Ligand: EAE

Total number of chains: 6
Active chains: 6
Total number of genes: 3
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 6 100.0% 6YTDA
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CLK1 CLK1_HUMAN 6YTDA P49759 148 484 484.0 EAE:60501 Type1 Active DFGin 7.218 14.624 BLAminus -129.04, -179.37 68.43, 75.26 -99.43, 5.66 289.75, 100.38 -57.22, -23.43 in-in in 8.789 Saltbr-in 2.743 HRD-in -67.84, -52.77 79.42, -15.7 in-in-in SNCiii in-in ActLoopNT-in 2.956 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.91, 160.56 APE9-dihe-na 78.51, 152.43 APE8-dihe-in -82.58, 136.21 APE8-rot-in 297.75 APE67-dihe-in -72.13, -8.69 -31.46, -59.55 APE12-dist-in 13.409 APE11-dist-in 11.117 APE10-dist-in 7.411 APE9-dist-in 2.986 V324A None None XRAY 2.0 0.182 0.228 A 339 337 0 0 0 0 [[161, 477]] 1.0 6ytd CMGC_CLK1_HUMAN CMGC 1.5e-93 319.2 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CMGC CLK1 CLK1_HUMAN 6YTEC P49759 148 484 484.0 EAE:60501 Type1 Active DFGin 7.145 14.111 BLAminus -123.36, 172.5 72.26, 86.11 -107.09, 11.71 295.65, 98.47 -58.29, -17.8 in-in in 8.544 Saltbr-in 2.225 HRD-in -60.42, -59.86 88.88, -8.99 in-in-in SNCiii in-in ActLoopNT-in 3.005 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.24, 160.76 APE9-dihe-na 81.35, 157.72 APE8-dihe-in -87.96, 130.83 APE8-rot-in 293.05 APE67-dihe-in -54.77, -23.25 -31.22, -65.53 APE12-dist-in 13.375 APE11-dist-in 11.44 APE10-dist-in 7.321 APE9-dist-in 3.082 None None None XRAY 2.3 0.184 0.258 C 339 337 0 0 0 0 [[161, 477]] 1.0 6yte CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CMGC CLK2 CLK2_HUMAN 6FYIA P49760 148 483 499.0 EAE:501 Type1 Active DFGin 7.059 14.247 BLAminus -118.89, -176.08 54.9, 90.13 -108.37, 24.54 295.21, 92.22 -68.08, -17.95 in-in in 8.873 Saltbr-in 2.761 HRD-in -71.46, -43.74 72.78, -37.63 in-in-in SNCiii in-in ActLoopNT-in 2.917 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.68, 170.24 APE9-dihe-na 75.27, 152.33 APE8-dihe-in -73.5, 140.46 APE8-rot-in 301.64 APE67-dihe-in -60.39, -24.06 -32.87, -56.62 APE12-dist-in 13.495 APE11-dist-in 11.894 APE10-dist-in 7.35 APE9-dist-in 3.174 None None None XRAY 2.6 0.219 0.233 A 368 336 0 0 0 0 [[163, 479]] 1.0 6fyi CMGC_CLK2_HUMAN CMGC 1.8e-92 315.6 1 301 301 326 327 328 330 332 193 208 212 287 289 288 290 363 351 346 345 344 343 342 341 340 244 Dual specificity protein kinase CLK2
CMGC CLK3 CLK3_HUMAN 6YTWA P49761 127 481 490.0 EAE:60512 Type1 Active DFGin 7.699 15.431 BLAminus -113.75, 171.77 74.13, 69.12 -90.55, 16.73 297.04, 88.04 -58.73, -29.5 in-in in 8.819 Saltbr-in 2.935 HRD-in -72.04, -52.05 86.8, -16.28 in-in-in SNCiii in-in ActLoopNT-in 2.787 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.86, 165.24 APE9-dihe-na 77.16, 162.31 APE8-dihe-in -85.84, 147.02 APE8-rot-in 293.49 APE67-dihe-in -61.4, -23.59 -33.01, -61.88 APE12-dist-in 13.169 APE11-dist-in 11.948 APE10-dist-in 7.472 APE9-dist-in 2.987 None None None XRAY 2.0 0.186 0.227 A 360 347 7 0 0 0 [[156, 472]] 1.0 6ytw CMGC_CLK3_HUMAN CMGC 1.2e-90 309.6 1 301 301 319 320 321 323 325 186 201 205 280 282 281 283 356 344 339 338 337 336 335 334 333 237 Dual specificity protein kinase CLK3
CMGC CLK3 CLK3_HUMAN 6YTWB P49761 134 481 490.0 EAE:60512 Type1 Active DFGin 7.603 15.557 BLAminus -118.7, 170.41 71.62, 71.79 -90.05, 12.92 288.99, 100.31 -52.9, -36.56 in-in in 8.998 Saltbr-in 3.178 HRD-in -73.9, -51.74 79.51, -16.54 in-in-in SNCiii in-in ActLoopNT-in 2.913 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.84, 174.67 APE9-dihe-na 70.75, 150.53 APE8-dihe-in -71.79, 141.9 APE8-rot-in 290.82 APE67-dihe-in -61.11, -25.78 -29.28, -64.93 APE12-dist-in 13.187 APE11-dist-in 11.77 APE10-dist-in 7.348 APE9-dist-in 2.921 None None None XRAY 2.0 0.186 0.227 B 360 339 7 0 0 0 [[156, 472]] 1.0 6ytw CMGC_CLK3_HUMAN CMGC 1.2e-90 309.6 1 301 301 319 320 321 323 325 186 201 205 280 282 281 283 356 344 339 338 337 336 335 334 333 237 Dual specificity protein kinase CLK3
CMGC CLK3 CLK3_HUMAN 6YTYA P49761 127 481 490.0 EAE:502 Type1 Active DFGin 7.292 14.727 BLAminus -118.42, -179.04 54.61, 81.07 -90.19, 20.66 288.13, 83.57 -71.98, -12.75 in-in in 8.863 Saltbr-in 2.708 HRD-in -69.86, -53.68 84.67, -14.39 in-in-in SNCiii in-in ActLoopNT-in 2.86 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -110.82, 173.51 APE9-dihe-na 70.8, 155.7 APE8-dihe-in -74.76, 144.22 APE8-rot-in 294.49 APE67-dihe-in -64.1, -22.37 -34.78, -62.17 APE12-dist-in 13.01 APE11-dist-in 12.048 APE10-dist-in 7.398 APE9-dist-in 2.965 A319V None None XRAY 1.76 0.188 0.224 A 360 353 5 0 0 0 [[156, 472]] 1.0 6yty CMGC_CLK3_HUMAN CMGC 2e-90 308.9 1 301 301 319 320 321 323 325 186 201 205 280 282 281 283 356 344 339 338 337 336 335 334 333 237 Dual specificity protein kinase CLK3

Ligand: EAE

Total number of chains: 6
Active chains: 6
Total number of genes: 3
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 6 100.0% 6YTDA
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CLK1 CLK1_HUMAN 6YTDA P49759 148 484 484.0 EAE:60501 Type1 Active DFGin 7.218 14.624 BLAminus -129.04, -179.37 68.43, 75.26 -99.43, 5.66 289.75, 100.38 -57.22, -23.43 in-in in 8.789 Saltbr-in 2.743 HRD-in -67.84, -52.77 79.42, -15.7 in-in-in SNCiii in-in ActLoopNT-in 2.956 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.91, 160.56 APE9-dihe-na 78.51, 152.43 APE8-dihe-in -82.58, 136.21 APE8-rot-in 297.75 APE67-dihe-in -72.13, -8.69 -31.46, -59.55 APE12-dist-in 13.409 APE11-dist-in 11.117 APE10-dist-in 7.411 APE9-dist-in 2.986 V324A None None XRAY 2.0 0.182 0.228 A 339 337 0 0 0 0 [[161, 477]] 1.0 6ytd Homo sapiens CMGC_CLK1_HUMAN CMGC 1.5e-93 319.2 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CMGC CLK1 CLK1_HUMAN 6YTEC P49759 148 484 484.0 EAE:60501 Type1 Active DFGin 7.145 14.111 BLAminus -123.36, 172.5 72.26, 86.11 -107.09, 11.71 295.65, 98.47 -58.29, -17.8 in-in in 8.544 Saltbr-in 2.225 HRD-in -60.42, -59.86 88.88, -8.99 in-in-in SNCiii in-in ActLoopNT-in 3.005 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.24, 160.76 APE9-dihe-na 81.35, 157.72 APE8-dihe-in -87.96, 130.83 APE8-rot-in 293.05 APE67-dihe-in -54.77, -23.25 -31.22, -65.53 APE12-dist-in 13.375 APE11-dist-in 11.44 APE10-dist-in 7.321 APE9-dist-in 3.082 None None None XRAY 2.3 0.184 0.258 C 339 337 0 0 0 0 [[161, 477]] 1.0 6yte Homo sapiens CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CMGC CLK2 CLK2_HUMAN 6FYIA P49760 148 483 499.0 EAE:501 Type1 Active DFGin 7.059 14.247 BLAminus -118.89, -176.08 54.9, 90.13 -108.37, 24.54 295.21, 92.22 -68.08, -17.95 in-in in 8.873 Saltbr-in 2.761 HRD-in -71.46, -43.74 72.78, -37.63 in-in-in SNCiii in-in ActLoopNT-in 2.917 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.68, 170.24 APE9-dihe-na 75.27, 152.33 APE8-dihe-in -73.5, 140.46 APE8-rot-in 301.64 APE67-dihe-in -60.39, -24.06 -32.87, -56.62 APE12-dist-in 13.495 APE11-dist-in 11.894 APE10-dist-in 7.35 APE9-dist-in 3.174 None None None XRAY 2.6 0.219 0.233 A 368 336 0 0 0 0 [[163, 479]] 1.0 6fyi Homo sapiens CMGC_CLK2_HUMAN CMGC 1.8e-92 315.6 1 301 301 326 327 328 330 332 193 208 212 287 289 288 290 363 351 346 345 344 343 342 341 340 244 Dual specificity protein kinase CLK2
CMGC CLK3 CLK3_HUMAN 6YTWA P49761 127 481 490.0 EAE:60512 Type1 Active DFGin 7.699 15.431 BLAminus -113.75, 171.77 74.13, 69.12 -90.55, 16.73 297.04, 88.04 -58.73, -29.5 in-in in 8.819 Saltbr-in 2.935 HRD-in -72.04, -52.05 86.8, -16.28 in-in-in SNCiii in-in ActLoopNT-in 2.787 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.86, 165.24 APE9-dihe-na 77.16, 162.31 APE8-dihe-in -85.84, 147.02 APE8-rot-in 293.49 APE67-dihe-in -61.4, -23.59 -33.01, -61.88 APE12-dist-in 13.169 APE11-dist-in 11.948 APE10-dist-in 7.472 APE9-dist-in 2.987 None None None XRAY 2.0 0.186 0.227 A 360 347 7 0 0 0 [[156, 472]] 1.0 6ytw Homo sapiens CMGC_CLK3_HUMAN CMGC 1.2e-90 309.6 1 301 301 319 320 321 323 325 186 201 205 280 282 281 283 356 344 339 338 337 336 335 334 333 237 Dual specificity protein kinase CLK3
CMGC CLK3 CLK3_HUMAN 6YTWB P49761 134 481 490.0 EAE:60512 Type1 Active DFGin 7.603 15.557 BLAminus -118.7, 170.41 71.62, 71.79 -90.05, 12.92 288.99, 100.31 -52.9, -36.56 in-in in 8.998 Saltbr-in 3.178 HRD-in -73.9, -51.74 79.51, -16.54 in-in-in SNCiii in-in ActLoopNT-in 2.913 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.84, 174.67 APE9-dihe-na 70.75, 150.53 APE8-dihe-in -71.79, 141.9 APE8-rot-in 290.82 APE67-dihe-in -61.11, -25.78 -29.28, -64.93 APE12-dist-in 13.187 APE11-dist-in 11.77 APE10-dist-in 7.348 APE9-dist-in 2.921 None None None XRAY 2.0 0.186 0.227 B 360 339 7 0 0 0 [[156, 472]] 1.0 6ytw Homo sapiens CMGC_CLK3_HUMAN CMGC 1.2e-90 309.6 1 301 301 319 320 321 323 325 186 201 205 280 282 281 283 356 344 339 338 337 336 335 334 333 237 Dual specificity protein kinase CLK3
CMGC CLK3 CLK3_HUMAN 6YTYA P49761 127 481 490.0 EAE:502 Type1 Active DFGin 7.292 14.727 BLAminus -118.42, -179.04 54.61, 81.07 -90.19, 20.66 288.13, 83.57 -71.98, -12.75 in-in in 8.863 Saltbr-in 2.708 HRD-in -69.86, -53.68 84.67, -14.39 in-in-in SNCiii in-in ActLoopNT-in 2.86 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -110.82, 173.51 APE9-dihe-na 70.8, 155.7 APE8-dihe-in -74.76, 144.22 APE8-rot-in 294.49 APE67-dihe-in -64.1, -22.37 -34.78, -62.17 APE12-dist-in 13.01 APE11-dist-in 12.048 APE10-dist-in 7.398 APE9-dist-in 2.965 A319V None None XRAY 1.76 0.188 0.224 A 360 353 5 0 0 0 [[156, 472]] 1.0 6yty Homo sapiens CMGC_CLK3_HUMAN CMGC 2e-90 308.9 1 301 301 319 320 321 323 325 186 201 205 280 282 281 283 356 344 339 338 337 336 335 334 333 237 Dual specificity protein kinase CLK3

Ligand: EAE

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name