Ligand: OLO

Total number of chains: 1
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBtrans 1 100.0% 1W0XC
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CDK2 CDK2_HUMAN 1W0XC P24941 1 298 298.0 OLO:1299 Type1 Inactive DFGin 10.635 18.434 BLBtrans -104.48, 149.93 70.96, 24.05 -67.85, 122.98 217.55, 109.56 85.65, -3.99 out-out out 14.815 Saltbr-out 15.461 HRD-in -90.26, -53.28 75.19, -6.69 out-out-out SNCooo out-out ActLoopNT-out 5.645 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 116.93 APE8-dihe-in -66.78, 124.27 APE8-rot-out 58.47 APE67-dihe-in -42.9, -37.07 -89.95, -9.23 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.546 None None None XRAY 2.2 0.19 0.27 C 298 280 18 0 0 11 [[4, 286]] 1.0 1w0x CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2

Ligand: OLO

Total number of chains: 2
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 1 50.0% 4ERKA
DFGin BLBtrans 1 50.0% 1W0XC
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CDK2 CDK2_HUMAN 1W0XC P24941 1 298 298.0 OLO:1299 Type1 Inactive DFGin 10.635 18.434 BLBtrans -104.48, 149.93 70.96, 24.05 -67.85, 122.98 217.55, 109.56 85.65, -3.99 out-out out 14.815 Saltbr-out 15.461 HRD-in -90.26, -53.28 75.19, -6.69 out-out-out SNCooo out-out ActLoopNT-out 5.645 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 116.93 APE8-dihe-in -66.78, 124.27 APE8-rot-out 58.47 APE67-dihe-in -42.9, -37.07 -89.95, -9.23 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.546 None None None XRAY 2.2 0.19 0.27 C 298 280 18 0 0 11 [[4, 286]] 1.0 1w0x Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC MAPK1 MK01_RAT 4ERKA P63086 6 355 358.0 OLO:800 Type1 Inactive DFGin 6.79 16.323 BLAminus -144.14, 171.66 76.96, 71.97 -100.05, 31.86 291.48, 73.72 -66.9, -29.11 in-out in 9.982 Saltbr-out 4.35 HRD-in -62.75, -51.24 74.6, -9.96 out-in-out SNCoio in-out ActLoopNT-in 2.825 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -92.93, -33.71 APE9-dihe-na -56.55, 147.82 APE8-dihe-in -47.77, 114.88 APE8-rot-in 305.72 APE67-dihe-in -41.49, -37.5 -39.09, -67.78 APE12-dist-out 14.516 APE11-dist-in 11.06 APE10-dist-in 7.262 APE9-dist-in 4.463 None None None XRAY 2.2 0.214 0.317 A 364 350 0 0 0 0 [[23, 311]] 1.0 4erk Rattus norvegicus CMGC_MAPK1_RAT CMGC 1.4e-85 293.1 1 301 301 164 165 166 168 170 52 69 73 144 146 145 147 208 195 190 189 188 187 186 185 184 104 Mitogen-activated protein kinase 1

Ligand: OLO

Total number of chains: 1
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 1 100.0% 4ERKA
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC MAPK1 MK01_RAT 4ERKA P63086 6 355 358.0 OLO:800 Type1 Inactive DFGin 6.79 16.323 BLAminus -144.14, 171.66 76.96, 71.97 -100.05, 31.86 291.48, 73.72 -66.9, -29.11 in-out in 9.982 Saltbr-out 4.35 HRD-in -62.75, -51.24 74.6, -9.96 out-in-out SNCoio in-out ActLoopNT-in 2.825 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -92.93, -33.71 APE9-dihe-na -56.55, 147.82 APE8-dihe-in -47.77, 114.88 APE8-rot-in 305.72 APE67-dihe-in -41.49, -37.5 -39.09, -67.78 APE12-dist-out 14.516 APE11-dist-in 11.06 APE10-dist-in 7.262 APE9-dist-in 4.463 None None None XRAY 2.2 0.214 0.317 A 364 350 0 0 0 0 [[23, 311]] 1.0 4erk Rattus norvegicus CMGC_MAPK1_RAT CMGC 1.4e-85 293.1 1 301 301 164 165 166 168 170 52 69 73 144 146 145 147 208 195 190 189 188 187 186 185 184 104 Mitogen-activated protein kinase 1