Ligand: B7B

Total number of chains: 4
Active chains: 2
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 6EIPA
All chains - renumbered by
Uniprot PDB Alignment

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Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC DYRK1A DYR1A_HUMAN 6EIPA Q13627 134 480 763.0 B7B:501 Type1 Inactive DFGin 7.259 15.24 BLAminus -125.43, 172.01 62.72, 86.19 -100.26, 27.0 284.48, 74.29 -66.18, -40.51 in-out in 8.947 Saltbr-out 3.641 HRD-in -62.34, -44.05 75.6, 8.2 out-in-in SNCoii in-in ActLoopNT-in 2.813 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.2, 165.59 APE9-dihe-na 64.6, 153.96 APE8-dihe-in -70.09, 140.96 APE8-rot-in 288.47 APE67-dihe-in -58.27, -33.16 -55.85, -46.32 APE12-dist-in 13.589 APE11-dist-in 11.661 APE10-dist-in 7.786 APE9-dist-in 3.253 None PTR321 PTR321 XRAY 2.56 0.243 0.266 A 368 342 5 0 0 0 [[159, 479]] 1.0 6eip CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 6EIPB Q13627 133 480 763.0 B7B:501 Type1 Active DFGin 7.3 15.137 BLAminus -116.31, 172.99 59.38, 82.91 -97.29, 38.15 294.47, 77.72 -74.08, -35.63 in-in in 9.09 Saltbr-in 2.899 HRD-in -65.81, -47.59 76.49, 9.41 in-in-in SNCiii in-in ActLoopNT-in 3.186 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.16, 160.62 APE9-dihe-na 70.79, 152.01 APE8-dihe-in -70.68, 148.82 APE8-rot-in 294.92 APE67-dihe-in -57.84, -32.79 -60.95, -46.44 APE12-dist-in 13.9 APE11-dist-in 11.499 APE10-dist-in 7.671 APE9-dist-in 3.306 None PTR321 PTR321 XRAY 2.56 0.243 0.266 B 368 340 8 0 0 0 [[159, 479]] 1.0 6eip CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 6EIPC Q13627 135 479 763.0 B7B:501 Type1 Inactive DFGin 7.364 15.276 BLAminus -125.37, 158.18 59.75, 86.95 -98.2, 25.76 287.16, 77.19 -71.86, -22.77 in-in in 8.799 Saltbr-in 3.16 HRD-in -69.43, -41.36 66.86, 11.92 in-in-out SNCiio in-out ActLoopNT-in 3.055 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioi APE10-dihe-na -123.33, 159.25 APE9-dihe-na 71.82, 144.57 APE8-dihe-in -70.74, 143.31 APE8-rot-out 53.41 APE67-dihe-in -64.2, -26.78 -50.51, -45.83 APE12-dist-out 14.057 APE11-dist-in 11.942 APE10-dist-out 8.124 APE9-dist-in 3.321 None PTR321 PTR321 XRAY 2.56 0.243 0.266 C 368 339 6 0 0 0 [[159, 479]] 1.0 6eip CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 6EIPD Q13627 134 479 763.0 B7B:501 Type1 Active DFGin 7.439 15.077 BLAminus -126.34, 172.93 62.79, 86.26 -101.23, 28.95 288.24, 77.28 -69.9, -27.46 in-in in 8.846 Saltbr-in 2.848 HRD-in -58.79, -41.55 67.62, 10.96 in-in-in SNCiii in-in ActLoopNT-in 2.852 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.57, 164.56 APE9-dihe-na 68.0, 151.01 APE8-dihe-in -69.91, 146.7 APE8-rot-in 286.07 APE67-dihe-in -59.83, -24.78 -58.38, -48.52 APE12-dist-in 13.863 APE11-dist-in 11.61 APE10-dist-in 7.782 APE9-dist-in 3.366 None PTR321 PTR321 XRAY 2.56 0.243 0.266 D 368 333 13 0 0 0 [[159, 479]] 1.0 6eip CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A

Ligand: B7B

Total number of chains: 4
Active chains: 2
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 6EIPA
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC DYRK1A DYR1A_HUMAN 6EIPA Q13627 134 480 763.0 B7B:501 Type1 Inactive DFGin 7.259 15.24 BLAminus -125.43, 172.01 62.72, 86.19 -100.26, 27.0 284.48, 74.29 -66.18, -40.51 in-out in 8.947 Saltbr-out 3.641 HRD-in -62.34, -44.05 75.6, 8.2 out-in-in SNCoii in-in ActLoopNT-in 2.813 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.2, 165.59 APE9-dihe-na 64.6, 153.96 APE8-dihe-in -70.09, 140.96 APE8-rot-in 288.47 APE67-dihe-in -58.27, -33.16 -55.85, -46.32 APE12-dist-in 13.589 APE11-dist-in 11.661 APE10-dist-in 7.786 APE9-dist-in 3.253 None PTR321 PTR321 XRAY 2.56 0.243 0.266 A 368 342 5 0 0 0 [[159, 479]] 1.0 6eip Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 6EIPB Q13627 133 480 763.0 B7B:501 Type1 Active DFGin 7.3 15.137 BLAminus -116.31, 172.99 59.38, 82.91 -97.29, 38.15 294.47, 77.72 -74.08, -35.63 in-in in 9.09 Saltbr-in 2.899 HRD-in -65.81, -47.59 76.49, 9.41 in-in-in SNCiii in-in ActLoopNT-in 3.186 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.16, 160.62 APE9-dihe-na 70.79, 152.01 APE8-dihe-in -70.68, 148.82 APE8-rot-in 294.92 APE67-dihe-in -57.84, -32.79 -60.95, -46.44 APE12-dist-in 13.9 APE11-dist-in 11.499 APE10-dist-in 7.671 APE9-dist-in 3.306 None PTR321 PTR321 XRAY 2.56 0.243 0.266 B 368 340 8 0 0 0 [[159, 479]] 1.0 6eip Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 6EIPC Q13627 135 479 763.0 B7B:501 Type1 Inactive DFGin 7.364 15.276 BLAminus -125.37, 158.18 59.75, 86.95 -98.2, 25.76 287.16, 77.19 -71.86, -22.77 in-in in 8.799 Saltbr-in 3.16 HRD-in -69.43, -41.36 66.86, 11.92 in-in-out SNCiio in-out ActLoopNT-in 3.055 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioi APE10-dihe-na -123.33, 159.25 APE9-dihe-na 71.82, 144.57 APE8-dihe-in -70.74, 143.31 APE8-rot-out 53.41 APE67-dihe-in -64.2, -26.78 -50.51, -45.83 APE12-dist-out 14.057 APE11-dist-in 11.942 APE10-dist-out 8.124 APE9-dist-in 3.321 None PTR321 PTR321 XRAY 2.56 0.243 0.266 C 368 339 6 0 0 0 [[159, 479]] 1.0 6eip Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 6EIPD Q13627 134 479 763.0 B7B:501 Type1 Active DFGin 7.439 15.077 BLAminus -126.34, 172.93 62.79, 86.26 -101.23, 28.95 288.24, 77.28 -69.9, -27.46 in-in in 8.846 Saltbr-in 2.848 HRD-in -58.79, -41.55 67.62, 10.96 in-in-in SNCiii in-in ActLoopNT-in 2.852 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.57, 164.56 APE9-dihe-na 68.0, 151.01 APE8-dihe-in -69.91, 146.7 APE8-rot-in 286.07 APE67-dihe-in -59.83, -24.78 -58.38, -48.52 APE12-dist-in 13.863 APE11-dist-in 11.61 APE10-dist-in 7.782 APE9-dist-in 3.366 None PTR321 PTR321 XRAY 2.56 0.243 0.266 D 368 333 13 0 0 0 [[159, 479]] 1.0 6eip Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A

Ligand: B7B

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name