Ligand: V25

Total number of chains: 4
Active chains: 2
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 6QTYA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CLK1 CLK1_HUMAN 6QTYA P49759 149 481 484.0 V25:501 Type1 Active DFGin 7.1891 13.8275 BLAminus -129.69, 172.83 71.11, 83.55 -99.13, 16.45 297.38, 96.6 -71.94, -15.11 in-in in 8.3243 Saltbr-in 2.6508 HRD-in -69.24, -51.3 77.68, -14.79 in-in-in SNCiii in-in ActLoopNT-in 2.9043 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.16, 166.1 APE9-dihe-na 76.64, 158.21 APE8-dihe-in -87.0, 137.14 APE8-rot-in 293.42 APE67-dihe-in -62.6, -10.5 -44.79, -53.3 APE12-dist-in 12.9806 APE11-dist-in 11.463 APE10-dist-in 7.4777 APE9-dist-in 3.0885 None None None XRAY 1.65 0.139 0.203 A 337.0 333.0 0 25 25 0 [[161, 477]] 1.0 6qty CMGC_CLK1_HUMAN CMGC 1.9e-93 318.9 1.0 301.0 301.0 324 325 326 328 330 191 206 210 285 287 286 288.0 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CMGC CLK1 CLK1_HUMAN 2VAGA P49759 148 481 484.0 V25:61482 Type1 Inactive DFGin 7.1077 14.0258 BLAminus -129.43, 175.64 66.18, 85.97 -104.96, 23.22 293.24, 95.17 -73.67, -15.41 in-in in 8.37 Saltbr-in 2.6268 HRD-in -71.48, -53.18 82.14, -13.71 in-in-out SNCiio in-out ActLoopNT-in 2.8437 ActLoopCT-out nonTYR APEdihe_aaino APEdist_oioo APE10-dihe-na -88.11, 138.68 APE9-dihe-na -83.4, -165.24 APE8-dihe-in -49.62, 134.22 APE8-rot-none 999.0 APE67-dihe-out -47.82, -50.26 -151.88, 142.32 APE12-dist-out 14.0645 APE11-dist-in 12.8642 APE10-dist-out 9.7767 APE9-dist-out 8.6182 None SEP341,TPO342 SEP341,TPO342 XRAY 1.8 0.182 0.225 A 339.0 331.0 3 25 25 0 [[161, 477]] 1.0 2vag CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1.0 301.0 301.0 324 325 326 328 330 191 206 210 285 287 286 288.0 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CMGC CLK1 CLK1_HUMAN 6TW2E P49759 148 484 484.0 V25:62301 Type1 Inactive DFGin 7.1046 14.057 BLAminus -132.08, 175.35 68.1, 86.44 -104.28, 22.11 293.58, 88.16 -72.28, -16.22 in-in in 8.3715 Saltbr-in 2.6068 HRD-in -73.71, -50.29 77.69, -11.9 in-in-out SNCiio in-out ActLoopNT-in 2.8741 ActLoopCT-out nonTYR APEdihe_aanao APEdist_oioo APE10-dihe-na -119.46, 133.12 APE9-dihe-na 999.0, -6.85 APE8-dihe-none 999.0, 103.3 APE8-rot-na 296.95 APE67-dihe-out -59.07, -41.0 14.44, 142.85 APE12-dist-out 14.8499 APE11-dist-in 13.5831 APE10-dist-out 9.9466 APE9-dist-out 8.7917 None SEP341,TPO342 SEP341,TPO342 XRAY 1.8 0.183 0.223 E 339.0 333.0 4 25 25 0 [[161, 477]] 1.0 6tw2 CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1.0 301.0 301.0 324 325 326 328 330 191 206 210 285 287 286 288.0 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CMGC CLK3 CLK3_HUMAN 2WU7A P49761 135 482 490.0 V25:1483 Type1 Active DFGin 7.2407 14.7136 BLAminus -114.75, 172.06 62.02, 79.06 -94.21, 16.42 291.52, 93.21 -58.97, -25.24 in-in in 8.6635 Saltbr-in 2.623 HRD-in -60.15, -57.82 78.68, -17.46 in-in-in SNCiii in-in ActLoopNT-in 2.8142 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.77, 172.35 APE9-dihe-na 73.64, 152.38 APE8-dihe-in -73.02, 138.27 APE8-rot-in 276.31 APE67-dihe-in -55.71, -20.76 -37.92, -58.02 APE12-dist-in 13.8253 APE11-dist-in 11.7731 APE10-dist-in 7.4367 APE9-dist-in 2.9646 None None None XRAY 2.25 0.193 0.246 A 381.0 348.0 2 25 25 0 [[156, 472]] 1.0 2wu7 CMGC_CLK3_HUMAN CMGC 1.5e-90 309.4 1.0 301.0 301.0 319 320 321 323 325 186 201 205 280 282 281 283.0 356 344 339 338 337 336 335 334 333 237 Dual specificity protein kinase CLK3

Ligand: V25

Total number of chains: 4
Active chains: 2
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 6QTYA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CLK1 CLK1_HUMAN 6QTYA P49759 149 481 484.0 V25:501 Type1 Active DFGin 7.1891 13.8275 BLAminus -129.69, 172.83 71.11, 83.55 -99.13, 16.45 297.38, 96.6 -71.94, -15.11 in-in in 8.3243 Saltbr-in 2.6508 HRD-in -69.24, -51.3 77.68, -14.79 in-in-in SNCiii in-in ActLoopNT-in 2.9043 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.16, 166.1 APE9-dihe-na 76.64, 158.21 APE8-dihe-in -87.0, 137.14 APE8-rot-in 293.42 APE67-dihe-in -62.6, -10.5 -44.79, -53.3 APE12-dist-in 12.9806 APE11-dist-in 11.463 APE10-dist-in 7.4777 APE9-dist-in 3.0885 None None None XRAY 1.65 0.139 0.203 A 337.0 333.0 0 25 25 0 [[161, 477]] 1.0 6qty Homo sapiens CMGC_CLK1_HUMAN CMGC 1.9e-93 318.9 1.0 301.0 301.0 324 325 326 328 330 191 206 210 285 287 286 288.0 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CMGC CLK1 CLK1_HUMAN 2VAGA P49759 148 481 484.0 V25:61482 Type1 Inactive DFGin 7.1077 14.0258 BLAminus -129.43, 175.64 66.18, 85.97 -104.96, 23.22 293.24, 95.17 -73.67, -15.41 in-in in 8.37 Saltbr-in 2.6268 HRD-in -71.48, -53.18 82.14, -13.71 in-in-out SNCiio in-out ActLoopNT-in 2.8437 ActLoopCT-out nonTYR APEdihe_aaino APEdist_oioo APE10-dihe-na -88.11, 138.68 APE9-dihe-na -83.4, -165.24 APE8-dihe-in -49.62, 134.22 APE8-rot-none 999.0 APE67-dihe-out -47.82, -50.26 -151.88, 142.32 APE12-dist-out 14.0645 APE11-dist-in 12.8642 APE10-dist-out 9.7767 APE9-dist-out 8.6182 None SEP341,TPO342 SEP341,TPO342 XRAY 1.8 0.182 0.225 A 339.0 331.0 3 25 25 0 [[161, 477]] 1.0 2vag Homo sapiens CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1.0 301.0 301.0 324 325 326 328 330 191 206 210 285 287 286 288.0 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CMGC CLK1 CLK1_HUMAN 6TW2E P49759 148 484 484.0 V25:62301 Type1 Inactive DFGin 7.1046 14.057 BLAminus -132.08, 175.35 68.1, 86.44 -104.28, 22.11 293.58, 88.16 -72.28, -16.22 in-in in 8.3715 Saltbr-in 2.6068 HRD-in -73.71, -50.29 77.69, -11.9 in-in-out SNCiio in-out ActLoopNT-in 2.8741 ActLoopCT-out nonTYR APEdihe_aanao APEdist_oioo APE10-dihe-na -119.46, 133.12 APE9-dihe-na 999.0, -6.85 APE8-dihe-none 999.0, 103.3 APE8-rot-na 296.95 APE67-dihe-out -59.07, -41.0 14.44, 142.85 APE12-dist-out 14.8499 APE11-dist-in 13.5831 APE10-dist-out 9.9466 APE9-dist-out 8.7917 None SEP341,TPO342 SEP341,TPO342 XRAY 1.8 0.183 0.223 E 339.0 333.0 4 25 25 0 [[161, 477]] 1.0 6tw2 Homo sapiens CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1.0 301.0 301.0 324 325 326 328 330 191 206 210 285 287 286 288.0 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CMGC CLK3 CLK3_HUMAN 2WU7A P49761 135 482 490.0 V25:1483 Type1 Active DFGin 7.2407 14.7136 BLAminus -114.75, 172.06 62.02, 79.06 -94.21, 16.42 291.52, 93.21 -58.97, -25.24 in-in in 8.6635 Saltbr-in 2.623 HRD-in -60.15, -57.82 78.68, -17.46 in-in-in SNCiii in-in ActLoopNT-in 2.8142 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.77, 172.35 APE9-dihe-na 73.64, 152.38 APE8-dihe-in -73.02, 138.27 APE8-rot-in 276.31 APE67-dihe-in -55.71, -20.76 -37.92, -58.02 APE12-dist-in 13.8253 APE11-dist-in 11.7731 APE10-dist-in 7.4367 APE9-dist-in 2.9646 None None None XRAY 2.25 0.193 0.246 A 381.0 348.0 2 25 25 0 [[156, 472]] 1.0 2wu7 Homo sapiens CMGC_CLK3_HUMAN CMGC 1.5e-90 309.4 1.0 301.0 301.0 319 320 321 323 325 186 201 205 280 282 281 283.0 356 344 339 338 337 336 335 334 333 237 Dual specificity protein kinase CLK3

Ligand: V25

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name