Ligand: DT5

Total number of chains: 3
Active chains: 2
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 66.7% 2C6TA
DFGin BLBtrans 1 33.3% 2C6MA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CDK2 CDK2_HUMAN 2C6TA P24941 1 296 298.0 DT5:1297 Type1 Active DFGin 6.7987 15.3521 BLAminus -134.06, 177.12 50.31, 82.89 -96.13, 18.51 277.35, 75.79 -53.62, -36.05 in-in in 8.8611 Saltbr-in 2.9993 HRD-in -80.9, -47.67 67.76, 13.99 in-in-in SNCiii in-in ActLoopNT-in 2.9108 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.31, 144.79 APE9-dihe-na 67.5, 141.86 APE8-dihe-in -68.03, 138.16 APE8-rot-in 289.35 APE67-dihe-in -64.46, -22.44 -44.45, -50.97 APE12-dist-in 13.0238 APE11-dist-in 10.2352 APE10-dist-in 7.5078 APE9-dist-in 3.2271 None TPO160 TPO160 XRAY 2.61 0.202 0.257 A 298.0 296.0 0 28 28 0 [[4, 286]] 1.0 2c6t CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 2C6TC P24941 1 296 298.0 DT5:1297 Type1 Active DFGin 6.6572 15.4043 BLAminus -131.57, -175.77 56.88, 80.2 -95.48, 27.17 280.99, 68.34 -80.53, -20.02 in-in in 8.7388 Saltbr-in 2.8868 HRD-in -82.32, -44.44 66.33, 11.16 in-in-in SNCiii in-in ActLoopNT-in 2.8435 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.28, 146.11 APE9-dihe-na 67.63, 123.05 APE8-dihe-in -49.46, 128.41 APE8-rot-in 317.45 APE67-dihe-in -69.48, -17.34 -29.8, -51.85 APE12-dist-in 13.1361 APE11-dist-in 10.7768 APE10-dist-in 7.4452 APE9-dist-in 3.3251 None TPO160 TPO160 XRAY 2.61 0.202 0.257 C 298.0 296.0 0 28 28 0 [[4, 286]] 1.0 2c6t CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 2C6MA P24941 1 296 298.0 DT5:1297 Type1 Inactive DFGin 10.7367 18.406 BLBtrans -99.56, 151.64 64.8, 23.03 -61.35, 135.89 223.66, 106.68 83.78, -17.16 out-out out 15.0993 Saltbr-out 17.4949 HRD-in -82.46, -59.33 77.2, -19.23 out-out-out SNCooo out-out ActLoopNT-out 5.6319 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -71.76, 130.16 APE9-dihe-na -74.21, 136.72 APE8-dihe-in -74.65, 138.26 APE8-rot-in 303.83 APE67-dihe-in -54.03, -32.67 -99.18, -6.49 APE12-dist-out 20.8752 APE11-dist-out 17.6674 APE10-dist-out 19.3566 APE9-dist-out 10.4852 None None None XRAY 1.9 0.201 0.27 A 298.0 290.0 6 28 28 0 [[4, 286]] 1.0 2c6m CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2

Ligand: DT5

Total number of chains: 3
Active chains: 2
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 66.7% 2C6TA
DFGin BLBtrans 1 33.3% 2C6MA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CDK2 CDK2_HUMAN 2C6TA P24941 1 296 298.0 DT5:1297 Type1 Active DFGin 6.7987 15.3521 BLAminus -134.06, 177.12 50.31, 82.89 -96.13, 18.51 277.35, 75.79 -53.62, -36.05 in-in in 8.8611 Saltbr-in 2.9993 HRD-in -80.9, -47.67 67.76, 13.99 in-in-in SNCiii in-in ActLoopNT-in 2.9108 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.31, 144.79 APE9-dihe-na 67.5, 141.86 APE8-dihe-in -68.03, 138.16 APE8-rot-in 289.35 APE67-dihe-in -64.46, -22.44 -44.45, -50.97 APE12-dist-in 13.0238 APE11-dist-in 10.2352 APE10-dist-in 7.5078 APE9-dist-in 3.2271 None TPO160 TPO160 XRAY 2.61 0.202 0.257 A 298.0 296.0 0 28 28 0 [[4, 286]] 1.0 2c6t Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 2C6TC P24941 1 296 298.0 DT5:1297 Type1 Active DFGin 6.6572 15.4043 BLAminus -131.57, -175.77 56.88, 80.2 -95.48, 27.17 280.99, 68.34 -80.53, -20.02 in-in in 8.7388 Saltbr-in 2.8868 HRD-in -82.32, -44.44 66.33, 11.16 in-in-in SNCiii in-in ActLoopNT-in 2.8435 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.28, 146.11 APE9-dihe-na 67.63, 123.05 APE8-dihe-in -49.46, 128.41 APE8-rot-in 317.45 APE67-dihe-in -69.48, -17.34 -29.8, -51.85 APE12-dist-in 13.1361 APE11-dist-in 10.7768 APE10-dist-in 7.4452 APE9-dist-in 3.3251 None TPO160 TPO160 XRAY 2.61 0.202 0.257 C 298.0 296.0 0 28 28 0 [[4, 286]] 1.0 2c6t Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 2C6MA P24941 1 296 298.0 DT5:1297 Type1 Inactive DFGin 10.7367 18.406 BLBtrans -99.56, 151.64 64.8, 23.03 -61.35, 135.89 223.66, 106.68 83.78, -17.16 out-out out 15.0993 Saltbr-out 17.4949 HRD-in -82.46, -59.33 77.2, -19.23 out-out-out SNCooo out-out ActLoopNT-out 5.6319 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -71.76, 130.16 APE9-dihe-na -74.21, 136.72 APE8-dihe-in -74.65, 138.26 APE8-rot-in 303.83 APE67-dihe-in -54.03, -32.67 -99.18, -6.49 APE12-dist-out 20.8752 APE11-dist-out 17.6674 APE10-dist-out 19.3566 APE9-dist-out 10.4852 None None None XRAY 1.9 0.201 0.27 A 298.0 290.0 6 28 28 0 [[4, 286]] 1.0 2c6m Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2

Ligand: DT5

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name