Ligand: REB

Total number of chains: 5
Active chains: 1
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 5 100.0% 3OP5A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CK1 VRK1 VRK1_HUMAN 3OP5A Q99986 21 341 396.0 REB:365 Type1 Inactive DFGin 7.9531 14.5341 BLAminus -114.82, 176.41 71.01, 96.34 -120.14, 18.32 297.72, 91.95 -64.04, -28.74 in-out in 7.905 Saltbr-out 4.4102 HRD-in -81.17, -51.65 71.32, 4.58 out-in-out SNCoio in-out ActLoopNT-in 2.8086 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -121.23, 18.55 APE9-dihe-na 75.48, -153.65 APE8-dihe-in -102.2, 117.44 APE8-rot-in 299.56 APE67-dihe-in -69.82, -27.08 -41.77, -48.52 APE12-dist-in 9.1954 APE11-dist-out 5.4796 APE10-dist-out 10.8304 APE9-dist-in 3.671 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.4 0.179 0.213 A 364.0 320.0 1 35 35 0 [[37, 326]] 1.0 3op5 CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1.0 261.0 261.0 196 197 198 200 202 71 83 87 174 176 175 177.0 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
CK1 VRK1 VRK1_HUMAN 3OP5B Q99986 21 341 396.0 REB:365 Type1 Inactive DFGin 7.9585 14.6427 BLAminus -113.97, 176.01 71.29, 96.02 -119.19, 18.9 297.8, 91.46 -64.52, -28.62 in-out in 8.1151 Saltbr-out 4.4057 HRD-in -81.96, -51.98 71.81, 3.7 out-in-out SNCoio in-out ActLoopNT-in 2.8098 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -118.98, 15.13 APE9-dihe-na 73.86, -155.53 APE8-dihe-in -100.82, 117.46 APE8-rot-in 300.82 APE67-dihe-in -69.97, -26.87 -41.58, -48.34 APE12-dist-in 9.2659 APE11-dist-out 5.3645 APE10-dist-out 10.7114 APE9-dist-in 3.7292 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.4 0.179 0.213 B 364.0 319.0 2 35 35 0 [[37, 326]] 1.0 3op5 CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1.0 261.0 261.0 196 197 198 200 202 71 83 87 174 176 175 177.0 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
CK1 VRK1 VRK1_HUMAN 3OP5C Q99986 22 341 396.0 REB:365 Type1 Inactive DFGin 7.9202 14.4308 BLAminus -113.54, 176.44 69.75, 97.17 -118.63, 20.05 296.44, 91.45 -64.33, -26.27 in-none in 8.3344 Saltbr-none 999.0 HRD-in -81.5, -52.35 71.18, 5.09 none-in-out SNCnio in-out ActLoopNT-in 2.8269 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -72.8, 159.76 APE9-dihe-na 87.63, -165.14 APE8-dihe-in -90.95, 116.06 APE8-rot-in 302.3 APE67-dihe-in -69.84, -27.29 -42.27, -48.51 APE12-dist-out 15.0487 APE11-dist-in 13.7843 APE10-dist-in 7.9657 APE9-dist-in 4.0068 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.4 0.179 0.213 C 364.0 308.0 12 35 35 0 [[37, 326]] 1.0 3op5 CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1.0 261.0 261.0 196 197 198 200 202 71 83 87 174 176 175 177.0 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
CK1 VRK1 VRK1_HUMAN 3OP5D Q99986 25 341 396.0 REB:365 Type1 Inactive DFGin 7.969 14.4525 BLAminus -112.89, 176.13 70.95, 97.27 -119.85, 19.74 297.32, 91.51 -64.31, -27.23 in-none in 7.9254 Saltbr-none 999.0 HRD-in -80.63, -52.15 71.05, 5.02 none-in-out SNCnio in-out ActLoopNT-in 2.8279 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooi APE10-dihe-na -69.13, 152.48 APE9-dihe-na 88.04, -168.28 APE8-dihe-in -88.02, 114.99 APE8-rot-in 302.83 APE67-dihe-in -62.29, -38.34 -40.98, -47.51 APE12-dist-out 15.3041 APE11-dist-out 14.0064 APE10-dist-out 8.2938 APE9-dist-in 4.0011 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.4 0.179 0.213 D 364.0 302.0 15 35 35 0 [[37, 326]] 1.0 3op5 CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1.0 261.0 261.0 196 197 198 200 202 71 83 87 174 176 175 177.0 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
CK1 VRK2 VRK2_HUMAN 9FETA Q86Y07 15 330 508.0 REB:401 Type1.5_Back Active DFGin 7.7569 14.1775 BLAminus -126.51, -179.88 62.99, 75.15 -90.88, 34.72 299.05, 76.11 -73.88, -23.01 in-in in 7.4719 Saltbr-in 3.1195 HRD-in -79.75, -50.35 72.0, 10.87 in-in-in SNCiii in-in ActLoopNT-in 2.8102 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -84.38, 169.25 APE9-dihe-na 101.33, -175.93 APE8-dihe-in -76.93, 108.74 APE8-rot-in 301.77 APE67-dihe-in -59.32, -37.67 -45.84, -39.32 APE12-dist-in 13.5609 APE11-dist-in 13.6582 APE10-dist-in 7.9227 APE9-dist-in 4.6041 None None None XRAY 2.4 0.224 0.269 A 324.0 313.0 3 35 35 0 [[29, 315]] 1.0 9fet CK1_VRK2_HUMAN CK1 1.6e-103 351.6 1.0 261.0 261.0 185 186 187 189 191 61 73 77 163 165 164 166.0 232 220 215 214 213 212 211 210 209 122 Serine/threonine-protein kinase VRK2

Ligand: REB

Total number of chains: 5
Active chains: 1
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 5 100.0% 3OP5A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CK1 VRK1 VRK1_HUMAN 3OP5A Q99986 21 341 396.0 REB:365 Type1 Inactive DFGin 7.9531 14.5341 BLAminus -114.82, 176.41 71.01, 96.34 -120.14, 18.32 297.72, 91.95 -64.04, -28.74 in-out in 7.905 Saltbr-out 4.4102 HRD-in -81.17, -51.65 71.32, 4.58 out-in-out SNCoio in-out ActLoopNT-in 2.8086 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -121.23, 18.55 APE9-dihe-na 75.48, -153.65 APE8-dihe-in -102.2, 117.44 APE8-rot-in 299.56 APE67-dihe-in -69.82, -27.08 -41.77, -48.52 APE12-dist-in 9.1954 APE11-dist-out 5.4796 APE10-dist-out 10.8304 APE9-dist-in 3.671 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.4 0.179 0.213 A 364.0 320.0 1 35 35 0 [[37, 326]] 1.0 3op5 Homo sapiens CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1.0 261.0 261.0 196 197 198 200 202 71 83 87 174 176 175 177.0 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
CK1 VRK1 VRK1_HUMAN 3OP5B Q99986 21 341 396.0 REB:365 Type1 Inactive DFGin 7.9585 14.6427 BLAminus -113.97, 176.01 71.29, 96.02 -119.19, 18.9 297.8, 91.46 -64.52, -28.62 in-out in 8.1151 Saltbr-out 4.4057 HRD-in -81.96, -51.98 71.81, 3.7 out-in-out SNCoio in-out ActLoopNT-in 2.8098 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -118.98, 15.13 APE9-dihe-na 73.86, -155.53 APE8-dihe-in -100.82, 117.46 APE8-rot-in 300.82 APE67-dihe-in -69.97, -26.87 -41.58, -48.34 APE12-dist-in 9.2659 APE11-dist-out 5.3645 APE10-dist-out 10.7114 APE9-dist-in 3.7292 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.4 0.179 0.213 B 364.0 319.0 2 35 35 0 [[37, 326]] 1.0 3op5 Homo sapiens CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1.0 261.0 261.0 196 197 198 200 202 71 83 87 174 176 175 177.0 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
CK1 VRK1 VRK1_HUMAN 3OP5C Q99986 22 341 396.0 REB:365 Type1 Inactive DFGin 7.9202 14.4308 BLAminus -113.54, 176.44 69.75, 97.17 -118.63, 20.05 296.44, 91.45 -64.33, -26.27 in-none in 8.3344 Saltbr-none 999.0 HRD-in -81.5, -52.35 71.18, 5.09 none-in-out SNCnio in-out ActLoopNT-in 2.8269 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -72.8, 159.76 APE9-dihe-na 87.63, -165.14 APE8-dihe-in -90.95, 116.06 APE8-rot-in 302.3 APE67-dihe-in -69.84, -27.29 -42.27, -48.51 APE12-dist-out 15.0487 APE11-dist-in 13.7843 APE10-dist-in 7.9657 APE9-dist-in 4.0068 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.4 0.179 0.213 C 364.0 308.0 12 35 35 0 [[37, 326]] 1.0 3op5 Homo sapiens CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1.0 261.0 261.0 196 197 198 200 202 71 83 87 174 176 175 177.0 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
CK1 VRK1 VRK1_HUMAN 3OP5D Q99986 25 341 396.0 REB:365 Type1 Inactive DFGin 7.969 14.4525 BLAminus -112.89, 176.13 70.95, 97.27 -119.85, 19.74 297.32, 91.51 -64.31, -27.23 in-none in 7.9254 Saltbr-none 999.0 HRD-in -80.63, -52.15 71.05, 5.02 none-in-out SNCnio in-out ActLoopNT-in 2.8279 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooi APE10-dihe-na -69.13, 152.48 APE9-dihe-na 88.04, -168.28 APE8-dihe-in -88.02, 114.99 APE8-rot-in 302.83 APE67-dihe-in -62.29, -38.34 -40.98, -47.51 APE12-dist-out 15.3041 APE11-dist-out 14.0064 APE10-dist-out 8.2938 APE9-dist-in 4.0011 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.4 0.179 0.213 D 364.0 302.0 15 35 35 0 [[37, 326]] 1.0 3op5 Homo sapiens CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1.0 261.0 261.0 196 197 198 200 202 71 83 87 174 176 175 177.0 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
CK1 VRK2 VRK2_HUMAN 9FETA Q86Y07 15 330 508.0 REB:401 Type1.5_Back Active DFGin 7.7569 14.1775 BLAminus -126.51, -179.88 62.99, 75.15 -90.88, 34.72 299.05, 76.11 -73.88, -23.01 in-in in 7.4719 Saltbr-in 3.1195 HRD-in -79.75, -50.35 72.0, 10.87 in-in-in SNCiii in-in ActLoopNT-in 2.8102 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -84.38, 169.25 APE9-dihe-na 101.33, -175.93 APE8-dihe-in -76.93, 108.74 APE8-rot-in 301.77 APE67-dihe-in -59.32, -37.67 -45.84, -39.32 APE12-dist-in 13.5609 APE11-dist-in 13.6582 APE10-dist-in 7.9227 APE9-dist-in 4.6041 None None None XRAY 2.4 0.224 0.269 A 324.0 313.0 3 35 35 0 [[29, 315]] 1.0 9fet Homo sapiens CK1_VRK2_HUMAN CK1 1.6e-103 351.6 1.0 261.0 261.0 185 186 187 189 191 61 73 77 163 165 164 166.0 232 220 215 214 213 212 211 210 209 122 Serine/threonine-protein kinase VRK2

Ligand: REB

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name