Ligand: S91

Total number of chains: 1
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 1 100.0% 2Z8CA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR INSR INSR_HUMAN 2Z8CA P06213 1011 1310 1382.0 S91:60001 Type1 Inactive DFGin 6.401 12.923 BLAminus -126.28, -180.0 45.53, 101.6 -113.26, 32.07 305.0, 102.45 -55.7, -35.78 in-out in 7.4783 Saltbr-out 3.6266 HRD-in -88.34, -29.28 53.1, 14.66 out-in-in SNCoii in-in ActLoopNT-in 2.8483 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -65.92, 127.58 APE9-dihe-in -136.04, 148.74 APE8-dihe-in -92.61, 86.13 APE8-rot-na 40.99 APE67-dihe-in -57.55, -15.17 -59.74, -44.88 APE12-dist-na 14.522 APE11-dist-na 10.6018 APE10-dist-na 9.7643 APE9-dist-in 6.8834 C1008S,Y1011F PTR1185,PTR1189,PTR1190 PTR1185,PTR1189,PTR1190 XRAY 3.25 0.217 0.292 A 303.0 300.0 0 30 30 0 [[1023, 1292]] 1.0 2z8c TYR_INSR_HUMAN TYR 1.4e-96 328.7 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor

Ligand: S91

Total number of chains: 2
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 100.0% 2Z8CA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR INSR INSR_HUMAN 2Z8CA P06213 1011 1310 1382.0 S91:60001 Type1 Inactive DFGin 6.401 12.923 BLAminus -126.28, -180.0 45.53, 101.6 -113.26, 32.07 305.0, 102.45 -55.7, -35.78 in-out in 7.4783 Saltbr-out 3.6266 HRD-in -88.34, -29.28 53.1, 14.66 out-in-in SNCoii in-in ActLoopNT-in 2.8483 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -65.92, 127.58 APE9-dihe-in -136.04, 148.74 APE8-dihe-in -92.61, 86.13 APE8-rot-na 40.99 APE67-dihe-in -57.55, -15.17 -59.74, -44.88 APE12-dist-na 14.522 APE11-dist-na 10.6018 APE10-dist-na 9.7643 APE9-dist-in 6.8834 C1008S,Y1011F PTR1185,PTR1189,PTR1190 PTR1185,PTR1189,PTR1190 XRAY 3.25 0.217 0.292 A 303.0 300.0 0 30 30 0 [[1023, 1292]] 1.0 2z8c Homo sapiens TYR_INSR_HUMAN TYR 1.4e-96 328.7 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
CMGC MAPK1 MK01_RAT 2Z7LA P63086 16 355 358.0 S91:61001 Type1 Inactive DFGin 6.8008 16.4338 BLAminus -136.9, 170.79 66.29, 86.62 -103.07, 34.52 288.59, 65.29 -58.02, -43.27 out-out out 10.2385 Saltbr-out 4.5892 HRD-in -77.28, -55.92 74.77, 0.96 out-in-in SNCoii in-in ActLoopNT-in 2.7255 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -88.62, -49.81 APE9-dihe-na -40.28, 150.05 APE8-dihe-in -49.12, 125.58 APE8-rot-in 308.41 APE67-dihe-in -53.59, -24.0 -51.3, -52.67 APE12-dist-in 13.9992 APE11-dist-in 10.9277 APE10-dist-in 6.843 APE9-dist-in 4.1581 None None None XRAY 2.41 0.223 0.276 A 366.0 329.0 3 31 31 0 [[23, 311]] 1.0 2z7l Rattus norvegicus CMGC_MAPK1_RAT CMGC 1.4e-85 293.1 1.0 301.0 301.0 164 165 166 168 170 52 69 73 144 146 145 147.0 208 195 190 189 188 187 186 185 184 104 Mitogen-activated protein kinase 1

Ligand: S91

Total number of chains: 1
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 1 100.0% 2Z7LA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC MAPK1 MK01_RAT 2Z7LA P63086 16 355 358.0 S91:61001 Type1 Inactive DFGin 6.8008 16.4338 BLAminus -136.9, 170.79 66.29, 86.62 -103.07, 34.52 288.59, 65.29 -58.02, -43.27 out-out out 10.2385 Saltbr-out 4.5892 HRD-in -77.28, -55.92 74.77, 0.96 out-in-in SNCoii in-in ActLoopNT-in 2.7255 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -88.62, -49.81 APE9-dihe-na -40.28, 150.05 APE8-dihe-in -49.12, 125.58 APE8-rot-in 308.41 APE67-dihe-in -53.59, -24.0 -51.3, -52.67 APE12-dist-in 13.9992 APE11-dist-in 10.9277 APE10-dist-in 6.843 APE9-dist-in 4.1581 None None None XRAY 2.41 0.223 0.276 A 366.0 329.0 3 31 31 0 [[23, 311]] 1.0 2z7l Rattus norvegicus CMGC_MAPK1_RAT CMGC 1.4e-85 293.1 1.0 301.0 301.0 164 165 166 168 170 52 69 73 144 146 145 147.0 208 195 190 189 188 187 186 185 184 104 Mitogen-activated protein kinase 1