Ligand: B6Z

Total number of chains: 4
Active chains: 1
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 6EIQA
All chains - renumbered by
Uniprot PDB Alignment

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Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC DYRK1A DYR1A_HUMAN 6EIQA Q13627 134 480 763.0 B6Z:501 Type1 Inactive DFGin 7.844 15.002 BLAminus -118.74, 166.17 66.15, 80.44 -94.35, 21.46 285.58, 78.61 -71.38, -21.76 in-in in 8.611 Saltbr-in 2.926 HRD-in -64.07, -39.42 69.31, 1.03 in-in-out SNCiio in-out ActLoopNT-in 2.923 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -140.51, 163.19 APE9-dihe-na 69.7, 156.6 APE8-dihe-in -69.88, 140.03 APE8-rot-in 262.24 APE67-dihe-in -50.14, -33.52 -54.08, -50.81 APE12-dist-in 13.87 APE11-dist-in 12.058 APE10-dist-out 8.058 APE9-dist-in 3.177 None PTR321 PTR321 XRAY 2.3 0.22 0.252 A 368 342 5 0 0 0 [[159, 479]] 1.0 6eiq CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 6EIQB Q13627 133 480 763.0 B6Z:501 Type1 Inactive DFGin 7.297 14.849 BLAminus -120.11, 166.43 71.57, 79.73 -95.19, 22.26 288.5, 77.93 -74.27, -18.06 in-in in 8.849 Saltbr-in 3.152 HRD-in -55.6, -50.6 83.2, -26.1 in-in-out SNCiio in-out ActLoopNT-in 2.76 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -126.72, 167.31 APE9-dihe-na 70.71, 154.35 APE8-dihe-in -72.28, 149.56 APE8-rot-in 304.02 APE67-dihe-in -63.36, -28.5 -63.02, -48.04 APE12-dist-out 14.336 APE11-dist-in 12.172 APE10-dist-out 8.104 APE9-dist-in 3.421 None PTR321 PTR321 XRAY 2.3 0.22 0.252 B 368 340 8 0 0 0 [[159, 479]] 1.0 6eiq CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 6EIQC Q13627 135 479 763.0 B6Z:501 Type1 Inactive DFGin 7.468 15.222 BLAminus -135.44, 157.29 69.01, 84.56 -97.19, 20.1 284.91, 77.49 -65.57, -27.64 in-in in 8.968 Saltbr-in 3.256 HRD-in -67.8, -34.77 66.66, 7.84 in-in-out SNCiio in-out ActLoopNT-in 2.69 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -132.75, 173.41 APE9-dihe-na 67.43, 156.08 APE8-dihe-in -71.33, 140.62 APE8-rot-in 274.81 APE67-dihe-in -64.01, -26.61 -57.83, -37.82 APE12-dist-out 14.005 APE11-dist-in 12.18 APE10-dist-out 8.189 APE9-dist-in 3.321 None PTR321 PTR321 XRAY 2.3 0.22 0.252 C 368 333 12 0 0 0 [[159, 479]] 1.0 6eiq CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 6EIQD Q13627 134 479 763.0 B6Z:501 Type1 Active DFGin 7.574 14.87 BLAminus -119.79, 171.42 62.12, 83.48 -94.95, 33.05 288.92, 76.92 -77.23, -31.31 in-in in 8.77 Saltbr-in 2.825 HRD-in -69.21, -45.78 80.19, 5.53 in-in-in SNCiii in-in ActLoopNT-in 2.954 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.36, 156.34 APE9-dihe-na 80.64, 155.49 APE8-dihe-in -79.45, 139.43 APE8-rot-in 279.91 APE67-dihe-in -60.72, -27.06 -52.76, -47.1 APE12-dist-in 13.959 APE11-dist-in 11.841 APE10-dist-in 7.989 APE9-dist-in 3.232 None PTR321 PTR321 XRAY 2.3 0.22 0.252 D 368 333 13 0 0 0 [[159, 479]] 1.0 6eiq CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A

Ligand: B6Z

Total number of chains: 4
Active chains: 1
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 6EIQA
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC DYRK1A DYR1A_HUMAN 6EIQA Q13627 134 480 763.0 B6Z:501 Type1 Inactive DFGin 7.844 15.002 BLAminus -118.74, 166.17 66.15, 80.44 -94.35, 21.46 285.58, 78.61 -71.38, -21.76 in-in in 8.611 Saltbr-in 2.926 HRD-in -64.07, -39.42 69.31, 1.03 in-in-out SNCiio in-out ActLoopNT-in 2.923 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -140.51, 163.19 APE9-dihe-na 69.7, 156.6 APE8-dihe-in -69.88, 140.03 APE8-rot-in 262.24 APE67-dihe-in -50.14, -33.52 -54.08, -50.81 APE12-dist-in 13.87 APE11-dist-in 12.058 APE10-dist-out 8.058 APE9-dist-in 3.177 None PTR321 PTR321 XRAY 2.3 0.22 0.252 A 368 342 5 0 0 0 [[159, 479]] 1.0 6eiq Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 6EIQB Q13627 133 480 763.0 B6Z:501 Type1 Inactive DFGin 7.297 14.849 BLAminus -120.11, 166.43 71.57, 79.73 -95.19, 22.26 288.5, 77.93 -74.27, -18.06 in-in in 8.849 Saltbr-in 3.152 HRD-in -55.6, -50.6 83.2, -26.1 in-in-out SNCiio in-out ActLoopNT-in 2.76 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -126.72, 167.31 APE9-dihe-na 70.71, 154.35 APE8-dihe-in -72.28, 149.56 APE8-rot-in 304.02 APE67-dihe-in -63.36, -28.5 -63.02, -48.04 APE12-dist-out 14.336 APE11-dist-in 12.172 APE10-dist-out 8.104 APE9-dist-in 3.421 None PTR321 PTR321 XRAY 2.3 0.22 0.252 B 368 340 8 0 0 0 [[159, 479]] 1.0 6eiq Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 6EIQC Q13627 135 479 763.0 B6Z:501 Type1 Inactive DFGin 7.468 15.222 BLAminus -135.44, 157.29 69.01, 84.56 -97.19, 20.1 284.91, 77.49 -65.57, -27.64 in-in in 8.968 Saltbr-in 3.256 HRD-in -67.8, -34.77 66.66, 7.84 in-in-out SNCiio in-out ActLoopNT-in 2.69 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -132.75, 173.41 APE9-dihe-na 67.43, 156.08 APE8-dihe-in -71.33, 140.62 APE8-rot-in 274.81 APE67-dihe-in -64.01, -26.61 -57.83, -37.82 APE12-dist-out 14.005 APE11-dist-in 12.18 APE10-dist-out 8.189 APE9-dist-in 3.321 None PTR321 PTR321 XRAY 2.3 0.22 0.252 C 368 333 12 0 0 0 [[159, 479]] 1.0 6eiq Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 6EIQD Q13627 134 479 763.0 B6Z:501 Type1 Active DFGin 7.574 14.87 BLAminus -119.79, 171.42 62.12, 83.48 -94.95, 33.05 288.92, 76.92 -77.23, -31.31 in-in in 8.77 Saltbr-in 2.825 HRD-in -69.21, -45.78 80.19, 5.53 in-in-in SNCiii in-in ActLoopNT-in 2.954 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.36, 156.34 APE9-dihe-na 80.64, 155.49 APE8-dihe-in -79.45, 139.43 APE8-rot-in 279.91 APE67-dihe-in -60.72, -27.06 -52.76, -47.1 APE12-dist-in 13.959 APE11-dist-in 11.841 APE10-dist-in 7.989 APE9-dist-in 3.232 None PTR321 PTR321 XRAY 2.3 0.22 0.252 D 368 333 13 0 0 0 [[159, 479]] 1.0 6eiq Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A

Ligand: B6Z

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name