| Group | Gene | SwissprotID | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TYR | JAK3-2 | JAK3_HUMAN | 7UYVA | P52333 | 814 | 1100 | 1124.0 | OV5:1201 | Type1 | Active | DFGin | 6.3763 | 14.2869 | BLAminus | -136.33, -178.14 | 60.47, 77.06 | -94.46, 22.49 | 283.21, 76.25 | -61.39, -33.76 | in-in | in | 8.2009 | Saltbr-in | 2.6421 | HRD-in | -69.18, -41.57 | 72.69, -12.85 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.7503 | ActLoopCT-in | TYR | APEdihe_iiiai | APEdist_aaai | APE10-dihe-in | -70.18, 82.75 | APE9-dihe-in | -112.58, 159.26 | APE8-dihe-in | -47.72, 129.83 | APE8-rot-na | 329.64 | APE67-dihe-in | -81.57, 1.11 | -69.92, -19.01 | APE12-dist-na | 11.5311 | APE11-dist-na | 8.0482 | APE10-dist-na | 11.6832 | APE9-dist-in | 7.3388 | None | PTR980,PTR981 | PTR980,PTR981 | XRAY | 2.15 | 0.222 | 0.263 | A | 291.0 | 278.0 | 9 | 31 | 31 | 0 | [[521, 779], [822, 1097]] | 2.0 | 7uyv | TYR_JAK3-2_HUMAN | TYR | 2e-81 | 279.0 | 1.0 | 260.0 | 260.0 | 966 | 967 | 968 | 970 | 972 | 855 | 871 | 875 | 946 | 948 | 947 | 949.0 | 1009 | 997 | 992 | 991 | 990 | 989 | 988 | 987 | 986 | 903 | Tyrosine-protein kinase JAK3 |
| TYR | JAK3-2 | JAK3_HUMAN | 7UYVB | P52333 | 814 | 1100 | 1124.0 | OV5:1201 | Type1 | Active | DFGin | 6.2251 | 14.2162 | BLAminus | -136.69, -173.44 | 56.56, 80.52 | -96.27, 21.5 | 284.08, 77.64 | -57.68, -39.3 | in-in | in | 8.1504 | Saltbr-in | 2.6309 | HRD-in | -80.27, -44.25 | 68.81, -0.6 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.7556 | ActLoopCT-in | TYR | APEdihe_iiiai | APEdist_aaai | APE10-dihe-in | -75.34, 85.59 | APE9-dihe-in | -127.16, 148.54 | APE8-dihe-in | -37.53, 121.21 | APE8-rot-na | 325.53 | APE67-dihe-in | -80.04, -3.68 | -72.05, -16.34 | APE12-dist-na | 11.5779 | APE11-dist-na | 9.1429 | APE10-dist-na | 12.2547 | APE9-dist-in | 7.3873 | None | PTR980,PTR981 | PTR980,PTR981 | XRAY | 2.15 | 0.222 | 0.263 | B | 291.0 | 284.0 | 3 | 31 | 31 | 0 | [[521, 779], [822, 1097]] | 2.0 | 7uyv | TYR_JAK3-2_HUMAN | TYR | 2e-81 | 279.0 | 1.0 | 260.0 | 260.0 | 966 | 967 | 968 | 970 | 972 | 855 | 871 | 875 | 946 | 948 | 947 | 949.0 | 1009 | 997 | 992 | 991 | 990 | 989 | 988 | 987 | 986 | 903 | Tyrosine-protein kinase JAK3 |
| TYR | JAK3-2 | JAK3_HUMAN | 7UYVC | P52333 | 812 | 1100 | 1124.0 | OV5:1201 | Type1 | Inactive | DFGin | 6.5497 | 14.2474 | BLAminus | -139.0, -178.89 | 62.41, 84.96 | -102.47, 24.54 | 285.05, 80.61 | -63.66, -34.31 | in-in | in | 8.1764 | Saltbr-in | 2.7239 | HRD-in | -72.48, -47.02 | 76.02, -14.38 | in-in-out | SNCiio | in-out | ActLoopNT-in | 2.6962 | ActLoopCT-out | TYR | APEdihe_iiiai | APEdist_aaao | APE10-dihe-in | -72.04, 75.71 | APE9-dihe-in | -159.34, 174.75 | APE8-dihe-in | -55.7, 114.03 | APE8-rot-na | 331.85 | APE67-dihe-in | -81.89, -1.84 | -68.05, -12.84 | APE12-dist-na | 12.9994 | APE11-dist-na | 8.9457 | APE10-dist-na | 10.9307 | APE9-dist-out | 8.0032 | None | PTR980,PTR981 | PTR980,PTR981 | XRAY | 2.15 | 0.222 | 0.263 | C | 291.0 | 281.0 | 8 | 31 | 31 | 0 | [[521, 779], [822, 1097]] | 2.0 | 7uyv | TYR_JAK3-2_HUMAN | TYR | 2e-81 | 279.0 | 1.0 | 260.0 | 260.0 | 966 | 967 | 968 | 970 | 972 | 855 | 871 | 875 | 946 | 948 | 947 | 949.0 | 1009 | 997 | 992 | 991 | 990 | 989 | 988 | 987 | 986 | 903 | Tyrosine-protein kinase JAK3 |
| TYR | JAK3-2 | JAK3_HUMAN | 7UYVD | P52333 | 814 | 1100 | 1124.0 | OV5:1201 | Type1 | None | DFGin | 6.4207 | 14.2582 | BLAminus | -133.29, -179.06 | 58.4, 83.86 | -99.71, 22.65 | 285.23, 81.71 | -62.49, -28.09 | in-in | in | 8.2976 | Saltbr-in | 2.6722 | HRD-in | -64.99, -48.29 | 76.96, -0.25 | in-in-none | SNCiin | in-none | ActLoopNT-in | 2.7457 | ActLoopCT-none | TYR | APEdihe_nniai | APEdist_aaai | APE10-dihe-none | 999.0, 999.0 | APE9-dihe-none | 999.0, 163.98 | APE8-dihe-in | -58.27, 129.89 | APE8-rot-na | 335.93 | APE67-dihe-in | -80.69, -3.3 | -71.81, -12.07 | APE12-dist-na | 999.0 | APE11-dist-na | 999.0 | APE10-dist-na | 999.0 | APE9-dist-in | 7.4681 | None | PTR980,PTR981 | PTR980,PTR981 | XRAY | 2.15 | 0.222 | 0.263 | D | 291.0 | 272.0 | 15 | 31 | 26 | 5 | [[521, 779], [822, 1097]] | 2.0 | 7uyv | TYR_JAK3-2_HUMAN | TYR | 2e-81 | 279.0 | 1.0 | 260.0 | 260.0 | 966 | 967 | 968 | 970 | 972 | 855 | 871 | 875 | 946 | 948 | 947 | 949.0 | 1009 | 997 | 992 | 991 | 990 | 989 | 988 | 987 | 986 | 903 | Tyrosine-protein kinase JAK3 |
| TYR | TYK2-2 | TYK2_HUMAN | 7UYTA | P29597 | 890 | 1177 | 1187.0 | OV5:1201 | Type1 | Active | DFGin | 6.6003 | 13.5627 | BLAminus | -113.96, -166.72 | 43.12, 92.69 | -104.69, 31.01 | 290.99, 83.76 | -63.14, -33.25 | in-in | in | 7.5542 | Saltbr-in | 3.1726 | HRD-in | -84.86, -57.24 | 78.5, -1.23 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.9356 | ActLoopCT-in | TYR | APEdihe_iiiai | APEdist_aaai | APE10-dihe-in | -83.23, 72.86 | APE9-dihe-in | -74.56, 127.74 | APE8-dihe-in | -83.18, 74.68 | APE8-rot-na | 37.06 | APE67-dihe-in | -71.62, -8.97 | -55.74, -33.87 | APE12-dist-na | 12.5922 | APE11-dist-na | 9.0278 | APE10-dist-na | 9.1995 | APE9-dist-in | 6.4892 | None | PTR1054,PTR1055 | PTR1054,PTR1055 | XRAY | 2.14 | 0.245 | 0.293 | A | 289.0 | 278.0 | 10 | 31 | 29 | 2 | [[589, 868], [897, 1171]] | 2.0 | 7uyt | TYR_TYK2-2_HUMAN | TYR | 1.1e-81 | 279.9 | 2.0 | 260.0 | 259.0 | 1040 | 1041 | 1042 | 1044 | 1046 | 930 | 947 | 951 | 1020 | 1022 | 1021 | 1023.0 | 1083 | 1071 | 1066 | 1065 | 1064 | 1063 | 1062 | 1061 | 1060 | 979 | Non-receptor tyrosine-protein kinase TYK2 |
| Group | Gene | SwissprotID | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Species | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TYR | JAK3-2 | JAK3_HUMAN | 7UYVA | P52333 | 814 | 1100 | 1124.0 | OV5:1201 | Type1 | Active | DFGin | 6.3763 | 14.2869 | BLAminus | -136.33, -178.14 | 60.47, 77.06 | -94.46, 22.49 | 283.21, 76.25 | -61.39, -33.76 | in-in | in | 8.2009 | Saltbr-in | 2.6421 | HRD-in | -69.18, -41.57 | 72.69, -12.85 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.7503 | ActLoopCT-in | TYR | APEdihe_iiiai | APEdist_aaai | APE10-dihe-in | -70.18, 82.75 | APE9-dihe-in | -112.58, 159.26 | APE8-dihe-in | -47.72, 129.83 | APE8-rot-na | 329.64 | APE67-dihe-in | -81.57, 1.11 | -69.92, -19.01 | APE12-dist-na | 11.5311 | APE11-dist-na | 8.0482 | APE10-dist-na | 11.6832 | APE9-dist-in | 7.3388 | None | PTR980,PTR981 | PTR980,PTR981 | XRAY | 2.15 | 0.222 | 0.263 | A | 291.0 | 278.0 | 9 | 31 | 31 | 0 | [[521, 779], [822, 1097]] | 2.0 | 7uyv | Homo sapiens | TYR_JAK3-2_HUMAN | TYR | 2e-81 | 279.0 | 1.0 | 260.0 | 260.0 | 966 | 967 | 968 | 970 | 972 | 855 | 871 | 875 | 946 | 948 | 947 | 949.0 | 1009 | 997 | 992 | 991 | 990 | 989 | 988 | 987 | 986 | 903 | Tyrosine-protein kinase JAK3 |
| TYR | JAK3-2 | JAK3_HUMAN | 7UYVB | P52333 | 814 | 1100 | 1124.0 | OV5:1201 | Type1 | Active | DFGin | 6.2251 | 14.2162 | BLAminus | -136.69, -173.44 | 56.56, 80.52 | -96.27, 21.5 | 284.08, 77.64 | -57.68, -39.3 | in-in | in | 8.1504 | Saltbr-in | 2.6309 | HRD-in | -80.27, -44.25 | 68.81, -0.6 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.7556 | ActLoopCT-in | TYR | APEdihe_iiiai | APEdist_aaai | APE10-dihe-in | -75.34, 85.59 | APE9-dihe-in | -127.16, 148.54 | APE8-dihe-in | -37.53, 121.21 | APE8-rot-na | 325.53 | APE67-dihe-in | -80.04, -3.68 | -72.05, -16.34 | APE12-dist-na | 11.5779 | APE11-dist-na | 9.1429 | APE10-dist-na | 12.2547 | APE9-dist-in | 7.3873 | None | PTR980,PTR981 | PTR980,PTR981 | XRAY | 2.15 | 0.222 | 0.263 | B | 291.0 | 284.0 | 3 | 31 | 31 | 0 | [[521, 779], [822, 1097]] | 2.0 | 7uyv | Homo sapiens | TYR_JAK3-2_HUMAN | TYR | 2e-81 | 279.0 | 1.0 | 260.0 | 260.0 | 966 | 967 | 968 | 970 | 972 | 855 | 871 | 875 | 946 | 948 | 947 | 949.0 | 1009 | 997 | 992 | 991 | 990 | 989 | 988 | 987 | 986 | 903 | Tyrosine-protein kinase JAK3 |
| TYR | JAK3-2 | JAK3_HUMAN | 7UYVC | P52333 | 812 | 1100 | 1124.0 | OV5:1201 | Type1 | Inactive | DFGin | 6.5497 | 14.2474 | BLAminus | -139.0, -178.89 | 62.41, 84.96 | -102.47, 24.54 | 285.05, 80.61 | -63.66, -34.31 | in-in | in | 8.1764 | Saltbr-in | 2.7239 | HRD-in | -72.48, -47.02 | 76.02, -14.38 | in-in-out | SNCiio | in-out | ActLoopNT-in | 2.6962 | ActLoopCT-out | TYR | APEdihe_iiiai | APEdist_aaao | APE10-dihe-in | -72.04, 75.71 | APE9-dihe-in | -159.34, 174.75 | APE8-dihe-in | -55.7, 114.03 | APE8-rot-na | 331.85 | APE67-dihe-in | -81.89, -1.84 | -68.05, -12.84 | APE12-dist-na | 12.9994 | APE11-dist-na | 8.9457 | APE10-dist-na | 10.9307 | APE9-dist-out | 8.0032 | None | PTR980,PTR981 | PTR980,PTR981 | XRAY | 2.15 | 0.222 | 0.263 | C | 291.0 | 281.0 | 8 | 31 | 31 | 0 | [[521, 779], [822, 1097]] | 2.0 | 7uyv | Homo sapiens | TYR_JAK3-2_HUMAN | TYR | 2e-81 | 279.0 | 1.0 | 260.0 | 260.0 | 966 | 967 | 968 | 970 | 972 | 855 | 871 | 875 | 946 | 948 | 947 | 949.0 | 1009 | 997 | 992 | 991 | 990 | 989 | 988 | 987 | 986 | 903 | Tyrosine-protein kinase JAK3 |
| TYR | JAK3-2 | JAK3_HUMAN | 7UYVD | P52333 | 814 | 1100 | 1124.0 | OV5:1201 | Type1 | None | DFGin | 6.4207 | 14.2582 | BLAminus | -133.29, -179.06 | 58.4, 83.86 | -99.71, 22.65 | 285.23, 81.71 | -62.49, -28.09 | in-in | in | 8.2976 | Saltbr-in | 2.6722 | HRD-in | -64.99, -48.29 | 76.96, -0.25 | in-in-none | SNCiin | in-none | ActLoopNT-in | 2.7457 | ActLoopCT-none | TYR | APEdihe_nniai | APEdist_aaai | APE10-dihe-none | 999.0, 999.0 | APE9-dihe-none | 999.0, 163.98 | APE8-dihe-in | -58.27, 129.89 | APE8-rot-na | 335.93 | APE67-dihe-in | -80.69, -3.3 | -71.81, -12.07 | APE12-dist-na | 999.0 | APE11-dist-na | 999.0 | APE10-dist-na | 999.0 | APE9-dist-in | 7.4681 | None | PTR980,PTR981 | PTR980,PTR981 | XRAY | 2.15 | 0.222 | 0.263 | D | 291.0 | 272.0 | 15 | 31 | 26 | 5 | [[521, 779], [822, 1097]] | 2.0 | 7uyv | Homo sapiens | TYR_JAK3-2_HUMAN | TYR | 2e-81 | 279.0 | 1.0 | 260.0 | 260.0 | 966 | 967 | 968 | 970 | 972 | 855 | 871 | 875 | 946 | 948 | 947 | 949.0 | 1009 | 997 | 992 | 991 | 990 | 989 | 988 | 987 | 986 | 903 | Tyrosine-protein kinase JAK3 |
| TYR | TYK2-2 | TYK2_HUMAN | 7UYTA | P29597 | 890 | 1177 | 1187.0 | OV5:1201 | Type1 | Active | DFGin | 6.6003 | 13.5627 | BLAminus | -113.96, -166.72 | 43.12, 92.69 | -104.69, 31.01 | 290.99, 83.76 | -63.14, -33.25 | in-in | in | 7.5542 | Saltbr-in | 3.1726 | HRD-in | -84.86, -57.24 | 78.5, -1.23 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.9356 | ActLoopCT-in | TYR | APEdihe_iiiai | APEdist_aaai | APE10-dihe-in | -83.23, 72.86 | APE9-dihe-in | -74.56, 127.74 | APE8-dihe-in | -83.18, 74.68 | APE8-rot-na | 37.06 | APE67-dihe-in | -71.62, -8.97 | -55.74, -33.87 | APE12-dist-na | 12.5922 | APE11-dist-na | 9.0278 | APE10-dist-na | 9.1995 | APE9-dist-in | 6.4892 | None | PTR1054,PTR1055 | PTR1054,PTR1055 | XRAY | 2.14 | 0.245 | 0.293 | A | 289.0 | 278.0 | 10 | 31 | 29 | 2 | [[589, 868], [897, 1171]] | 2.0 | 7uyt | Homo sapiens | TYR_TYK2-2_HUMAN | TYR | 1.1e-81 | 279.9 | 2.0 | 260.0 | 259.0 | 1040 | 1041 | 1042 | 1044 | 1046 | 930 | 947 | 951 | 1020 | 1022 | 1021 | 1023.0 | 1083 | 1071 | 1066 | 1065 | 1064 | 1063 | 1062 | 1061 | 1060 | 979 | Non-receptor tyrosine-protein kinase TYK2 |
| Spatial label | Dihedral label | Number of Chains | Percent | Representative |
|---|
| Group | Gene | SwissprotID | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Species | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
|---|