Ligand: B7W

Total number of chains: 4
Active chains: 1
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 6EJ4A
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC DYRK1A DYR1A_HUMAN 6EJ4A Q13627 134 480 763.0 B7W:501 Type1 Inactive DFGin 7.338 14.948 BLAminus -132.19, 174.27 73.69, 75.25 -98.32, 20.37 284.23, 94.63 -75.42, -26.2 in-out in 8.869 Saltbr-out 4.041 HRD-in -58.96, -48.23 70.58, 13.6 out-in-out SNCoio in-out ActLoopNT-in 2.854 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -125.35, 166.33 APE9-dihe-na 69.65, 156.05 APE8-dihe-in -76.23, 139.99 APE8-rot-in 286.29 APE67-dihe-in -51.41, -21.41 -54.65, -48.5 APE12-dist-in 13.897 APE11-dist-in 11.661 APE10-dist-out 8.075 APE9-dist-in 3.187 None PTR321 PTR321 XRAY 2.88 0.222 0.27 A 368 344 3 0 0 0 [[159, 479]] 1.0 6ej4 CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 6EJ4B Q13627 133 480 763.0 B7W:501 Type1 Inactive DFGin 7.107 14.76 BLAminus -124.17, 168.72 61.19, 91.64 -101.7, 11.62 289.3, 74.52 -55.92, -30.33 in-in in 8.759 Saltbr-in 2.833 HRD-in -65.73, -48.81 75.08, 26.7 in-in-out SNCiio in-out ActLoopNT-in 3.123 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -164.85, 149.17 APE9-dihe-na 68.91, 175.03 APE8-dihe-in -91.13, 144.68 APE8-rot-in 309.9 APE67-dihe-in -69.08, -39.33 -60.28, -35.15 APE12-dist-in 13.849 APE11-dist-in 11.526 APE10-dist-out 8.561 APE9-dist-in 3.913 None PTR321 PTR321 XRAY 2.88 0.222 0.27 B 368 338 10 0 0 0 [[159, 479]] 1.0 6ej4 CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 6EJ4C Q13627 135 479 763.0 B7W:501 Type1 Active DFGin 7.399 14.621 BLAminus -127.52, 168.2 60.93, 96.68 -107.48, 20.89 285.11, 74.4 -57.11, -40.86 in-in in 9.022 Saltbr-in 2.977 HRD-in -60.32, -39.77 73.57, -0.65 in-in-in SNCiii in-in ActLoopNT-in 3.283 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.12, 159.98 APE9-dihe-na 72.27, 158.6 APE8-dihe-in -74.01, 154.25 APE8-rot-in 280.21 APE67-dihe-in -64.21, -35.15 -55.76, -52.46 APE12-dist-in 13.833 APE11-dist-in 11.799 APE10-dist-in 7.982 APE9-dist-in 3.286 None PTR321 PTR321 XRAY 2.88 0.222 0.27 C 368 332 13 0 0 0 [[159, 479]] 1.0 6ej4 CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 6EJ4D Q13627 134 479 763.0 B7W:501 Type1 Inactive DFGin 7.849 14.665 BLAminus -127.93, 170.7 58.86, 87.06 -99.94, 27.16 296.94, 82.16 -71.66, -18.74 in-in in 8.69 Saltbr-in 2.71 HRD-in -59.65, -49.19 78.06, 3.89 in-in-out SNCiio in-out ActLoopNT-in 3.11 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -134.94, 163.29 APE9-dihe-na 74.33, 157.36 APE8-dihe-in -70.12, 155.62 APE8-rot-in 287.38 APE67-dihe-in -63.74, -29.78 -64.08, -46.32 APE12-dist-out 14.079 APE11-dist-in 11.966 APE10-dist-in 7.846 APE9-dist-in 3.243 None PTR321 PTR321 XRAY 2.88 0.222 0.27 D 368 331 15 0 0 0 [[159, 479]] 1.0 6ej4 CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A

Ligand: B7W

Total number of chains: 4
Active chains: 1
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 6EJ4A
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC DYRK1A DYR1A_HUMAN 6EJ4A Q13627 134 480 763.0 B7W:501 Type1 Inactive DFGin 7.338 14.948 BLAminus -132.19, 174.27 73.69, 75.25 -98.32, 20.37 284.23, 94.63 -75.42, -26.2 in-out in 8.869 Saltbr-out 4.041 HRD-in -58.96, -48.23 70.58, 13.6 out-in-out SNCoio in-out ActLoopNT-in 2.854 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -125.35, 166.33 APE9-dihe-na 69.65, 156.05 APE8-dihe-in -76.23, 139.99 APE8-rot-in 286.29 APE67-dihe-in -51.41, -21.41 -54.65, -48.5 APE12-dist-in 13.897 APE11-dist-in 11.661 APE10-dist-out 8.075 APE9-dist-in 3.187 None PTR321 PTR321 XRAY 2.88 0.222 0.27 A 368 344 3 0 0 0 [[159, 479]] 1.0 6ej4 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 6EJ4B Q13627 133 480 763.0 B7W:501 Type1 Inactive DFGin 7.107 14.76 BLAminus -124.17, 168.72 61.19, 91.64 -101.7, 11.62 289.3, 74.52 -55.92, -30.33 in-in in 8.759 Saltbr-in 2.833 HRD-in -65.73, -48.81 75.08, 26.7 in-in-out SNCiio in-out ActLoopNT-in 3.123 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -164.85, 149.17 APE9-dihe-na 68.91, 175.03 APE8-dihe-in -91.13, 144.68 APE8-rot-in 309.9 APE67-dihe-in -69.08, -39.33 -60.28, -35.15 APE12-dist-in 13.849 APE11-dist-in 11.526 APE10-dist-out 8.561 APE9-dist-in 3.913 None PTR321 PTR321 XRAY 2.88 0.222 0.27 B 368 338 10 0 0 0 [[159, 479]] 1.0 6ej4 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 6EJ4C Q13627 135 479 763.0 B7W:501 Type1 Active DFGin 7.399 14.621 BLAminus -127.52, 168.2 60.93, 96.68 -107.48, 20.89 285.11, 74.4 -57.11, -40.86 in-in in 9.022 Saltbr-in 2.977 HRD-in -60.32, -39.77 73.57, -0.65 in-in-in SNCiii in-in ActLoopNT-in 3.283 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.12, 159.98 APE9-dihe-na 72.27, 158.6 APE8-dihe-in -74.01, 154.25 APE8-rot-in 280.21 APE67-dihe-in -64.21, -35.15 -55.76, -52.46 APE12-dist-in 13.833 APE11-dist-in 11.799 APE10-dist-in 7.982 APE9-dist-in 3.286 None PTR321 PTR321 XRAY 2.88 0.222 0.27 C 368 332 13 0 0 0 [[159, 479]] 1.0 6ej4 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 6EJ4D Q13627 134 479 763.0 B7W:501 Type1 Inactive DFGin 7.849 14.665 BLAminus -127.93, 170.7 58.86, 87.06 -99.94, 27.16 296.94, 82.16 -71.66, -18.74 in-in in 8.69 Saltbr-in 2.71 HRD-in -59.65, -49.19 78.06, 3.89 in-in-out SNCiio in-out ActLoopNT-in 3.11 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -134.94, 163.29 APE9-dihe-na 74.33, 157.36 APE8-dihe-in -70.12, 155.62 APE8-rot-in 287.38 APE67-dihe-in -63.74, -29.78 -64.08, -46.32 APE12-dist-out 14.079 APE11-dist-in 11.966 APE10-dist-in 7.846 APE9-dist-in 3.243 None PTR321 PTR321 XRAY 2.88 0.222 0.27 D 368 331 15 0 0 0 [[159, 479]] 1.0 6ej4 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A

Ligand: B7W

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name