Ligand: EAZ

Total number of chains: 3
Active chains: 3
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 100.0% 6FYKA
All chains - renumbered by
Uniprot PDB Alignment

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Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CLK2 CLK2_HUMAN 6FYKA P49760 137 485 499.0 EAZ:501 Type1 Active DFGin 7.025 13.933 BLAminus -128.78, 177.13 62.38, 94.51 -113.34, 21.4 294.8, 89.41 -67.4, -12.68 in-in in 8.693 Saltbr-in 2.614 HRD-in -66.97, -50.97 77.07, -17.13 in-in-in SNCiii in-in ActLoopNT-in 2.793 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.9, 169.97 APE9-dihe-na 71.5, 144.52 APE8-dihe-in -67.7, 143.43 APE8-rot-in 294.43 APE67-dihe-in -55.56, -28.09 -39.63, -56.25 APE12-dist-in 13.29 APE11-dist-in 11.706 APE10-dist-in 7.41 APE9-dist-in 2.951 None None None XRAY 2.39 0.196 0.228 A 363 349 0 0 0 0 [[163, 479]] 1.0 6fyk CMGC_CLK2_HUMAN CMGC 1.7e-92 315.7 1 301 301 326 327 328 330 332 193 208 212 287 289 288 290 363 351 346 345 344 343 342 341 340 244 Dual specificity protein kinase CLK2
CMGC CLK2 CLK2_HUMAN 6FYKB P49760 137 485 499.0 EAZ:501 Type1 Active DFGin 6.979 13.545 BLAminus -126.36, 176.1 65.04, 89.02 -110.3, 25.2 302.84, 96.68 -72.78, -13.24 in-in in 8.571 Saltbr-in 2.692 HRD-in -74.27, -47.13 73.72, -15.28 in-in-in SNCiii in-in ActLoopNT-in 2.834 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -119.26, 173.72 APE9-dihe-na 72.32, 147.64 APE8-dihe-in -71.42, 138.78 APE8-rot-in 296.31 APE67-dihe-in -62.52, -26.37 -31.99, -52.81 APE12-dist-in 13.304 APE11-dist-in 11.879 APE10-dist-in 7.365 APE9-dist-in 2.896 None None None XRAY 2.39 0.196 0.228 B 363 349 0 0 0 0 [[163, 479]] 1.0 6fyk CMGC_CLK2_HUMAN CMGC 1.7e-92 315.7 1 301 301 326 327 328 330 332 193 208 212 287 289 288 290 363 351 346 345 344 343 342 341 340 244 Dual specificity protein kinase CLK2
CMGC CLK2 CLK2_HUMAN 6FYKC P49760 137 485 499.0 EAZ:501 Type1 Active DFGin 7.18 13.809 BLAminus -122.42, 175.39 66.62, 94.13 -114.05, 24.08 298.67, 87.87 -71.48, -13.77 in-in in 8.558 Saltbr-in 2.75 HRD-in -70.0, -49.32 73.58, -20.32 in-in-in SNCiii in-in ActLoopNT-in 2.824 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.75, 171.99 APE9-dihe-na 73.44, 147.9 APE8-dihe-in -74.12, 135.91 APE8-rot-in 297.57 APE67-dihe-in -59.91, -18.18 -29.96, -58.43 APE12-dist-in 13.437 APE11-dist-in 12.042 APE10-dist-in 7.471 APE9-dist-in 3.03 None None None XRAY 2.39 0.196 0.228 C 363 349 0 0 0 0 [[163, 479]] 1.0 6fyk CMGC_CLK2_HUMAN CMGC 1.7e-92 315.7 1 301 301 326 327 328 330 332 193 208 212 287 289 288 290 363 351 346 345 344 343 342 341 340 244 Dual specificity protein kinase CLK2

Ligand: EAZ

Total number of chains: 3
Active chains: 3
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 100.0% 6FYKA
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CLK2 CLK2_HUMAN 6FYKA P49760 137 485 499.0 EAZ:501 Type1 Active DFGin 7.025 13.933 BLAminus -128.78, 177.13 62.38, 94.51 -113.34, 21.4 294.8, 89.41 -67.4, -12.68 in-in in 8.693 Saltbr-in 2.614 HRD-in -66.97, -50.97 77.07, -17.13 in-in-in SNCiii in-in ActLoopNT-in 2.793 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.9, 169.97 APE9-dihe-na 71.5, 144.52 APE8-dihe-in -67.7, 143.43 APE8-rot-in 294.43 APE67-dihe-in -55.56, -28.09 -39.63, -56.25 APE12-dist-in 13.29 APE11-dist-in 11.706 APE10-dist-in 7.41 APE9-dist-in 2.951 None None None XRAY 2.39 0.196 0.228 A 363 349 0 0 0 0 [[163, 479]] 1.0 6fyk Homo sapiens CMGC_CLK2_HUMAN CMGC 1.7e-92 315.7 1 301 301 326 327 328 330 332 193 208 212 287 289 288 290 363 351 346 345 344 343 342 341 340 244 Dual specificity protein kinase CLK2
CMGC CLK2 CLK2_HUMAN 6FYKB P49760 137 485 499.0 EAZ:501 Type1 Active DFGin 6.979 13.545 BLAminus -126.36, 176.1 65.04, 89.02 -110.3, 25.2 302.84, 96.68 -72.78, -13.24 in-in in 8.571 Saltbr-in 2.692 HRD-in -74.27, -47.13 73.72, -15.28 in-in-in SNCiii in-in ActLoopNT-in 2.834 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -119.26, 173.72 APE9-dihe-na 72.32, 147.64 APE8-dihe-in -71.42, 138.78 APE8-rot-in 296.31 APE67-dihe-in -62.52, -26.37 -31.99, -52.81 APE12-dist-in 13.304 APE11-dist-in 11.879 APE10-dist-in 7.365 APE9-dist-in 2.896 None None None XRAY 2.39 0.196 0.228 B 363 349 0 0 0 0 [[163, 479]] 1.0 6fyk Homo sapiens CMGC_CLK2_HUMAN CMGC 1.7e-92 315.7 1 301 301 326 327 328 330 332 193 208 212 287 289 288 290 363 351 346 345 344 343 342 341 340 244 Dual specificity protein kinase CLK2
CMGC CLK2 CLK2_HUMAN 6FYKC P49760 137 485 499.0 EAZ:501 Type1 Active DFGin 7.18 13.809 BLAminus -122.42, 175.39 66.62, 94.13 -114.05, 24.08 298.67, 87.87 -71.48, -13.77 in-in in 8.558 Saltbr-in 2.75 HRD-in -70.0, -49.32 73.58, -20.32 in-in-in SNCiii in-in ActLoopNT-in 2.824 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.75, 171.99 APE9-dihe-na 73.44, 147.9 APE8-dihe-in -74.12, 135.91 APE8-rot-in 297.57 APE67-dihe-in -59.91, -18.18 -29.96, -58.43 APE12-dist-in 13.437 APE11-dist-in 12.042 APE10-dist-in 7.471 APE9-dist-in 3.03 None None None XRAY 2.39 0.196 0.228 C 363 349 0 0 0 0 [[163, 479]] 1.0 6fyk Homo sapiens CMGC_CLK2_HUMAN CMGC 1.7e-92 315.7 1 301 301 326 327 328 330 332 193 208 212 287 289 288 290 363 351 346 345 344 343 342 341 340 244 Dual specificity protein kinase CLK2

Ligand: EAZ

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name