Ligand: KHC

Total number of chains: 4
Active chains: 3
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 6YU1c
All chains - renumbered by
Uniprot PDB Alignment

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Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CLK1 CLK1_HUMAN 6YTGA P49759 148 483 484.0 KHC:60501,KHC:60502 Type1,Allosteric Active DFGin 7.109 14.378 BLAminus -123.68, -179.19 66.81, 76.1 -102.89, 15.19 291.91, 90.06 -75.03, -12.8 in-in in 8.55 Saltbr-in 2.696 HRD-in -64.66, -54.29 85.54, -10.78 in-in-in SNCiii in-in ActLoopNT-in 2.832 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -106.45, 156.23 APE9-dihe-na 81.17, 153.49 APE8-dihe-in -77.75, 128.48 APE8-rot-in 300.43 APE67-dihe-in -69.97, -17.37 -12.96, -64.06 APE12-dist-in 13.337 APE11-dist-in 11.403 APE10-dist-in 7.756 APE9-dist-in 2.982 None None None XRAY 1.95 0.207 0.261 A 339 329 7 0 0 0 [[161, 477]] 1.0 6ytg CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CMGC CLK3 CLK3_HUMAN 6YU1A P49761 135 481 490.0 KHC:60510 Type1 Active DFGin 7.572 15.602 BLAminus -115.89, 173.22 73.33, 69.85 -91.55, 15.73 290.43, 91.45 -61.37, -25.51 in-in in 9.029 Saltbr-in 3.294 HRD-in -66.59, -53.53 80.71, -11.41 in-in-in SNCiii in-in ActLoopNT-in 2.862 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.25, 166.12 APE9-dihe-na 71.09, 151.47 APE8-dihe-in -74.24, 146.96 APE8-rot-in 288.86 APE67-dihe-in -60.23, -26.89 -39.13, -58.8 APE12-dist-in 13.208 APE11-dist-in 11.355 APE10-dist-in 7.517 APE9-dist-in 2.941 None None None XRAY 1.9 0.177 0.203 a 360 340 7 0 0 0 [[156, 472]] 1.0 6yu1 CMGC_CLK3_HUMAN CMGC 1.2e-90 309.6 1 301 301 319 320 321 323 325 186 201 205 280 282 281 283 356 344 339 338 337 336 335 334 333 237 Dual specificity protein kinase CLK3
CMGC CLK3 CLK3_HUMAN 6YU1C P49761 127 481 490.0 KHC:60519 Type1 Active DFGin 7.76 15.811 BLAminus -119.69, 170.73 79.72, 68.48 -90.33, 8.2 290.58, 93.01 -62.31, -16.94 in-in in 8.811 Saltbr-in 2.72 HRD-in -67.22, -54.95 86.99, -15.49 in-in-in SNCiii in-in ActLoopNT-in 2.831 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.81, 165.34 APE9-dihe-na 71.62, 159.9 APE8-dihe-in -82.73, 144.18 APE8-rot-in 292.06 APE67-dihe-in -70.08, -20.3 -29.27, -62.39 APE12-dist-in 13.256 APE11-dist-in 11.534 APE10-dist-in 7.599 APE9-dist-in 2.945 None None None XRAY 1.9 0.177 0.203 c 360 348 6 0 0 0 [[156, 472]] 1.0 6yu1 CMGC_CLK3_HUMAN CMGC 1.2e-90 309.6 1 301 301 319 320 321 323 325 186 201 205 280 282 281 283 356 344 339 338 337 336 335 334 333 237 Dual specificity protein kinase CLK3
CMGC CLK3 CLK3_HUMAN 6Z2VA P49761 134 480 490.0 KHC:501 Type1 Inactive DFGin 7.354 14.838 BLAminus -146.99, 161.86 65.01, 78.44 -89.71, 17.58 291.55, 82.78 -63.88, -18.76 in-in in 8.43 Saltbr-in 3.12 HRD-in -84.04, -51.62 87.06, -5.78 in-in-out SNCiio in-out ActLoopNT-in 3.03 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -157.4, 157.64 APE9-dihe-na 69.72, 152.96 APE8-dihe-in -83.82, 151.16 APE8-rot-out 81.04 APE67-dihe-in -60.61, -31.57 -38.95, -59.12 APE12-dist-in 13.062 APE11-dist-in 12.039 APE10-dist-in 7.865 APE9-dist-in 2.853 A319V None None XRAY 2.6 0.205 0.265 A 360 339 8 0 0 0 [[156, 472]] 1.0 6z2v CMGC_CLK3_HUMAN CMGC 2e-90 308.9 1 301 301 319 320 321 323 325 186 201 205 280 282 281 283 356 344 339 338 337 336 335 334 333 237 Dual specificity protein kinase CLK3

Ligand: KHC

Total number of chains: 4
Active chains: 3
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 6YU1c
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CLK1 CLK1_HUMAN 6YTGA P49759 148 483 484.0 KHC:60501,KHC:60502 Type1,Allosteric Active DFGin 7.109 14.378 BLAminus -123.68, -179.19 66.81, 76.1 -102.89, 15.19 291.91, 90.06 -75.03, -12.8 in-in in 8.55 Saltbr-in 2.696 HRD-in -64.66, -54.29 85.54, -10.78 in-in-in SNCiii in-in ActLoopNT-in 2.832 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -106.45, 156.23 APE9-dihe-na 81.17, 153.49 APE8-dihe-in -77.75, 128.48 APE8-rot-in 300.43 APE67-dihe-in -69.97, -17.37 -12.96, -64.06 APE12-dist-in 13.337 APE11-dist-in 11.403 APE10-dist-in 7.756 APE9-dist-in 2.982 None None None XRAY 1.95 0.207 0.261 A 339 329 7 0 0 0 [[161, 477]] 1.0 6ytg Homo sapiens CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CMGC CLK3 CLK3_HUMAN 6YU1A P49761 135 481 490.0 KHC:60510 Type1 Active DFGin 7.572 15.602 BLAminus -115.89, 173.22 73.33, 69.85 -91.55, 15.73 290.43, 91.45 -61.37, -25.51 in-in in 9.029 Saltbr-in 3.294 HRD-in -66.59, -53.53 80.71, -11.41 in-in-in SNCiii in-in ActLoopNT-in 2.862 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.25, 166.12 APE9-dihe-na 71.09, 151.47 APE8-dihe-in -74.24, 146.96 APE8-rot-in 288.86 APE67-dihe-in -60.23, -26.89 -39.13, -58.8 APE12-dist-in 13.208 APE11-dist-in 11.355 APE10-dist-in 7.517 APE9-dist-in 2.941 None None None XRAY 1.9 0.177 0.203 a 360 340 7 0 0 0 [[156, 472]] 1.0 6yu1 Homo sapiens CMGC_CLK3_HUMAN CMGC 1.2e-90 309.6 1 301 301 319 320 321 323 325 186 201 205 280 282 281 283 356 344 339 338 337 336 335 334 333 237 Dual specificity protein kinase CLK3
CMGC CLK3 CLK3_HUMAN 6YU1C P49761 127 481 490.0 KHC:60519 Type1 Active DFGin 7.76 15.811 BLAminus -119.69, 170.73 79.72, 68.48 -90.33, 8.2 290.58, 93.01 -62.31, -16.94 in-in in 8.811 Saltbr-in 2.72 HRD-in -67.22, -54.95 86.99, -15.49 in-in-in SNCiii in-in ActLoopNT-in 2.831 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.81, 165.34 APE9-dihe-na 71.62, 159.9 APE8-dihe-in -82.73, 144.18 APE8-rot-in 292.06 APE67-dihe-in -70.08, -20.3 -29.27, -62.39 APE12-dist-in 13.256 APE11-dist-in 11.534 APE10-dist-in 7.599 APE9-dist-in 2.945 None None None XRAY 1.9 0.177 0.203 c 360 348 6 0 0 0 [[156, 472]] 1.0 6yu1 Homo sapiens CMGC_CLK3_HUMAN CMGC 1.2e-90 309.6 1 301 301 319 320 321 323 325 186 201 205 280 282 281 283 356 344 339 338 337 336 335 334 333 237 Dual specificity protein kinase CLK3
CMGC CLK3 CLK3_HUMAN 6Z2VA P49761 134 480 490.0 KHC:501 Type1 Inactive DFGin 7.354 14.838 BLAminus -146.99, 161.86 65.01, 78.44 -89.71, 17.58 291.55, 82.78 -63.88, -18.76 in-in in 8.43 Saltbr-in 3.12 HRD-in -84.04, -51.62 87.06, -5.78 in-in-out SNCiio in-out ActLoopNT-in 3.03 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -157.4, 157.64 APE9-dihe-na 69.72, 152.96 APE8-dihe-in -83.82, 151.16 APE8-rot-out 81.04 APE67-dihe-in -60.61, -31.57 -38.95, -59.12 APE12-dist-in 13.062 APE11-dist-in 12.039 APE10-dist-in 7.865 APE9-dist-in 2.853 A319V None None XRAY 2.6 0.205 0.265 A 360 339 8 0 0 0 [[156, 472]] 1.0 6z2v Homo sapiens CMGC_CLK3_HUMAN CMGC 2e-90 308.9 1 301 301 319 320 321 323 325 186 201 205 280 282 281 283 356 344 339 338 337 336 335 334 333 237 Dual specificity protein kinase CLK3

Ligand: KHC

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name