Ligand: EAE

Total number of chains: 6
Active chains: 6
Total number of genes: 3
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 6 100.0% 6YTDA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CLK1 CLK1_HUMAN 6YTDA P49759 148 484 484.0 EAE:60501 Type1 Active DFGin 7.2177 14.6236 BLAminus -129.04, -179.37 68.43, 75.26 -99.43, 5.66 289.75, 100.38 -57.22, -23.43 in-in in 8.7889 Saltbr-in 2.7429 HRD-in -67.84, -52.77 79.42, -15.7 in-in-in SNCiii in-in ActLoopNT-in 2.9558 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.91, 160.56 APE9-dihe-na 78.51, 152.43 APE8-dihe-in -82.58, 136.21 APE8-rot-in 297.75 APE67-dihe-in -72.13, -8.69 -31.46, -59.55 APE12-dist-in 13.4088 APE11-dist-in 11.1174 APE10-dist-in 7.4109 APE9-dist-in 2.9862 V324A None None XRAY 2.0 0.182 0.228 A 339.0 337.0 0 25 25 0 [[161, 477]] 1.0 6ytd CMGC_CLK1_HUMAN CMGC 1.5e-93 319.2 1.0 301.0 301.0 324 325 326 328 330 191 206 210 285 287 286 288.0 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CMGC CLK1 CLK1_HUMAN 6YTEC P49759 148 484 484.0 EAE:60501 Type1 Active DFGin 7.1447 14.1109 BLAminus -123.36, 172.5 72.26, 86.11 -107.09, 11.71 295.65, 98.47 -58.29, -17.8 in-in in 8.5445 Saltbr-in 2.2253 HRD-in -60.42, -59.86 88.88, -8.99 in-in-in SNCiii in-in ActLoopNT-in 3.0048 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.24, 160.76 APE9-dihe-na 81.35, 157.72 APE8-dihe-in -87.96, 130.83 APE8-rot-in 293.05 APE67-dihe-in -54.77, -23.25 -31.22, -65.53 APE12-dist-in 13.3746 APE11-dist-in 11.4404 APE10-dist-in 7.3205 APE9-dist-in 3.082 None None None XRAY 2.3 0.184 0.258 C 339.0 337.0 0 25 25 0 [[161, 477]] 1.0 6yte CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1.0 301.0 301.0 324 325 326 328 330 191 206 210 285 287 286 288.0 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CMGC CLK2 CLK2_HUMAN 6FYIA P49760 148 483 499.0 EAE:501 Type1 Active DFGin 7.0594 14.2469 BLAminus -118.89, -176.08 54.9, 90.13 -108.37, 24.54 295.21, 92.22 -68.08, -17.95 in-in in 8.8735 Saltbr-in 2.761 HRD-in -71.46, -43.74 72.78, -37.63 in-in-in SNCiii in-in ActLoopNT-in 2.9169 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.68, 170.24 APE9-dihe-na 75.27, 152.33 APE8-dihe-in -73.5, 140.46 APE8-rot-in 301.64 APE67-dihe-in -60.39, -24.06 -32.87, -56.62 APE12-dist-in 13.495 APE11-dist-in 11.8939 APE10-dist-in 7.3503 APE9-dist-in 3.1742 None None None XRAY 2.6 0.219 0.233 A 368.0 336.0 0 25 25 0 [[163, 479]] 1.0 6fyi CMGC_CLK2_HUMAN CMGC 1.8e-92 315.6 1.0 301.0 301.0 326 327 328 330 332 193 208 212 287 289 288 290.0 363 351 346 345 344 343 342 341 340 244 Dual specificity protein kinase CLK2
CMGC CLK3 CLK3_HUMAN 6YTWA P49761 127 481 490.0 EAE:60512 Type1 Active DFGin 7.6993 15.4307 BLAminus -113.75, 171.77 74.13, 69.12 -90.55, 16.73 297.04, 88.04 -58.73, -29.5 in-in in 8.8185 Saltbr-in 2.9354 HRD-in -72.04, -52.05 86.8, -16.28 in-in-in SNCiii in-in ActLoopNT-in 2.7869 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.86, 165.24 APE9-dihe-na 77.16, 162.31 APE8-dihe-in -85.84, 147.02 APE8-rot-in 293.49 APE67-dihe-in -61.4, -23.59 -33.01, -61.88 APE12-dist-in 13.1691 APE11-dist-in 11.9482 APE10-dist-in 7.4722 APE9-dist-in 2.9872 None None None XRAY 2.0 0.186 0.227 A 360.0 347.0 7 25 25 0 [[156, 472]] 1.0 6ytw CMGC_CLK3_HUMAN CMGC 1.2e-90 309.6 1.0 301.0 301.0 319 320 321 323 325 186 201 205 280 282 281 283.0 356 344 339 338 337 336 335 334 333 237 Dual specificity protein kinase CLK3
CMGC CLK3 CLK3_HUMAN 6YTWB P49761 134 481 490.0 EAE:60512 Type1 Active DFGin 7.6031 15.557 BLAminus -118.7, 170.41 71.62, 71.79 -90.05, 12.92 288.99, 100.31 -52.9, -36.56 in-in in 8.998 Saltbr-in 3.1779 HRD-in -73.9, -51.74 79.51, -16.54 in-in-in SNCiii in-in ActLoopNT-in 2.913 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.84, 174.67 APE9-dihe-na 70.75, 150.53 APE8-dihe-in -71.79, 141.9 APE8-rot-in 290.82 APE67-dihe-in -61.11, -25.78 -29.28, -64.93 APE12-dist-in 13.1874 APE11-dist-in 11.7704 APE10-dist-in 7.348 APE9-dist-in 2.921 None None None XRAY 2.0 0.186 0.227 B 360.0 339.0 7 25 25 0 [[156, 472]] 1.0 6ytw CMGC_CLK3_HUMAN CMGC 1.2e-90 309.6 1.0 301.0 301.0 319 320 321 323 325 186 201 205 280 282 281 283.0 356 344 339 338 337 336 335 334 333 237 Dual specificity protein kinase CLK3
CMGC CLK3 CLK3_HUMAN 6YTYA P49761 127 481 490.0 EAE:502 Type1 Active DFGin 7.2922 14.7268 BLAminus -118.42, -179.04 54.61, 81.07 -90.19, 20.66 288.13, 83.57 -71.98, -12.75 in-in in 8.8632 Saltbr-in 2.7085 HRD-in -69.86, -53.68 84.67, -14.39 in-in-in SNCiii in-in ActLoopNT-in 2.8598 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -110.82, 173.51 APE9-dihe-na 70.8, 155.7 APE8-dihe-in -74.76, 144.22 APE8-rot-in 294.49 APE67-dihe-in -64.1, -22.37 -34.78, -62.17 APE12-dist-in 13.0097 APE11-dist-in 12.0482 APE10-dist-in 7.3983 APE9-dist-in 2.9654 A319V None None XRAY 1.76 0.188 0.224 A 360.0 353.0 5 25 25 0 [[156, 472]] 1.0 6yty CMGC_CLK3_HUMAN CMGC 2e-90 308.9 1.0 301.0 301.0 319 320 321 323 325 186 201 205 280 282 281 283.0 356 344 339 338 337 336 335 334 333 237 Dual specificity protein kinase CLK3

Ligand: EAE

Total number of chains: 6
Active chains: 6
Total number of genes: 3
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 6 100.0% 6YTDA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CLK1 CLK1_HUMAN 6YTDA P49759 148 484 484.0 EAE:60501 Type1 Active DFGin 7.2177 14.6236 BLAminus -129.04, -179.37 68.43, 75.26 -99.43, 5.66 289.75, 100.38 -57.22, -23.43 in-in in 8.7889 Saltbr-in 2.7429 HRD-in -67.84, -52.77 79.42, -15.7 in-in-in SNCiii in-in ActLoopNT-in 2.9558 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.91, 160.56 APE9-dihe-na 78.51, 152.43 APE8-dihe-in -82.58, 136.21 APE8-rot-in 297.75 APE67-dihe-in -72.13, -8.69 -31.46, -59.55 APE12-dist-in 13.4088 APE11-dist-in 11.1174 APE10-dist-in 7.4109 APE9-dist-in 2.9862 V324A None None XRAY 2.0 0.182 0.228 A 339.0 337.0 0 25 25 0 [[161, 477]] 1.0 6ytd Homo sapiens CMGC_CLK1_HUMAN CMGC 1.5e-93 319.2 1.0 301.0 301.0 324 325 326 328 330 191 206 210 285 287 286 288.0 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CMGC CLK1 CLK1_HUMAN 6YTEC P49759 148 484 484.0 EAE:60501 Type1 Active DFGin 7.1447 14.1109 BLAminus -123.36, 172.5 72.26, 86.11 -107.09, 11.71 295.65, 98.47 -58.29, -17.8 in-in in 8.5445 Saltbr-in 2.2253 HRD-in -60.42, -59.86 88.88, -8.99 in-in-in SNCiii in-in ActLoopNT-in 3.0048 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.24, 160.76 APE9-dihe-na 81.35, 157.72 APE8-dihe-in -87.96, 130.83 APE8-rot-in 293.05 APE67-dihe-in -54.77, -23.25 -31.22, -65.53 APE12-dist-in 13.3746 APE11-dist-in 11.4404 APE10-dist-in 7.3205 APE9-dist-in 3.082 None None None XRAY 2.3 0.184 0.258 C 339.0 337.0 0 25 25 0 [[161, 477]] 1.0 6yte Homo sapiens CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1.0 301.0 301.0 324 325 326 328 330 191 206 210 285 287 286 288.0 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CMGC CLK2 CLK2_HUMAN 6FYIA P49760 148 483 499.0 EAE:501 Type1 Active DFGin 7.0594 14.2469 BLAminus -118.89, -176.08 54.9, 90.13 -108.37, 24.54 295.21, 92.22 -68.08, -17.95 in-in in 8.8735 Saltbr-in 2.761 HRD-in -71.46, -43.74 72.78, -37.63 in-in-in SNCiii in-in ActLoopNT-in 2.9169 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.68, 170.24 APE9-dihe-na 75.27, 152.33 APE8-dihe-in -73.5, 140.46 APE8-rot-in 301.64 APE67-dihe-in -60.39, -24.06 -32.87, -56.62 APE12-dist-in 13.495 APE11-dist-in 11.8939 APE10-dist-in 7.3503 APE9-dist-in 3.1742 None None None XRAY 2.6 0.219 0.233 A 368.0 336.0 0 25 25 0 [[163, 479]] 1.0 6fyi Homo sapiens CMGC_CLK2_HUMAN CMGC 1.8e-92 315.6 1.0 301.0 301.0 326 327 328 330 332 193 208 212 287 289 288 290.0 363 351 346 345 344 343 342 341 340 244 Dual specificity protein kinase CLK2
CMGC CLK3 CLK3_HUMAN 6YTWA P49761 127 481 490.0 EAE:60512 Type1 Active DFGin 7.6993 15.4307 BLAminus -113.75, 171.77 74.13, 69.12 -90.55, 16.73 297.04, 88.04 -58.73, -29.5 in-in in 8.8185 Saltbr-in 2.9354 HRD-in -72.04, -52.05 86.8, -16.28 in-in-in SNCiii in-in ActLoopNT-in 2.7869 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.86, 165.24 APE9-dihe-na 77.16, 162.31 APE8-dihe-in -85.84, 147.02 APE8-rot-in 293.49 APE67-dihe-in -61.4, -23.59 -33.01, -61.88 APE12-dist-in 13.1691 APE11-dist-in 11.9482 APE10-dist-in 7.4722 APE9-dist-in 2.9872 None None None XRAY 2.0 0.186 0.227 A 360.0 347.0 7 25 25 0 [[156, 472]] 1.0 6ytw Homo sapiens CMGC_CLK3_HUMAN CMGC 1.2e-90 309.6 1.0 301.0 301.0 319 320 321 323 325 186 201 205 280 282 281 283.0 356 344 339 338 337 336 335 334 333 237 Dual specificity protein kinase CLK3
CMGC CLK3 CLK3_HUMAN 6YTWB P49761 134 481 490.0 EAE:60512 Type1 Active DFGin 7.6031 15.557 BLAminus -118.7, 170.41 71.62, 71.79 -90.05, 12.92 288.99, 100.31 -52.9, -36.56 in-in in 8.998 Saltbr-in 3.1779 HRD-in -73.9, -51.74 79.51, -16.54 in-in-in SNCiii in-in ActLoopNT-in 2.913 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.84, 174.67 APE9-dihe-na 70.75, 150.53 APE8-dihe-in -71.79, 141.9 APE8-rot-in 290.82 APE67-dihe-in -61.11, -25.78 -29.28, -64.93 APE12-dist-in 13.1874 APE11-dist-in 11.7704 APE10-dist-in 7.348 APE9-dist-in 2.921 None None None XRAY 2.0 0.186 0.227 B 360.0 339.0 7 25 25 0 [[156, 472]] 1.0 6ytw Homo sapiens CMGC_CLK3_HUMAN CMGC 1.2e-90 309.6 1.0 301.0 301.0 319 320 321 323 325 186 201 205 280 282 281 283.0 356 344 339 338 337 336 335 334 333 237 Dual specificity protein kinase CLK3
CMGC CLK3 CLK3_HUMAN 6YTYA P49761 127 481 490.0 EAE:502 Type1 Active DFGin 7.2922 14.7268 BLAminus -118.42, -179.04 54.61, 81.07 -90.19, 20.66 288.13, 83.57 -71.98, -12.75 in-in in 8.8632 Saltbr-in 2.7085 HRD-in -69.86, -53.68 84.67, -14.39 in-in-in SNCiii in-in ActLoopNT-in 2.8598 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -110.82, 173.51 APE9-dihe-na 70.8, 155.7 APE8-dihe-in -74.76, 144.22 APE8-rot-in 294.49 APE67-dihe-in -64.1, -22.37 -34.78, -62.17 APE12-dist-in 13.0097 APE11-dist-in 12.0482 APE10-dist-in 7.3983 APE9-dist-in 2.9654 A319V None None XRAY 1.76 0.188 0.224 A 360.0 353.0 5 25 25 0 [[156, 472]] 1.0 6yty Homo sapiens CMGC_CLK3_HUMAN CMGC 2e-90 308.9 1.0 301.0 301.0 319 320 321 323 325 186 201 205 280 282 281 283.0 356 344 339 338 337 336 335 334 333 237 Dual specificity protein kinase CLK3

Ligand: EAE

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name