Ligand: KQE

Total number of chains: 2
Active chains: 1
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 100.0% 6S11A
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC DYRK1A DYR1A_HUMAN 6S11A Q13627 134 480 763.0 KQE:502 Type1 Active DFGin 7.296 14.892 BLAminus -121.55, 164.1 72.87, 91.72 -105.74, 27.5 285.62, 74.33 -70.05, -23.97 in-in in 8.616 Saltbr-in 2.709 HRD-in -66.61, -45.0 72.81, 4.62 in-in-in SNCiii in-in ActLoopNT-in 2.804 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -97.87, 171.94 APE9-dihe-na 69.56, 141.33 APE8-dihe-in -63.19, 142.1 APE8-rot-in 291.08 APE67-dihe-in -52.63, -29.59 -57.6, -48.58 APE12-dist-in 13.815 APE11-dist-in 12.051 APE10-dist-in 7.349 APE9-dist-in 3.108 None PTR321 PTR321 XRAY 2.445 0.173 0.21 A 361 344 3 25 25 0 [[159, 479]] 1.0 6s11 CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 6S11B Q13627 136 480 763.0 KQE:501 Type1 None DFGin 7.321 14.74 BLAminus -122.66, 164.68 70.6, 90.6 -105.94, 27.83 286.74, 77.35 -71.95, -23.72 in-in in 8.564 Saltbr-in 3.103 HRD-in -69.08, -43.23 70.93, 5.16 in-in-none SNCiin in-none ActLoopNT-in 2.871 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -126.36, 176.02 APE9-dihe-na 69.06, 141.8 APE8-dihe-in -64.1, 141.34 APE8-rot-in 291.06 APE67-dihe-in -52.52, -31.33 -58.27, -46.65 APE12-dist-none 999.0 APE11-dist-in 11.465 APE10-dist-in 7.262 APE9-dist-in 3.159 None PTR321 PTR321 XRAY 2.445 0.173 0.21 B 361 330 15 25 22 3 [[159, 479]] 1.0 6s11 CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A

Ligand: KQE

Total number of chains: 2
Active chains: 1
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 100.0% 6S11A
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC DYRK1A DYR1A_HUMAN 6S11A Q13627 134 480 763.0 KQE:502 Type1 Active DFGin 7.296 14.892 BLAminus -121.55, 164.1 72.87, 91.72 -105.74, 27.5 285.62, 74.33 -70.05, -23.97 in-in in 8.616 Saltbr-in 2.709 HRD-in -66.61, -45.0 72.81, 4.62 in-in-in SNCiii in-in ActLoopNT-in 2.804 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -97.87, 171.94 APE9-dihe-na 69.56, 141.33 APE8-dihe-in -63.19, 142.1 APE8-rot-in 291.08 APE67-dihe-in -52.63, -29.59 -57.6, -48.58 APE12-dist-in 13.815 APE11-dist-in 12.051 APE10-dist-in 7.349 APE9-dist-in 3.108 None PTR321 PTR321 XRAY 2.445 0.173 0.21 A 361 344 3 25 25 0 [[159, 479]] 1.0 6s11 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 6S11B Q13627 136 480 763.0 KQE:501 Type1 None DFGin 7.321 14.74 BLAminus -122.66, 164.68 70.6, 90.6 -105.94, 27.83 286.74, 77.35 -71.95, -23.72 in-in in 8.564 Saltbr-in 3.103 HRD-in -69.08, -43.23 70.93, 5.16 in-in-none SNCiin in-none ActLoopNT-in 2.871 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -126.36, 176.02 APE9-dihe-na 69.06, 141.8 APE8-dihe-in -64.1, 141.34 APE8-rot-in 291.06 APE67-dihe-in -52.52, -31.33 -58.27, -46.65 APE12-dist-none 999.0 APE11-dist-in 11.465 APE10-dist-in 7.262 APE9-dist-in 3.159 None PTR321 PTR321 XRAY 2.445 0.173 0.21 B 361 330 15 25 22 3 [[159, 479]] 1.0 6s11 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A

Ligand: KQE

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name