Ligand: IIS

Total number of chains: 2
Active chains: 2
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 100.0% 9ET8A
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CDK2 CDK2_HUMAN 9ET8A P24941 1 298 298.0 IIS:60601,IIS:60602,IIS:60603 Allosteric,Type1,Allosteric Active DFGin 6.66 15.267 BLAminus -132.18, 175.72 56.92, 87.06 -99.25, 17.56 279.65, 74.77 -56.71, -31.95 in-in in 8.83 Saltbr-in 2.915 HRD-in -79.06, -57.11 80.34, 14.99 in-in-in SNCiii in-in ActLoopNT-in 3.01 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.88, 138.7 APE9-dihe-na 86.37, 127.57 APE8-dihe-in -49.12, 131.32 APE8-rot-in 301.39 APE67-dihe-in -60.3, -18.72 -49.04, -49.16 APE12-dist-in 13.188 APE11-dist-in 10.728 APE10-dist-in 7.284 APE9-dist-in 3.31 None TPO160 TPO160 XRAY 2.31 0.226 0.242 A 302 298 0 0 0 0 [[4, 286]] 1.0 9et8 CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 9ET8C P24941 1 296 298.0 IIS:60301,IIS:60302,IIS:60303 Type1,Allosteric,Allosteric Active DFGin 6.522 15.277 BLAminus -138.22, -178.04 53.64, 77.44 -93.34, 27.5 282.32, 70.76 -68.0, -30.89 in-in in 8.567 Saltbr-in 2.796 HRD-in -80.95, -56.88 70.51, 15.08 in-in-in SNCiii in-in ActLoopNT-in 2.875 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.44, 149.31 APE9-dihe-na 74.52, 129.52 APE8-dihe-in -54.76, 135.97 APE8-rot-in 303.9 APE67-dihe-in -62.13, -18.99 -42.4, -52.2 APE12-dist-in 12.842 APE11-dist-in 10.128 APE10-dist-in 6.95 APE9-dist-in 3.297 None TPO160 TPO160 XRAY 2.31 0.226 0.242 C 302 296 0 0 0 0 [[4, 286]] 1.0 9et8 CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2

Ligand: IIS

Total number of chains: 2
Active chains: 2
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 100.0% 9ET8A
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CDK2 CDK2_HUMAN 9ET8A P24941 1 298 298.0 IIS:60601,IIS:60602,IIS:60603 Allosteric,Type1,Allosteric Active DFGin 6.66 15.267 BLAminus -132.18, 175.72 56.92, 87.06 -99.25, 17.56 279.65, 74.77 -56.71, -31.95 in-in in 8.83 Saltbr-in 2.915 HRD-in -79.06, -57.11 80.34, 14.99 in-in-in SNCiii in-in ActLoopNT-in 3.01 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.88, 138.7 APE9-dihe-na 86.37, 127.57 APE8-dihe-in -49.12, 131.32 APE8-rot-in 301.39 APE67-dihe-in -60.3, -18.72 -49.04, -49.16 APE12-dist-in 13.188 APE11-dist-in 10.728 APE10-dist-in 7.284 APE9-dist-in 3.31 None TPO160 TPO160 XRAY 2.31 0.226 0.242 A 302 298 0 0 0 0 [[4, 286]] 1.0 9et8 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 9ET8C P24941 1 296 298.0 IIS:60301,IIS:60302,IIS:60303 Type1,Allosteric,Allosteric Active DFGin 6.522 15.277 BLAminus -138.22, -178.04 53.64, 77.44 -93.34, 27.5 282.32, 70.76 -68.0, -30.89 in-in in 8.567 Saltbr-in 2.796 HRD-in -80.95, -56.88 70.51, 15.08 in-in-in SNCiii in-in ActLoopNT-in 2.875 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.44, 149.31 APE9-dihe-na 74.52, 129.52 APE8-dihe-in -54.76, 135.97 APE8-rot-in 303.9 APE67-dihe-in -62.13, -18.99 -42.4, -52.2 APE12-dist-in 12.842 APE11-dist-in 10.128 APE10-dist-in 6.95 APE9-dist-in 3.297 None TPO160 TPO160 XRAY 2.31 0.226 0.242 C 302 296 0 0 0 0 [[4, 286]] 1.0 9et8 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2

Ligand: IIS

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name