Ligand: HH8

Total number of chains: 3
Active chains: 2
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 66.7% 9ESYA
DFGin BLBtrans 1 33.3% 6Q4CA
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CDK2 CDK2_HUMAN 9ESYA P24941 1 296 298.0 HH8:60601,HH8:60602 Allosteric,Type1 Active DFGin 6.914 15.445 BLAminus -139.64, -178.33 56.3, 76.8 -98.54, 32.68 277.01, 73.22 -78.73, -25.27 in-in in 8.706 Saltbr-in 3.122 HRD-in -81.47, -55.44 76.61, 11.71 in-in-in SNCiii in-in ActLoopNT-in 3.027 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -105.23, 175.02 APE9-dihe-na 74.59, 128.83 APE8-dihe-in -54.03, 132.08 APE8-rot-in 290.61 APE67-dihe-in -59.72, -15.02 -41.89, -48.16 APE12-dist-in 13.107 APE11-dist-in 12.117 APE10-dist-in 7.098 APE9-dist-in 3.172 None TPO160 TPO160 XRAY 2.394 0.257 0.262 A 302 296 0 0 0 0 [[4, 286]] 1.0 9esy CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 9ESYC P24941 1 296 298.0 HH8:60601 Type1 Active DFGin 6.815 15.392 BLAminus -143.51, -171.61 48.8, 76.72 -98.69, 31.73 280.0, 78.65 -75.94, -27.79 in-in in 8.704 Saltbr-in 2.739 HRD-in -81.36, -63.29 73.99, 13.09 in-in-in SNCiii in-in ActLoopNT-in 2.948 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.04, 152.88 APE9-dihe-na 70.43, 129.81 APE8-dihe-in -56.88, 139.73 APE8-rot-in 314.35 APE67-dihe-in -55.17, -26.22 -41.74, -56.57 APE12-dist-in 12.652 APE11-dist-in 9.842 APE10-dist-in 6.698 APE9-dist-in 3.152 None TPO160 TPO160 XRAY 2.394 0.257 0.262 C 302 265 31 0 0 0 [[4, 286]] 1.0 9esy CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 6Q4CA P24941 1 298 298.0 HH8:60301 Type1 Inactive DFGin 10.803 18.281 BLBtrans -99.7, 151.19 74.85, 22.65 -57.9, 138.98 239.02, 98.87 71.58, -4.6 out-out out 15.77 Saltbr-out 16.722 HRD-in -88.21, -60.63 80.87, -13.25 out-out-out SNCooo out-out ActLoopNT-out 5.858 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -76.34, 128.11 APE9-dihe-na -74.88, 130.64 APE8-dihe-in -71.7, 136.54 APE8-rot-out 190.87 APE67-dihe-in -66.44, -25.99 -93.82, -2.36 APE12-dist-out 20.184 APE11-dist-out 17.867 APE10-dist-out 19.012 APE9-dist-out 10.574 None None None XRAY 1.73 0.182 0.223 A 306 291 7 0 0 0 [[4, 286]] 1.0 6q4c CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2

Ligand: HH8

Total number of chains: 3
Active chains: 2
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 66.7% 9ESYA
DFGin BLBtrans 1 33.3% 6Q4CA
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CDK2 CDK2_HUMAN 9ESYA P24941 1 296 298.0 HH8:60601,HH8:60602 Allosteric,Type1 Active DFGin 6.914 15.445 BLAminus -139.64, -178.33 56.3, 76.8 -98.54, 32.68 277.01, 73.22 -78.73, -25.27 in-in in 8.706 Saltbr-in 3.122 HRD-in -81.47, -55.44 76.61, 11.71 in-in-in SNCiii in-in ActLoopNT-in 3.027 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -105.23, 175.02 APE9-dihe-na 74.59, 128.83 APE8-dihe-in -54.03, 132.08 APE8-rot-in 290.61 APE67-dihe-in -59.72, -15.02 -41.89, -48.16 APE12-dist-in 13.107 APE11-dist-in 12.117 APE10-dist-in 7.098 APE9-dist-in 3.172 None TPO160 TPO160 XRAY 2.394 0.257 0.262 A 302 296 0 0 0 0 [[4, 286]] 1.0 9esy Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 9ESYC P24941 1 296 298.0 HH8:60601 Type1 Active DFGin 6.815 15.392 BLAminus -143.51, -171.61 48.8, 76.72 -98.69, 31.73 280.0, 78.65 -75.94, -27.79 in-in in 8.704 Saltbr-in 2.739 HRD-in -81.36, -63.29 73.99, 13.09 in-in-in SNCiii in-in ActLoopNT-in 2.948 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.04, 152.88 APE9-dihe-na 70.43, 129.81 APE8-dihe-in -56.88, 139.73 APE8-rot-in 314.35 APE67-dihe-in -55.17, -26.22 -41.74, -56.57 APE12-dist-in 12.652 APE11-dist-in 9.842 APE10-dist-in 6.698 APE9-dist-in 3.152 None TPO160 TPO160 XRAY 2.394 0.257 0.262 C 302 265 31 0 0 0 [[4, 286]] 1.0 9esy Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 6Q4CA P24941 1 298 298.0 HH8:60301 Type1 Inactive DFGin 10.803 18.281 BLBtrans -99.7, 151.19 74.85, 22.65 -57.9, 138.98 239.02, 98.87 71.58, -4.6 out-out out 15.77 Saltbr-out 16.722 HRD-in -88.21, -60.63 80.87, -13.25 out-out-out SNCooo out-out ActLoopNT-out 5.858 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -76.34, 128.11 APE9-dihe-na -74.88, 130.64 APE8-dihe-in -71.7, 136.54 APE8-rot-out 190.87 APE67-dihe-in -66.44, -25.99 -93.82, -2.36 APE12-dist-out 20.184 APE11-dist-out 17.867 APE10-dist-out 19.012 APE9-dist-out 10.574 None None None XRAY 1.73 0.182 0.223 A 306 291 7 0 0 0 [[4, 286]] 1.0 6q4c Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2

Ligand: HH8

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name