Ligand: 4WD

Total number of chains: 4
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 7FHTA
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC DYRK1A DYR1A_HUMAN 7FHTA Q13627 134 481 763.0 4WD:501 Type1 Inactive DFGin 7.385 15.04 BLAminus -115.56, 172.1 66.07, 83.84 -100.52, 20.7 283.28, 78.58 -68.54, -23.03 in-in in 8.7 Saltbr-in 3.285 HRD-in -57.68, -43.02 74.5, -0.17 in-in-out SNCiio in-out ActLoopNT-in 2.768 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -135.55, 163.58 APE9-dihe-na 69.38, 153.5 APE8-dihe-in -68.25, 140.14 APE8-rot-in 282.31 APE67-dihe-in -63.83, -23.96 -47.13, -50.62 APE12-dist-in 13.845 APE11-dist-in 12.051 APE10-dist-out 8.165 APE9-dist-in 3.074 None PTR321 PTR321 XRAY 2.68 0.191 0.249 A 361 343 5 0 0 0 [[159, 479]] 1.0 7fht CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 7FHTB Q13627 134 480 763.0 4WD:501 Type1 Inactive DFGin 7.552 14.875 BLAminus -130.16, 173.47 60.71, 76.23 -98.42, 21.02 279.61, 81.43 -74.75, -28.83 in-in in 8.627 Saltbr-in 2.693 HRD-in -57.11, -44.93 77.29, 4.6 in-in-out SNCiio in-out ActLoopNT-in 2.833 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -136.63, 166.07 APE9-dihe-na 72.34, 153.51 APE8-dihe-in -70.32, 130.86 APE8-rot-in 279.96 APE67-dihe-in -61.47, -23.44 -50.08, -46.31 APE12-dist-in 13.847 APE11-dist-in 11.829 APE10-dist-out 8.0 APE9-dist-in 3.279 None PTR321 PTR321 XRAY 2.68 0.191 0.249 B 361 341 6 0 0 0 [[159, 479]] 1.0 7fht CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 7FHTC Q13627 134 480 763.0 4WD:501 Type1 Inactive DFGin 7.372 15.027 BLAminus -125.03, 174.37 63.18, 83.49 -99.9, 20.78 282.36, 79.78 -79.83, -7.76 in-in in 8.723 Saltbr-in 3.03 HRD-in -55.31, -47.7 76.16, 8.53 in-in-out SNCiio in-out ActLoopNT-in 3.021 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -126.03, 164.79 APE9-dihe-na 71.34, 164.59 APE8-dihe-in -70.74, 135.69 APE8-rot-in 297.13 APE67-dihe-in -61.65, -39.99 -48.8, -48.72 APE12-dist-out 14.132 APE11-dist-in 11.947 APE10-dist-out 8.075 APE9-dist-in 3.185 None PTR321 PTR321 XRAY 2.68 0.191 0.249 C 361 341 6 0 0 0 [[159, 479]] 1.0 7fht CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 7FHTD Q13627 134 480 763.0 4WD:501 Type1 Inactive DFGin 7.413 15.13 BLAminus -127.5, 171.04 65.84, 77.76 -97.3, 15.13 281.72, 82.6 -61.5, -43.31 in-in in 8.663 Saltbr-in 2.595 HRD-in -56.98, -47.37 76.71, 7.39 in-in-out SNCiio in-out ActLoopNT-in 2.932 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -125.8, 168.64 APE9-dihe-na 68.47, 157.81 APE8-dihe-in -75.05, 138.24 APE8-rot-in 287.07 APE67-dihe-in -63.35, -29.18 -50.59, -48.07 APE12-dist-out 14.251 APE11-dist-in 12.098 APE10-dist-out 8.34 APE9-dist-in 3.344 None PTR321 PTR321 XRAY 2.68 0.191 0.249 D 361 342 5 0 0 0 [[159, 479]] 1.0 7fht CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A

Ligand: 4WD

Total number of chains: 4
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 7FHTA
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC DYRK1A DYR1A_HUMAN 7FHTA Q13627 134 481 763.0 4WD:501 Type1 Inactive DFGin 7.385 15.04 BLAminus -115.56, 172.1 66.07, 83.84 -100.52, 20.7 283.28, 78.58 -68.54, -23.03 in-in in 8.7 Saltbr-in 3.285 HRD-in -57.68, -43.02 74.5, -0.17 in-in-out SNCiio in-out ActLoopNT-in 2.768 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -135.55, 163.58 APE9-dihe-na 69.38, 153.5 APE8-dihe-in -68.25, 140.14 APE8-rot-in 282.31 APE67-dihe-in -63.83, -23.96 -47.13, -50.62 APE12-dist-in 13.845 APE11-dist-in 12.051 APE10-dist-out 8.165 APE9-dist-in 3.074 None PTR321 PTR321 XRAY 2.68 0.191 0.249 A 361 343 5 0 0 0 [[159, 479]] 1.0 7fht Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 7FHTB Q13627 134 480 763.0 4WD:501 Type1 Inactive DFGin 7.552 14.875 BLAminus -130.16, 173.47 60.71, 76.23 -98.42, 21.02 279.61, 81.43 -74.75, -28.83 in-in in 8.627 Saltbr-in 2.693 HRD-in -57.11, -44.93 77.29, 4.6 in-in-out SNCiio in-out ActLoopNT-in 2.833 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -136.63, 166.07 APE9-dihe-na 72.34, 153.51 APE8-dihe-in -70.32, 130.86 APE8-rot-in 279.96 APE67-dihe-in -61.47, -23.44 -50.08, -46.31 APE12-dist-in 13.847 APE11-dist-in 11.829 APE10-dist-out 8.0 APE9-dist-in 3.279 None PTR321 PTR321 XRAY 2.68 0.191 0.249 B 361 341 6 0 0 0 [[159, 479]] 1.0 7fht Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 7FHTC Q13627 134 480 763.0 4WD:501 Type1 Inactive DFGin 7.372 15.027 BLAminus -125.03, 174.37 63.18, 83.49 -99.9, 20.78 282.36, 79.78 -79.83, -7.76 in-in in 8.723 Saltbr-in 3.03 HRD-in -55.31, -47.7 76.16, 8.53 in-in-out SNCiio in-out ActLoopNT-in 3.021 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -126.03, 164.79 APE9-dihe-na 71.34, 164.59 APE8-dihe-in -70.74, 135.69 APE8-rot-in 297.13 APE67-dihe-in -61.65, -39.99 -48.8, -48.72 APE12-dist-out 14.132 APE11-dist-in 11.947 APE10-dist-out 8.075 APE9-dist-in 3.185 None PTR321 PTR321 XRAY 2.68 0.191 0.249 C 361 341 6 0 0 0 [[159, 479]] 1.0 7fht Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 7FHTD Q13627 134 480 763.0 4WD:501 Type1 Inactive DFGin 7.413 15.13 BLAminus -127.5, 171.04 65.84, 77.76 -97.3, 15.13 281.72, 82.6 -61.5, -43.31 in-in in 8.663 Saltbr-in 2.595 HRD-in -56.98, -47.37 76.71, 7.39 in-in-out SNCiio in-out ActLoopNT-in 2.932 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -125.8, 168.64 APE9-dihe-na 68.47, 157.81 APE8-dihe-in -75.05, 138.24 APE8-rot-in 287.07 APE67-dihe-in -63.35, -29.18 -50.59, -48.07 APE12-dist-out 14.251 APE11-dist-in 12.098 APE10-dist-out 8.34 APE9-dist-in 3.344 None PTR321 PTR321 XRAY 2.68 0.191 0.249 D 361 342 5 0 0 0 [[159, 479]] 1.0 7fht Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A

Ligand: 4WD

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name