CMGC_MAPK3 (Mitogen-activated protein kinase 3)

Total number of chains: 13
Active chains: 2
Family: CMGC
Uniprot: MK03_HUMAN
Kinase Domain Residues: 42 - 330
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 13 100.0% AF-P27361-K1A

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PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label DFG-Asp_rot_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Asp
χ1,χ2
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AF-P27361-K1A 34 338 379.0 No_ligand No_ligand Active DFGin 6.593 14.896 BLAminus DFGAsp-rot-in -130.53, -179.67 55.56, 73.68 193.69, 31.1 -81.57, 15.4 283.43, 73.42 -60.15, -27.17 in-in in 9.098 Saltbr-in 2.699 HRD-in -71.43, -46.13 64.54, 6.96 in-in-in SNCiii in-in ActLoopNT-in 2.863 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -74.91, 170.97 APE9-dihe-na 59.86, 147.58 APE8-dihe-in -63.62, 134.74 APE8-rot-in 298.27 APE67-dihe-in -68.94, -17.88 -46.37, -48.07 APE12-dist-in 12.835 APE11-dist-in 11.325 APE10-dist-in 6.818 APE9-dist-in 3.037 None None None AF2 -1.0 1.0 1.0 A 305 305 0 0 0 0 [[42, 330]] 1.0 AF-P27361-K1 CMGC_MAPK3_HUMAN CMGC 1.5e-87 299.6 1 301 301 183 184 185 187 189 71 88 92 163 165 164 166 227 214 209 208 207 206 205 204 203 123 Mitogen-activated protein kinase 3
AF-P27361-K3A 34 338 379.0 No_ligand No_ligand Active DFGin 6.535 14.634 BLAminus DFGAsp-rot-in -133.14, -176.56 56.67, 65.23 191.09, 33.73 -76.5, 14.43 283.46, 73.65 -63.2, -17.33 in-in in 9.037 Saltbr-in 2.688 HRD-in -77.08, -46.07 62.9, 16.83 in-in-in SNCiii in-in ActLoopNT-in 2.852 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -69.1, 168.93 APE9-dihe-na 59.76, 143.47 APE8-dihe-in -62.52, 135.83 APE8-rot-in 298.7 APE67-dihe-in -69.69, -17.66 -48.0, -47.1 APE12-dist-in 12.485 APE11-dist-in 11.079 APE10-dist-in 6.616 APE9-dist-in 3.06 None None None AF2 -1.0 1.0 1.0 A 305 305 0 0 0 0 [[42, 330]] 1.0 AF-P27361-K3 CMGC_MAPK3_HUMAN CMGC 1.5e-87 299.6 1 301 301 183 184 185 187 189 71 88 92 163 165 164 166 227 214 209 208 207 206 205 204 203 123 Mitogen-activated protein kinase 3
9UURB 26 374 379.0 ANP:60402 ATPlike Inactive DFGin 7.046 16.721 BLAminus DFGAsp-rot-in -125.2774, -171.8504 57.8871, 62.6574 204.6215, -38.0138 -83.9318, 70.2924 271.3877, 98.988 -91.2011, -102.4627 in-out in 9.841 Saltbr-out 3.702 HRD-in -63.3287, -44.4231 65.9337, -2.9097 out-in-out SNCoio in-out ActLoopNT-in 3.31 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oooo APE10-dihe-na -73.149, 154.5025 APE9-dihe-na -157.2089, 162.6587 APE8-dihe-in -97.0192, 119.1986 APE8-rot-out 59.5672 APE67-dihe-out -91.6183, -7.4904 -122.261, 114.9769 APE12-dist-out 15.931 APE11-dist-out 15.9 APE10-dist-out 18.061 APE9-dist-out 13.143 None None None EM 3.36 999.0 999.0 B 388 349 0 0 0 0 [[42, 330]] 1.0 9uur CMGC_MAPK3_HUMAN CMGC 3.5e-87 298.4 1 301 301 183 184 185 187 189 71 88 92 163 165 164 166 227 214 209 208 207 206 205 204 203 123 Mitogen-activated protein kinase 3
9UUXB 27 375 379.0 ANP:402 ATPlike Inactive DFGin 6.891 16.04 BLAminus DFGAsp-rot-in -128.6144, -170.7726 60.7427, 64.232 216.4748, -27.5773 -88.6666, 67.791 282.4698, 94.6501 -92.1054, -102.8214 in-out in 9.911 Saltbr-out 3.817 HRD-in -62.507, -44.9226 64.1255, 0.0529 out-in-out SNCoio in-out ActLoopNT-in 3.101 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oooo APE10-dihe-na -76.5628, 148.2674 APE9-dihe-na -156.7962, 164.5301 APE8-dihe-in -92.5475, 120.8909 APE8-rot-out 64.3077 APE67-dihe-out -82.9887, -10.3381 -122.7899, 105.1205 APE12-dist-out 15.979 APE11-dist-out 15.42 APE10-dist-out 18.001 APE9-dist-out 13.025 None TPO202 TPO202 EM 3.12 999.0 999.0 B 388 349 0 0 0 0 [[42, 330]] 1.0 9uux CMGC_MAPK3_HUMAN CMGC 3.5e-87 298.4 1 301 301 183 184 185 187 189 71 88 92 163 165 164 166 227 214 209 208 207 206 205 204 203 123 Mitogen-activated protein kinase 3
9UW3B 27 374 379.0 ANP:402 ATPlike Inactive DFGin 6.911 16.194 BLAminus DFGAsp-rot-in -125.6031, -169.6008 62.0638, 57.1616 204.8277, -13.4842 -79.084, 77.2875 280.4089, 80.549 -98.4869, -96.1009 in-in in 9.776 Saltbr-in 3.564 HRD-in -65.0056, -43.9908 63.361, 3.8208 in-in-out SNCiio in-out ActLoopNT-in 3.482 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oooo APE10-dihe-na -112.9812, 147.8659 APE9-dihe-na -157.6409, 163.2759 APE8-dihe-in -92.3175, 124.3346 APE8-rot-out 75.5113 APE67-dihe-out -87.7767, -4.4272 -128.9449, 106.9042 APE12-dist-out 16.25 APE11-dist-out 15.863 APE10-dist-out 17.941 APE9-dist-out 13.309 None PTR204 PTR204 EM 3.36 999.0 999.0 B 388 348 0 0 0 0 [[42, 330]] 1.0 9uw3 CMGC_MAPK3_HUMAN CMGC 3.5e-87 298.4 1 301 301 183 184 185 187 189 71 88 92 163 165 164 166 227 214 209 208 207 206 205 204 203 123 Mitogen-activated protein kinase 3
9UW4B 29 374 379.0 ANP:402 ATPlike Inactive DFGin 6.904 15.983 BLAminus DFGAsp-rot-in -137.547, -167.3693 59.7522, 64.3544 201.1871, -43.5971 -88.5285, 51.6599 292.6306, 79.5591 -72.0921, -64.5527 in-out in 9.85 Saltbr-out 4.731 HRD-in -63.7037, -42.698 63.7695, 2.2218 out-in-out SNCoio in-out ActLoopNT-in 3.119 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oooo APE10-dihe-na -71.7213, 146.7494 APE9-dihe-na -156.6838, 164.4469 APE8-dihe-in -95.2675, 129.2723 APE8-rot-out 86.0069 APE67-dihe-out -93.875, -29.8394 -129.7461, 119.2822 APE12-dist-out 16.501 APE11-dist-out 16.066 APE10-dist-out 18.486 APE9-dist-out 13.259 None None None EM 3.2 999.0 999.0 B 388 346 0 0 0 0 [[42, 330]] 1.0 9uw4 CMGC_MAPK3_HUMAN CMGC 3.5e-87 298.4 1 301 301 183 184 185 187 189 71 88 92 163 165 164 166 227 214 209 208 207 206 205 204 203 123 Mitogen-activated protein kinase 3
9TU0A 28 373 379.0 No_ligand No_ligand Inactive DFGin 6.68 15.472 BLAminus DFGAsp-rot-in -131.5025, 179.4792 63.2076, 80.3646 220.9388, -24.1556 -100.8534, 28.0556 291.6623, 79.8078 -67.8218, -38.8244 in-out in 9.502 Saltbr-out 3.749 HRD-in -72.3925, -45.5743 65.33, 4.0014 out-in-none SNCoin in-none ActLoopNT-in 2.953 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 84.1516, -12.7837 999.0, -80.7019 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None SEP286 SEP286 XRAY 2.17 0.24 0.292 A 379 327 19 0 0 16 [[42, 330]] 1.0 9tu0 CMGC_MAPK3_HUMAN CMGC 3.3e-87 298.5 1 301 301 183 184 185 187 189 71 88 92 163 165 164 166 227 214 209 208 207 206 205 204 203 123 Mitogen-activated protein kinase 3
6GESB 25 374 379.0 6H3:401 Type1 Inactive DFGin 6.894 15.497 BLAminus DFGAsp-rot-in -138.79, 174.04 68.33, 84.06 209.57, -41.47 -104.81, 19.96 280.63, 68.61 -61.52, -24.52 in-in in 9.366 Saltbr-in 2.931 HRD-in -74.27, -56.06 78.37, 3.28 in-in-out SNCiio in-out ActLoopNT-in 2.784 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -97.48, -39.89 APE9-dihe-na -63.16, 160.66 APE8-dihe-in -55.88, 126.17 APE8-rot-in 317.05 APE67-dihe-in -63.74, -19.63 -50.02, -51.48 APE12-dist-out 14.329 APE11-dist-in 10.952 APE10-dist-in 6.917 APE9-dist-in 4.424 None None None XRAY 2.07 0.172 0.213 B 380 350 0 0 0 0 [[42, 330]] 1.0 6ges CMGC_MAPK3_HUMAN CMGC 3.3e-87 298.5 1 301 301 183 184 185 187 189 71 88 92 163 165 164 166 227 214 209 208 207 206 205 204 203 123 Mitogen-activated protein kinase 3
2ZOQA 24 375 379.0 5ID:382 Type1 Inactive DFGin 6.822 14.876 BLAminus DFGAsp-rot-out -110.57, 174.03 16.61, 106.79 309.81, -40.78 -100.79, 23.94 292.4, 62.55 -56.98, -29.52 in-in in 9.223 Saltbr-in 2.858 HRD-in -74.22, -49.1 69.67, -4.29 in-in-out SNCiio in-out ActLoopNT-in 2.715 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -88.46, -39.85 APE9-dihe-na -45.11, 153.81 APE8-dihe-in -55.88, 121.07 APE8-rot-in 311.89 APE67-dihe-in -58.47, -14.87 -49.12, -49.9 APE12-dist-out 14.379 APE11-dist-in 9.797 APE10-dist-in 6.865 APE9-dist-in 4.614 None PTR204 PTR204 XRAY 2.39 0.249 0.267 A 382 352 0 0 0 0 [[42, 330]] 1.0 2zoq CMGC_MAPK3_HUMAN CMGC 3.3e-87 298.5 1 301 301 183 184 185 187 189 71 88 92 163 165 164 166 227 214 209 208 207 206 205 204 203 123 Mitogen-activated protein kinase 3
2ZOQB 24 375 379.0 5ID:382 Type1 Inactive DFGin 7.081 14.696 BLAminus DFGAsp-rot-out -126.97, -169.7 58.49, 71.36 278.72, 21.57 -96.75, 32.61 283.64, 67.73 -68.29, -24.37 in-out in 9.648 Saltbr-out 3.747 HRD-in -67.75, -54.76 76.39, 2.97 out-in-out SNCoio in-out ActLoopNT-in 2.787 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_iiii APE10-dihe-na -62.22, -135.12 APE9-dihe-na -49.82, -170.24 APE8-dihe-out -38.65, -56.7 APE8-rot-in 299.06 APE67-dihe-out -72.56, -16.77 136.84, -44.19 APE12-dist-in 13.667 APE11-dist-in 11.413 APE10-dist-in 7.869 APE9-dist-in 4.076 None PTR204 PTR204 XRAY 2.39 0.249 0.267 B 382 352 0 0 0 0 [[42, 330]] 1.0 2zoq CMGC_MAPK3_HUMAN CMGC 3.3e-87 298.5 1 301 301 183 184 185 187 189 71 88 92 163 165 164 166 227 214 209 208 207 206 205 204 203 123 Mitogen-activated protein kinase 3
6GESA 25 374 379.0 6H3:401,EWH:402 Type1,Allosteric Inactive DFGin 6.952 15.557 BLAminus DFGAsp-rot-in -139.32, 176.86 65.58, 87.64 205.48, -28.41 -106.07, 21.81 281.49, 72.32 -67.67, -20.97 in-in in 9.464 Saltbr-in 2.866 HRD-in -74.62, -54.83 79.01, 3.71 in-in-out SNCiio in-out ActLoopNT-in 2.75 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -96.37, -37.93 APE9-dihe-na -66.29, 158.31 APE8-dihe-in -54.71, 127.96 APE8-rot-in 319.22 APE67-dihe-in -62.74, -20.38 -53.12, -50.26 APE12-dist-out 14.227 APE11-dist-in 11.026 APE10-dist-in 6.934 APE9-dist-in 4.409 None None None XRAY 2.07 0.172 0.213 A 380 350 0 0 0 0 [[42, 330]] 1.0 6ges CMGC_MAPK3_HUMAN CMGC 3.3e-87 298.5 1 301 301 183 184 185 187 189 71 88 92 163 165 164 166 227 214 209 208 207 206 205 204 203 123 Mitogen-activated protein kinase 3
4QTBA 24 374 379.0 38Z:418 Type1.5_Front Inactive DFGin 6.963 16.192 BLAminus DFGAsp-rot-in -128.63, 172.06 72.12, 87.31 200.35, -19.7 -104.64, 23.58 286.23, 74.76 -64.07, -28.14 in-in in 9.638 Saltbr-in 2.654 HRD-in -72.11, -54.76 73.09, 8.34 in-in-out SNCiio in-out ActLoopNT-in 2.768 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -93.95, -29.12 APE9-dihe-na -67.78, 160.1 APE8-dihe-in -53.91, 125.98 APE8-rot-in 310.28 APE67-dihe-in -65.26, -17.27 -52.54, -50.1 APE12-dist-out 14.155 APE11-dist-in 10.804 APE10-dist-in 6.843 APE9-dist-in 4.412 None None None XRAY 1.4 0.148 0.175 A 380 351 0 0 0 0 [[42, 330]] 1.0 4qtb CMGC_MAPK3_HUMAN CMGC 3.3e-87 298.5 1 301 301 183 184 185 187 189 71 88 92 163 165 164 166 227 214 209 208 207 206 205 204 203 123 Mitogen-activated protein kinase 3
4QTBB 27 374 379.0 38Z:412 Type1.5_Front Inactive DFGin 6.989 16.095 BLAminus DFGAsp-rot-in -131.38, 169.9 76.01, 86.99 200.97, -17.02 -105.18, 21.27 288.36, 77.86 -59.51, -32.2 in-in in 9.594 Saltbr-in 2.709 HRD-in -72.51, -53.5 77.51, 5.81 in-in-out SNCiio in-out ActLoopNT-in 2.824 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -90.9, -27.9 APE9-dihe-na -67.55, 157.04 APE8-dihe-in -54.84, 126.95 APE8-rot-in 308.82 APE67-dihe-in -67.72, -16.58 -53.94, -47.75 APE12-dist-out 14.188 APE11-dist-in 10.858 APE10-dist-in 7.082 APE9-dist-in 4.411 None None None XRAY 1.4 0.148 0.175 B 380 348 0 0 0 0 [[42, 330]] 1.0 4qtb CMGC_MAPK3_HUMAN CMGC 3.3e-87 298.5 1 301 301 183 184 185 187 189 71 88 92 163 165 164 166 227 214 209 208 207 206 205 204 203 123 Mitogen-activated protein kinase 3

CMGC_MAPK3 (Mitogen-activated protein kinase 3)

Total number of chains: 13
Active chains: 2
Family: CMGC
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 13 100.0% AF-P27361-K1A

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label DFG-Asp_rot_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Asp
χ1,χ2
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
MK03_HUMAN AF-P27361-K1A P27361 34 338 379.0 No_ligand No_ligand Active DFGin 6.593 14.896 BLAminus DFGAsp-rot-in -130.53, -179.67 55.56, 73.68 193.69, 31.1 -81.57, 15.4 283.43, 73.42 -60.15, -27.17 in-in in 9.098 Saltbr-in 2.699 HRD-in -71.43, -46.13 64.54, 6.96 in-in-in SNCiii in-in ActLoopNT-in 2.863 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -74.91, 170.97 APE9-dihe-na 59.86, 147.58 APE8-dihe-in -63.62, 134.74 APE8-rot-in 298.27 APE67-dihe-in -68.94, -17.88 -46.37, -48.07 APE12-dist-in 12.835 APE11-dist-in 11.325 APE10-dist-in 6.818 APE9-dist-in 3.037 None None None AF2 -1.0 1.0 1.0 A 305 305 0 0 0 0 [[42, 330]] 1.0 AF-P27361-K1 Homo sapiens CMGC_MAPK3_HUMAN CMGC 1.5e-87 299.6 1 301 301 183 184 185 187 189 71 88 92 163 165 164 166 227 214 209 208 207 206 205 204 203 123 Mitogen-activated protein kinase 3
MK03_HUMAN AF-P27361-K3A P27361 34 338 379.0 No_ligand No_ligand Active DFGin 6.535 14.634 BLAminus DFGAsp-rot-in -133.14, -176.56 56.67, 65.23 191.09, 33.73 -76.5, 14.43 283.46, 73.65 -63.2, -17.33 in-in in 9.037 Saltbr-in 2.688 HRD-in -77.08, -46.07 62.9, 16.83 in-in-in SNCiii in-in ActLoopNT-in 2.852 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -69.1, 168.93 APE9-dihe-na 59.76, 143.47 APE8-dihe-in -62.52, 135.83 APE8-rot-in 298.7 APE67-dihe-in -69.69, -17.66 -48.0, -47.1 APE12-dist-in 12.485 APE11-dist-in 11.079 APE10-dist-in 6.616 APE9-dist-in 3.06 None None None AF2 -1.0 1.0 1.0 A 305 305 0 0 0 0 [[42, 330]] 1.0 AF-P27361-K3 Homo sapiens CMGC_MAPK3_HUMAN CMGC 1.5e-87 299.6 1 301 301 183 184 185 187 189 71 88 92 163 165 164 166 227 214 209 208 207 206 205 204 203 123 Mitogen-activated protein kinase 3
MK03_HUMAN 9UURB P27361 26 374 379.0 ANP:60402 ATPlike Inactive DFGin 7.046 16.721 BLAminus DFGAsp-rot-in -125.2774, -171.8504 57.8871, 62.6574 204.6215, -38.0138 -83.9318, 70.2924 271.3877, 98.988 -91.2011, -102.4627 in-out in 9.841 Saltbr-out 3.702 HRD-in -63.3287, -44.4231 65.9337, -2.9097 out-in-out SNCoio in-out ActLoopNT-in 3.31 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oooo APE10-dihe-na -73.149, 154.5025 APE9-dihe-na -157.2089, 162.6587 APE8-dihe-in -97.0192, 119.1986 APE8-rot-out 59.5672 APE67-dihe-out -91.6183, -7.4904 -122.261, 114.9769 APE12-dist-out 15.931 APE11-dist-out 15.9 APE10-dist-out 18.061 APE9-dist-out 13.143 None None None EM 3.36 999.0 999.0 B 388 349 0 0 0 0 [[42, 330]] 1.0 9uur Homo sapiens CMGC_MAPK3_HUMAN CMGC 3.5e-87 298.4 1 301 301 183 184 185 187 189 71 88 92 163 165 164 166 227 214 209 208 207 206 205 204 203 123 Mitogen-activated protein kinase 3
MK03_HUMAN 9UUXB P27361 27 375 379.0 ANP:402 ATPlike Inactive DFGin 6.891 16.04 BLAminus DFGAsp-rot-in -128.6144, -170.7726 60.7427, 64.232 216.4748, -27.5773 -88.6666, 67.791 282.4698, 94.6501 -92.1054, -102.8214 in-out in 9.911 Saltbr-out 3.817 HRD-in -62.507, -44.9226 64.1255, 0.0529 out-in-out SNCoio in-out ActLoopNT-in 3.101 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oooo APE10-dihe-na -76.5628, 148.2674 APE9-dihe-na -156.7962, 164.5301 APE8-dihe-in -92.5475, 120.8909 APE8-rot-out 64.3077 APE67-dihe-out -82.9887, -10.3381 -122.7899, 105.1205 APE12-dist-out 15.979 APE11-dist-out 15.42 APE10-dist-out 18.001 APE9-dist-out 13.025 None TPO202 TPO202 EM 3.12 999.0 999.0 B 388 349 0 0 0 0 [[42, 330]] 1.0 9uux Homo sapiens CMGC_MAPK3_HUMAN CMGC 3.5e-87 298.4 1 301 301 183 184 185 187 189 71 88 92 163 165 164 166 227 214 209 208 207 206 205 204 203 123 Mitogen-activated protein kinase 3
MK03_HUMAN 9UW3B P27361 27 374 379.0 ANP:402 ATPlike Inactive DFGin 6.911 16.194 BLAminus DFGAsp-rot-in -125.6031, -169.6008 62.0638, 57.1616 204.8277, -13.4842 -79.084, 77.2875 280.4089, 80.549 -98.4869, -96.1009 in-in in 9.776 Saltbr-in 3.564 HRD-in -65.0056, -43.9908 63.361, 3.8208 in-in-out SNCiio in-out ActLoopNT-in 3.482 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oooo APE10-dihe-na -112.9812, 147.8659 APE9-dihe-na -157.6409, 163.2759 APE8-dihe-in -92.3175, 124.3346 APE8-rot-out 75.5113 APE67-dihe-out -87.7767, -4.4272 -128.9449, 106.9042 APE12-dist-out 16.25 APE11-dist-out 15.863 APE10-dist-out 17.941 APE9-dist-out 13.309 None PTR204 PTR204 EM 3.36 999.0 999.0 B 388 348 0 0 0 0 [[42, 330]] 1.0 9uw3 Homo sapiens CMGC_MAPK3_HUMAN CMGC 3.5e-87 298.4 1 301 301 183 184 185 187 189 71 88 92 163 165 164 166 227 214 209 208 207 206 205 204 203 123 Mitogen-activated protein kinase 3
MK03_HUMAN 9UW4B P27361 29 374 379.0 ANP:402 ATPlike Inactive DFGin 6.904 15.983 BLAminus DFGAsp-rot-in -137.547, -167.3693 59.7522, 64.3544 201.1871, -43.5971 -88.5285, 51.6599 292.6306, 79.5591 -72.0921, -64.5527 in-out in 9.85 Saltbr-out 4.731 HRD-in -63.7037, -42.698 63.7695, 2.2218 out-in-out SNCoio in-out ActLoopNT-in 3.119 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oooo APE10-dihe-na -71.7213, 146.7494 APE9-dihe-na -156.6838, 164.4469 APE8-dihe-in -95.2675, 129.2723 APE8-rot-out 86.0069 APE67-dihe-out -93.875, -29.8394 -129.7461, 119.2822 APE12-dist-out 16.501 APE11-dist-out 16.066 APE10-dist-out 18.486 APE9-dist-out 13.259 None None None EM 3.2 999.0 999.0 B 388 346 0 0 0 0 [[42, 330]] 1.0 9uw4 Homo sapiens CMGC_MAPK3_HUMAN CMGC 3.5e-87 298.4 1 301 301 183 184 185 187 189 71 88 92 163 165 164 166 227 214 209 208 207 206 205 204 203 123 Mitogen-activated protein kinase 3
MK03_HUMAN 9TU0A P27361 28 373 379.0 No_ligand No_ligand Inactive DFGin 6.68 15.472 BLAminus DFGAsp-rot-in -131.5025, 179.4792 63.2076, 80.3646 220.9388, -24.1556 -100.8534, 28.0556 291.6623, 79.8078 -67.8218, -38.8244 in-out in 9.502 Saltbr-out 3.749 HRD-in -72.3925, -45.5743 65.33, 4.0014 out-in-none SNCoin in-none ActLoopNT-in 2.953 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 84.1516, -12.7837 999.0, -80.7019 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None SEP286 SEP286 XRAY 2.17 0.24 0.292 A 379 327 19 0 0 16 [[42, 330]] 1.0 9tu0 Homo sapiens CMGC_MAPK3_HUMAN CMGC 3.3e-87 298.5 1 301 301 183 184 185 187 189 71 88 92 163 165 164 166 227 214 209 208 207 206 205 204 203 123 Mitogen-activated protein kinase 3
MK03_HUMAN 6GESB P27361 25 374 379.0 6H3:401 Type1 Inactive DFGin 6.894 15.497 BLAminus DFGAsp-rot-in -138.79, 174.04 68.33, 84.06 209.57, -41.47 -104.81, 19.96 280.63, 68.61 -61.52, -24.52 in-in in 9.366 Saltbr-in 2.931 HRD-in -74.27, -56.06 78.37, 3.28 in-in-out SNCiio in-out ActLoopNT-in 2.784 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -97.48, -39.89 APE9-dihe-na -63.16, 160.66 APE8-dihe-in -55.88, 126.17 APE8-rot-in 317.05 APE67-dihe-in -63.74, -19.63 -50.02, -51.48 APE12-dist-out 14.329 APE11-dist-in 10.952 APE10-dist-in 6.917 APE9-dist-in 4.424 None None None XRAY 2.07 0.172 0.213 B 380 350 0 0 0 0 [[42, 330]] 1.0 6ges Homo sapiens CMGC_MAPK3_HUMAN CMGC 3.3e-87 298.5 1 301 301 183 184 185 187 189 71 88 92 163 165 164 166 227 214 209 208 207 206 205 204 203 123 Mitogen-activated protein kinase 3
MK03_HUMAN 2ZOQA P27361 24 375 379.0 5ID:382 Type1 Inactive DFGin 6.822 14.876 BLAminus DFGAsp-rot-out -110.57, 174.03 16.61, 106.79 309.81, -40.78 -100.79, 23.94 292.4, 62.55 -56.98, -29.52 in-in in 9.223 Saltbr-in 2.858 HRD-in -74.22, -49.1 69.67, -4.29 in-in-out SNCiio in-out ActLoopNT-in 2.715 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -88.46, -39.85 APE9-dihe-na -45.11, 153.81 APE8-dihe-in -55.88, 121.07 APE8-rot-in 311.89 APE67-dihe-in -58.47, -14.87 -49.12, -49.9 APE12-dist-out 14.379 APE11-dist-in 9.797 APE10-dist-in 6.865 APE9-dist-in 4.614 None PTR204 PTR204 XRAY 2.39 0.249 0.267 A 382 352 0 0 0 0 [[42, 330]] 1.0 2zoq Homo sapiens CMGC_MAPK3_HUMAN CMGC 3.3e-87 298.5 1 301 301 183 184 185 187 189 71 88 92 163 165 164 166 227 214 209 208 207 206 205 204 203 123 Mitogen-activated protein kinase 3
MK03_HUMAN 2ZOQB P27361 24 375 379.0 5ID:382 Type1 Inactive DFGin 7.081 14.696 BLAminus DFGAsp-rot-out -126.97, -169.7 58.49, 71.36 278.72, 21.57 -96.75, 32.61 283.64, 67.73 -68.29, -24.37 in-out in 9.648 Saltbr-out 3.747 HRD-in -67.75, -54.76 76.39, 2.97 out-in-out SNCoio in-out ActLoopNT-in 2.787 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_iiii APE10-dihe-na -62.22, -135.12 APE9-dihe-na -49.82, -170.24 APE8-dihe-out -38.65, -56.7 APE8-rot-in 299.06 APE67-dihe-out -72.56, -16.77 136.84, -44.19 APE12-dist-in 13.667 APE11-dist-in 11.413 APE10-dist-in 7.869 APE9-dist-in 4.076 None PTR204 PTR204 XRAY 2.39 0.249 0.267 B 382 352 0 0 0 0 [[42, 330]] 1.0 2zoq Homo sapiens CMGC_MAPK3_HUMAN CMGC 3.3e-87 298.5 1 301 301 183 184 185 187 189 71 88 92 163 165 164 166 227 214 209 208 207 206 205 204 203 123 Mitogen-activated protein kinase 3
MK03_HUMAN 6GESA P27361 25 374 379.0 6H3:401,EWH:402 Type1,Allosteric Inactive DFGin 6.952 15.557 BLAminus DFGAsp-rot-in -139.32, 176.86 65.58, 87.64 205.48, -28.41 -106.07, 21.81 281.49, 72.32 -67.67, -20.97 in-in in 9.464 Saltbr-in 2.866 HRD-in -74.62, -54.83 79.01, 3.71 in-in-out SNCiio in-out ActLoopNT-in 2.75 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -96.37, -37.93 APE9-dihe-na -66.29, 158.31 APE8-dihe-in -54.71, 127.96 APE8-rot-in 319.22 APE67-dihe-in -62.74, -20.38 -53.12, -50.26 APE12-dist-out 14.227 APE11-dist-in 11.026 APE10-dist-in 6.934 APE9-dist-in 4.409 None None None XRAY 2.07 0.172 0.213 A 380 350 0 0 0 0 [[42, 330]] 1.0 6ges Homo sapiens CMGC_MAPK3_HUMAN CMGC 3.3e-87 298.5 1 301 301 183 184 185 187 189 71 88 92 163 165 164 166 227 214 209 208 207 206 205 204 203 123 Mitogen-activated protein kinase 3
MK03_HUMAN 4QTBA P27361 24 374 379.0 38Z:418 Type1.5_Front Inactive DFGin 6.963 16.192 BLAminus DFGAsp-rot-in -128.63, 172.06 72.12, 87.31 200.35, -19.7 -104.64, 23.58 286.23, 74.76 -64.07, -28.14 in-in in 9.638 Saltbr-in 2.654 HRD-in -72.11, -54.76 73.09, 8.34 in-in-out SNCiio in-out ActLoopNT-in 2.768 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -93.95, -29.12 APE9-dihe-na -67.78, 160.1 APE8-dihe-in -53.91, 125.98 APE8-rot-in 310.28 APE67-dihe-in -65.26, -17.27 -52.54, -50.1 APE12-dist-out 14.155 APE11-dist-in 10.804 APE10-dist-in 6.843 APE9-dist-in 4.412 None None None XRAY 1.4 0.148 0.175 A 380 351 0 0 0 0 [[42, 330]] 1.0 4qtb Homo sapiens CMGC_MAPK3_HUMAN CMGC 3.3e-87 298.5 1 301 301 183 184 185 187 189 71 88 92 163 165 164 166 227 214 209 208 207 206 205 204 203 123 Mitogen-activated protein kinase 3
MK03_HUMAN 4QTBB P27361 27 374 379.0 38Z:412 Type1.5_Front Inactive DFGin 6.989 16.095 BLAminus DFGAsp-rot-in -131.38, 169.9 76.01, 86.99 200.97, -17.02 -105.18, 21.27 288.36, 77.86 -59.51, -32.2 in-in in 9.594 Saltbr-in 2.709 HRD-in -72.51, -53.5 77.51, 5.81 in-in-out SNCiio in-out ActLoopNT-in 2.824 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -90.9, -27.9 APE9-dihe-na -67.55, 157.04 APE8-dihe-in -54.84, 126.95 APE8-rot-in 308.82 APE67-dihe-in -67.72, -16.58 -53.94, -47.75 APE12-dist-out 14.188 APE11-dist-in 10.858 APE10-dist-in 7.082 APE9-dist-in 4.411 None None None XRAY 1.4 0.148 0.175 B 380 348 0 0 0 0 [[42, 330]] 1.0 4qtb Homo sapiens CMGC_MAPK3_HUMAN CMGC 3.3e-87 298.5 1 301 301 183 184 185 187 189 71 88 92 163 165 164 166 227 214 209 208 207 206 205 204 203 123 Mitogen-activated protein kinase 3

CMGC_MAPK3 (Mitogen-activated protein kinase 3)

Total number of chains: 0
Active chains: 0
Family: CMGC
Spatial label Dihedral label Number of Chains Percent Representative

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label DFG-Asp_rot_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Asp
χ1,χ2
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name