Ligand: EAZ

Total number of chains: 3
Active chains: 3
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 100.0% 6FYKA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CLK2 CLK2_HUMAN 6FYKA P49760 137 485 499.0 EAZ:501 Type1 Active DFGin 7.0247 13.933 BLAminus -128.78, 177.13 62.38, 94.51 -113.34, 21.4 294.8, 89.41 -67.4, -12.68 in-in in 8.6929 Saltbr-in 2.6136 HRD-in -66.97, -50.97 77.07, -17.13 in-in-in SNCiii in-in ActLoopNT-in 2.7927 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.9, 169.97 APE9-dihe-na 71.5, 144.52 APE8-dihe-in -67.7, 143.43 APE8-rot-in 294.43 APE67-dihe-in -55.56, -28.09 -39.63, -56.25 APE12-dist-in 13.2898 APE11-dist-in 11.7062 APE10-dist-in 7.4097 APE9-dist-in 2.9513 None None None XRAY 2.39 0.196 0.228 A 363.0 349.0 0 25 25 0 [[163, 479]] 1.0 6fyk CMGC_CLK2_HUMAN CMGC 1.7e-92 315.7 1.0 301.0 301.0 326 327 328 330 332 193 208 212 287 289 288 290.0 363 351 346 345 344 343 342 341 340 244 Dual specificity protein kinase CLK2
CMGC CLK2 CLK2_HUMAN 6FYKB P49760 137 485 499.0 EAZ:501 Type1 Active DFGin 6.9791 13.5453 BLAminus -126.36, 176.1 65.04, 89.02 -110.3, 25.2 302.84, 96.68 -72.78, -13.24 in-in in 8.5714 Saltbr-in 2.6918 HRD-in -74.27, -47.13 73.72, -15.28 in-in-in SNCiii in-in ActLoopNT-in 2.834 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -119.26, 173.72 APE9-dihe-na 72.32, 147.64 APE8-dihe-in -71.42, 138.78 APE8-rot-in 296.31 APE67-dihe-in -62.52, -26.37 -31.99, -52.81 APE12-dist-in 13.304 APE11-dist-in 11.8792 APE10-dist-in 7.3646 APE9-dist-in 2.8961 None None None XRAY 2.39 0.196 0.228 B 363.0 349.0 0 25 25 0 [[163, 479]] 1.0 6fyk CMGC_CLK2_HUMAN CMGC 1.7e-92 315.7 1.0 301.0 301.0 326 327 328 330 332 193 208 212 287 289 288 290.0 363 351 346 345 344 343 342 341 340 244 Dual specificity protein kinase CLK2
CMGC CLK2 CLK2_HUMAN 6FYKC P49760 137 485 499.0 EAZ:501 Type1 Active DFGin 7.1797 13.8088 BLAminus -122.42, 175.39 66.62, 94.13 -114.05, 24.08 298.67, 87.87 -71.48, -13.77 in-in in 8.5576 Saltbr-in 2.7503 HRD-in -70.0, -49.32 73.58, -20.32 in-in-in SNCiii in-in ActLoopNT-in 2.8236 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.75, 171.99 APE9-dihe-na 73.44, 147.9 APE8-dihe-in -74.12, 135.91 APE8-rot-in 297.57 APE67-dihe-in -59.91, -18.18 -29.96, -58.43 APE12-dist-in 13.4365 APE11-dist-in 12.0418 APE10-dist-in 7.4714 APE9-dist-in 3.0303 None None None XRAY 2.39 0.196 0.228 C 363.0 349.0 0 25 25 0 [[163, 479]] 1.0 6fyk CMGC_CLK2_HUMAN CMGC 1.7e-92 315.7 1.0 301.0 301.0 326 327 328 330 332 193 208 212 287 289 288 290.0 363 351 346 345 344 343 342 341 340 244 Dual specificity protein kinase CLK2

Ligand: EAZ

Total number of chains: 3
Active chains: 3
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 100.0% 6FYKA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CLK2 CLK2_HUMAN 6FYKA P49760 137 485 499.0 EAZ:501 Type1 Active DFGin 7.0247 13.933 BLAminus -128.78, 177.13 62.38, 94.51 -113.34, 21.4 294.8, 89.41 -67.4, -12.68 in-in in 8.6929 Saltbr-in 2.6136 HRD-in -66.97, -50.97 77.07, -17.13 in-in-in SNCiii in-in ActLoopNT-in 2.7927 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.9, 169.97 APE9-dihe-na 71.5, 144.52 APE8-dihe-in -67.7, 143.43 APE8-rot-in 294.43 APE67-dihe-in -55.56, -28.09 -39.63, -56.25 APE12-dist-in 13.2898 APE11-dist-in 11.7062 APE10-dist-in 7.4097 APE9-dist-in 2.9513 None None None XRAY 2.39 0.196 0.228 A 363.0 349.0 0 25 25 0 [[163, 479]] 1.0 6fyk Homo sapiens CMGC_CLK2_HUMAN CMGC 1.7e-92 315.7 1.0 301.0 301.0 326 327 328 330 332 193 208 212 287 289 288 290.0 363 351 346 345 344 343 342 341 340 244 Dual specificity protein kinase CLK2
CMGC CLK2 CLK2_HUMAN 6FYKB P49760 137 485 499.0 EAZ:501 Type1 Active DFGin 6.9791 13.5453 BLAminus -126.36, 176.1 65.04, 89.02 -110.3, 25.2 302.84, 96.68 -72.78, -13.24 in-in in 8.5714 Saltbr-in 2.6918 HRD-in -74.27, -47.13 73.72, -15.28 in-in-in SNCiii in-in ActLoopNT-in 2.834 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -119.26, 173.72 APE9-dihe-na 72.32, 147.64 APE8-dihe-in -71.42, 138.78 APE8-rot-in 296.31 APE67-dihe-in -62.52, -26.37 -31.99, -52.81 APE12-dist-in 13.304 APE11-dist-in 11.8792 APE10-dist-in 7.3646 APE9-dist-in 2.8961 None None None XRAY 2.39 0.196 0.228 B 363.0 349.0 0 25 25 0 [[163, 479]] 1.0 6fyk Homo sapiens CMGC_CLK2_HUMAN CMGC 1.7e-92 315.7 1.0 301.0 301.0 326 327 328 330 332 193 208 212 287 289 288 290.0 363 351 346 345 344 343 342 341 340 244 Dual specificity protein kinase CLK2
CMGC CLK2 CLK2_HUMAN 6FYKC P49760 137 485 499.0 EAZ:501 Type1 Active DFGin 7.1797 13.8088 BLAminus -122.42, 175.39 66.62, 94.13 -114.05, 24.08 298.67, 87.87 -71.48, -13.77 in-in in 8.5576 Saltbr-in 2.7503 HRD-in -70.0, -49.32 73.58, -20.32 in-in-in SNCiii in-in ActLoopNT-in 2.8236 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.75, 171.99 APE9-dihe-na 73.44, 147.9 APE8-dihe-in -74.12, 135.91 APE8-rot-in 297.57 APE67-dihe-in -59.91, -18.18 -29.96, -58.43 APE12-dist-in 13.4365 APE11-dist-in 12.0418 APE10-dist-in 7.4714 APE9-dist-in 3.0303 None None None XRAY 2.39 0.196 0.228 C 363.0 349.0 0 25 25 0 [[163, 479]] 1.0 6fyk Homo sapiens CMGC_CLK2_HUMAN CMGC 1.7e-92 315.7 1.0 301.0 301.0 326 327 328 330 332 193 208 212 287 289 288 290.0 363 351 346 345 344 343 342 341 340 244 Dual specificity protein kinase CLK2

Ligand: EAZ

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name