Ligand: B6N

Total number of chains: 4
Active chains: 2
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 6EISA
All chains - renumbered by
Uniprot PDB Alignment

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Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC DYRK1A DYR1A_HUMAN 6EISA Q13627 134 480 763.0 B6N:501 Type1 Inactive DFGin 7.388 15.073 BLAminus -121.06, 176.79 59.09, 85.05 -102.98, 23.5 282.6, 78.49 -72.76, -28.73 in-in in 8.522 Saltbr-in 2.684 HRD-in -60.79, -45.9 71.73, 8.72 in-in-out SNCiio in-out ActLoopNT-in 2.965 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -123.11, 168.92 APE9-dihe-na 67.38, 154.43 APE8-dihe-in -70.15, 143.5 APE8-rot-in 292.25 APE67-dihe-in -58.07, -26.24 -55.8, -46.96 APE12-dist-in 13.889 APE11-dist-in 11.917 APE10-dist-out 8.032 APE9-dist-in 3.263 None PTR321 PTR321 XRAY 2.36 0.223 0.262 A 368 345 2 0 0 0 [[159, 479]] 1.0 6eis CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 6EISB Q13627 133 480 763.0 B6N:501 Type1 Active DFGin 7.364 15.01 BLAminus -121.04, 176.25 60.21, 78.92 -98.69, 24.99 286.57, 87.15 -70.6, -24.44 in-in in 8.697 Saltbr-in 2.736 HRD-in -63.78, -47.49 73.12, 4.16 in-in-in SNCiii in-in ActLoopNT-in 2.796 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.07, 170.33 APE9-dihe-na 64.55, 152.61 APE8-dihe-in -67.26, 141.38 APE8-rot-in 300.27 APE67-dihe-in -63.11, -23.65 -52.42, -46.34 APE12-dist-in 13.8 APE11-dist-in 11.772 APE10-dist-in 7.906 APE9-dist-in 3.181 None PTR321 PTR321 XRAY 2.36 0.223 0.262 B 368 340 8 0 0 0 [[159, 479]] 1.0 6eis CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 6EISC Q13627 135 479 763.0 B6N:501 Type1 Inactive DFGin 7.252 15.079 BLAminus -126.53, 168.59 63.16, 91.31 -107.92, 22.87 278.58, 80.44 -66.2, -35.95 in-in in 8.493 Saltbr-in 2.624 HRD-in -60.79, -42.31 68.89, 12.84 in-in-out SNCiio in-out ActLoopNT-in 2.758 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -121.65, 170.02 APE9-dihe-na 65.71, 162.09 APE8-dihe-in -78.55, 143.24 APE8-rot-in 293.4 APE67-dihe-in -58.46, -25.81 -54.9, -49.25 APE12-dist-in 13.875 APE11-dist-in 11.986 APE10-dist-out 8.187 APE9-dist-in 3.364 None PTR321 PTR321 XRAY 2.36 0.223 0.262 C 368 341 4 0 0 0 [[159, 479]] 1.0 6eis CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 6EISD Q13627 134 479 763.0 B6N:501 Type1 Active DFGin 7.286 15.141 BLAminus -125.52, 165.07 68.69, 87.86 -104.24, 31.22 282.79, 81.9 -77.49, -25.71 in-in in 8.619 Saltbr-in 2.657 HRD-in -61.8, -42.91 69.44, 6.24 in-in-in SNCiii in-in ActLoopNT-in 2.742 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.63, 168.78 APE9-dihe-na 66.0, 152.38 APE8-dihe-in -69.65, 137.97 APE8-rot-in 298.51 APE67-dihe-in -59.57, -25.22 -50.11, -45.93 APE12-dist-in 13.975 APE11-dist-in 11.877 APE10-dist-in 7.865 APE9-dist-in 3.336 None PTR321 PTR321 XRAY 2.36 0.223 0.262 D 368 339 7 0 0 0 [[159, 479]] 1.0 6eis CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A

Ligand: B6N

Total number of chains: 4
Active chains: 2
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 6EISA
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC DYRK1A DYR1A_HUMAN 6EISA Q13627 134 480 763.0 B6N:501 Type1 Inactive DFGin 7.388 15.073 BLAminus -121.06, 176.79 59.09, 85.05 -102.98, 23.5 282.6, 78.49 -72.76, -28.73 in-in in 8.522 Saltbr-in 2.684 HRD-in -60.79, -45.9 71.73, 8.72 in-in-out SNCiio in-out ActLoopNT-in 2.965 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -123.11, 168.92 APE9-dihe-na 67.38, 154.43 APE8-dihe-in -70.15, 143.5 APE8-rot-in 292.25 APE67-dihe-in -58.07, -26.24 -55.8, -46.96 APE12-dist-in 13.889 APE11-dist-in 11.917 APE10-dist-out 8.032 APE9-dist-in 3.263 None PTR321 PTR321 XRAY 2.36 0.223 0.262 A 368 345 2 0 0 0 [[159, 479]] 1.0 6eis Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 6EISB Q13627 133 480 763.0 B6N:501 Type1 Active DFGin 7.364 15.01 BLAminus -121.04, 176.25 60.21, 78.92 -98.69, 24.99 286.57, 87.15 -70.6, -24.44 in-in in 8.697 Saltbr-in 2.736 HRD-in -63.78, -47.49 73.12, 4.16 in-in-in SNCiii in-in ActLoopNT-in 2.796 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.07, 170.33 APE9-dihe-na 64.55, 152.61 APE8-dihe-in -67.26, 141.38 APE8-rot-in 300.27 APE67-dihe-in -63.11, -23.65 -52.42, -46.34 APE12-dist-in 13.8 APE11-dist-in 11.772 APE10-dist-in 7.906 APE9-dist-in 3.181 None PTR321 PTR321 XRAY 2.36 0.223 0.262 B 368 340 8 0 0 0 [[159, 479]] 1.0 6eis Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 6EISC Q13627 135 479 763.0 B6N:501 Type1 Inactive DFGin 7.252 15.079 BLAminus -126.53, 168.59 63.16, 91.31 -107.92, 22.87 278.58, 80.44 -66.2, -35.95 in-in in 8.493 Saltbr-in 2.624 HRD-in -60.79, -42.31 68.89, 12.84 in-in-out SNCiio in-out ActLoopNT-in 2.758 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -121.65, 170.02 APE9-dihe-na 65.71, 162.09 APE8-dihe-in -78.55, 143.24 APE8-rot-in 293.4 APE67-dihe-in -58.46, -25.81 -54.9, -49.25 APE12-dist-in 13.875 APE11-dist-in 11.986 APE10-dist-out 8.187 APE9-dist-in 3.364 None PTR321 PTR321 XRAY 2.36 0.223 0.262 C 368 341 4 0 0 0 [[159, 479]] 1.0 6eis Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 6EISD Q13627 134 479 763.0 B6N:501 Type1 Active DFGin 7.286 15.141 BLAminus -125.52, 165.07 68.69, 87.86 -104.24, 31.22 282.79, 81.9 -77.49, -25.71 in-in in 8.619 Saltbr-in 2.657 HRD-in -61.8, -42.91 69.44, 6.24 in-in-in SNCiii in-in ActLoopNT-in 2.742 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.63, 168.78 APE9-dihe-na 66.0, 152.38 APE8-dihe-in -69.65, 137.97 APE8-rot-in 298.51 APE67-dihe-in -59.57, -25.22 -50.11, -45.93 APE12-dist-in 13.975 APE11-dist-in 11.877 APE10-dist-in 7.865 APE9-dist-in 3.336 None PTR321 PTR321 XRAY 2.36 0.223 0.262 D 368 339 7 0 0 0 [[159, 479]] 1.0 6eis Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A

Ligand: B6N

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name