Ligand: QKG

Total number of chains: 4
Active chains: 4
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 6UWYA
All chains - renumbered by
Uniprot PDB Alignment

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Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC DYRK1A DYR1A_HUMAN 6UWYA Q13627 135 481 763.0 QKG:501 Type1 Active DFGin 7.239 14.867 BLAminus -132.26, 176.05 58.86, 71.25 -90.67, 13.27 278.59, 82.94 -60.39, -40.77 in-in in 8.735 Saltbr-in 3.081 HRD-in -61.71, -47.36 76.81, -2.22 in-in-in SNCiii in-in ActLoopNT-in 2.655 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.12, 167.04 APE9-dihe-na 74.27, 150.88 APE8-dihe-in -72.73, 138.41 APE8-rot-in 284.49 APE67-dihe-in -57.43, -28.19 -49.04, -49.4 APE12-dist-in 12.812 APE11-dist-in 11.524 APE10-dist-in 7.209 APE9-dist-in 3.017 None PTR321 PTR321 XRAY 2.95 0.197 0.227 A 361 347 0 0 0 0 [[159, 479]] 1.0 6uwy CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 6UWYB Q13627 134 481 763.0 QKG:501 Type1 Active DFGin 7.311 15.09 BLAminus -132.37, 173.46 57.96, 71.45 -90.43, 13.0 277.8, 80.83 -60.37, -40.54 in-in in 8.779 Saltbr-in 3.014 HRD-in -61.63, -47.91 76.71, -1.04 in-in-in SNCiii in-in ActLoopNT-in 2.716 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -63.7, 163.69 APE9-dihe-na 74.19, 154.88 APE8-dihe-in -72.83, 138.38 APE8-rot-in 286.89 APE67-dihe-in -59.92, -29.1 -50.36, -49.5 APE12-dist-in 13.664 APE11-dist-in 11.132 APE10-dist-in 7.037 APE9-dist-in 3.012 None PTR321 PTR321 XRAY 2.95 0.197 0.227 B 361 348 0 0 0 0 [[159, 479]] 1.0 6uwy CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 6UWYC Q13627 135 481 763.0 QKG:501 Type1 Active DFGin 7.448 14.961 BLAminus -132.44, 172.18 56.85, 71.63 -90.4, 12.5 280.91, 80.19 -61.16, -41.17 in-in in 8.661 Saltbr-in 2.875 HRD-in -61.46, -47.79 77.42, -2.34 in-in-in SNCiii in-in ActLoopNT-in 2.77 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.48, 167.68 APE9-dihe-na 74.27, 151.37 APE8-dihe-in -72.8, 138.22 APE8-rot-in 285.1 APE67-dihe-in -57.33, -28.79 -48.84, -49.36 APE12-dist-in 12.866 APE11-dist-in 11.736 APE10-dist-in 7.357 APE9-dist-in 3.02 None PTR321 PTR321 XRAY 2.95 0.197 0.227 C 361 347 0 0 0 0 [[159, 479]] 1.0 6uwy CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 6UWYD Q13627 134 481 763.0 QKG:501 Type1 Active DFGin 7.138 14.987 BLAminus -133.07, 174.34 57.8, 73.05 -90.03, 14.24 279.65, 81.22 -60.16, -40.68 in-in in 8.748 Saltbr-in 2.975 HRD-in -62.11, -48.37 77.72, -2.5 in-in-in SNCiii in-in ActLoopNT-in 2.725 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.78, 167.27 APE9-dihe-na 74.09, 151.84 APE8-dihe-in -72.45, 137.48 APE8-rot-in 284.95 APE67-dihe-in -57.53, -28.78 -49.33, -49.3 APE12-dist-in 12.8 APE11-dist-in 11.611 APE10-dist-in 7.385 APE9-dist-in 3.072 None PTR321 PTR321 XRAY 2.95 0.197 0.227 D 361 348 0 0 0 0 [[159, 479]] 1.0 6uwy CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A

Ligand: QKG

Total number of chains: 4
Active chains: 4
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 6UWYA
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC DYRK1A DYR1A_HUMAN 6UWYA Q13627 135 481 763.0 QKG:501 Type1 Active DFGin 7.239 14.867 BLAminus -132.26, 176.05 58.86, 71.25 -90.67, 13.27 278.59, 82.94 -60.39, -40.77 in-in in 8.735 Saltbr-in 3.081 HRD-in -61.71, -47.36 76.81, -2.22 in-in-in SNCiii in-in ActLoopNT-in 2.655 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.12, 167.04 APE9-dihe-na 74.27, 150.88 APE8-dihe-in -72.73, 138.41 APE8-rot-in 284.49 APE67-dihe-in -57.43, -28.19 -49.04, -49.4 APE12-dist-in 12.812 APE11-dist-in 11.524 APE10-dist-in 7.209 APE9-dist-in 3.017 None PTR321 PTR321 XRAY 2.95 0.197 0.227 A 361 347 0 0 0 0 [[159, 479]] 1.0 6uwy Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 6UWYB Q13627 134 481 763.0 QKG:501 Type1 Active DFGin 7.311 15.09 BLAminus -132.37, 173.46 57.96, 71.45 -90.43, 13.0 277.8, 80.83 -60.37, -40.54 in-in in 8.779 Saltbr-in 3.014 HRD-in -61.63, -47.91 76.71, -1.04 in-in-in SNCiii in-in ActLoopNT-in 2.716 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -63.7, 163.69 APE9-dihe-na 74.19, 154.88 APE8-dihe-in -72.83, 138.38 APE8-rot-in 286.89 APE67-dihe-in -59.92, -29.1 -50.36, -49.5 APE12-dist-in 13.664 APE11-dist-in 11.132 APE10-dist-in 7.037 APE9-dist-in 3.012 None PTR321 PTR321 XRAY 2.95 0.197 0.227 B 361 348 0 0 0 0 [[159, 479]] 1.0 6uwy Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 6UWYC Q13627 135 481 763.0 QKG:501 Type1 Active DFGin 7.448 14.961 BLAminus -132.44, 172.18 56.85, 71.63 -90.4, 12.5 280.91, 80.19 -61.16, -41.17 in-in in 8.661 Saltbr-in 2.875 HRD-in -61.46, -47.79 77.42, -2.34 in-in-in SNCiii in-in ActLoopNT-in 2.77 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.48, 167.68 APE9-dihe-na 74.27, 151.37 APE8-dihe-in -72.8, 138.22 APE8-rot-in 285.1 APE67-dihe-in -57.33, -28.79 -48.84, -49.36 APE12-dist-in 12.866 APE11-dist-in 11.736 APE10-dist-in 7.357 APE9-dist-in 3.02 None PTR321 PTR321 XRAY 2.95 0.197 0.227 C 361 347 0 0 0 0 [[159, 479]] 1.0 6uwy Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 6UWYD Q13627 134 481 763.0 QKG:501 Type1 Active DFGin 7.138 14.987 BLAminus -133.07, 174.34 57.8, 73.05 -90.03, 14.24 279.65, 81.22 -60.16, -40.68 in-in in 8.748 Saltbr-in 2.975 HRD-in -62.11, -48.37 77.72, -2.5 in-in-in SNCiii in-in ActLoopNT-in 2.725 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.78, 167.27 APE9-dihe-na 74.09, 151.84 APE8-dihe-in -72.45, 137.48 APE8-rot-in 284.95 APE67-dihe-in -57.53, -28.78 -49.33, -49.3 APE12-dist-in 12.8 APE11-dist-in 11.611 APE10-dist-in 7.385 APE9-dist-in 3.072 None PTR321 PTR321 XRAY 2.95 0.197 0.227 D 361 348 0 0 0 0 [[159, 479]] 1.0 6uwy Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A

Ligand: QKG

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name