Ligand: EA7

Total number of chains: 3
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 100.0% 6CFMA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CK1 VRK1 VRK1_HUMAN 6CFMA Q99986 21 341 396.0 EA7:402 Type1.5_Back Inactive DFGin 7.9328 14.899 BLAminus -117.58, 176.75 72.41, 88.99 -112.73, 20.45 295.51, 81.82 -65.94, -31.03 in-in in 8.006 Saltbr-in 2.8026 HRD-in -85.02, -45.25 73.38, 1.8 in-in-out SNCiio in-out ActLoopNT-in 2.8558 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -91.82, -9.86 APE9-dihe-na 106.18, -160.45 APE8-dihe-in -96.34, 127.15 APE8-rot-in 301.27 APE67-dihe-in -64.83, -27.76 -58.79, -43.46 APE12-dist-in 10.3521 APE11-dist-out 5.6455 APE10-dist-out 11.1575 APE9-dist-in 3.9448 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.45 0.203 0.245 A 364.0 316.0 5 35 35 0 [[37, 326]] 1.0 6cfm CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1.0 261.0 261.0 196 197 198 200 202 71 83 87 174 176 175 177.0 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
CK1 VRK1 VRK1_HUMAN 6CFMB Q99986 23 341 396.0 EA7:404 Type1.5_Back Inactive DFGin 8.2593 14.5743 BLAminus -108.91, 171.8 67.7, 85.06 -98.24, 31.31 296.73, 81.09 -74.11, -26.93 in-in in 7.8457 Saltbr-in 2.9114 HRD-in -82.37, -57.05 82.98, 0.57 in-in-out SNCiio in-out ActLoopNT-in 2.8902 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -59.4, 149.31 APE9-dihe-na 89.85, -169.27 APE8-dihe-in -85.72, 119.65 APE8-rot-in 304.36 APE67-dihe-in -63.02, -39.12 -55.36, -40.94 APE12-dist-out 14.8585 APE11-dist-in 13.191 APE10-dist-in 7.5189 APE9-dist-in 4.2431 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.45 0.203 0.245 B 364.0 297.0 22 35 35 0 [[37, 326]] 1.0 6cfm CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1.0 261.0 261.0 196 197 198 200 202 71 83 87 174 176 175 177.0 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
CK1 VRK1 VRK1_HUMAN 6CFMD Q99986 22 341 396.0 EA7:404 Type1.5_Back Inactive DFGin 8.2848 14.625 BLAminus -115.09, 177.32 62.35, 80.54 -92.56, 30.44 294.07, 75.4 -61.95, -31.49 in-in in 7.8836 Saltbr-in 2.9816 HRD-in -82.48, -51.09 79.06, -6.93 in-in-out SNCiio in-out ActLoopNT-in 3.041 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -62.33, 153.26 APE9-dihe-na 93.87, -172.4 APE8-dihe-in -86.94, 125.09 APE8-rot-in 306.96 APE67-dihe-in -67.38, -30.96 -59.67, -38.18 APE12-dist-out 14.7401 APE11-dist-in 13.2371 APE10-dist-in 7.3866 APE9-dist-in 4.2795 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.45 0.203 0.245 D 364.0 313.0 7 35 35 0 [[37, 326]] 1.0 6cfm CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1.0 261.0 261.0 196 197 198 200 202 71 83 87 174 176 175 177.0 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1

Ligand: EA7

Total number of chains: 3
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 100.0% 6CFMA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CK1 VRK1 VRK1_HUMAN 6CFMA Q99986 21 341 396.0 EA7:402 Type1.5_Back Inactive DFGin 7.9328 14.899 BLAminus -117.58, 176.75 72.41, 88.99 -112.73, 20.45 295.51, 81.82 -65.94, -31.03 in-in in 8.006 Saltbr-in 2.8026 HRD-in -85.02, -45.25 73.38, 1.8 in-in-out SNCiio in-out ActLoopNT-in 2.8558 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -91.82, -9.86 APE9-dihe-na 106.18, -160.45 APE8-dihe-in -96.34, 127.15 APE8-rot-in 301.27 APE67-dihe-in -64.83, -27.76 -58.79, -43.46 APE12-dist-in 10.3521 APE11-dist-out 5.6455 APE10-dist-out 11.1575 APE9-dist-in 3.9448 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.45 0.203 0.245 A 364.0 316.0 5 35 35 0 [[37, 326]] 1.0 6cfm Homo sapiens CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1.0 261.0 261.0 196 197 198 200 202 71 83 87 174 176 175 177.0 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
CK1 VRK1 VRK1_HUMAN 6CFMB Q99986 23 341 396.0 EA7:404 Type1.5_Back Inactive DFGin 8.2593 14.5743 BLAminus -108.91, 171.8 67.7, 85.06 -98.24, 31.31 296.73, 81.09 -74.11, -26.93 in-in in 7.8457 Saltbr-in 2.9114 HRD-in -82.37, -57.05 82.98, 0.57 in-in-out SNCiio in-out ActLoopNT-in 2.8902 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -59.4, 149.31 APE9-dihe-na 89.85, -169.27 APE8-dihe-in -85.72, 119.65 APE8-rot-in 304.36 APE67-dihe-in -63.02, -39.12 -55.36, -40.94 APE12-dist-out 14.8585 APE11-dist-in 13.191 APE10-dist-in 7.5189 APE9-dist-in 4.2431 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.45 0.203 0.245 B 364.0 297.0 22 35 35 0 [[37, 326]] 1.0 6cfm Homo sapiens CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1.0 261.0 261.0 196 197 198 200 202 71 83 87 174 176 175 177.0 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
CK1 VRK1 VRK1_HUMAN 6CFMD Q99986 22 341 396.0 EA7:404 Type1.5_Back Inactive DFGin 8.2848 14.625 BLAminus -115.09, 177.32 62.35, 80.54 -92.56, 30.44 294.07, 75.4 -61.95, -31.49 in-in in 7.8836 Saltbr-in 2.9816 HRD-in -82.48, -51.09 79.06, -6.93 in-in-out SNCiio in-out ActLoopNT-in 3.041 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -62.33, 153.26 APE9-dihe-na 93.87, -172.4 APE8-dihe-in -86.94, 125.09 APE8-rot-in 306.96 APE67-dihe-in -67.38, -30.96 -59.67, -38.18 APE12-dist-out 14.7401 APE11-dist-in 13.2371 APE10-dist-in 7.3866 APE9-dist-in 4.2795 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.45 0.203 0.245 D 364.0 313.0 7 35 35 0 [[37, 326]] 1.0 6cfm Homo sapiens CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1.0 261.0 261.0 196 197 198 200 202 71 83 87 174 176 175 177.0 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1

Ligand: EA7

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name