Ligand: MFR

Total number of chains: 4
Active chains: 3
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 3BHTA
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CDK2 CDK2_HUMAN 3BHTA P24941 1 298 298.0 MFR:60299 Type1 Active DFGin 6.726 14.916 BLAminus -135.33, 171.78 58.94, 90.09 -105.98, 17.26 279.11, 66.84 -57.88, -30.44 in-in in 8.524 Saltbr-in 2.721 HRD-in -76.97, -54.3 74.08, 10.3 in-in-in SNCiii in-in ActLoopNT-in 2.89 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.38, 161.15 APE9-dihe-na 78.42, 133.04 APE8-dihe-in -54.1, 134.71 APE8-rot-in 298.86 APE67-dihe-in -59.06, -22.55 -47.47, -49.38 APE12-dist-in 13.275 APE11-dist-in 8.918 APE10-dist-in 7.502 APE9-dist-in 3.144 None TPO160 TPO160 XRAY 2.0 0.183 0.22 A 300 296 2 0 0 0 [[4, 286]] 1.0 3bht CMGC_CDK2_HUMAN CMGC 6.5e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 3BHTC P24941 1 296 298.0 MFR:60299 Type1 Active DFGin 6.648 14.904 BLAminus -135.56, 175.64 54.19, 83.05 -97.02, 23.87 283.3, 65.03 -60.61, -30.29 in-in in 8.364 Saltbr-in 2.63 HRD-in -78.59, -55.59 71.83, 12.5 in-in-in SNCiii in-in ActLoopNT-in 2.914 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na 49.0, 126.65 APE9-dihe-na 70.83, 124.33 APE8-dihe-in -53.09, 136.38 APE8-rot-in 313.14 APE67-dihe-in -65.14, -18.51 -41.66, -49.3 APE12-dist-in 12.892 APE11-dist-in 9.398 APE10-dist-in 7.12 APE9-dist-in 3.267 None TPO160 TPO160 XRAY 2.0 0.183 0.22 C 300 270 26 0 0 0 [[4, 286]] 1.0 3bht CMGC_CDK2_HUMAN CMGC 6.5e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC DYRK1A DYR1A_HUMAN 7A5BA Q13627 136 481 763.0 MFR:501 Type1 Active DFGin 7.453 14.846 BLAminus -123.33, 168.55 72.72, 88.97 -105.77, 23.56 281.26, 83.72 -72.41, -22.85 in-in in 8.485 Saltbr-in 2.953 HRD-in -66.22, -48.04 76.25, -4.46 in-in-in SNCiii in-in ActLoopNT-in 2.984 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.35, 172.6 APE9-dihe-na 68.45, 154.81 APE8-dihe-in -72.07, 143.61 APE8-rot-in 303.66 APE67-dihe-in -68.11, -19.27 -52.63, -42.7 APE12-dist-in 9.784 APE11-dist-in 11.923 APE10-dist-in 7.448 APE9-dist-in 3.103 None PTR321 PTR321 XRAY 2.6 0.155 0.192 A 382 340 6 0 0 0 [[159, 479]] 1.0 7a5b CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 7A5BB Q13627 134 481 763.0 MFR:501 Type1 Inactive DFGin 7.363 14.842 BLAminus -128.7, 170.78 69.52, 88.76 -102.46, 24.68 283.18, 76.24 -69.64, -30.01 in-in in 8.335 Saltbr-in 2.7 HRD-in -58.52, -51.24 77.14, -0.56 in-in-out SNCiio in-out ActLoopNT-in 2.875 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -95.16, 165.26 APE9-dihe-na 71.85, 148.34 APE8-dihe-in -58.61, 134.95 APE8-rot-in 282.87 APE67-dihe-in -61.06, -26.55 -48.36, -47.01 APE12-dist-out 14.169 APE11-dist-in 12.052 APE10-dist-in 7.643 APE9-dist-in 2.983 None PTR321 PTR321 XRAY 2.6 0.155 0.192 B 382 341 7 0 0 0 [[159, 479]] 1.0 7a5b CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A

Ligand: MFR

Total number of chains: 4
Active chains: 3
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 3BHTA
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CDK2 CDK2_HUMAN 3BHTA P24941 1 298 298.0 MFR:60299 Type1 Active DFGin 6.726 14.916 BLAminus -135.33, 171.78 58.94, 90.09 -105.98, 17.26 279.11, 66.84 -57.88, -30.44 in-in in 8.524 Saltbr-in 2.721 HRD-in -76.97, -54.3 74.08, 10.3 in-in-in SNCiii in-in ActLoopNT-in 2.89 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.38, 161.15 APE9-dihe-na 78.42, 133.04 APE8-dihe-in -54.1, 134.71 APE8-rot-in 298.86 APE67-dihe-in -59.06, -22.55 -47.47, -49.38 APE12-dist-in 13.275 APE11-dist-in 8.918 APE10-dist-in 7.502 APE9-dist-in 3.144 None TPO160 TPO160 XRAY 2.0 0.183 0.22 A 300 296 2 0 0 0 [[4, 286]] 1.0 3bht Homo sapiens CMGC_CDK2_HUMAN CMGC 6.5e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 3BHTC P24941 1 296 298.0 MFR:60299 Type1 Active DFGin 6.648 14.904 BLAminus -135.56, 175.64 54.19, 83.05 -97.02, 23.87 283.3, 65.03 -60.61, -30.29 in-in in 8.364 Saltbr-in 2.63 HRD-in -78.59, -55.59 71.83, 12.5 in-in-in SNCiii in-in ActLoopNT-in 2.914 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na 49.0, 126.65 APE9-dihe-na 70.83, 124.33 APE8-dihe-in -53.09, 136.38 APE8-rot-in 313.14 APE67-dihe-in -65.14, -18.51 -41.66, -49.3 APE12-dist-in 12.892 APE11-dist-in 9.398 APE10-dist-in 7.12 APE9-dist-in 3.267 None TPO160 TPO160 XRAY 2.0 0.183 0.22 C 300 270 26 0 0 0 [[4, 286]] 1.0 3bht Homo sapiens CMGC_CDK2_HUMAN CMGC 6.5e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC DYRK1A DYR1A_HUMAN 7A5BA Q13627 136 481 763.0 MFR:501 Type1 Active DFGin 7.453 14.846 BLAminus -123.33, 168.55 72.72, 88.97 -105.77, 23.56 281.26, 83.72 -72.41, -22.85 in-in in 8.485 Saltbr-in 2.953 HRD-in -66.22, -48.04 76.25, -4.46 in-in-in SNCiii in-in ActLoopNT-in 2.984 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.35, 172.6 APE9-dihe-na 68.45, 154.81 APE8-dihe-in -72.07, 143.61 APE8-rot-in 303.66 APE67-dihe-in -68.11, -19.27 -52.63, -42.7 APE12-dist-in 9.784 APE11-dist-in 11.923 APE10-dist-in 7.448 APE9-dist-in 3.103 None PTR321 PTR321 XRAY 2.6 0.155 0.192 A 382 340 6 0 0 0 [[159, 479]] 1.0 7a5b Homo sapiens CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 7A5BB Q13627 134 481 763.0 MFR:501 Type1 Inactive DFGin 7.363 14.842 BLAminus -128.7, 170.78 69.52, 88.76 -102.46, 24.68 283.18, 76.24 -69.64, -30.01 in-in in 8.335 Saltbr-in 2.7 HRD-in -58.52, -51.24 77.14, -0.56 in-in-out SNCiio in-out ActLoopNT-in 2.875 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -95.16, 165.26 APE9-dihe-na 71.85, 148.34 APE8-dihe-in -58.61, 134.95 APE8-rot-in 282.87 APE67-dihe-in -61.06, -26.55 -48.36, -47.01 APE12-dist-out 14.169 APE11-dist-in 12.052 APE10-dist-in 7.643 APE9-dist-in 2.983 None PTR321 PTR321 XRAY 2.6 0.155 0.192 B 382 341 7 0 0 0 [[159, 479]] 1.0 7a5b Homo sapiens CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A

Ligand: MFR

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name