Ligand: CUR

Total number of chains: 2
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 100.0% 5ZTNA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC DYRK2 DYRK2_HUMAN 5ZTNA Q92630 146 536 601.0 CUR:60501 Type1 Inactive DFGin 7.0437 14.9172 BLAminus -121.02, -170.84 55.37, 74.14 -90.27, 24.89 284.91, 71.59 -68.02, -21.72 in-in in 9.0378 Saltbr-in 3.2009 HRD-in -75.34, -43.05 70.76, 4.4 in-in-out SNCiio in-out ActLoopNT-in 2.9913 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -133.75, -1.92 APE9-dihe-na -118.6, 178.64 APE8-dihe-in -75.97, 135.26 APE8-rot-out 181.93 APE67-dihe-in -60.16, -23.88 -54.39, -47.99 APE12-dist-in 13.019 APE11-dist-in 11.6003 APE10-dist-in 7.1559 APE9-dist-in 3.639 None PTR382,SEP458 PTR382,SEP458 XRAY 2.496 0.2 0.244 A 429.0 384.0 7 25 25 0 [[222, 535]] 1.0 5ztn CMGC_DYRK2_HUMAN CMGC 1.5e-98 335.8 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
CMGC DYRK2 DYRK2_HUMAN 5ZTNB Q92630 146 536 601.0 CUR:60501 Type1 Inactive DFGin 6.9849 14.9376 BLAminus -121.23, -170.26 54.62, 73.44 -89.58, 24.17 284.13, 70.16 -67.88, -20.27 in-in in 9.1252 Saltbr-in 3.3183 HRD-in -75.96, -42.97 70.51, 4.22 in-in-out SNCiio in-out ActLoopNT-in 2.9154 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -132.98, -2.03 APE9-dihe-na -118.4, 178.1 APE8-dihe-in -73.54, 134.92 APE8-rot-out 181.22 APE67-dihe-in -60.19, -23.13 -53.91, -47.68 APE12-dist-in 13.0555 APE11-dist-in 11.5514 APE10-dist-in 7.147 APE9-dist-in 3.6627 None PTR382,SEP458 PTR382,SEP458 XRAY 2.496 0.2 0.244 B 429.0 384.0 7 25 25 0 [[222, 535]] 1.0 5ztn CMGC_DYRK2_HUMAN CMGC 1.5e-98 335.8 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2

Ligand: CUR

Total number of chains: 2
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 100.0% 5ZTNA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC DYRK2 DYRK2_HUMAN 5ZTNA Q92630 146 536 601.0 CUR:60501 Type1 Inactive DFGin 7.0437 14.9172 BLAminus -121.02, -170.84 55.37, 74.14 -90.27, 24.89 284.91, 71.59 -68.02, -21.72 in-in in 9.0378 Saltbr-in 3.2009 HRD-in -75.34, -43.05 70.76, 4.4 in-in-out SNCiio in-out ActLoopNT-in 2.9913 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -133.75, -1.92 APE9-dihe-na -118.6, 178.64 APE8-dihe-in -75.97, 135.26 APE8-rot-out 181.93 APE67-dihe-in -60.16, -23.88 -54.39, -47.99 APE12-dist-in 13.019 APE11-dist-in 11.6003 APE10-dist-in 7.1559 APE9-dist-in 3.639 None PTR382,SEP458 PTR382,SEP458 XRAY 2.496 0.2 0.244 A 429.0 384.0 7 25 25 0 [[222, 535]] 1.0 5ztn Homo sapiens CMGC_DYRK2_HUMAN CMGC 1.5e-98 335.8 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
CMGC DYRK2 DYRK2_HUMAN 5ZTNB Q92630 146 536 601.0 CUR:60501 Type1 Inactive DFGin 6.9849 14.9376 BLAminus -121.23, -170.26 54.62, 73.44 -89.58, 24.17 284.13, 70.16 -67.88, -20.27 in-in in 9.1252 Saltbr-in 3.3183 HRD-in -75.96, -42.97 70.51, 4.22 in-in-out SNCiio in-out ActLoopNT-in 2.9154 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -132.98, -2.03 APE9-dihe-na -118.4, 178.1 APE8-dihe-in -73.54, 134.92 APE8-rot-out 181.22 APE67-dihe-in -60.19, -23.13 -53.91, -47.68 APE12-dist-in 13.0555 APE11-dist-in 11.5514 APE10-dist-in 7.147 APE9-dist-in 3.6627 None PTR382,SEP458 PTR382,SEP458 XRAY 2.496 0.2 0.244 B 429.0 384.0 7 25 25 0 [[222, 535]] 1.0 5ztn Homo sapiens CMGC_DYRK2_HUMAN CMGC 1.5e-98 335.8 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2

Ligand: CUR

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name