AGC_PRKX (cAMP-dependent protein kinase catalytic subunit PRKX)

Total number of chains: 2
Active chains: 2
Uniprot: PRKX_HUMAN
Kinase Domain Residues: 49 - 303
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 100.0% AF-P51817-K1A

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PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AF-P51817-K1A 41 311 358.0 No_ligand No_ligand Active DFGin 6.667 14.553 BLAminus -121.72, -174.69 49.59, 81.61 -95.04, 16.66 288.42, 82.22 -70.51, -23.61 in-in in 8.911 Saltbr-in 2.708 HRD-in -86.78, -47.49 65.73, 2.37 in-in-in SNCiii in-in ActLoopNT-in 2.888 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.15, 159.34 APE9-dihe-na 109.64, 178.29 APE8-dihe-in -81.97, 127.99 APE8-rot-in 303.22 APE67-dihe-in -65.66, -24.04 -47.75, -43.09 APE12-dist-in 8.315 APE11-dist-in 11.312 APE10-dist-in 5.621 APE9-dist-in 3.592 None None None AF2 -1.0 1.0 1.0 A 271 271 0 0 0 0 [[49, 303]] 1.0 AF-P51817-K1 AGC_PRKX_HUMAN AGC 5.4e-91 310.2 1 260 260 189 190 191 193 195 78 97 101 169 171 170 172 226 214 209 208 207 206 205 204 203 127 cAMP-dependent protein kinase catalytic subunit PRKX
AF-P51817-K3A 41 311 358.0 No_ligand No_ligand Active DFGin 6.24 14.365 BLAminus -126.23, -173.14 47.02, 78.73 -87.6, 16.57 289.31, 79.51 -57.8, -34.93 in-in in 8.808 Saltbr-in 2.688 HRD-in -84.22, -46.74 70.42, -1.61 in-in-in SNCiii in-in ActLoopNT-in 2.897 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.47, 160.07 APE9-dihe-na 104.92, 173.58 APE8-dihe-in -75.13, 134.82 APE8-rot-in 294.67 APE67-dihe-in -64.87, -22.2 -48.45, -44.36 APE12-dist-in 7.788 APE11-dist-in 11.149 APE10-dist-in 5.605 APE9-dist-in 4.253 None None None AF2 -1.0 1.0 1.0 A 271 271 0 0 0 0 [[49, 303]] 1.0 AF-P51817-K3 AGC_PRKX_HUMAN AGC 5.4e-91 310.2 1 260 260 189 190 191 193 195 78 97 101 169 171 170 172 226 214 209 208 207 206 205 204 203 127 cAMP-dependent protein kinase catalytic subunit PRKX

AGC_PRKX (cAMP-dependent protein kinase catalytic subunit PRKX)

Total number of chains: 2
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 100.0% AF-P51817-K1A

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
PRKX_HUMAN AF-P51817-K1A P51817 41 311 358.0 No_ligand No_ligand Active DFGin 6.667 14.553 BLAminus -121.72, -174.69 49.59, 81.61 -95.04, 16.66 288.42, 82.22 -70.51, -23.61 in-in in 8.911 Saltbr-in 2.708 HRD-in -86.78, -47.49 65.73, 2.37 in-in-in SNCiii in-in ActLoopNT-in 2.888 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.15, 159.34 APE9-dihe-na 109.64, 178.29 APE8-dihe-in -81.97, 127.99 APE8-rot-in 303.22 APE67-dihe-in -65.66, -24.04 -47.75, -43.09 APE12-dist-in 8.315 APE11-dist-in 11.312 APE10-dist-in 5.621 APE9-dist-in 3.592 None None None AF2 -1.0 1.0 1.0 A 271 271 0 0 0 0 [[49, 303]] 1.0 AF-P51817-K1 Homo sapiens AGC_PRKX_HUMAN AGC 5.4e-91 310.2 1 260 260 189 190 191 193 195 78 97 101 169 171 170 172 226 214 209 208 207 206 205 204 203 127 cAMP-dependent protein kinase catalytic subunit PRKX
PRKX_HUMAN AF-P51817-K3A P51817 41 311 358.0 No_ligand No_ligand Active DFGin 6.24 14.365 BLAminus -126.23, -173.14 47.02, 78.73 -87.6, 16.57 289.31, 79.51 -57.8, -34.93 in-in in 8.808 Saltbr-in 2.688 HRD-in -84.22, -46.74 70.42, -1.61 in-in-in SNCiii in-in ActLoopNT-in 2.897 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.47, 160.07 APE9-dihe-na 104.92, 173.58 APE8-dihe-in -75.13, 134.82 APE8-rot-in 294.67 APE67-dihe-in -64.87, -22.2 -48.45, -44.36 APE12-dist-in 7.788 APE11-dist-in 11.149 APE10-dist-in 5.605 APE9-dist-in 4.253 None None None AF2 -1.0 1.0 1.0 A 271 271 0 0 0 0 [[49, 303]] 1.0 AF-P51817-K3 Homo sapiens AGC_PRKX_HUMAN AGC 5.4e-91 310.2 1 260 260 189 190 191 193 195 78 97 101 169 171 170 172 226 214 209 208 207 206 205 204 203 127 cAMP-dependent protein kinase catalytic subunit PRKX

AGC_PRKX (cAMP-dependent protein kinase catalytic subunit PRKX)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name