Ligand: OV5

Total number of chains: 5
Active chains: 3
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 5 100.0% 7UYVB
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR JAK3-2 JAK3_HUMAN 7UYVA P52333 814 1100 1124.0 OV5:1201 Type1 Active DFGin 6.376 14.287 BLAminus -136.33, -178.14 60.47, 77.06 -94.46, 22.49 283.21, 76.25 -61.39, -33.76 in-in in 8.201 Saltbr-in 2.642 HRD-in -69.18, -41.57 72.69, -12.85 in-in-in SNCiii in-in ActLoopNT-in 2.75 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -70.18, 82.75 APE9-dihe-in -112.58, 159.26 APE8-dihe-in -47.72, 129.83 APE8-rot-na 329.64 APE67-dihe-in -81.57, 1.11 -69.92, -19.01 APE12-dist-na 11.531 APE11-dist-na 8.048 APE10-dist-na 11.683 APE9-dist-in 7.339 None PTR980,PTR981 PTR980,PTR981 XRAY 2.15 0.222 0.263 A 291 278 9 0 0 0 [[521, 779], [822, 1097]] 2.0 7uyv TYR_JAK3-2_HUMAN TYR 2e-81 279.0 1 260 260 966 967 968 970 972 855 871 875 946 948 947 949 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
TYR JAK3-2 JAK3_HUMAN 7UYVB P52333 814 1100 1124.0 OV5:1201 Type1 Active DFGin 6.225 14.216 BLAminus -136.69, -173.44 56.56, 80.52 -96.27, 21.5 284.08, 77.64 -57.68, -39.3 in-in in 8.15 Saltbr-in 2.631 HRD-in -80.27, -44.25 68.81, -0.6 in-in-in SNCiii in-in ActLoopNT-in 2.756 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -75.34, 85.59 APE9-dihe-in -127.16, 148.54 APE8-dihe-in -37.53, 121.21 APE8-rot-na 325.53 APE67-dihe-in -80.04, -3.68 -72.05, -16.34 APE12-dist-na 11.578 APE11-dist-na 9.143 APE10-dist-na 12.255 APE9-dist-in 7.387 None PTR980,PTR981 PTR980,PTR981 XRAY 2.15 0.222 0.263 B 291 284 3 0 0 0 [[521, 779], [822, 1097]] 2.0 7uyv TYR_JAK3-2_HUMAN TYR 2e-81 279.0 1 260 260 966 967 968 970 972 855 871 875 946 948 947 949 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
TYR JAK3-2 JAK3_HUMAN 7UYVC P52333 812 1100 1124.0 OV5:1201 Type1 Inactive DFGin 6.55 14.247 BLAminus -139.0, -178.89 62.41, 84.96 -102.47, 24.54 285.05, 80.61 -63.66, -34.31 in-in in 8.176 Saltbr-in 2.724 HRD-in -72.48, -47.02 76.02, -14.38 in-in-out SNCiio in-out ActLoopNT-in 2.696 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -72.04, 75.71 APE9-dihe-in -159.34, 174.75 APE8-dihe-in -55.7, 114.03 APE8-rot-na 331.85 APE67-dihe-in -81.89, -1.84 -68.05, -12.84 APE12-dist-na 12.999 APE11-dist-na 8.946 APE10-dist-na 10.931 APE9-dist-out 8.003 None PTR980,PTR981 PTR980,PTR981 XRAY 2.15 0.222 0.263 C 291 281 8 0 0 0 [[521, 779], [822, 1097]] 2.0 7uyv TYR_JAK3-2_HUMAN TYR 2e-81 279.0 1 260 260 966 967 968 970 972 855 871 875 946 948 947 949 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
TYR JAK3-2 JAK3_HUMAN 7UYVD P52333 814 1100 1124.0 OV5:1201 Type1 None DFGin 6.421 14.258 BLAminus -133.29, -179.06 58.4, 83.86 -99.71, 22.65 285.23, 81.71 -62.49, -28.09 in-in in 8.298 Saltbr-in 2.672 HRD-in -64.99, -48.29 76.96, -0.25 in-in-none SNCiin in-none ActLoopNT-in 2.746 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 163.98 APE8-dihe-in -58.27, 129.89 APE8-rot-na 335.93 APE67-dihe-in -80.69, -3.3 -71.81, -12.07 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.468 None PTR980,PTR981 PTR980,PTR981 XRAY 2.15 0.222 0.263 D 291 272 15 0 0 5 [[521, 779], [822, 1097]] 2.0 7uyv TYR_JAK3-2_HUMAN TYR 2e-81 279.0 1 260 260 966 967 968 970 972 855 871 875 946 948 947 949 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
TYR TYK2-2 TYK2_HUMAN 7UYTA P29597 890 1177 1187.0 OV5:1201 Type1 Active DFGin 6.6 13.563 BLAminus -113.96, -166.72 43.12, 92.69 -104.69, 31.01 290.99, 83.76 -63.14, -33.25 in-in in 7.554 Saltbr-in 3.173 HRD-in -84.86, -57.24 78.5, -1.23 in-in-in SNCiii in-in ActLoopNT-in 2.936 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -83.23, 72.86 APE9-dihe-in -74.56, 127.74 APE8-dihe-in -83.18, 74.68 APE8-rot-na 37.06 APE67-dihe-in -71.62, -8.97 -55.74, -33.87 APE12-dist-na 12.592 APE11-dist-na 9.028 APE10-dist-na 9.2 APE9-dist-in 6.489 None PTR1054,PTR1055 PTR1054,PTR1055 XRAY 2.14 0.245 0.293 A 289 278 10 0 0 2 [[589, 868], [897, 1171]] 2.0 7uyt TYR_TYK2-2_HUMAN TYR 1.1e-81 279.9 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2

Ligand: OV5

Total number of chains: 5
Active chains: 3
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 5 100.0% 7UYVB
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR JAK3-2 JAK3_HUMAN 7UYVA P52333 814 1100 1124.0 OV5:1201 Type1 Active DFGin 6.376 14.287 BLAminus -136.33, -178.14 60.47, 77.06 -94.46, 22.49 283.21, 76.25 -61.39, -33.76 in-in in 8.201 Saltbr-in 2.642 HRD-in -69.18, -41.57 72.69, -12.85 in-in-in SNCiii in-in ActLoopNT-in 2.75 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -70.18, 82.75 APE9-dihe-in -112.58, 159.26 APE8-dihe-in -47.72, 129.83 APE8-rot-na 329.64 APE67-dihe-in -81.57, 1.11 -69.92, -19.01 APE12-dist-na 11.531 APE11-dist-na 8.048 APE10-dist-na 11.683 APE9-dist-in 7.339 None PTR980,PTR981 PTR980,PTR981 XRAY 2.15 0.222 0.263 A 291 278 9 0 0 0 [[521, 779], [822, 1097]] 2.0 7uyv Homo sapiens TYR_JAK3-2_HUMAN TYR 2e-81 279.0 1 260 260 966 967 968 970 972 855 871 875 946 948 947 949 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
TYR JAK3-2 JAK3_HUMAN 7UYVB P52333 814 1100 1124.0 OV5:1201 Type1 Active DFGin 6.225 14.216 BLAminus -136.69, -173.44 56.56, 80.52 -96.27, 21.5 284.08, 77.64 -57.68, -39.3 in-in in 8.15 Saltbr-in 2.631 HRD-in -80.27, -44.25 68.81, -0.6 in-in-in SNCiii in-in ActLoopNT-in 2.756 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -75.34, 85.59 APE9-dihe-in -127.16, 148.54 APE8-dihe-in -37.53, 121.21 APE8-rot-na 325.53 APE67-dihe-in -80.04, -3.68 -72.05, -16.34 APE12-dist-na 11.578 APE11-dist-na 9.143 APE10-dist-na 12.255 APE9-dist-in 7.387 None PTR980,PTR981 PTR980,PTR981 XRAY 2.15 0.222 0.263 B 291 284 3 0 0 0 [[521, 779], [822, 1097]] 2.0 7uyv Homo sapiens TYR_JAK3-2_HUMAN TYR 2e-81 279.0 1 260 260 966 967 968 970 972 855 871 875 946 948 947 949 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
TYR JAK3-2 JAK3_HUMAN 7UYVC P52333 812 1100 1124.0 OV5:1201 Type1 Inactive DFGin 6.55 14.247 BLAminus -139.0, -178.89 62.41, 84.96 -102.47, 24.54 285.05, 80.61 -63.66, -34.31 in-in in 8.176 Saltbr-in 2.724 HRD-in -72.48, -47.02 76.02, -14.38 in-in-out SNCiio in-out ActLoopNT-in 2.696 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -72.04, 75.71 APE9-dihe-in -159.34, 174.75 APE8-dihe-in -55.7, 114.03 APE8-rot-na 331.85 APE67-dihe-in -81.89, -1.84 -68.05, -12.84 APE12-dist-na 12.999 APE11-dist-na 8.946 APE10-dist-na 10.931 APE9-dist-out 8.003 None PTR980,PTR981 PTR980,PTR981 XRAY 2.15 0.222 0.263 C 291 281 8 0 0 0 [[521, 779], [822, 1097]] 2.0 7uyv Homo sapiens TYR_JAK3-2_HUMAN TYR 2e-81 279.0 1 260 260 966 967 968 970 972 855 871 875 946 948 947 949 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
TYR JAK3-2 JAK3_HUMAN 7UYVD P52333 814 1100 1124.0 OV5:1201 Type1 None DFGin 6.421 14.258 BLAminus -133.29, -179.06 58.4, 83.86 -99.71, 22.65 285.23, 81.71 -62.49, -28.09 in-in in 8.298 Saltbr-in 2.672 HRD-in -64.99, -48.29 76.96, -0.25 in-in-none SNCiin in-none ActLoopNT-in 2.746 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 163.98 APE8-dihe-in -58.27, 129.89 APE8-rot-na 335.93 APE67-dihe-in -80.69, -3.3 -71.81, -12.07 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.468 None PTR980,PTR981 PTR980,PTR981 XRAY 2.15 0.222 0.263 D 291 272 15 0 0 5 [[521, 779], [822, 1097]] 2.0 7uyv Homo sapiens TYR_JAK3-2_HUMAN TYR 2e-81 279.0 1 260 260 966 967 968 970 972 855 871 875 946 948 947 949 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
TYR TYK2-2 TYK2_HUMAN 7UYTA P29597 890 1177 1187.0 OV5:1201 Type1 Active DFGin 6.6 13.563 BLAminus -113.96, -166.72 43.12, 92.69 -104.69, 31.01 290.99, 83.76 -63.14, -33.25 in-in in 7.554 Saltbr-in 3.173 HRD-in -84.86, -57.24 78.5, -1.23 in-in-in SNCiii in-in ActLoopNT-in 2.936 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -83.23, 72.86 APE9-dihe-in -74.56, 127.74 APE8-dihe-in -83.18, 74.68 APE8-rot-na 37.06 APE67-dihe-in -71.62, -8.97 -55.74, -33.87 APE12-dist-na 12.592 APE11-dist-na 9.028 APE10-dist-na 9.2 APE9-dist-in 6.489 None PTR1054,PTR1055 PTR1054,PTR1055 XRAY 2.14 0.245 0.293 A 289 278 10 0 0 2 [[589, 868], [897, 1171]] 2.0 7uyt Homo sapiens TYR_TYK2-2_HUMAN TYR 1.1e-81 279.9 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2

Ligand: OV5

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name