72.28, -16.22 in-in in 8.371 Saltbr-in 2.607 HRD-in -73.71, -50.29 77.69, -11.9 in-in-out SNCiio in-out ActLoopNT-in 2.874 ActLoopCT-out nonTYR APEdihe_aanao APEdist_oioo APE10-dihe-na -119.46, 133.12 APE9-dihe-na 999.0, -6.85 APE8-dihe-none 999.0, 103.3 APE8-rot-na 296.95 APE67-dihe-out -59.07, -41.0 14.44, 142.85 APE12-dist-out 14.85 APE11-dist-in 13.583 APE10-dist-out 9.947 APE9-dist-out 8.792 None SEP341,TPO342 SEP341,TPO342 XRAY 1.8 0.183 0.223 E 339 333 4 0 0 0 [[161, 477]] 1.0 6tw2 CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CMGC CLK3 CLK3_HUMAN 2WU7A P49761 135 482 490.0 V25:1483 Type1 Active DFGin 7.241 14.714 BLAminus -114.75, 172.06 62.02, 79.06 -94.21, 16.42 291.52, 93.21 -58.97, -25.24 in-in in 8.664 Saltbr-in 2.623 HRD-in -60.15, -57.82 78.68, -17.46 in-in-in SNCiii in-in ActLoopNT-in 2.814 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.77, 172.35 APE9-dihe-na 73.64, 152.38 APE8-dihe-in -73.02, 138.27 APE8-rot-in 276.31 APE67-dihe-in -55.71, -20.76 -37.92, -58.02 APE12-dist-in 13.825 APE11-dist-in 11.773 APE10-dist-in 7.437 APE9-dist-in 2.965 None None None XRAY 2.25 0.193 0.246 A 381 348 2 0 0 0 [[156, 472]] 1.0 2wu7 CMGC_CLK3_HUMAN CMGC 1.5e-90 309.4 1 301 301 319 320 321 323 325 186 201 205 280 282 281 283 356 344 339 338 337 336 335 334 333 237 Dual specificity protein kinase CLK3

Ligand: V25

Total number of chains: 4
Active chains: 2
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 6QTYA
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CLK1 CLK1_HUMAN 6QTYA P49759 149 481 484.0 V25:501 Type1 Active DFGin 7.189 13.828 BLAminus -129.69, 172.83 71.11, 83.55 -99.13, 16.45 297.38, 96.6 -71.94, -15.11 in-in in 8.324 Saltbr-in 2.651 HRD-in -69.24, -51.3 77.68, -14.79 in-in-in SNCiii in-in ActLoopNT-in 2.904 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.16, 166.1 APE9-dihe-na 76.64, 158.21 APE8-dihe-in -87.0, 137.14 APE8-rot-in 293.42 APE67-dihe-in -62.6, -10.5 -44.79, -53.3 APE12-dist-in 12.981 APE11-dist-in 11.463 APE10-dist-in 7.478 APE9-dist-in 3.088 None None None XRAY 1.65 0.139 0.203 A 337 333 0 0 0 0 [[161, 477]] 1.0 6qty Homo sapiens CMGC_CLK1_HUMAN CMGC 1.9e-93 318.9 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CMGC CLK1 CLK1_HUMAN 2VAGA P49759 148 481 484.0 V25:61482 Type1 Inactive DFGin 7.108 14.026 BLAminus -129.43, 175.64 66.18, 85.97 -104.96, 23.22 293.24, 95.17 -73.67, -15.41 in-in in 8.37 Saltbr-in 2.627 HRD-in -71.48, -53.18 82.14, -13.71 in-in-out SNCiio in-out ActLoopNT-in 2.844 ActLoopCT-out nonTYR APEdihe_aaino APEdist_oioo APE10-dihe-na -88.11, 138.68 APE9-dihe-na -83.4, -165.24 APE8-dihe-in -49.62, 134.22 APE8-rot-none 999.0 APE67-dihe-out -47.82, -50.26 -151.88, 142.32 APE12-dist-out 14.065 APE11-dist-in 12.864 APE10-dist-out 9.777 APE9-dist-out 8.618 None SEP341,TPO342 SEP341,TPO342 XRAY 1.8 0.182 0.225 A 339 331 3 0 0 0 [[161, 477]] 1.0 2vag Homo sapiens CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CMGC CLK1 CLK1_HUMAN 6TW2E P49759 148 484 484.0 V25:62301 Type1 Inactive DFGin 7.105 14.057 BLAminus -132.08, 175.35 68.1, 86.44 -104.28, 22.11 293.58, 88.16 -72.28, -16.22 in-in in 8.371 Saltbr-in 2.607 HRD-in -73.71, -50.29 77.69, -11.9 in-in-out SNCiio in-out ActLoopNT-in 2.874 ActLoopCT-out nonTYR APEdihe_aanao APEdist_oioo APE10-dihe-na -119.46, 133.12 APE9-dihe-na 999.0, -6.85 APE8-dihe-none 999.0, 103.3 APE8-rot-na 296.95 APE67-dihe-out -59.07, -41.0 14.44, 142.85 APE12-dist-out 14.85 APE11-dist-in 13.583 APE10-dist-out 9.947 APE9-dist-out 8.792 None SEP341,TPO342 SEP341,TPO342 XRAY 1.8 0.183 0.223 E 339 333 4 0 0 0 [[161, 477]] 1.0 6tw2 Homo sapiens CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CMGC CLK3 CLK3_HUMAN 2WU7A P49761 135 482 490.0 V25:1483 Type1 Active DFGin 7.241 14.714 BLAminus -114.75, 172.06 62.02, 79.06 -94.21, 16.42 291.52, 93.21 -58.97, -25.24 in-in in 8.664 Saltbr-in 2.623 HRD-in -60.15, -57.82 78.68, -17.46 in-in-in SNCiii in-in ActLoopNT-in 2.814 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.77, 172.35 APE9-dihe-na 73.64, 152.38 APE8-dihe-in -73.02, 138.27 APE8-rot-in 276.31 APE67-dihe-in -55.71, -20.76 -37.92, -58.02 APE12-dist-in 13.825 APE11-dist-in 11.773 APE10-dist-in 7.437 APE9-dist-in 2.965 None None None XRAY 2.25 0.193 0.246 A 381 348 2 0 0 0 [[156, 472]] 1.0 2wu7 Homo sapiens CMGC_CLK3_HUMAN CMGC 1.5e-90 309.4 1 301 301 319 320 321 323 325 186 201 205 280 282 281 283 356 344 339 338 337 336 335 334 333 237 Dual specificity protein kinase CLK3

Ligand: V25

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name