CMGC_DYRK3 (Dual specificity tyrosine-phosphorylation-regulated kinase 3)

Total number of chains: 3
Active chains: 3
Uniprot: DYRK3_HUMAN
Kinase Domain Residues: 209 - 522
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 100.0% AF-O43781-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
DYRK3 AF-O43781-K1A O43781 201 530 588.0 No_ligand No_ligand Active DFGin 6.8957 14.7356 BLAminus -125.76, 177.96 61.68, 64.54 -80.53, 12.4 284.01, 79.01 -65.9, -19.89 in-in in 8.7645 Saltbr-in 2.7015 HRD-in -66.43, -38.69 65.96, -14.18 in-in-in SNCiii in-in ActLoopNT-in 2.8539 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.27, 176.65 APE9-dihe-na 61.22, 144.37 APE8-dihe-in -63.95, 137.79 APE8-rot-in 293.67 APE67-dihe-in -64.95, -21.16 -52.9, -45.2 APE12-dist-in 12.8866 APE11-dist-in 11.436 APE10-dist-in 7.1483 APE9-dist-in 3.0114 None None None AF2 -1.0 1.0 1.0 A 330.0 330.0 0 25 25 0 [[209, 522]] 1.0 AF-O43781-K1 CMGC_DYRK3_HUMAN CMGC 2.8e-98 334.7 1.0 301.0 301.0 354 355 356 358 360 238 253 257 332 334 333 335.0 391 379 374 373 372 371 370 369 368 289 Dual specificity tyrosine-phosphorylation-regulated kinase 3
DYRK3 AF-O43781-K3A O43781 201 530 588.0 No_ligand No_ligand Active DFGin 6.5358 14.3512 BLAminus -129.63, 178.84 59.27, 67.13 -75.42, 11.36 288.63, 89.26 -60.45, -29.54 in-in in 8.7653 Saltbr-in 2.6887 HRD-in -70.89, -38.53 68.1, -8.83 in-in-in SNCiii in-in ActLoopNT-in 2.8519 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.43, 174.83 APE9-dihe-na 62.47, 136.52 APE8-dihe-in -64.01, 139.68 APE8-rot-in 295.78 APE67-dihe-in -66.78, -20.92 -49.21, -49.97 APE12-dist-in 12.218 APE11-dist-in 10.7418 APE10-dist-in 6.6088 APE9-dist-in 3.2117 None None None AF2 -1.0 1.0 1.0 A 330.0 330.0 0 25 25 0 [[209, 522]] 1.0 AF-O43781-K3 CMGC_DYRK3_HUMAN CMGC 2.8e-98 334.7 1.0 301.0 301.0 354 355 356 358 360 238 253 257 332 334 333 335.0 391 379 374 373 372 371 370 369 368 289 Dual specificity tyrosine-phosphorylation-regulated kinase 3
DYRK3 5Y86A O43781 138 532 588.0 HRM:601 Type1 Active DFGin 6.8785 14.4347 BLAminus -121.42, 179.23 66.2, 57.54 -80.8, 21.54 289.69, 73.67 -71.73, -12.45 in-in in 8.7751 Saltbr-in 2.7965 HRD-in -69.17, -46.88 74.51, 0.82 in-in-in SNCiii in-in ActLoopNT-in 2.947 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.75, 169.09 APE9-dihe-na 75.29, 154.26 APE8-dihe-in -74.45, 137.02 APE8-rot-in 292.62 APE67-dihe-in -59.3, -23.84 -52.98, -46.9 APE12-dist-in 12.6939 APE11-dist-in 11.5005 APE10-dist-in 7.0456 APE9-dist-in 3.0767 None SEP350,PTR369,SEP445,TPO512 SEP350,PTR369,SEP445,TPO512 XRAY 1.9 0.168 0.196 A 588.0 395.0 0 25 25 0 [[209, 522]] 1.0 5y86 CMGC_DYRK3_HUMAN CMGC 1.8e-97 332.3 1.0 301.0 301.0 354 355 356 358 360 238 253 257 332 334 333 335.0 391 379 374 373 372 371 370 369 368 289 Dual specificity tyrosine-phosphorylation-regulated kinase 3

CMGC_DYRK3 (Dual specificity tyrosine-phosphorylation-regulated kinase 3)

Total number of chains: 3
Active chains: 3
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 100.0% AF-O43781-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
DYRK3 DYRK3_HUMAN AF-O43781-K1A O43781 201 530 588.0 No_ligand No_ligand Active DFGin 6.8957 14.7356 BLAminus -125.76, 177.96 61.68, 64.54 -80.53, 12.4 284.01, 79.01 -65.9, -19.89 in-in in 8.7645 Saltbr-in 2.7015 HRD-in -66.43, -38.69 65.96, -14.18 in-in-in SNCiii in-in ActLoopNT-in 2.8539 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.27, 176.65 APE9-dihe-na 61.22, 144.37 APE8-dihe-in -63.95, 137.79 APE8-rot-in 293.67 APE67-dihe-in -64.95, -21.16 -52.9, -45.2 APE12-dist-in 12.8866 APE11-dist-in 11.436 APE10-dist-in 7.1483 APE9-dist-in 3.0114 None None None AF2 -1.0 1.0 1.0 A 330.0 330.0 0 25 25 0 [[209, 522]] 1.0 AF-O43781-K1 Homo sapiens CMGC_DYRK3_HUMAN CMGC 2.8e-98 334.7 1.0 301.0 301.0 354 355 356 358 360 238 253 257 332 334 333 335.0 391 379 374 373 372 371 370 369 368 289 Dual specificity tyrosine-phosphorylation-regulated kinase 3
DYRK3 DYRK3_HUMAN AF-O43781-K3A O43781 201 530 588.0 No_ligand No_ligand Active DFGin 6.5358 14.3512 BLAminus -129.63, 178.84 59.27, 67.13 -75.42, 11.36 288.63, 89.26 -60.45, -29.54 in-in in 8.7653 Saltbr-in 2.6887 HRD-in -70.89, -38.53 68.1, -8.83 in-in-in SNCiii in-in ActLoopNT-in 2.8519 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.43, 174.83 APE9-dihe-na 62.47, 136.52 APE8-dihe-in -64.01, 139.68 APE8-rot-in 295.78 APE67-dihe-in -66.78, -20.92 -49.21, -49.97 APE12-dist-in 12.218 APE11-dist-in 10.7418 APE10-dist-in 6.6088 APE9-dist-in 3.2117 None None None AF2 -1.0 1.0 1.0 A 330.0 330.0 0 25 25 0 [[209, 522]] 1.0 AF-O43781-K3 Homo sapiens CMGC_DYRK3_HUMAN CMGC 2.8e-98 334.7 1.0 301.0 301.0 354 355 356 358 360 238 253 257 332 334 333 335.0 391 379 374 373 372 371 370 369 368 289 Dual specificity tyrosine-phosphorylation-regulated kinase 3
DYRK3 DYRK3_HUMAN 5Y86A O43781 138 532 588.0 HRM:601 Type1 Active DFGin 6.8785 14.4347 BLAminus -121.42, 179.23 66.2, 57.54 -80.8, 21.54 289.69, 73.67 -71.73, -12.45 in-in in 8.7751 Saltbr-in 2.7965 HRD-in -69.17, -46.88 74.51, 0.82 in-in-in SNCiii in-in ActLoopNT-in 2.947 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.75, 169.09 APE9-dihe-na 75.29, 154.26 APE8-dihe-in -74.45, 137.02 APE8-rot-in 292.62 APE67-dihe-in -59.3, -23.84 -52.98, -46.9 APE12-dist-in 12.6939 APE11-dist-in 11.5005 APE10-dist-in 7.0456 APE9-dist-in 3.0767 None SEP350,PTR369,SEP445,TPO512 SEP350,PTR369,SEP445,TPO512 XRAY 1.9 0.168 0.196 A 588.0 395.0 0 25 25 0 [[209, 522]] 1.0 5y86 Homo sapiens CMGC_DYRK3_HUMAN CMGC 1.8e-97 332.3 1.0 301.0 301.0 354 355 356 358 360 238 253 257 332 334 333 335.0 391 379 374 373 372 371 370 369 368 289 Dual specificity tyrosine-phosphorylation-regulated kinase 3

CMGC_DYRK3 (Dual specificity tyrosine-phosphorylation-regulated kinase 3)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name