Ligand: QIV

Total number of chains: 4
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 5A3XA
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC DYRK1A DYR1A_HUMAN 5A3XA Q13627 134 481 763.0 QIV:1482 Type1 Inactive DFGin 7.664 15.187 BLAminus -121.3, 168.45 66.25, 87.13 -106.05, 27.07 283.2, 80.21 -83.81, -17.62 in-in in 8.617 Saltbr-in 2.997 HRD-in -59.25, -48.79 80.55, -0.05 in-in-out SNCiio in-out ActLoopNT-in 3.11 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -138.85, 162.88 APE9-dihe-na 69.36, 143.48 APE8-dihe-in -71.67, 143.32 APE8-rot-in 287.54 APE67-dihe-in -58.85, -26.94 -58.65, -43.64 APE12-dist-in 13.952 APE11-dist-in 12.011 APE10-dist-out 8.258 APE9-dist-in 3.21 None PTR321 PTR321 XRAY 2.26 0.236 0.259 A 368 343 5 0 0 0 [[159, 479]] 1.0 5a3x CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 5A3XB Q13627 133 481 763.0 QIV:1482 Type1 Inactive DFGin 7.772 15.505 BLAminus -125.81, 167.9 65.94, 85.46 -101.51, 31.91 279.0, 78.69 -86.09, -27.09 in-in in 8.599 Saltbr-in 2.745 HRD-in -56.46, -45.32 74.34, 3.15 in-in-out SNCiio in-out ActLoopNT-in 2.725 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -137.85, 164.62 APE9-dihe-na 69.98, 148.5 APE8-dihe-in -66.5, 143.45 APE8-rot-in 290.78 APE67-dihe-in -60.87, -33.02 -55.76, -43.48 APE12-dist-out 14.034 APE11-dist-in 11.882 APE10-dist-out 8.292 APE9-dist-in 3.258 None PTR321 PTR321 XRAY 2.26 0.236 0.259 B 368 341 8 0 0 0 [[159, 479]] 1.0 5a3x CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 5A3XC Q13627 134 481 763.0 QIV:1482 Type1 Inactive DFGin 7.235 14.805 BLAminus -120.77, 156.43 72.71, 88.81 -105.04, 42.02 290.66, 77.33 -99.01, -30.56 in-in in 8.549 Saltbr-in 2.645 HRD-in -62.04, -42.75 76.63, -18.75 in-in-out SNCiio in-out ActLoopNT-in 2.77 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -123.59, -60.32 APE9-dihe-na -74.24, 162.28 APE8-dihe-in -68.19, 134.61 APE8-rot-in 295.26 APE67-dihe-in -59.28, -25.8 -56.62, -43.45 APE12-dist-in 13.971 APE11-dist-in 12.104 APE10-dist-out 8.003 APE9-dist-in 3.467 None PTR321 PTR321 XRAY 2.26 0.236 0.259 C 368 334 14 0 0 0 [[159, 479]] 1.0 5a3x CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 5A3XD Q13627 134 480 763.0 QIV:1481 Type1 Inactive DFGin 7.745 15.107 BLAminus -112.42, 164.72 67.39, 90.55 -104.31, 19.84 285.07, 76.07 -77.1, -18.41 in-in in 8.438 Saltbr-in 2.756 HRD-in -55.52, -51.58 81.21, 8.94 in-in-out SNCiio in-out ActLoopNT-in 3.003 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -143.8, 163.41 APE9-dihe-na 70.65, 146.94 APE8-dihe-in -69.56, 144.9 APE8-rot-in 290.59 APE67-dihe-in -57.48, -32.7 -57.78, -42.42 APE12-dist-out 14.424 APE11-dist-in 12.129 APE10-dist-out 8.513 APE9-dist-in 3.22 None PTR321 PTR321 XRAY 2.26 0.236 0.259 D 368 332 15 0 0 0 [[159, 479]] 1.0 5a3x CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A

Ligand: QIV

Total number of chains: 4
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 5A3XA
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC DYRK1A DYR1A_HUMAN 5A3XA Q13627 134 481 763.0 QIV:1482 Type1 Inactive DFGin 7.664 15.187 BLAminus -121.3, 168.45 66.25, 87.13 -106.05, 27.07 283.2, 80.21 -83.81, -17.62 in-in in 8.617 Saltbr-in 2.997 HRD-in -59.25, -48.79 80.55, -0.05 in-in-out SNCiio in-out ActLoopNT-in 3.11 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -138.85, 162.88 APE9-dihe-na 69.36, 143.48 APE8-dihe-in -71.67, 143.32 APE8-rot-in 287.54 APE67-dihe-in -58.85, -26.94 -58.65, -43.64 APE12-dist-in 13.952 APE11-dist-in 12.011 APE10-dist-out 8.258 APE9-dist-in 3.21 None PTR321 PTR321 XRAY 2.26 0.236 0.259 A 368 343 5 0 0 0 [[159, 479]] 1.0 5a3x Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 5A3XB Q13627 133 481 763.0 QIV:1482 Type1 Inactive DFGin 7.772 15.505 BLAminus -125.81, 167.9 65.94, 85.46 -101.51, 31.91 279.0, 78.69 -86.09, -27.09 in-in in 8.599 Saltbr-in 2.745 HRD-in -56.46, -45.32 74.34, 3.15 in-in-out SNCiio in-out ActLoopNT-in 2.725 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -137.85, 164.62 APE9-dihe-na 69.98, 148.5 APE8-dihe-in -66.5, 143.45 APE8-rot-in 290.78 APE67-dihe-in -60.87, -33.02 -55.76, -43.48 APE12-dist-out 14.034 APE11-dist-in 11.882 APE10-dist-out 8.292 APE9-dist-in 3.258 None PTR321 PTR321 XRAY 2.26 0.236 0.259 B 368 341 8 0 0 0 [[159, 479]] 1.0 5a3x Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 5A3XC Q13627 134 481 763.0 QIV:1482 Type1 Inactive DFGin 7.235 14.805 BLAminus -120.77, 156.43 72.71, 88.81 -105.04, 42.02 290.66, 77.33 -99.01, -30.56 in-in in 8.549 Saltbr-in 2.645 HRD-in -62.04, -42.75 76.63, -18.75 in-in-out SNCiio in-out ActLoopNT-in 2.77 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -123.59, -60.32 APE9-dihe-na -74.24, 162.28 APE8-dihe-in -68.19, 134.61 APE8-rot-in 295.26 APE67-dihe-in -59.28, -25.8 -56.62, -43.45 APE12-dist-in 13.971 APE11-dist-in 12.104 APE10-dist-out 8.003 APE9-dist-in 3.467 None PTR321 PTR321 XRAY 2.26 0.236 0.259 C 368 334 14 0 0 0 [[159, 479]] 1.0 5a3x Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 5A3XD Q13627 134 480 763.0 QIV:1481 Type1 Inactive DFGin 7.745 15.107 BLAminus -112.42, 164.72 67.39, 90.55 -104.31, 19.84 285.07, 76.07 -77.1, -18.41 in-in in 8.438 Saltbr-in 2.756 HRD-in -55.52, -51.58 81.21, 8.94 in-in-out SNCiio in-out ActLoopNT-in 3.003 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -143.8, 163.41 APE9-dihe-na 70.65, 146.94 APE8-dihe-in -69.56, 144.9 APE8-rot-in 290.59 APE67-dihe-in -57.48, -32.7 -57.78, -42.42 APE12-dist-out 14.424 APE11-dist-in 12.129 APE10-dist-out 8.513 APE9-dist-in 3.22 None PTR321 PTR321 XRAY 2.26 0.236 0.259 D 368 332 15 0 0 0 [[159, 479]] 1.0 5a3x Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A

Ligand: QIV

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name