Ligand: 0X5

Total number of chains: 2
Active chains: 1
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 100.0% 4GIHA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
TYR JAK2-2 JAK2_HUMAN 4GMYA 2.403 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 0X5 Type1 833 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
TYR TYK2-2 TYK2_HUMAN 4GIHA 2.0 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 0X5 Type1 890 - 1176 0 None C936A,Q969A,E971A,K972A,D1023N,C1142A Non-receptor tyrosine-protein kinase TYK2

Ligand: 0X5

Total number of chains: 2
Active chains: 1
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 100.0% 4GIHA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
TYR JAK2-2 JAK2_HUMAN 4GMYA 2.403 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 0X5 Type1 833 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
TYR TYK2-2 TYK2_HUMAN 4GIHA 2.0 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 0X5 Type1 890 - 1176 0 None C936A,Q969A,E971A,K972A,D1023N,C1142A Non-receptor tyrosine-protein kinase TYK2 Homo sapiens

Ligand: 0X5

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism