Ligand: UUG

Total number of chains: 2
Active chains: 2
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 100.0% 9ESSA
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CDK2 CDK2_HUMAN 9ESSA P24941 1 298 298.0 UUG:60601,UUG:60603,UUG:60604,UUG:60605 Allosteric,Type1,Allosteric,Allosteric Active DFGin 6.695 15.291 BLAminus -143.55, -172.69 50.57, 82.8 -101.61, 18.26 274.16, 75.73 -70.34, -22.45 in-in in 8.76 Saltbr-in 3.285 HRD-in -76.11, -53.71 67.29, 25.09 in-in-in SNCiii in-in ActLoopNT-in 2.856 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.09, 136.89 APE9-dihe-na 78.9, 132.52 APE8-dihe-in -60.77, 137.94 APE8-rot-in 287.48 APE67-dihe-in -68.63, -13.58 -48.45, -45.96 APE12-dist-in 12.975 APE11-dist-in 10.05 APE10-dist-in 7.581 APE9-dist-in 3.313 None TPO160 TPO160 XRAY 2.44 0.212 0.219 A 302 298 0 0 0 0 [[4, 286]] 1.0 9ess CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 9ESSC P24941 1 296 298.0 UUG:60501,UUG:60502 Type1,Allosteric Active DFGin 6.631 14.933 BLAminus -142.84, 175.97 51.2, 79.73 -89.56, 21.72 284.95, 67.51 -58.42, -34.37 in-in in 8.295 Saltbr-in 2.868 HRD-in -75.14, -63.05 75.45, 9.68 in-in-in SNCiii in-in ActLoopNT-in 2.962 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.9, 146.77 APE9-dihe-na 74.13, 121.78 APE8-dihe-in -44.27, 147.71 APE8-rot-in 310.11 APE67-dihe-in -53.57, -23.24 -51.44, -55.49 APE12-dist-in 12.636 APE11-dist-in 9.974 APE10-dist-in 6.855 APE9-dist-in 3.245 None TPO160 TPO160 XRAY 2.44 0.212 0.219 C 302 265 31 0 0 0 [[4, 286]] 1.0 9ess CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2

Ligand: UUG

Total number of chains: 2
Active chains: 2
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 100.0% 9ESSA
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CDK2 CDK2_HUMAN 9ESSA P24941 1 298 298.0 UUG:60601,UUG:60603,UUG:60604,UUG:60605 Allosteric,Type1,Allosteric,Allosteric Active DFGin 6.695 15.291 BLAminus -143.55, -172.69 50.57, 82.8 -101.61, 18.26 274.16, 75.73 -70.34, -22.45 in-in in 8.76 Saltbr-in 3.285 HRD-in -76.11, -53.71 67.29, 25.09 in-in-in SNCiii in-in ActLoopNT-in 2.856 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.09, 136.89 APE9-dihe-na 78.9, 132.52 APE8-dihe-in -60.77, 137.94 APE8-rot-in 287.48 APE67-dihe-in -68.63, -13.58 -48.45, -45.96 APE12-dist-in 12.975 APE11-dist-in 10.05 APE10-dist-in 7.581 APE9-dist-in 3.313 None TPO160 TPO160 XRAY 2.44 0.212 0.219 A 302 298 0 0 0 0 [[4, 286]] 1.0 9ess Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 9ESSC P24941 1 296 298.0 UUG:60501,UUG:60502 Type1,Allosteric Active DFGin 6.631 14.933 BLAminus -142.84, 175.97 51.2, 79.73 -89.56, 21.72 284.95, 67.51 -58.42, -34.37 in-in in 8.295 Saltbr-in 2.868 HRD-in -75.14, -63.05 75.45, 9.68 in-in-in SNCiii in-in ActLoopNT-in 2.962 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.9, 146.77 APE9-dihe-na 74.13, 121.78 APE8-dihe-in -44.27, 147.71 APE8-rot-in 310.11 APE67-dihe-in -53.57, -23.24 -51.44, -55.49 APE12-dist-in 12.636 APE11-dist-in 9.974 APE10-dist-in 6.855 APE9-dist-in 3.245 None TPO160 TPO160 XRAY 2.44 0.212 0.219 C 302 265 31 0 0 0 [[4, 286]] 1.0 9ess Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2

Ligand: UUG

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name