CMGC_GSK3A (Glycogen synthase kinase-3 alpha)

Total number of chains: 4
Active chains: 2
Family: CMGC
Uniprot: GSK3A_HUMAN
Kinase Domain Residues: 119 - 403
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% AF-P49840-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AF-P49840-K1A 111 411 483.0 No_ligand No_ligand Active DFGin 6.816 14.155 BLAminus -136.34, 177.0 63.33, 69.3 -82.21, 17.19 286.03, 79.28 -59.05, -35.54 in-in in 8.367 Saltbr-in 2.69 HRD-in -73.78, -43.15 63.43, 18.79 in-in-in SNCiii in-in ActLoopNT-in 2.888 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -117.15, -176.83 APE9-dihe-na 58.82, 147.58 APE8-dihe-in -68.7, 143.88 APE8-rot-in 298.4 APE67-dihe-in -62.38, -10.59 -47.35, -61.1 APE12-dist-in 13.087 APE11-dist-in 11.381 APE10-dist-in 6.439 APE9-dist-in 3.268 None None None AF2 -1.0 1.0 1.0 A 301 301 0 0 0 0 [[119, 403]] 1.0 AF-P49840-K1 CMGC_GSK3A_HUMAN CMGC 1.8e-71 246.9 1 301 301 262 263 264 266 268 148 160 164 241 243 242 244 302 289 284 283 282 281 280 279 278 196 Glycogen synthase kinase-3 alpha
AF-P49840-K3A 111 411 483.0 No_ligand No_ligand Active DFGin 6.415 13.935 BLAminus -135.7, -179.24 65.02, 58.96 -72.97, 11.86 288.95, 87.58 -59.3, -33.59 in-in in 8.363 Saltbr-in 2.723 HRD-in -76.83, -42.45 66.04, 16.17 in-in-in SNCiii in-in ActLoopNT-in 2.931 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.09, 176.26 APE9-dihe-na 65.16, 143.39 APE8-dihe-in -63.93, 134.82 APE8-rot-in 295.56 APE67-dihe-in -64.29, -15.04 -51.07, -50.55 APE12-dist-in 13.428 APE11-dist-in 11.996 APE10-dist-in 7.002 APE9-dist-in 3.098 None None None AF2 -1.0 1.0 1.0 A 301 301 0 0 0 0 [[119, 403]] 1.0 AF-P49840-K3 CMGC_GSK3A_HUMAN CMGC 1.8e-71 246.9 1 301 301 262 263 264 266 268 148 160 164 241 243 242 244 302 289 284 283 282 281 280 279 278 196 Glycogen synthase kinase-3 alpha
7SXGA 103 445 483.0 D1E:60501 Type1 Inactive DFGin 6.952 14.493 BLAminus -137.84, -175.37 58.28, 67.78 -87.6, 23.71 285.65, 78.86 -65.11, -37.26 in-in in 8.483 Saltbr-in 2.205 HRD-in -64.7, -49.43 66.93, 5.65 in-in-out SNCiio in-out ActLoopNT-in 2.947 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -131.83, 165.91 APE9-dihe-na 66.59, 162.4 APE8-dihe-in -70.46, 145.8 APE8-rot-out 189.07 APE67-dihe-in -61.0, -24.1 -60.57, -43.83 APE12-dist-in 13.691 APE11-dist-in 12.027 APE10-dist-in 7.38 APE9-dist-in 3.202 None PTR279 PTR279 XRAY 2.4 0.233 0.261 A 343 334 6 0 0 0 [[119, 403]] 1.0 7sxg CMGC_GSK3A_HUMAN CMGC 3e-71 246.2 1 301 301 262 263 264 266 268 148 160 164 241 243 242 244 302 289 284 283 282 281 280 279 278 196 Glycogen synthase kinase-3 alpha
7SXFA 101 444 483.0 6VL:60501 Type1 Inactive DFGin 6.945 14.406 BLAminus -138.66, -179.66 58.35, 74.17 -87.15, 23.37 287.05, 76.59 -71.28, -20.49 in-in in 7.977 Saltbr-in 2.592 HRD-in -76.01, -44.97 68.39, 9.08 in-in-out SNCiio in-out ActLoopNT-in 2.885 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -136.96, 168.03 APE9-dihe-na 72.18, 166.78 APE8-dihe-in -81.25, 143.45 APE8-rot-out 170.94 APE67-dihe-in -61.81, -22.82 -59.2, -46.19 APE12-dist-in 13.573 APE11-dist-in 12.026 APE10-dist-in 7.229 APE9-dist-in 3.178 None PTR279 PTR279 XRAY 1.94 0.203 0.235 A 345 339 5 0 0 0 [[119, 403]] 1.0 7sxf CMGC_GSK3A_HUMAN CMGC 3e-71 246.1 1 301 301 262 263 264 266 268 148 160 164 241 243 242 244 302 289 284 283 282 281 280 279 278 196 Glycogen synthase kinase-3 alpha

CMGC_GSK3A (Glycogen synthase kinase-3 alpha)

Total number of chains: 4
Active chains: 2
Family: CMGC
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% AF-P49840-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
GSK3A_HUMAN AF-P49840-K1A P49840 111 411 483.0 No_ligand No_ligand Active DFGin 6.816 14.155 BLAminus -136.34, 177.0 63.33, 69.3 -82.21, 17.19 286.03, 79.28 -59.05, -35.54 in-in in 8.367 Saltbr-in 2.69 HRD-in -73.78, -43.15 63.43, 18.79 in-in-in SNCiii in-in ActLoopNT-in 2.888 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -117.15, -176.83 APE9-dihe-na 58.82, 147.58 APE8-dihe-in -68.7, 143.88 APE8-rot-in 298.4 APE67-dihe-in -62.38, -10.59 -47.35, -61.1 APE12-dist-in 13.087 APE11-dist-in 11.381 APE10-dist-in 6.439 APE9-dist-in 3.268 None None None AF2 -1.0 1.0 1.0 A 301 301 0 0 0 0 [[119, 403]] 1.0 AF-P49840-K1 Homo sapiens CMGC_GSK3A_HUMAN CMGC 1.8e-71 246.9 1 301 301 262 263 264 266 268 148 160 164 241 243 242 244 302 289 284 283 282 281 280 279 278 196 Glycogen synthase kinase-3 alpha
GSK3A_HUMAN AF-P49840-K3A P49840 111 411 483.0 No_ligand No_ligand Active DFGin 6.415 13.935 BLAminus -135.7, -179.24 65.02, 58.96 -72.97, 11.86 288.95, 87.58 -59.3, -33.59 in-in in 8.363 Saltbr-in 2.723 HRD-in -76.83, -42.45 66.04, 16.17 in-in-in SNCiii in-in ActLoopNT-in 2.931 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.09, 176.26 APE9-dihe-na 65.16, 143.39 APE8-dihe-in -63.93, 134.82 APE8-rot-in 295.56 APE67-dihe-in -64.29, -15.04 -51.07, -50.55 APE12-dist-in 13.428 APE11-dist-in 11.996 APE10-dist-in 7.002 APE9-dist-in 3.098 None None None AF2 -1.0 1.0 1.0 A 301 301 0 0 0 0 [[119, 403]] 1.0 AF-P49840-K3 Homo sapiens CMGC_GSK3A_HUMAN CMGC 1.8e-71 246.9 1 301 301 262 263 264 266 268 148 160 164 241 243 242 244 302 289 284 283 282 281 280 279 278 196 Glycogen synthase kinase-3 alpha
GSK3A_HUMAN 7SXGA P49840 103 445 483.0 D1E:60501 Type1 Inactive DFGin 6.952 14.493 BLAminus -137.84, -175.37 58.28, 67.78 -87.6, 23.71 285.65, 78.86 -65.11, -37.26 in-in in 8.483 Saltbr-in 2.205 HRD-in -64.7, -49.43 66.93, 5.65 in-in-out SNCiio in-out ActLoopNT-in 2.947 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -131.83, 165.91 APE9-dihe-na 66.59, 162.4 APE8-dihe-in -70.46, 145.8 APE8-rot-out 189.07 APE67-dihe-in -61.0, -24.1 -60.57, -43.83 APE12-dist-in 13.691 APE11-dist-in 12.027 APE10-dist-in 7.38 APE9-dist-in 3.202 None PTR279 PTR279 XRAY 2.4 0.233 0.261 A 343 334 6 0 0 0 [[119, 403]] 1.0 7sxg Homo sapiens CMGC_GSK3A_HUMAN CMGC 3e-71 246.2 1 301 301 262 263 264 266 268 148 160 164 241 243 242 244 302 289 284 283 282 281 280 279 278 196 Glycogen synthase kinase-3 alpha
GSK3A_HUMAN 7SXFA P49840 101 444 483.0 6VL:60501 Type1 Inactive DFGin 6.945 14.406 BLAminus -138.66, -179.66 58.35, 74.17 -87.15, 23.37 287.05, 76.59 -71.28, -20.49 in-in in 7.977 Saltbr-in 2.592 HRD-in -76.01, -44.97 68.39, 9.08 in-in-out SNCiio in-out ActLoopNT-in 2.885 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -136.96, 168.03 APE9-dihe-na 72.18, 166.78 APE8-dihe-in -81.25, 143.45 APE8-rot-out 170.94 APE67-dihe-in -61.81, -22.82 -59.2, -46.19 APE12-dist-in 13.573 APE11-dist-in 12.026 APE10-dist-in 7.229 APE9-dist-in 3.178 None PTR279 PTR279 XRAY 1.94 0.203 0.235 A 345 339 5 0 0 0 [[119, 403]] 1.0 7sxf Homo sapiens CMGC_GSK3A_HUMAN CMGC 3e-71 246.1 1 301 301 262 263 264 266 268 148 160 164 241 243 242 244 302 289 284 283 282 281 280 279 278 196 Glycogen synthase kinase-3 alpha

CMGC_GSK3A (Glycogen synthase kinase-3 alpha)

Total number of chains: 0
Active chains: 0
Family: CMGC
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name