Ligand: R6D (Lanraplenib)

Total number of chains: 2
Active chains: 1
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 100.0% 6VOVB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR SYK KSYK_HUMAN 6VOVA P43405 363 629 635.0 R6D:701 Type1 None DFGin 6.4909 14.5508 BLAminus -133.59, -172.02 59.62, 69.16 -89.35, 17.8 288.33, 91.38 -60.0, -27.27 in-in in 7.9938 Saltbr-in 2.6903 HRD-in -77.79, -51.77 71.65, 6.09 in-in-none SNCiin in-none ActLoopNT-in 2.9903 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 145.03 APE8-dihe-in -78.95, 69.83 APE8-rot-na 28.75 APE67-dihe-in -65.35, -15.72 -44.66, -41.68 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.1965 None None None XRAY 1.95 0.22 0.268 A 281.0 258.0 9 31 27 4 [[370, 628]] 1.0 6vov TYR_SYK_HUMAN TYR 4.8e-90 307.3 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
TYR SYK KSYK_HUMAN 6VOVB P43405 364 633 635.0 R6D:701 Type1 Active DFGin 6.6739 14.6282 BLAminus -133.89, -172.81 60.07, 70.15 -88.26, 20.03 288.32, 89.62 -58.86, -27.32 in-in in 8.0798 Saltbr-in 2.6221 HRD-in -78.67, -51.68 71.89, 6.23 in-in-in SNCiii in-in ActLoopNT-in 2.8816 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -81.76, 97.82 APE9-dihe-in -115.45, 146.07 APE8-dihe-in -78.23, 69.53 APE8-rot-na 28.65 APE67-dihe-in -63.96, -14.94 -44.81, -41.99 APE12-dist-na 13.6462 APE11-dist-na 10.4481 APE10-dist-na 11.0328 APE9-dist-in 6.8137 None None None XRAY 1.95 0.22 0.268 B 281.0 264.0 6 31 31 0 [[370, 628]] 1.0 6vov TYR_SYK_HUMAN TYR 4.8e-90 307.3 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK

Ligand: R6D (Lanraplenib)

Total number of chains: 2
Active chains: 1
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 100.0% 6VOVB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR SYK KSYK_HUMAN 6VOVA P43405 363 629 635.0 R6D:701 Type1 None DFGin 6.4909 14.5508 BLAminus -133.59, -172.02 59.62, 69.16 -89.35, 17.8 288.33, 91.38 -60.0, -27.27 in-in in 7.9938 Saltbr-in 2.6903 HRD-in -77.79, -51.77 71.65, 6.09 in-in-none SNCiin in-none ActLoopNT-in 2.9903 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 145.03 APE8-dihe-in -78.95, 69.83 APE8-rot-na 28.75 APE67-dihe-in -65.35, -15.72 -44.66, -41.68 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.1965 None None None XRAY 1.95 0.22 0.268 A 281.0 258.0 9 31 27 4 [[370, 628]] 1.0 6vov Homo sapiens TYR_SYK_HUMAN TYR 4.8e-90 307.3 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
TYR SYK KSYK_HUMAN 6VOVB P43405 364 633 635.0 R6D:701 Type1 Active DFGin 6.6739 14.6282 BLAminus -133.89, -172.81 60.07, 70.15 -88.26, 20.03 288.32, 89.62 -58.86, -27.32 in-in in 8.0798 Saltbr-in 2.6221 HRD-in -78.67, -51.68 71.89, 6.23 in-in-in SNCiii in-in ActLoopNT-in 2.8816 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -81.76, 97.82 APE9-dihe-in -115.45, 146.07 APE8-dihe-in -78.23, 69.53 APE8-rot-na 28.65 APE67-dihe-in -63.96, -14.94 -44.81, -41.99 APE12-dist-na 13.6462 APE11-dist-na 10.4481 APE10-dist-na 11.0328 APE9-dist-in 6.8137 None None None XRAY 1.95 0.22 0.268 B 281.0 264.0 6 31 31 0 [[370, 628]] 1.0 6vov Homo sapiens TYR_SYK_HUMAN TYR 4.8e-90 307.3 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK

Ligand: R6D (Lanraplenib)

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name