Ligand: ITQ

Total number of chains: 3
Active chains: 1
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 100.0% 2ITQA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR EGFR EGFR_HUMAN 2ITWA P00533 696 1018 1210.0 ITQ:2018 Type1 Inactive DFGin 5.8533 15.4727 BLAminus -142.09, -169.34 57.7, 89.5 -104.27, 29.57 295.26, 97.45 -82.52, 26.8 in-out in 9.1148 Saltbr-out 3.9241 HRD-in -65.22, -40.15 57.71, 1.3 out-in-in SNCoii in-in ActLoopNT-in 3.0149 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -54.02, 133.84 APE9-dihe-in -142.1, 144.15 APE8-dihe-in -78.28, 106.03 APE8-rot-na 33.32 APE67-dihe-in -72.11, 0.73 -63.71, -37.22 APE12-dist-na 12.4764 APE11-dist-na 10.8329 APE10-dist-na 10.6437 APE9-dist-in 6.4541 None None None XRAY 2.88 0.191 0.256 A 327.0 301.0 0 30 30 0 [[712, 970]] 1.0 2itw TYR_EGFR_HUMAN TYR 1e-87 299.8 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 2ITQA P00533 697 1018 1210.0 ITQ:2019 Type1 Active DFGin 6.0783 15.1642 BLAminus -134.28, -154.87 40.05, 86.95 -97.26, 14.78 286.7, 93.76 -49.66, -18.35 in-in in 8.2118 Saltbr-in 2.4962 HRD-in -68.58, -43.07 56.84, -0.76 in-in-in SNCiii in-in ActLoopNT-in 2.9845 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -55.75, 129.22 APE9-dihe-in -146.28, 133.97 APE8-dihe-in -72.77, 108.98 APE8-rot-na 28.27 APE67-dihe-in -74.85, -6.78 -74.35, -36.29 APE12-dist-na 12.3666 APE11-dist-na 10.7514 APE10-dist-na 10.7455 APE9-dist-in 6.8811 G719S None None XRAY 2.68 0.2 0.263 A 327.0 300.0 0 30 30 0 [[712, 970]] 1.0 2itq TYR_EGFR_HUMAN TYR 9.6e-87 296.6 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 2ITUA P00533 696 1019 1210.0 ITQ:2020 Type1 Inactive DFGin 6.2713 15.6269 BLAminus -134.44, -171.23 59.25, 91.54 -108.34, 5.63 292.29, 91.0 -53.91, 9.05 in-out in 9.0436 Saltbr-out 3.7739 HRD-in -68.49, -42.0 55.69, 2.63 out-in-none SNCoin in-none ActLoopNT-in 2.8929 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 124.97 APE8-dihe-in -92.92, 81.72 APE8-rot-na 21.85 APE67-dihe-in -65.11, -0.4 -64.03, -44.58 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.6657 L858R None None XRAY 2.8 0.201 0.258 A 327.0 304.0 10 30 20 10 [[712, 970]] 1.0 2itu TYR_EGFR_HUMAN TYR 1.1e-86 296.4 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor

Ligand: ITQ

Total number of chains: 3
Active chains: 1
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 100.0% 2ITQA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR EGFR EGFR_HUMAN 2ITWA P00533 696 1018 1210.0 ITQ:2018 Type1 Inactive DFGin 5.8533 15.4727 BLAminus -142.09, -169.34 57.7, 89.5 -104.27, 29.57 295.26, 97.45 -82.52, 26.8 in-out in 9.1148 Saltbr-out 3.9241 HRD-in -65.22, -40.15 57.71, 1.3 out-in-in SNCoii in-in ActLoopNT-in 3.0149 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -54.02, 133.84 APE9-dihe-in -142.1, 144.15 APE8-dihe-in -78.28, 106.03 APE8-rot-na 33.32 APE67-dihe-in -72.11, 0.73 -63.71, -37.22 APE12-dist-na 12.4764 APE11-dist-na 10.8329 APE10-dist-na 10.6437 APE9-dist-in 6.4541 None None None XRAY 2.88 0.191 0.256 A 327.0 301.0 0 30 30 0 [[712, 970]] 1.0 2itw Homo sapiens TYR_EGFR_HUMAN TYR 1e-87 299.8 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 2ITQA P00533 697 1018 1210.0 ITQ:2019 Type1 Active DFGin 6.0783 15.1642 BLAminus -134.28, -154.87 40.05, 86.95 -97.26, 14.78 286.7, 93.76 -49.66, -18.35 in-in in 8.2118 Saltbr-in 2.4962 HRD-in -68.58, -43.07 56.84, -0.76 in-in-in SNCiii in-in ActLoopNT-in 2.9845 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -55.75, 129.22 APE9-dihe-in -146.28, 133.97 APE8-dihe-in -72.77, 108.98 APE8-rot-na 28.27 APE67-dihe-in -74.85, -6.78 -74.35, -36.29 APE12-dist-na 12.3666 APE11-dist-na 10.7514 APE10-dist-na 10.7455 APE9-dist-in 6.8811 G719S None None XRAY 2.68 0.2 0.263 A 327.0 300.0 0 30 30 0 [[712, 970]] 1.0 2itq Homo sapiens TYR_EGFR_HUMAN TYR 9.6e-87 296.6 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 2ITUA P00533 696 1019 1210.0 ITQ:2020 Type1 Inactive DFGin 6.2713 15.6269 BLAminus -134.44, -171.23 59.25, 91.54 -108.34, 5.63 292.29, 91.0 -53.91, 9.05 in-out in 9.0436 Saltbr-out 3.7739 HRD-in -68.49, -42.0 55.69, 2.63 out-in-none SNCoin in-none ActLoopNT-in 2.8929 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 124.97 APE8-dihe-in -92.92, 81.72 APE8-rot-na 21.85 APE67-dihe-in -65.11, -0.4 -64.03, -44.58 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.6657 L858R None None XRAY 2.8 0.201 0.258 A 327.0 304.0 10 30 20 10 [[712, 970]] 1.0 2itu Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-86 296.4 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor

Ligand: ITQ

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name