Ligand: B5T

Total number of chains: 4
Active chains: 1
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 6EIFA
All chains - renumbered by
Uniprot PDB Alignment

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Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC DYRK1A DYR1A_HUMAN 6EIFA Q13627 134 480 763.0 B5T:501 Type1 Active DFGin 7.715 15.153 BLAminus -108.17, 168.64 68.55, 82.38 -98.62, 28.92 285.39, 77.1 -72.07, -30.89 in-in in 8.846 Saltbr-in 2.978 HRD-in -66.36, -44.8 74.98, 9.71 in-in-in SNCiii in-in ActLoopNT-in 2.782 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.64, 161.63 APE9-dihe-na 71.89, 150.46 APE8-dihe-in -78.88, 144.18 APE8-rot-in 300.04 APE67-dihe-in -58.53, -31.8 -55.12, -42.87 APE12-dist-in 13.989 APE11-dist-in 11.748 APE10-dist-in 7.965 APE9-dist-in 3.281 None PTR321 PTR321 XRAY 2.22 0.22 0.25 A 368 344 3 0 0 0 [[159, 479]] 1.0 6eif CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 6EIFB Q13627 133 480 763.0 B5T:501 Type1 Inactive DFGin 7.437 15.011 BLAminus -117.53, 169.82 65.45, 81.5 -101.1, 26.98 294.5, 81.24 -78.02, -31.68 in-in in 8.976 Saltbr-in 2.829 HRD-in -63.16, -42.31 73.8, 14.91 in-in-out SNCiio in-out ActLoopNT-in 2.878 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -135.66, 162.2 APE9-dihe-na 65.08, 155.43 APE8-dihe-in -69.9, 152.14 APE8-rot-in 294.46 APE67-dihe-in -60.84, -36.77 -65.76, -40.73 APE12-dist-out 14.096 APE11-dist-in 11.816 APE10-dist-out 8.23 APE9-dist-in 3.428 None PTR321 PTR321 XRAY 2.22 0.22 0.25 B 368 338 10 0 0 0 [[159, 479]] 1.0 6eif CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 6EIFC Q13627 135 479 763.0 B5T:501 Type1 Inactive DFGin 7.626 14.968 BLAminus -125.16, 167.64 65.65, 86.42 -102.01, 28.2 285.76, 74.26 -70.95, -35.41 in-in in 8.71 Saltbr-in 3.053 HRD-in -64.14, -45.72 70.72, 21.75 in-in-out SNCiio in-out ActLoopNT-in 2.79 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -144.86, 166.67 APE9-dihe-na 68.87, 169.54 APE8-dihe-in -80.46, 148.42 APE8-rot-in 289.45 APE67-dihe-in -66.62, -23.66 -60.62, -43.05 APE12-dist-out 14.237 APE11-dist-in 12.046 APE10-dist-out 8.222 APE9-dist-in 3.494 None PTR321 PTR321 XRAY 2.22 0.22 0.25 C 368 317 28 0 0 0 [[159, 479]] 1.0 6eif CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 6EIFD Q13627 134 479 763.0 B5T:501 Type1 Inactive DFGin 7.545 15.131 BLAminus -129.8, 155.34 72.75, 87.67 -101.7, 34.46 287.1, 75.24 -73.21, -33.11 in-in in 8.874 Saltbr-in 2.757 HRD-in -60.8, -47.28 75.52, 7.01 in-in-out SNCiio in-out ActLoopNT-in 2.797 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioi APE10-dihe-na -135.58, 162.36 APE9-dihe-na 71.89, 152.04 APE8-dihe-in -66.91, 143.91 APE8-rot-out 183.99 APE67-dihe-in -59.93, -30.1 -58.92, -45.25 APE12-dist-out 14.091 APE11-dist-in 11.962 APE10-dist-out 8.149 APE9-dist-in 3.292 None PTR321 PTR321 XRAY 2.22 0.22 0.25 D 368 331 15 0 0 0 [[159, 479]] 1.0 6eif CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A

Ligand: B5T

Total number of chains: 4
Active chains: 1
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 6EIFA
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC DYRK1A DYR1A_HUMAN 6EIFA Q13627 134 480 763.0 B5T:501 Type1 Active DFGin 7.715 15.153 BLAminus -108.17, 168.64 68.55, 82.38 -98.62, 28.92 285.39, 77.1 -72.07, -30.89 in-in in 8.846 Saltbr-in 2.978 HRD-in -66.36, -44.8 74.98, 9.71 in-in-in SNCiii in-in ActLoopNT-in 2.782 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.64, 161.63 APE9-dihe-na 71.89, 150.46 APE8-dihe-in -78.88, 144.18 APE8-rot-in 300.04 APE67-dihe-in -58.53, -31.8 -55.12, -42.87 APE12-dist-in 13.989 APE11-dist-in 11.748 APE10-dist-in 7.965 APE9-dist-in 3.281 None PTR321 PTR321 XRAY 2.22 0.22 0.25 A 368 344 3 0 0 0 [[159, 479]] 1.0 6eif Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 6EIFB Q13627 133 480 763.0 B5T:501 Type1 Inactive DFGin 7.437 15.011 BLAminus -117.53, 169.82 65.45, 81.5 -101.1, 26.98 294.5, 81.24 -78.02, -31.68 in-in in 8.976 Saltbr-in 2.829 HRD-in -63.16, -42.31 73.8, 14.91 in-in-out SNCiio in-out ActLoopNT-in 2.878 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -135.66, 162.2 APE9-dihe-na 65.08, 155.43 APE8-dihe-in -69.9, 152.14 APE8-rot-in 294.46 APE67-dihe-in -60.84, -36.77 -65.76, -40.73 APE12-dist-out 14.096 APE11-dist-in 11.816 APE10-dist-out 8.23 APE9-dist-in 3.428 None PTR321 PTR321 XRAY 2.22 0.22 0.25 B 368 338 10 0 0 0 [[159, 479]] 1.0 6eif Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 6EIFC Q13627 135 479 763.0 B5T:501 Type1 Inactive DFGin 7.626 14.968 BLAminus -125.16, 167.64 65.65, 86.42 -102.01, 28.2 285.76, 74.26 -70.95, -35.41 in-in in 8.71 Saltbr-in 3.053 HRD-in -64.14, -45.72 70.72, 21.75 in-in-out SNCiio in-out ActLoopNT-in 2.79 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -144.86, 166.67 APE9-dihe-na 68.87, 169.54 APE8-dihe-in -80.46, 148.42 APE8-rot-in 289.45 APE67-dihe-in -66.62, -23.66 -60.62, -43.05 APE12-dist-out 14.237 APE11-dist-in 12.046 APE10-dist-out 8.222 APE9-dist-in 3.494 None PTR321 PTR321 XRAY 2.22 0.22 0.25 C 368 317 28 0 0 0 [[159, 479]] 1.0 6eif Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 6EIFD Q13627 134 479 763.0 B5T:501 Type1 Inactive DFGin 7.545 15.131 BLAminus -129.8, 155.34 72.75, 87.67 -101.7, 34.46 287.1, 75.24 -73.21, -33.11 in-in in 8.874 Saltbr-in 2.757 HRD-in -60.8, -47.28 75.52, 7.01 in-in-out SNCiio in-out ActLoopNT-in 2.797 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioi APE10-dihe-na -135.58, 162.36 APE9-dihe-na 71.89, 152.04 APE8-dihe-in -66.91, 143.91 APE8-rot-out 183.99 APE67-dihe-in -59.93, -30.1 -58.92, -45.25 APE12-dist-out 14.091 APE11-dist-in 11.962 APE10-dist-out 8.149 APE9-dist-in 3.292 None PTR321 PTR321 XRAY 2.22 0.22 0.25 D 368 331 15 0 0 0 [[159, 479]] 1.0 6eif Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A

Ligand: B5T

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name