Ligand: 3QS

Total number of chains: 2
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 1 50.0% 4RJ8A
DFGin BLBtrans 1 50.0% 4RJ3A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CDK2 CDK2_HUMAN 4RJ3A P24941 1 295 298.0 3QS:302 Type1 Inactive DFGin 10.8441 18.4788 BLBtrans -103.26, 157.57 67.1, 20.45 -61.5, 131.71 229.9, 107.13 88.12, -11.06 out-na out 15.2453 Saltbr-na 16.0151 HRD-in -86.0, -60.04 83.03, -12.63 na-out-out SNCaoo out-out ActLoopNT-out 5.6619 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -70.8, 126.77 APE9-dihe-na -74.75, 124.45 APE8-dihe-in -64.43, 140.32 APE8-rot-out 189.03 APE67-dihe-in -62.82, -26.74 -95.98, -4.59 APE12-dist-out 19.5701 APE11-dist-out 17.1266 APE10-dist-out 18.6606 APE9-dist-out 10.2825 None None ALY33 XRAY 1.63 0.177 0.21 A 298.0 288.0 7 28 28 0 [[4, 286]] 1.0 4rj3 CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
TYR EGFR EGFR_HUMAN 4RJ8A P00533 697 1018 1210.0 3QS:1102 Type1 None DFGin 5.739 14.8391 BLAminus -139.18, -167.47 68.29, 77.56 -89.12, 10.26 294.1, 106.72 -54.86, -20.91 in-in in 8.3957 Saltbr-in 2.7941 HRD-in -60.49, -55.01 73.42, -2.13 in-in-none SNCiin in-none ActLoopNT-in 2.7808 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 133.62 APE8-dihe-in -86.58, 81.4 APE8-rot-na 26.4 APE67-dihe-in -68.07, -3.17 -48.59, -54.74 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.12 T790M,L858R,E865A,E866A,K867A None None XRAY 2.5 0.197 0.226 A 331.0 298.0 18 30 16 14 [[712, 970]] 1.0 4rj8 TYR_EGFR_HUMAN TYR 4.6e-86 294.4 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor

Ligand: 3QS

Total number of chains: 2
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 1 50.0% 4RJ8A
DFGin BLBtrans 1 50.0% 4RJ3A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CDK2 CDK2_HUMAN 4RJ3A P24941 1 295 298.0 3QS:302 Type1 Inactive DFGin 10.8441 18.4788 BLBtrans -103.26, 157.57 67.1, 20.45 -61.5, 131.71 229.9, 107.13 88.12, -11.06 out-na out 15.2453 Saltbr-na 16.0151 HRD-in -86.0, -60.04 83.03, -12.63 na-out-out SNCaoo out-out ActLoopNT-out 5.6619 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -70.8, 126.77 APE9-dihe-na -74.75, 124.45 APE8-dihe-in -64.43, 140.32 APE8-rot-out 189.03 APE67-dihe-in -62.82, -26.74 -95.98, -4.59 APE12-dist-out 19.5701 APE11-dist-out 17.1266 APE10-dist-out 18.6606 APE9-dist-out 10.2825 None None ALY33 XRAY 1.63 0.177 0.21 A 298.0 288.0 7 28 28 0 [[4, 286]] 1.0 4rj3 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
TYR EGFR EGFR_HUMAN 4RJ8A P00533 697 1018 1210.0 3QS:1102 Type1 None DFGin 5.739 14.8391 BLAminus -139.18, -167.47 68.29, 77.56 -89.12, 10.26 294.1, 106.72 -54.86, -20.91 in-in in 8.3957 Saltbr-in 2.7941 HRD-in -60.49, -55.01 73.42, -2.13 in-in-none SNCiin in-none ActLoopNT-in 2.7808 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 133.62 APE8-dihe-in -86.58, 81.4 APE8-rot-na 26.4 APE67-dihe-in -68.07, -3.17 -48.59, -54.74 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.12 T790M,L858R,E865A,E866A,K867A None None XRAY 2.5 0.197 0.226 A 331.0 298.0 18 30 16 14 [[712, 970]] 1.0 4rj8 Homo sapiens TYR_EGFR_HUMAN TYR 4.6e-86 294.4 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor

Ligand: 3QS

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name