Ligand: 4VZ

Total number of chains: 4
Active chains: 1
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 7FHSA
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC DYRK1A DYR1A_HUMAN 7FHSA Q13627 134 481 763.0 4VZ:501 Type1 Inactive DFGin 7.241 14.926 BLAminus -121.39, 176.07 62.5, 85.89 -99.63, 18.4 279.74, 77.39 -67.82, -18.09 in-in in 8.534 Saltbr-in 2.505 HRD-in -59.16, -48.2 82.44, -2.99 in-in-out SNCiio in-out ActLoopNT-in 2.942 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -129.74, 161.14 APE9-dihe-na 76.96, 152.88 APE8-dihe-in -66.51, 139.46 APE8-rot-in 276.14 APE67-dihe-in -65.33, -20.38 -53.89, -45.41 APE12-dist-out 14.124 APE11-dist-in 12.105 APE10-dist-out 8.132 APE9-dist-in 3.11 None PTR321 PTR321 XRAY 2.42 0.234 0.275 A 361 343 5 0 0 0 [[159, 479]] 1.0 7fhs CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 7FHSB Q13627 134 481 763.0 4VZ:501 Type1 Active DFGin 7.385 15.0 BLAminus -125.73, 165.21 71.88, 83.89 -101.28, 23.85 281.27, 80.83 -70.35, -20.86 in-in in 8.799 Saltbr-in 2.715 HRD-in -62.95, -48.52 82.4, -4.32 in-in-in SNCiii in-in ActLoopNT-in 2.785 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.22, 160.69 APE9-dihe-na 79.18, 154.0 APE8-dihe-in -69.6, 130.45 APE8-rot-in 276.76 APE67-dihe-in -56.8, -23.49 -48.13, -49.11 APE12-dist-in 13.918 APE11-dist-in 11.969 APE10-dist-in 7.951 APE9-dist-in 3.132 None PTR321 PTR321 XRAY 2.42 0.234 0.275 B 361 342 6 0 0 0 [[159, 479]] 1.0 7fhs CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 7FHSC Q13627 134 480 763.0 4VZ:501 Type1 Inactive DFGin 7.147 14.803 BLAminus -122.76, 175.78 63.26, 85.37 -100.76, 19.54 285.72, 82.11 -73.67, -2.97 in-in in 8.844 Saltbr-in 2.717 HRD-in -56.19, -50.9 88.82, -2.51 in-in-out SNCiio in-out ActLoopNT-in 2.933 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -138.77, 162.39 APE9-dihe-na 77.37, 153.1 APE8-dihe-in -64.98, 135.39 APE8-rot-in 268.68 APE67-dihe-in -55.6, -25.7 -46.74, -55.19 APE12-dist-in 13.909 APE11-dist-in 11.996 APE10-dist-out 8.024 APE9-dist-in 3.256 None PTR321 PTR321 XRAY 2.42 0.234 0.275 C 361 341 6 0 0 0 [[159, 479]] 1.0 7fhs CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 7FHSD Q13627 134 480 763.0 4VZ:501 Type1 Inactive DFGin 7.411 15.065 BLAminus -127.1, 176.87 62.95, 73.78 -97.03, 21.7 278.97, 80.32 -71.98, -32.85 in-in in 8.797 Saltbr-in 2.973 HRD-in -62.79, -46.25 79.63, -0.41 in-in-out SNCiio in-out ActLoopNT-in 2.734 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -142.76, 171.2 APE9-dihe-na 70.9, 168.34 APE8-dihe-in -89.11, 136.94 APE8-rot-in 273.67 APE67-dihe-in -56.34, -27.28 -43.9, -54.58 APE12-dist-out 14.334 APE11-dist-in 11.899 APE10-dist-out 8.219 APE9-dist-in 3.105 None PTR321 PTR321 XRAY 2.42 0.234 0.275 D 361 342 5 0 0 0 [[159, 479]] 1.0 7fhs CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A

Ligand: 4VZ

Total number of chains: 4
Active chains: 1
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 7FHSA
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC DYRK1A DYR1A_HUMAN 7FHSA Q13627 134 481 763.0 4VZ:501 Type1 Inactive DFGin 7.241 14.926 BLAminus -121.39, 176.07 62.5, 85.89 -99.63, 18.4 279.74, 77.39 -67.82, -18.09 in-in in 8.534 Saltbr-in 2.505 HRD-in -59.16, -48.2 82.44, -2.99 in-in-out SNCiio in-out ActLoopNT-in 2.942 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -129.74, 161.14 APE9-dihe-na 76.96, 152.88 APE8-dihe-in -66.51, 139.46 APE8-rot-in 276.14 APE67-dihe-in -65.33, -20.38 -53.89, -45.41 APE12-dist-out 14.124 APE11-dist-in 12.105 APE10-dist-out 8.132 APE9-dist-in 3.11 None PTR321 PTR321 XRAY 2.42 0.234 0.275 A 361 343 5 0 0 0 [[159, 479]] 1.0 7fhs Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 7FHSB Q13627 134 481 763.0 4VZ:501 Type1 Active DFGin 7.385 15.0 BLAminus -125.73, 165.21 71.88, 83.89 -101.28, 23.85 281.27, 80.83 -70.35, -20.86 in-in in 8.799 Saltbr-in 2.715 HRD-in -62.95, -48.52 82.4, -4.32 in-in-in SNCiii in-in ActLoopNT-in 2.785 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.22, 160.69 APE9-dihe-na 79.18, 154.0 APE8-dihe-in -69.6, 130.45 APE8-rot-in 276.76 APE67-dihe-in -56.8, -23.49 -48.13, -49.11 APE12-dist-in 13.918 APE11-dist-in 11.969 APE10-dist-in 7.951 APE9-dist-in 3.132 None PTR321 PTR321 XRAY 2.42 0.234 0.275 B 361 342 6 0 0 0 [[159, 479]] 1.0 7fhs Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 7FHSC Q13627 134 480 763.0 4VZ:501 Type1 Inactive DFGin 7.147 14.803 BLAminus -122.76, 175.78 63.26, 85.37 -100.76, 19.54 285.72, 82.11 -73.67, -2.97 in-in in 8.844 Saltbr-in 2.717 HRD-in -56.19, -50.9 88.82, -2.51 in-in-out SNCiio in-out ActLoopNT-in 2.933 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -138.77, 162.39 APE9-dihe-na 77.37, 153.1 APE8-dihe-in -64.98, 135.39 APE8-rot-in 268.68 APE67-dihe-in -55.6, -25.7 -46.74, -55.19 APE12-dist-in 13.909 APE11-dist-in 11.996 APE10-dist-out 8.024 APE9-dist-in 3.256 None PTR321 PTR321 XRAY 2.42 0.234 0.275 C 361 341 6 0 0 0 [[159, 479]] 1.0 7fhs Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 7FHSD Q13627 134 480 763.0 4VZ:501 Type1 Inactive DFGin 7.411 15.065 BLAminus -127.1, 176.87 62.95, 73.78 -97.03, 21.7 278.97, 80.32 -71.98, -32.85 in-in in 8.797 Saltbr-in 2.973 HRD-in -62.79, -46.25 79.63, -0.41 in-in-out SNCiio in-out ActLoopNT-in 2.734 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -142.76, 171.2 APE9-dihe-na 70.9, 168.34 APE8-dihe-in -89.11, 136.94 APE8-rot-in 273.67 APE67-dihe-in -56.34, -27.28 -43.9, -54.58 APE12-dist-out 14.334 APE11-dist-in 11.899 APE10-dist-out 8.219 APE9-dist-in 3.105 None PTR321 PTR321 XRAY 2.42 0.234 0.275 D 361 342 5 0 0 0 [[159, 479]] 1.0 7fhs Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A

Ligand: 4VZ

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name