TYR_EPHA8 (Ephrin type-A receptor 8)

Total number of chains: 4
Active chains: 3
Uniprot: EPHA8_HUMAN
Kinase Domain Residues: 635 - 894
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% AF-P29322-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
EPHA8 AF-P29322-K1A P29322 627 902 1005.0 No_ligand No_ligand Active DFGin 5.8636 14.2428 BLAminus -139.19, 176.85 62.03, 69.69 -85.37, 12.93 300.5, 98.49 -58.55, -33.63 in-in in 8.0974 Saltbr-in 2.6581 HRD-in -76.26, -43.73 68.79, -15.75 in-in-in SNCiii in-in ActLoopNT-in 2.8722 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -71.7, 133.94 APE9-dihe-in -116.64, 130.08 APE8-dihe-in -76.32, 73.8 APE8-rot-na 36.17 APE67-dihe-in -70.97, -12.31 -35.98, -51.38 APE12-dist-na 11.5068 APE11-dist-na 9.09 APE10-dist-na 9.3775 APE9-dist-in 6.1974 None None None AF2 -1.0 1.0 1.0 A 276.0 276.0 0 31 31 0 [[635, 894]] 1.0 AF-P29322-K1 TYR_EPHA8_HUMAN TYR 6.8e-103 349.4 1.0 260.0 260.0 777 778 779 781 783 667 684 688 757 759 758 760.0 820 808 803 802 801 800 799 798 797 714 Ephrin type-A receptor 8
EPHA8 AF-P29322-K3A P29322 627 902 1005.0 No_ligand No_ligand Active DFGin 5.9512 14.1621 BLAminus -143.15, -176.41 60.12, 66.09 -80.6, 10.09 297.33, 94.49 -60.4, -30.12 in-in in 8.2368 Saltbr-in 2.7509 HRD-in -84.31, -45.54 67.44, -8.44 in-in-in SNCiii in-in ActLoopNT-in 2.9339 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -75.77, 147.8 APE9-dihe-in -131.47, 142.6 APE8-dihe-in -79.76, 76.1 APE8-rot-na 36.41 APE67-dihe-in -64.45, -27.4 -39.73, -46.05 APE12-dist-na 11.8705 APE11-dist-na 9.4496 APE10-dist-na 10.0949 APE9-dist-in 5.8935 None None None AF2 -1.0 1.0 1.0 A 276.0 276.0 0 31 31 0 [[635, 894]] 1.0 AF-P29322-K3 TYR_EPHA8_HUMAN TYR 6.8e-103 349.4 1.0 260.0 260.0 777 778 779 781 783 667 684 688 757 759 758 760.0 820 808 803 802 801 800 799 798 797 714 Ephrin type-A receptor 8
EPHA8 3KULB P29322 627 899 1005.0 No_ligand No_ligand Active DFGin 6.3965 13.8707 BLAminus -134.27, -179.13 60.87, 80.28 -99.14, 17.07 298.73, 99.47 -61.45, -32.9 in-in in 8.5975 Saltbr-in 2.9526 HRD-in -79.27, -50.32 80.27, -9.05 in-in-in SNCiii in-in ActLoopNT-in 2.9181 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -43.9, 124.05 APE9-dihe-in -91.07, 145.26 APE8-dihe-in -79.16, 94.43 APE8-rot-na 25.36 APE67-dihe-in -66.23, -18.41 -52.77, -43.76 APE12-dist-na 10.99 APE11-dist-na 9.0905 APE10-dist-na 11.78 APE9-dist-in 6.839 None PTR793 PTR793 XRAY 2.15 0.19 0.244 B 325.0 272.0 1 31 30 1 [[635, 894]] 1.0 3kul TYR_EPHA8_HUMAN TYR 1.2e-102 348.6 1.0 260.0 260.0 777 778 779 781 783 667 684 688 757 759 758 760.0 820 808 803 802 801 800 799 798 797 714 Ephrin type-A receptor 8
EPHA8 3KULA P29322 627 900 1005.0 No_ligand No_ligand None DFGin 6.33 13.4263 BLAminus -132.25, 178.69 63.32, 84.46 -103.71, 28.05 296.17, 106.15 -76.22, -31.33 in-in in 8.8651 Saltbr-in 2.3191 HRD-in -84.23, -53.19 81.45, -9.81 in-in-none SNCiin in-none ActLoopNT-in 2.881 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 148.1 APE8-dihe-in -72.66, 90.4 APE8-rot-na 22.79 APE67-dihe-in -74.46, -16.08 -47.23, -40.17 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.844 None None None XRAY 2.15 0.19 0.244 A 325.0 267.0 7 31 24 7 [[635, 894]] 1.0 3kul TYR_EPHA8_HUMAN TYR 1.2e-102 348.6 1.0 260.0 260.0 777 778 779 781 783 667 684 688 757 759 758 760.0 820 808 803 802 801 800 799 798 797 714 Ephrin type-A receptor 8

TYR_EPHA8 (Ephrin type-A receptor 8)

Total number of chains: 4
Active chains: 3
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% AF-P29322-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
EPHA8 EPHA8_HUMAN AF-P29322-K1A P29322 627 902 1005.0 No_ligand No_ligand Active DFGin 5.8636 14.2428 BLAminus -139.19, 176.85 62.03, 69.69 -85.37, 12.93 300.5, 98.49 -58.55, -33.63 in-in in 8.0974 Saltbr-in 2.6581 HRD-in -76.26, -43.73 68.79, -15.75 in-in-in SNCiii in-in ActLoopNT-in 2.8722 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -71.7, 133.94 APE9-dihe-in -116.64, 130.08 APE8-dihe-in -76.32, 73.8 APE8-rot-na 36.17 APE67-dihe-in -70.97, -12.31 -35.98, -51.38 APE12-dist-na 11.5068 APE11-dist-na 9.09 APE10-dist-na 9.3775 APE9-dist-in 6.1974 None None None AF2 -1.0 1.0 1.0 A 276.0 276.0 0 31 31 0 [[635, 894]] 1.0 AF-P29322-K1 Homo sapiens TYR_EPHA8_HUMAN TYR 6.8e-103 349.4 1.0 260.0 260.0 777 778 779 781 783 667 684 688 757 759 758 760.0 820 808 803 802 801 800 799 798 797 714 Ephrin type-A receptor 8
EPHA8 EPHA8_HUMAN AF-P29322-K3A P29322 627 902 1005.0 No_ligand No_ligand Active DFGin 5.9512 14.1621 BLAminus -143.15, -176.41 60.12, 66.09 -80.6, 10.09 297.33, 94.49 -60.4, -30.12 in-in in 8.2368 Saltbr-in 2.7509 HRD-in -84.31, -45.54 67.44, -8.44 in-in-in SNCiii in-in ActLoopNT-in 2.9339 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -75.77, 147.8 APE9-dihe-in -131.47, 142.6 APE8-dihe-in -79.76, 76.1 APE8-rot-na 36.41 APE67-dihe-in -64.45, -27.4 -39.73, -46.05 APE12-dist-na 11.8705 APE11-dist-na 9.4496 APE10-dist-na 10.0949 APE9-dist-in 5.8935 None None None AF2 -1.0 1.0 1.0 A 276.0 276.0 0 31 31 0 [[635, 894]] 1.0 AF-P29322-K3 Homo sapiens TYR_EPHA8_HUMAN TYR 6.8e-103 349.4 1.0 260.0 260.0 777 778 779 781 783 667 684 688 757 759 758 760.0 820 808 803 802 801 800 799 798 797 714 Ephrin type-A receptor 8
EPHA8 EPHA8_HUMAN 3KULB P29322 627 899 1005.0 No_ligand No_ligand Active DFGin 6.3965 13.8707 BLAminus -134.27, -179.13 60.87, 80.28 -99.14, 17.07 298.73, 99.47 -61.45, -32.9 in-in in 8.5975 Saltbr-in 2.9526 HRD-in -79.27, -50.32 80.27, -9.05 in-in-in SNCiii in-in ActLoopNT-in 2.9181 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -43.9, 124.05 APE9-dihe-in -91.07, 145.26 APE8-dihe-in -79.16, 94.43 APE8-rot-na 25.36 APE67-dihe-in -66.23, -18.41 -52.77, -43.76 APE12-dist-na 10.99 APE11-dist-na 9.0905 APE10-dist-na 11.78 APE9-dist-in 6.839 None PTR793 PTR793 XRAY 2.15 0.19 0.244 B 325.0 272.0 1 31 30 1 [[635, 894]] 1.0 3kul Homo sapiens TYR_EPHA8_HUMAN TYR 1.2e-102 348.6 1.0 260.0 260.0 777 778 779 781 783 667 684 688 757 759 758 760.0 820 808 803 802 801 800 799 798 797 714 Ephrin type-A receptor 8
EPHA8 EPHA8_HUMAN 3KULA P29322 627 900 1005.0 No_ligand No_ligand None DFGin 6.33 13.4263 BLAminus -132.25, 178.69 63.32, 84.46 -103.71, 28.05 296.17, 106.15 -76.22, -31.33 in-in in 8.8651 Saltbr-in 2.3191 HRD-in -84.23, -53.19 81.45, -9.81 in-in-none SNCiin in-none ActLoopNT-in 2.881 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 148.1 APE8-dihe-in -72.66, 90.4 APE8-rot-na 22.79 APE67-dihe-in -74.46, -16.08 -47.23, -40.17 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.844 None None None XRAY 2.15 0.19 0.244 A 325.0 267.0 7 31 24 7 [[635, 894]] 1.0 3kul Homo sapiens TYR_EPHA8_HUMAN TYR 1.2e-102 348.6 1.0 260.0 260.0 777 778 779 781 783 667 684 688 757 759 758 760.0 820 808 803 802 801 800 799 798 797 714 Ephrin type-A receptor 8

TYR_EPHA8 (Ephrin type-A receptor 8)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name