TYR_TYRO3 (Tyrosine-protein kinase receptor TYRO3)

Total number of chains: 2
Active chains: 2
Uniprot: TYRO3_HUMAN
Kinase Domain Residues: 518 - 788
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 100.0% AF-Q06418-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYRO3 AF-Q06418-K1A Q06418 510 796 890.0 No_ligand No_ligand Active DFGin 6.6658 13.5962 BLAminus -142.32, -172.24 49.52, 79.9 -93.28, 19.29 306.33, 109.16 -61.07, -35.49 in-in in 8.1942 Saltbr-in 2.6892 HRD-in -72.75, -46.03 67.57, -6.57 in-in-in SNCiii in-in ActLoopNT-in 2.8854 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -71.86, 121.0 APE9-dihe-in -121.03, 153.62 APE8-dihe-in -77.35, 69.27 APE8-rot-na 36.73 APE67-dihe-in -72.95, -10.91 -44.51, -40.11 APE12-dist-na 13.7609 APE11-dist-na 8.3995 APE10-dist-na 10.7257 APE9-dist-in 6.7941 None None None AF2 -1.0 1.0 1.0 A 287.0 287.0 0 30 30 0 [[518, 788]] 1.0 AF-Q06418-K1 TYR_TYRO3_HUMAN TYR 1.7e-90 308.8 2.0 260.0 259.0 672 673 674 676 678 550 568 572 652 654 653 655.0 714 702 697 696 695 694 693 692 691 604 Tyrosine-protein kinase receptor TYRO3
TYRO3 AF-Q06418-K3A Q06418 510 796 890.0 No_ligand No_ligand Active DFGin 6.3732 13.5913 BLAminus -146.13, -175.06 56.98, 70.08 -86.1, 17.12 302.46, 104.91 -58.16, -44.4 in-in in 8.305 Saltbr-in 2.7029 HRD-in -77.97, -46.62 65.36, -8.31 in-in-in SNCiii in-in ActLoopNT-in 2.8888 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -69.97, 133.69 APE9-dihe-in -137.01, 148.85 APE8-dihe-in -79.87, 66.53 APE8-rot-na 37.11 APE67-dihe-in -72.27, -10.46 -44.75, -40.42 APE12-dist-na 13.4719 APE11-dist-na 7.7831 APE10-dist-na 9.5652 APE9-dist-in 6.3024 None None None AF2 -1.0 1.0 1.0 A 287.0 287.0 0 30 30 0 [[518, 788]] 1.0 AF-Q06418-K3 TYR_TYRO3_HUMAN TYR 1.7e-90 308.8 2.0 260.0 259.0 672 673 674 676 678 550 568 572 652 654 653 655.0 714 702 697 696 695 694 693 692 691 604 Tyrosine-protein kinase receptor TYRO3

TYR_TYRO3 (Tyrosine-protein kinase receptor TYRO3)

Total number of chains: 5
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 80.0% AF-Q06418-K1A
None None 1 20.0% 4FF8A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYRO3 TYRO3_HUMAN AF-Q06418-K1A Q06418 510 796 890.0 No_ligand No_ligand Active DFGin 6.6658 13.5962 BLAminus -142.32, -172.24 49.52, 79.9 -93.28, 19.29 306.33, 109.16 -61.07, -35.49 in-in in 8.1942 Saltbr-in 2.6892 HRD-in -72.75, -46.03 67.57, -6.57 in-in-in SNCiii in-in ActLoopNT-in 2.8854 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -71.86, 121.0 APE9-dihe-in -121.03, 153.62 APE8-dihe-in -77.35, 69.27 APE8-rot-na 36.73 APE67-dihe-in -72.95, -10.91 -44.51, -40.11 APE12-dist-na 13.7609 APE11-dist-na 8.3995 APE10-dist-na 10.7257 APE9-dist-in 6.7941 None None None AF2 -1.0 1.0 1.0 A 287.0 287.0 0 30 30 0 [[518, 788]] 1.0 AF-Q06418-K1 Homo sapiens TYR_TYRO3_HUMAN TYR 1.7e-90 308.8 2.0 260.0 259.0 672 673 674 676 678 550 568 572 652 654 653 655.0 714 702 697 696 695 694 693 692 691 604 Tyrosine-protein kinase receptor TYRO3
TYRO3 TYRO3_HUMAN AF-Q06418-K3A Q06418 510 796 890.0 No_ligand No_ligand Active DFGin 6.3732 13.5913 BLAminus -146.13, -175.06 56.98, 70.08 -86.1, 17.12 302.46, 104.91 -58.16, -44.4 in-in in 8.305 Saltbr-in 2.7029 HRD-in -77.97, -46.62 65.36, -8.31 in-in-in SNCiii in-in ActLoopNT-in 2.8888 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -69.97, 133.69 APE9-dihe-in -137.01, 148.85 APE8-dihe-in -79.87, 66.53 APE8-rot-na 37.11 APE67-dihe-in -72.27, -10.46 -44.75, -40.42 APE12-dist-na 13.4719 APE11-dist-na 7.7831 APE10-dist-na 9.5652 APE9-dist-in 6.3024 None None None AF2 -1.0 1.0 1.0 A 287.0 287.0 0 30 30 0 [[518, 788]] 1.0 AF-Q06418-K3 Homo sapiens TYR_TYRO3_HUMAN TYR 1.7e-90 308.8 2.0 260.0 259.0 672 673 674 676 678 550 568 572 652 654 653 655.0 714 702 697 696 695 694 693 692 691 604 Tyrosine-protein kinase receptor TYRO3
TYRO3 TYRO3_MOUSE 3QUPA P55144 499 782 880.0 LUN:1 Type1 Inactive DFGin 6.8964 12.8564 BLAminus -139.51, -179.91 59.3, 72.13 -82.08, -17.71 313.79, 114.67 123.96, 27.7 out-out out 13.7627 Saltbr-out 10.716 HRD-in -66.38, -50.77 76.88, -20.29 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -44.66 APE8-dihe-in -81.35, 72.41 APE8-rot-na 30.25 APE67-dihe-in -64.54, -14.8 -57.21, -43.49 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.2255 None None None XRAY 1.9 0.239 0.262 A 323.0 241.0 40 30 13 17 [[508, 778]] 1.0 3qup Mus musculus TYR_TYRO3_MOUSE TYR 1.7e-90 308.8 2.0 260.0 259.0 662 663 664 666 668 540 558 562 642 644 643 645.0 704 692 687 686 685 684 683 682 681 594 Tyrosine-protein kinase receptor TYRO3
TYRO3 TYRO3_MOUSE 4FEQA P55144 505 783 880.0 0T8:901 Type1 Inactive DFGin 5.3795 13.0287 BLAminus -119.42, 171.09 80.98, 86.52 -73.23, -8.72 298.97, 107.36 86.02, 999.0 out-out out 13.9467 Saltbr-out 11.6098 HRD-in -80.86, -48.87 83.51, -24.85 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnan APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-na 999.0 APE67-dihe-none -73.54, -16.56 999.0, -16.27 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.2 0.278 0.327 A 323.0 224.0 55 30 10 20 [[508, 778]] 1.0 4feq Mus musculus TYR_TYRO3_MOUSE TYR 1.7e-90 308.8 2.0 260.0 259.0 662 663 664 666 668 540 558 562 642 644 643 645.0 704 692 687 686 685 684 683 682 681 594 Tyrosine-protein kinase receptor TYRO3
TYRO3 TYRO3_MOUSE 4FF8A P55144 563 780 880.0 14S:901 Type1 Inactive None 999.0 999.0 None -119.71, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 none-none none 999.0 Saltbr-none 999.0 HRD-in -80.09, -48.59 81.95, -6.39 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnan APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-na 999.0 APE67-dihe-none -78.3, -10.69 999.0, -21.76 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.279 0.324 A 323.0 169.0 104 30 7 23 [[508, 778]] 1.0 4ff8 Mus musculus TYR_TYRO3_MOUSE TYR 1.7e-90 308.8 2.0 260.0 259.0 662 663 664 666 668 540 558 562 642 644 643 645.0 704 692 687 686 685 684 683 682 681 594 Tyrosine-protein kinase receptor TYRO3

TYR_TYRO3 (Tyrosine-protein kinase receptor TYRO3)

Total number of chains: 3
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 66.7% 3QUPA
None None 1 33.3% 4FF8A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYRO3 TYRO3_MOUSE 3QUPA P55144 499 782 880.0 LUN:1 Type1 Inactive DFGin 6.8964 12.8564 BLAminus -139.51, -179.91 59.3, 72.13 -82.08, -17.71 313.79, 114.67 123.96, 27.7 out-out out 13.7627 Saltbr-out 10.716 HRD-in -66.38, -50.77 76.88, -20.29 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -44.66 APE8-dihe-in -81.35, 72.41 APE8-rot-na 30.25 APE67-dihe-in -64.54, -14.8 -57.21, -43.49 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.2255 None None None XRAY 1.9 0.239 0.262 A 323.0 241.0 40 30 13 17 [[508, 778]] 1.0 3qup Mus musculus TYR_TYRO3_MOUSE TYR 1.7e-90 308.8 2.0 260.0 259.0 662 663 664 666 668 540 558 562 642 644 643 645.0 704 692 687 686 685 684 683 682 681 594 Tyrosine-protein kinase receptor TYRO3
TYRO3 TYRO3_MOUSE 4FEQA P55144 505 783 880.0 0T8:901 Type1 Inactive DFGin 5.3795 13.0287 BLAminus -119.42, 171.09 80.98, 86.52 -73.23, -8.72 298.97, 107.36 86.02, 999.0 out-out out 13.9467 Saltbr-out 11.6098 HRD-in -80.86, -48.87 83.51, -24.85 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnan APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-na 999.0 APE67-dihe-none -73.54, -16.56 999.0, -16.27 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.2 0.278 0.327 A 323.0 224.0 55 30 10 20 [[508, 778]] 1.0 4feq Mus musculus TYR_TYRO3_MOUSE TYR 1.7e-90 308.8 2.0 260.0 259.0 662 663 664 666 668 540 558 562 642 644 643 645.0 704 692 687 686 685 684 683 682 681 594 Tyrosine-protein kinase receptor TYRO3
TYRO3 TYRO3_MOUSE 4FF8A P55144 563 780 880.0 14S:901 Type1 Inactive None 999.0 999.0 None -119.71, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 none-none none 999.0 Saltbr-none 999.0 HRD-in -80.09, -48.59 81.95, -6.39 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnan APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-na 999.0 APE67-dihe-none -78.3, -10.69 999.0, -21.76 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.279 0.324 A 323.0 169.0 104 30 7 23 [[508, 778]] 1.0 4ff8 Mus musculus TYR_TYRO3_MOUSE TYR 1.7e-90 308.8 2.0 260.0 259.0 662 663 664 666 668 540 558 562 642 644 643 645.0 704 692 687 686 685 684 683 682 681 594 Tyrosine-protein kinase receptor TYRO3