Ligand: 859

Total number of chains: 2
Active chains: 2
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 100.0% 2NO3A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC MAPK8 MK08_HUMAN 2NO3A P45983 8 364 427.0 859:901 Type1 Active DFGin 5.8629 13.8896 BLAminus -141.07, 148.97 75.82, 137.69 -138.71, 16.78 294.85, 98.43 -54.01, -64.02 in-in in 8.4814 Saltbr-in 2.7915 HRD-in -92.56, -31.18 61.32, -24.16 in-in-in SNCiii in-in ActLoopNT-in 2.5506 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -47.4, -34.85 APE9-dihe-na -77.56, 142.56 APE8-dihe-in -59.37, 120.51 APE8-rot-in 310.95 APE67-dihe-in -29.44, -22.2 -32.85, -87.31 APE12-dist-in 11.9332 APE11-dist-in 12.0435 APE10-dist-in 6.6597 APE9-dist-in 4.8178 T183E,Y185E None None XRAY 3.2 0.233 0.276 A 370.0 357.0 0 27 27 0 [[26, 321]] 1.0 2no3 CMGC_MAPK8_HUMAN CMGC 2.6e-83 285.6 1.0 301.0 301.0 168 169 170 172 174 55 73 77 148 150 149 151.0 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
CMGC MAPK8 MK08_HUMAN 2NO3B P45983 7 363 427.0 859:902 Type1 Active DFGin 6.4988 14.1591 BLAminus -157.78, 177.02 69.64, 114.69 -132.65, 1.82 296.08, 106.12 -53.25, -7.72 in-in in 9.1606 Saltbr-in 3.0003 HRD-in -57.79, -52.24 74.94, -7.51 in-in-in SNCiii in-in ActLoopNT-in 3.1052 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -98.63, -57.06 APE9-dihe-na -57.37, 144.61 APE8-dihe-in -64.67, 111.29 APE8-rot-in 358.49 APE67-dihe-in -34.54, -28.75 -26.01, -79.7 APE12-dist-in 12.833 APE11-dist-in 13.3757 APE10-dist-in 7.5425 APE9-dist-in 4.8072 T183E,Y185E None None XRAY 3.2 0.233 0.276 B 370.0 357.0 0 27 27 0 [[26, 321]] 1.0 2no3 CMGC_MAPK8_HUMAN CMGC 2.6e-83 285.6 1.0 301.0 301.0 168 169 170 172 174 55 73 77 148 150 149 151.0 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8

Ligand: 859

Total number of chains: 2
Active chains: 2
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 100.0% 2NO3A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC MAPK8 MK08_HUMAN 2NO3A P45983 8 364 427.0 859:901 Type1 Active DFGin 5.8629 13.8896 BLAminus -141.07, 148.97 75.82, 137.69 -138.71, 16.78 294.85, 98.43 -54.01, -64.02 in-in in 8.4814 Saltbr-in 2.7915 HRD-in -92.56, -31.18 61.32, -24.16 in-in-in SNCiii in-in ActLoopNT-in 2.5506 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -47.4, -34.85 APE9-dihe-na -77.56, 142.56 APE8-dihe-in -59.37, 120.51 APE8-rot-in 310.95 APE67-dihe-in -29.44, -22.2 -32.85, -87.31 APE12-dist-in 11.9332 APE11-dist-in 12.0435 APE10-dist-in 6.6597 APE9-dist-in 4.8178 T183E,Y185E None None XRAY 3.2 0.233 0.276 A 370.0 357.0 0 27 27 0 [[26, 321]] 1.0 2no3 Homo sapiens CMGC_MAPK8_HUMAN CMGC 2.6e-83 285.6 1.0 301.0 301.0 168 169 170 172 174 55 73 77 148 150 149 151.0 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
CMGC MAPK8 MK08_HUMAN 2NO3B P45983 7 363 427.0 859:902 Type1 Active DFGin 6.4988 14.1591 BLAminus -157.78, 177.02 69.64, 114.69 -132.65, 1.82 296.08, 106.12 -53.25, -7.72 in-in in 9.1606 Saltbr-in 3.0003 HRD-in -57.79, -52.24 74.94, -7.51 in-in-in SNCiii in-in ActLoopNT-in 3.1052 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -98.63, -57.06 APE9-dihe-na -57.37, 144.61 APE8-dihe-in -64.67, 111.29 APE8-rot-in 358.49 APE67-dihe-in -34.54, -28.75 -26.01, -79.7 APE12-dist-in 12.833 APE11-dist-in 13.3757 APE10-dist-in 7.5425 APE9-dist-in 4.8072 T183E,Y185E None None XRAY 3.2 0.233 0.276 B 370.0 357.0 0 27 27 0 [[26, 321]] 1.0 2no3 Homo sapiens CMGC_MAPK8_HUMAN CMGC 2.6e-83 285.6 1.0 301.0 301.0 168 169 170 172 174 55 73 77 148 150 149 151.0 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8

Ligand: 859

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name