Ligand: AWR

Total number of chains: 4
Active chains: 4
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 5AIKA
All chains - renumbered by
Uniprot PDB Alignment

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Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC DYRK1A DYR1A_HUMAN 5AIKA Q13627 134 481 763.0 AWR:900 Type1 Active DFGin 7.488 15.138 BLAminus -123.8, 165.61 68.96, 89.37 -99.53, 20.4 284.53, 79.68 -68.37, -30.16 in-in in 8.457 Saltbr-in 2.716 HRD-in -69.39, -41.54 73.14, 9.89 in-in-in SNCiii in-in ActLoopNT-in 2.763 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.11, 166.6 APE9-dihe-na 72.45, 139.9 APE8-dihe-in -58.6, 139.24 APE8-rot-in 263.46 APE67-dihe-in -61.38, -25.4 -48.26, -51.05 APE12-dist-in 13.515 APE11-dist-in 11.757 APE10-dist-in 7.939 APE9-dist-in 3.238 None PTR321 PTR321 XRAY 2.7 0.228 0.252 A 382 345 3 0 0 0 [[159, 479]] 1.0 5aik CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 5AIKB Q13627 134 481 763.0 AWR:900 Type1 Active DFGin 7.471 15.176 BLAminus -125.22, 165.11 67.89, 88.91 -100.53, 21.33 285.51, 80.4 -65.48, -31.48 in-in in 8.424 Saltbr-in 2.707 HRD-in -68.57, -40.82 71.56, 10.16 in-in-in SNCiii in-in ActLoopNT-in 2.777 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.21, 166.46 APE9-dihe-na 73.88, 141.73 APE8-dihe-in -58.72, 138.35 APE8-rot-in 264.56 APE67-dihe-in -61.35, -26.09 -50.07, -49.03 APE12-dist-in 13.527 APE11-dist-in 11.708 APE10-dist-in 7.938 APE9-dist-in 3.208 None PTR321 PTR321 XRAY 2.7 0.228 0.252 B 382 343 5 0 0 0 [[159, 479]] 1.0 5aik CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 5AIKC Q13627 134 481 763.0 AWR:900 Type1 Active DFGin 7.496 15.188 BLAminus -123.03, 165.69 69.38, 87.6 -99.21, 19.82 285.24, 79.6 -64.68, -32.8 in-in in 8.455 Saltbr-in 2.713 HRD-in -68.63, -41.21 72.74, 9.64 in-in-in SNCiii in-in ActLoopNT-in 2.787 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.44, 166.36 APE9-dihe-na 71.77, 141.71 APE8-dihe-in -59.81, 140.84 APE8-rot-in 262.61 APE67-dihe-in -60.57, -26.31 -49.76, -50.14 APE12-dist-in 13.385 APE11-dist-in 11.642 APE10-dist-in 7.885 APE9-dist-in 3.217 None PTR321 PTR321 XRAY 2.7 0.228 0.252 C 382 343 5 0 0 0 [[159, 479]] 1.0 5aik CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 5AIKD Q13627 134 480 763.0 AWR:900 Type1 Active DFGin 7.476 15.15 BLAminus -124.79, 165.65 68.79, 87.65 -99.81, 21.12 284.88, 80.68 -66.8, -31.32 in-in in 8.421 Saltbr-in 2.707 HRD-in -68.57, -41.65 72.65, 9.66 in-in-in SNCiii in-in ActLoopNT-in 2.78 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.19, 166.91 APE9-dihe-na 72.86, 141.73 APE8-dihe-in -58.81, 138.66 APE8-rot-in 264.48 APE67-dihe-in -59.64, -26.2 -50.08, -49.71 APE12-dist-in 13.488 APE11-dist-in 11.764 APE10-dist-in 7.955 APE9-dist-in 3.231 None PTR321 PTR321 XRAY 2.7 0.228 0.252 D 382 343 4 0 0 0 [[159, 479]] 1.0 5aik CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A

Ligand: AWR

Total number of chains: 4
Active chains: 4
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 5AIKA
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC DYRK1A DYR1A_HUMAN 5AIKA Q13627 134 481 763.0 AWR:900 Type1 Active DFGin 7.488 15.138 BLAminus -123.8, 165.61 68.96, 89.37 -99.53, 20.4 284.53, 79.68 -68.37, -30.16 in-in in 8.457 Saltbr-in 2.716 HRD-in -69.39, -41.54 73.14, 9.89 in-in-in SNCiii in-in ActLoopNT-in 2.763 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.11, 166.6 APE9-dihe-na 72.45, 139.9 APE8-dihe-in -58.6, 139.24 APE8-rot-in 263.46 APE67-dihe-in -61.38, -25.4 -48.26, -51.05 APE12-dist-in 13.515 APE11-dist-in 11.757 APE10-dist-in 7.939 APE9-dist-in 3.238 None PTR321 PTR321 XRAY 2.7 0.228 0.252 A 382 345 3 0 0 0 [[159, 479]] 1.0 5aik Homo sapiens CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 5AIKB Q13627 134 481 763.0 AWR:900 Type1 Active DFGin 7.471 15.176 BLAminus -125.22, 165.11 67.89, 88.91 -100.53, 21.33 285.51, 80.4 -65.48, -31.48 in-in in 8.424 Saltbr-in 2.707 HRD-in -68.57, -40.82 71.56, 10.16 in-in-in SNCiii in-in ActLoopNT-in 2.777 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.21, 166.46 APE9-dihe-na 73.88, 141.73 APE8-dihe-in -58.72, 138.35 APE8-rot-in 264.56 APE67-dihe-in -61.35, -26.09 -50.07, -49.03 APE12-dist-in 13.527 APE11-dist-in 11.708 APE10-dist-in 7.938 APE9-dist-in 3.208 None PTR321 PTR321 XRAY 2.7 0.228 0.252 B 382 343 5 0 0 0 [[159, 479]] 1.0 5aik Homo sapiens CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 5AIKC Q13627 134 481 763.0 AWR:900 Type1 Active DFGin 7.496 15.188 BLAminus -123.03, 165.69 69.38, 87.6 -99.21, 19.82 285.24, 79.6 -64.68, -32.8 in-in in 8.455 Saltbr-in 2.713 HRD-in -68.63, -41.21 72.74, 9.64 in-in-in SNCiii in-in ActLoopNT-in 2.787 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.44, 166.36 APE9-dihe-na 71.77, 141.71 APE8-dihe-in -59.81, 140.84 APE8-rot-in 262.61 APE67-dihe-in -60.57, -26.31 -49.76, -50.14 APE12-dist-in 13.385 APE11-dist-in 11.642 APE10-dist-in 7.885 APE9-dist-in 3.217 None PTR321 PTR321 XRAY 2.7 0.228 0.252 C 382 343 5 0 0 0 [[159, 479]] 1.0 5aik Homo sapiens CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 5AIKD Q13627 134 480 763.0 AWR:900 Type1 Active DFGin 7.476 15.15 BLAminus -124.79, 165.65 68.79, 87.65 -99.81, 21.12 284.88, 80.68 -66.8, -31.32 in-in in 8.421 Saltbr-in 2.707 HRD-in -68.57, -41.65 72.65, 9.66 in-in-in SNCiii in-in ActLoopNT-in 2.78 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.19, 166.91 APE9-dihe-na 72.86, 141.73 APE8-dihe-in -58.81, 138.66 APE8-rot-in 264.48 APE67-dihe-in -59.64, -26.2 -50.08, -49.71 APE12-dist-in 13.488 APE11-dist-in 11.764 APE10-dist-in 7.955 APE9-dist-in 3.231 None PTR321 PTR321 XRAY 2.7 0.228 0.252 D 382 343 4 0 0 0 [[159, 479]] 1.0 5aik Homo sapiens CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A

Ligand: AWR

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name