CMGC_GSK3A (Glycogen synthase kinase-3 alpha)

Total number of chains: 4
Active chains: 2
Uniprot: GSK3A_HUMAN
Kinase Domain Residues: 119 - 403
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% AF-P49840-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
GSK3A AF-P49840-K1A P49840 111 411 483.0 No_ligand No_ligand Active DFGin 6.8165 14.155 BLAminus -136.34, 177.0 63.33, 69.3 -82.21, 17.19 286.03, 79.28 -59.05, -35.54 in-in in 8.3672 Saltbr-in 2.6898 HRD-in -73.78, -43.15 63.43, 18.79 in-in-in SNCiii in-in ActLoopNT-in 2.8884 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -117.15, -176.83 APE9-dihe-na 58.82, 147.58 APE8-dihe-in -68.7, 143.88 APE8-rot-in 298.4 APE67-dihe-in -62.38, -10.59 -47.35, -61.1 APE12-dist-in 13.0866 APE11-dist-in 11.3808 APE10-dist-in 6.4385 APE9-dist-in 3.2685 None None None AF2 -1.0 1.0 1.0 A 301.0 301.0 0 27 27 0 [[119, 403]] 1.0 AF-P49840-K1 CMGC_GSK3A_HUMAN CMGC 1.8e-71 246.9 1.0 301.0 301.0 262 263 264 266 268 148 160 164 241 243 242 244.0 302 289 284 283 282 281 280 279 278 196 Glycogen synthase kinase-3 alpha
GSK3A AF-P49840-K3A P49840 111 411 483.0 No_ligand No_ligand Active DFGin 6.4155 13.9347 BLAminus -135.7, -179.24 65.02, 58.96 -72.97, 11.86 288.95, 87.58 -59.3, -33.59 in-in in 8.3631 Saltbr-in 2.7225 HRD-in -76.83, -42.45 66.04, 16.17 in-in-in SNCiii in-in ActLoopNT-in 2.9313 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.09, 176.26 APE9-dihe-na 65.16, 143.39 APE8-dihe-in -63.93, 134.82 APE8-rot-in 295.56 APE67-dihe-in -64.29, -15.04 -51.07, -50.55 APE12-dist-in 13.4276 APE11-dist-in 11.9964 APE10-dist-in 7.0016 APE9-dist-in 3.0975 None None None AF2 -1.0 1.0 1.0 A 301.0 301.0 0 27 27 0 [[119, 403]] 1.0 AF-P49840-K3 CMGC_GSK3A_HUMAN CMGC 1.8e-71 246.9 1.0 301.0 301.0 262 263 264 266 268 148 160 164 241 243 242 244.0 302 289 284 283 282 281 280 279 278 196 Glycogen synthase kinase-3 alpha
GSK3A 7SXGA P49840 103 445 483.0 D1E:60501 Type1 Inactive DFGin 6.9519 14.4934 BLAminus -137.84, -175.37 58.28, 67.78 -87.6, 23.71 285.65, 78.86 -65.11, -37.26 in-in in 8.4832 Saltbr-in 2.2055 HRD-in -64.7, -49.43 66.93, 5.65 in-in-out SNCiio in-out ActLoopNT-in 2.9473 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -131.83, 165.91 APE9-dihe-na 66.59, 162.4 APE8-dihe-in -70.46, 145.8 APE8-rot-out 189.07 APE67-dihe-in -61.0, -24.1 -60.57, -43.83 APE12-dist-in 13.6909 APE11-dist-in 12.0265 APE10-dist-in 7.3798 APE9-dist-in 3.2018 None PTR279 PTR279 XRAY 2.4 0.233 0.261 A 343.0 334.0 6 27 27 0 [[119, 403]] 1.0 7sxg CMGC_GSK3A_HUMAN CMGC 3e-71 246.2 1.0 301.0 301.0 262 263 264 266 268 148 160 164 241 243 242 244.0 302 289 284 283 282 281 280 279 278 196 Glycogen synthase kinase-3 alpha
GSK3A 7SXFA P49840 101 444 483.0 6VL:60501 Type1 Inactive DFGin 6.9451 14.4058 BLAminus -138.66, -179.66 58.35, 74.17 -87.15, 23.37 287.05, 76.59 -71.28, -20.49 in-in in 7.9768 Saltbr-in 2.5921 HRD-in -76.01, -44.97 68.39, 9.08 in-in-out SNCiio in-out ActLoopNT-in 2.8853 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -136.96, 168.03 APE9-dihe-na 72.18, 166.78 APE8-dihe-in -81.25, 143.45 APE8-rot-out 170.94 APE67-dihe-in -61.81, -22.82 -59.2, -46.19 APE12-dist-in 13.5732 APE11-dist-in 12.026 APE10-dist-in 7.2288 APE9-dist-in 3.1779 None PTR279 PTR279 XRAY 1.94 0.203 0.235 A 345.0 339.0 5 27 27 0 [[119, 403]] 1.0 7sxf CMGC_GSK3A_HUMAN CMGC 3e-71 246.1 1.0 301.0 301.0 262 263 264 266 268 148 160 164 241 243 242 244.0 302 289 284 283 282 281 280 279 278 196 Glycogen synthase kinase-3 alpha

CMGC_GSK3A (Glycogen synthase kinase-3 alpha)

Total number of chains: 4
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% AF-P49840-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
GSK3A GSK3A_HUMAN AF-P49840-K1A P49840 111 411 483.0 No_ligand No_ligand Active DFGin 6.8165 14.155 BLAminus -136.34, 177.0 63.33, 69.3 -82.21, 17.19 286.03, 79.28 -59.05, -35.54 in-in in 8.3672 Saltbr-in 2.6898 HRD-in -73.78, -43.15 63.43, 18.79 in-in-in SNCiii in-in ActLoopNT-in 2.8884 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -117.15, -176.83 APE9-dihe-na 58.82, 147.58 APE8-dihe-in -68.7, 143.88 APE8-rot-in 298.4 APE67-dihe-in -62.38, -10.59 -47.35, -61.1 APE12-dist-in 13.0866 APE11-dist-in 11.3808 APE10-dist-in 6.4385 APE9-dist-in 3.2685 None None None AF2 -1.0 1.0 1.0 A 301.0 301.0 0 27 27 0 [[119, 403]] 1.0 AF-P49840-K1 Homo sapiens CMGC_GSK3A_HUMAN CMGC 1.8e-71 246.9 1.0 301.0 301.0 262 263 264 266 268 148 160 164 241 243 242 244.0 302 289 284 283 282 281 280 279 278 196 Glycogen synthase kinase-3 alpha
GSK3A GSK3A_HUMAN AF-P49840-K3A P49840 111 411 483.0 No_ligand No_ligand Active DFGin 6.4155 13.9347 BLAminus -135.7, -179.24 65.02, 58.96 -72.97, 11.86 288.95, 87.58 -59.3, -33.59 in-in in 8.3631 Saltbr-in 2.7225 HRD-in -76.83, -42.45 66.04, 16.17 in-in-in SNCiii in-in ActLoopNT-in 2.9313 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.09, 176.26 APE9-dihe-na 65.16, 143.39 APE8-dihe-in -63.93, 134.82 APE8-rot-in 295.56 APE67-dihe-in -64.29, -15.04 -51.07, -50.55 APE12-dist-in 13.4276 APE11-dist-in 11.9964 APE10-dist-in 7.0016 APE9-dist-in 3.0975 None None None AF2 -1.0 1.0 1.0 A 301.0 301.0 0 27 27 0 [[119, 403]] 1.0 AF-P49840-K3 Homo sapiens CMGC_GSK3A_HUMAN CMGC 1.8e-71 246.9 1.0 301.0 301.0 262 263 264 266 268 148 160 164 241 243 242 244.0 302 289 284 283 282 281 280 279 278 196 Glycogen synthase kinase-3 alpha
GSK3A GSK3A_HUMAN 7SXGA P49840 103 445 483.0 D1E:60501 Type1 Inactive DFGin 6.9519 14.4934 BLAminus -137.84, -175.37 58.28, 67.78 -87.6, 23.71 285.65, 78.86 -65.11, -37.26 in-in in 8.4832 Saltbr-in 2.2055 HRD-in -64.7, -49.43 66.93, 5.65 in-in-out SNCiio in-out ActLoopNT-in 2.9473 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -131.83, 165.91 APE9-dihe-na 66.59, 162.4 APE8-dihe-in -70.46, 145.8 APE8-rot-out 189.07 APE67-dihe-in -61.0, -24.1 -60.57, -43.83 APE12-dist-in 13.6909 APE11-dist-in 12.0265 APE10-dist-in 7.3798 APE9-dist-in 3.2018 None PTR279 PTR279 XRAY 2.4 0.233 0.261 A 343.0 334.0 6 27 27 0 [[119, 403]] 1.0 7sxg Homo sapiens CMGC_GSK3A_HUMAN CMGC 3e-71 246.2 1.0 301.0 301.0 262 263 264 266 268 148 160 164 241 243 242 244.0 302 289 284 283 282 281 280 279 278 196 Glycogen synthase kinase-3 alpha
GSK3A GSK3A_HUMAN 7SXFA P49840 101 444 483.0 6VL:60501 Type1 Inactive DFGin 6.9451 14.4058 BLAminus -138.66, -179.66 58.35, 74.17 -87.15, 23.37 287.05, 76.59 -71.28, -20.49 in-in in 7.9768 Saltbr-in 2.5921 HRD-in -76.01, -44.97 68.39, 9.08 in-in-out SNCiio in-out ActLoopNT-in 2.8853 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -136.96, 168.03 APE9-dihe-na 72.18, 166.78 APE8-dihe-in -81.25, 143.45 APE8-rot-out 170.94 APE67-dihe-in -61.81, -22.82 -59.2, -46.19 APE12-dist-in 13.5732 APE11-dist-in 12.026 APE10-dist-in 7.2288 APE9-dist-in 3.1779 None PTR279 PTR279 XRAY 1.94 0.203 0.235 A 345.0 339.0 5 27 27 0 [[119, 403]] 1.0 7sxf Homo sapiens CMGC_GSK3A_HUMAN CMGC 3e-71 246.1 1.0 301.0 301.0 262 263 264 266 268 148 160 164 241 243 242 244.0 302 289 284 283 282 281 280 279 278 196 Glycogen synthase kinase-3 alpha

CMGC_GSK3A (Glycogen synthase kinase-3 alpha)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name