CAMK_DAPK2 (Death-associated protein kinase 2)

Total number of chains: 41
Active chains: 32
Family: CAMK
Uniprot: DAPK2_HUMAN
Kinase Domain Residues: 23 - 285
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 41 100.0% AF-Q9UIK4-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AF-Q9UIK4-K1A 15 293 370.0 No_ligand No_ligand Active DFGin 6.737 14.239 BLAminus -125.32, 174.59 58.75, 76.17 -83.05, 18.0 284.14, 75.43 -59.61, -33.51 in-in in 9.135 Saltbr-in 2.714 HRD-in -75.9, -40.25 62.39, -2.72 in-in-in SNCiii in-in ActLoopNT-in 2.865 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.72, -178.17 APE9-dihe-na 84.15, 175.65 APE8-dihe-in -84.33, 122.57 APE8-rot-in 300.43 APE67-dihe-in -62.19, -26.76 -48.87, -35.92 APE12-dist-in 9.14 APE11-dist-in 11.981 APE10-dist-in 6.411 APE9-dist-in 4.841 None None None AF2 -1.0 1.0 1.0 A 279 279 0 0 0 0 [[23, 285]] 1.0 AF-Q9UIK4-K1 CAMK_DAPK2_HUMAN CAMK 2.3e-93 318.1 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
AF-Q9UIK4-K3A 15 293 370.0 No_ligand No_ligand Active DFGin 6.792 14.164 BLAminus -129.71, 178.32 56.42, 68.87 -80.44, 15.54 285.17, 79.99 -60.17, -30.61 in-in in 9.185 Saltbr-in 2.677 HRD-in -81.54, -39.53 61.7, 6.77 in-in-in SNCiii in-in ActLoopNT-in 2.874 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.83, -174.16 APE9-dihe-na 83.87, 170.68 APE8-dihe-in -76.0, 126.83 APE8-rot-in 296.82 APE67-dihe-in -76.45, -22.52 -53.19, -25.87 APE12-dist-in 8.65 APE11-dist-in 11.681 APE10-dist-in 6.104 APE9-dist-in 4.249 None None None AF2 -1.0 1.0 1.0 A 279 279 0 0 0 0 [[23, 285]] 1.0 AF-Q9UIK4-K3 CAMK_DAPK2_HUMAN CAMK 2.3e-93 318.1 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
1ZWSA 12 289 370.0 No_ligand No_ligand Active DFGin 6.576 14.283 BLAminus -132.15, -167.45 56.41, 94.99 -115.1, 28.9 282.7, 67.14 -71.51, -40.03 in-in in 9.278 Saltbr-in 2.788 HRD-in -64.12, -34.32 52.39, 5.5 in-in-in SNCiii in-in ActLoopNT-in 3.003 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.54, 176.58 APE9-dihe-na 83.2, 172.18 APE8-dihe-in -70.67, 133.8 APE8-rot-in 287.45 APE67-dihe-in -61.47, -41.51 -48.38, -43.38 APE12-dist-in 9.394 APE11-dist-in 11.901 APE10-dist-in 6.479 APE9-dist-in 5.166 None None None XRAY 2.9 0.22 0.258 A 288 278 0 0 0 0 [[23, 285]] 1.0 1zws CAMK_DAPK2_HUMAN CAMK 2.2e-93 318.2 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
1ZWSB 12 289 370.0 No_ligand No_ligand Active DFGin 6.36 13.912 BLAminus -137.19, -168.37 55.98, 91.07 -111.53, 32.85 283.82, 65.98 -73.55, -40.26 in-in in 9.232 Saltbr-in 2.567 HRD-in -63.39, -39.72 55.12, 8.12 in-in-in SNCiii in-in ActLoopNT-in 2.967 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.71, 173.58 APE9-dihe-na 82.9, 175.15 APE8-dihe-in -68.55, 129.72 APE8-rot-in 290.27 APE67-dihe-in -61.35, -40.7 -46.71, -44.32 APE12-dist-in 9.395 APE11-dist-in 11.866 APE10-dist-in 6.463 APE9-dist-in 5.311 None None None XRAY 2.9 0.22 0.258 B 288 278 0 0 0 0 [[23, 285]] 1.0 1zws CAMK_DAPK2_HUMAN CAMK 2.2e-93 318.2 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
1ZWSC 12 289 370.0 No_ligand No_ligand Active DFGin 6.319 13.862 BLAminus -132.5, -167.2 53.15, 90.88 -112.82, 31.85 284.73, 65.04 -73.27, -38.01 in-in in 9.284 Saltbr-in 2.688 HRD-in -68.16, -32.65 50.21, 8.96 in-in-in SNCiii in-in ActLoopNT-in 2.891 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.56, 174.55 APE9-dihe-na 83.13, 169.1 APE8-dihe-in -67.01, 134.85 APE8-rot-in 292.8 APE67-dihe-in -59.52, -42.93 -50.35, -45.83 APE12-dist-in 9.371 APE11-dist-in 11.85 APE10-dist-in 6.423 APE9-dist-in 5.142 None None None XRAY 2.9 0.22 0.258 C 288 278 0 0 0 0 [[23, 285]] 1.0 1zws CAMK_DAPK2_HUMAN CAMK 2.2e-93 318.2 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
1ZWSD 12 289 370.0 No_ligand No_ligand Active DFGin 6.814 14.156 BLAminus -134.17, -169.15 57.65, 90.27 -112.42, 30.44 284.65, 67.8 -71.85, -40.65 in-in in 9.282 Saltbr-in 2.871 HRD-in -67.33, -33.5 50.97, 9.13 in-in-in SNCiii in-in ActLoopNT-in 2.941 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.48, 173.83 APE9-dihe-na 84.93, 170.2 APE8-dihe-in -68.1, 133.86 APE8-rot-in 288.9 APE67-dihe-in -62.51, -41.81 -51.68, -40.28 APE12-dist-in 9.373 APE11-dist-in 11.857 APE10-dist-in 6.479 APE9-dist-in 5.155 None None None XRAY 2.9 0.22 0.258 D 288 278 0 0 0 0 [[23, 285]] 1.0 1zws CAMK_DAPK2_HUMAN CAMK 2.2e-93 318.2 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
1ZWSE 12 289 370.0 No_ligand No_ligand Active DFGin 6.505 14.264 BLAminus -135.58, -169.39 57.54, 90.45 -111.37, 28.44 284.97, 67.41 -69.3, -41.51 in-in in 9.274 Saltbr-in 2.623 HRD-in -64.71, -33.2 48.39, 10.72 in-in-in SNCiii in-in ActLoopNT-in 2.941 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.29, 176.06 APE9-dihe-na 80.99, 170.16 APE8-dihe-in -67.96, 130.54 APE8-rot-in 286.66 APE67-dihe-in -60.14, -42.3 -46.67, -45.24 APE12-dist-in 9.454 APE11-dist-in 11.901 APE10-dist-in 6.481 APE9-dist-in 5.143 None None None XRAY 2.9 0.22 0.258 E 288 278 0 0 0 0 [[23, 285]] 1.0 1zws CAMK_DAPK2_HUMAN CAMK 2.2e-93 318.2 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
1ZWSF 12 289 370.0 No_ligand No_ligand Active DFGin 6.616 14.119 BLAminus -134.89, -171.11 59.13, 90.4 -111.83, 30.75 284.9, 68.52 -70.77, -42.22 in-in in 9.252 Saltbr-in 2.717 HRD-in -68.15, -31.91 48.69, 8.26 in-in-in SNCiii in-in ActLoopNT-in 2.924 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.01, 175.17 APE9-dihe-na 83.79, 172.67 APE8-dihe-in -69.6, 133.37 APE8-rot-in 288.79 APE67-dihe-in -55.11, -42.77 -48.58, -49.06 APE12-dist-in 9.345 APE11-dist-in 11.879 APE10-dist-in 6.468 APE9-dist-in 5.182 None None None XRAY 2.9 0.22 0.258 F 288 278 0 0 0 0 [[23, 285]] 1.0 1zws CAMK_DAPK2_HUMAN CAMK 2.2e-93 318.2 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
1ZWSG 12 289 370.0 No_ligand No_ligand Active DFGin 6.494 14.314 BLAminus -135.82, -167.53 53.97, 90.48 -113.32, 35.99 285.56, 66.11 -76.17, -40.16 in-in in 9.308 Saltbr-in 2.761 HRD-in -70.16, -30.04 48.89, 6.41 in-in-in SNCiii in-in ActLoopNT-in 3.012 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.82, 170.5 APE9-dihe-na 87.99, 169.2 APE8-dihe-in -66.17, 133.35 APE8-rot-in 288.2 APE67-dihe-in -59.33, -41.0 -48.7, -47.09 APE12-dist-in 9.465 APE11-dist-in 11.898 APE10-dist-in 6.496 APE9-dist-in 5.212 None None None XRAY 2.9 0.22 0.258 G 288 278 0 0 0 0 [[23, 285]] 1.0 1zws CAMK_DAPK2_HUMAN CAMK 2.2e-93 318.2 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
1ZWSH 12 289 370.0 No_ligand No_ligand Active DFGin 6.27 14.197 BLAminus -133.4, -170.17 58.61, 87.07 -108.85, 31.49 285.83, 66.74 -71.93, -40.32 in-in in 9.277 Saltbr-in 2.741 HRD-in -64.8, -35.37 53.61, 6.34 in-in-in SNCiii in-in ActLoopNT-in 3.009 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.03, 173.5 APE9-dihe-na 82.53, 171.84 APE8-dihe-in -65.87, 135.25 APE8-rot-in 288.98 APE67-dihe-in -60.79, -46.0 -54.44, -40.56 APE12-dist-in 9.404 APE11-dist-in 11.849 APE10-dist-in 6.494 APE9-dist-in 5.251 None None None XRAY 2.9 0.22 0.258 H 288 278 0 0 0 0 [[23, 285]] 1.0 1zws CAMK_DAPK2_HUMAN CAMK 2.2e-93 318.2 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
1Z9XA 12 314 370.0 No_ligand No_ligand Active DFGin 6.816 14.366 BLAminus -122.37, 177.57 56.53, 86.55 -100.47, 35.14 283.04, 77.57 -68.13, -25.45 in-in in 9.056 Saltbr-in 2.769 HRD-in -75.07, -45.14 67.51, 4.68 in-in-in SNCiii in-in ActLoopNT-in 2.993 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.7, -179.11 APE9-dihe-na 83.76, 179.39 APE8-dihe-in -86.47, 121.49 APE8-rot-in 309.23 APE67-dihe-in -48.81, -31.88 -43.95, -49.24 APE12-dist-in 8.92 APE11-dist-in 11.918 APE10-dist-in 6.415 APE9-dist-in 4.86 W315S,S318A None None XRAY 3.93 0.33 0.351 A 321 303 0 0 0 0 [[23, 285]] 1.0 1z9x CAMK_DAPK2_HUMAN CAMK 3.3e-93 317.7 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
1Z9XB 12 314 370.0 No_ligand No_ligand Active DFGin 6.806 14.377 BLAminus -121.42, 177.63 56.47, 86.85 -100.52, 34.69 283.29, 77.46 -67.57, -26.04 in-in in 9.067 Saltbr-in 2.764 HRD-in -74.83, -45.4 68.23, 4.11 in-in-in SNCiii in-in ActLoopNT-in 2.983 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.57, -178.94 APE9-dihe-na 83.9, 179.12 APE8-dihe-in -86.59, 121.31 APE8-rot-in 309.2 APE67-dihe-in -49.13, -32.19 -43.92, -48.8 APE12-dist-in 8.924 APE11-dist-in 11.92 APE10-dist-in 6.411 APE9-dist-in 4.858 W315S,S318A None None XRAY 3.93 0.33 0.351 B 321 303 0 0 0 0 [[23, 285]] 1.0 1z9x CAMK_DAPK2_HUMAN CAMK 3.3e-93 317.7 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
1Z9XC 12 314 370.0 No_ligand No_ligand Active DFGin 7.547 15.118 BLAminus -121.58, 177.96 56.36, 86.72 -100.47, 34.43 282.81, 77.57 -67.06, -26.01 in-in in 9.066 Saltbr-in 2.763 HRD-in -75.38, -45.42 68.46, 3.57 in-in-in SNCiii in-in ActLoopNT-in 3.0 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.2, -179.43 APE9-dihe-na 84.44, 179.57 APE8-dihe-in -86.83, 121.87 APE8-rot-in 309.46 APE67-dihe-in -47.91, -32.76 -44.6, -49.36 APE12-dist-in 8.906 APE11-dist-in 11.912 APE10-dist-in 6.407 APE9-dist-in 4.844 W315S,S318A None None XRAY 3.93 0.33 0.351 C 321 303 0 0 0 0 [[23, 285]] 1.0 1z9x CAMK_DAPK2_HUMAN CAMK 3.3e-93 317.7 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
2A2AA 11 314 370.0 No_ligand No_ligand Active DFGin 6.684 14.383 BLAminus -119.69, 176.81 61.75, 81.41 -93.47, 23.98 279.88, 74.53 -64.03, -23.6 in-in in 9.123 Saltbr-in 2.683 HRD-in -79.25, -46.58 67.96, 6.69 in-in-in SNCiii in-in ActLoopNT-in 2.962 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -162.47, 174.87 APE9-dihe-na 87.2, -175.68 APE8-dihe-in -94.34, 118.35 APE8-rot-in 300.79 APE67-dihe-in -42.19, -35.19 -47.04, -45.86 APE12-dist-in 9.043 APE11-dist-in 11.952 APE10-dist-in 6.521 APE9-dist-in 5.011 None None None XRAY 1.47 0.15 0.207 A 321 304 0 0 0 0 [[23, 285]] 1.0 2a2a CAMK_DAPK2_HUMAN CAMK 3.3e-93 317.7 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
2A2AB 12 314 370.0 No_ligand No_ligand Active DFGin 6.744 14.433 BLAminus -122.21, 176.05 67.68, 77.6 -93.12, 25.58 282.77, 69.19 -68.39, -22.13 in-in in 9.205 Saltbr-in 2.677 HRD-in -72.99, -49.0 70.27, 4.72 in-in-in SNCiii in-in ActLoopNT-in 2.916 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -162.25, 174.69 APE9-dihe-na 93.45, -177.28 APE8-dihe-in -94.41, 118.68 APE8-rot-in 298.27 APE67-dihe-in -43.8, -34.91 -44.15, -50.24 APE12-dist-in 9.252 APE11-dist-in 12.047 APE10-dist-in 6.554 APE9-dist-in 4.958 None None None XRAY 1.47 0.15 0.207 B 321 303 0 0 0 0 [[23, 285]] 1.0 2a2a CAMK_DAPK2_HUMAN CAMK 3.3e-93 317.7 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
2A2AC 12 314 370.0 No_ligand No_ligand Active DFGin 6.674 14.357 BLAminus -119.2, 175.64 65.74, 81.62 -92.41, 23.02 284.57, 71.19 -59.72, -25.65 in-in in 9.154 Saltbr-in 2.768 HRD-in -71.23, -46.84 64.68, 10.26 in-in-in SNCiii in-in ActLoopNT-in 2.973 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -162.68, 178.36 APE9-dihe-na 94.02, -175.35 APE8-dihe-in -101.38, 118.1 APE8-rot-in 296.46 APE67-dihe-in -47.95, -31.42 -44.91, -46.17 APE12-dist-in 9.26 APE11-dist-in 11.995 APE10-dist-in 6.54 APE9-dist-in 4.91 None None None XRAY 1.47 0.15 0.207 C 321 303 0 0 0 0 [[23, 285]] 1.0 2a2a CAMK_DAPK2_HUMAN CAMK 3.3e-93 317.7 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
2A2AD 12 314 370.0 No_ligand No_ligand Active DFGin 6.736 14.315 BLAminus -119.82, 176.82 65.08, 80.61 -93.47, 23.05 280.52, 72.68 -60.48, -25.95 in-in in 9.057 Saltbr-in 2.602 HRD-in -77.29, -46.94 69.67, 10.05 in-in-in SNCiii in-in ActLoopNT-in 2.909 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -166.96, 171.02 APE9-dihe-na 99.63, -176.16 APE8-dihe-in -99.77, 118.11 APE8-rot-in 296.93 APE67-dihe-in -46.19, -31.96 -45.17, -49.15 APE12-dist-in 9.188 APE11-dist-in 11.973 APE10-dist-in 6.51 APE9-dist-in 4.815 None None None XRAY 1.47 0.15 0.207 D 321 303 0 0 0 0 [[23, 285]] 1.0 2a2a CAMK_DAPK2_HUMAN CAMK 3.3e-93 317.7 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
2A27A 12 315 370.0 No_ligand No_ligand Active DFGin 6.681 14.248 BLAminus -127.78, 179.29 58.65, 91.35 -105.91, 29.68 286.17, 76.56 -61.63, -31.63 in-in in 9.384 Saltbr-in 2.881 HRD-in -69.88, -45.14 64.75, 7.97 in-in-in SNCiii in-in ActLoopNT-in 2.996 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -171.1, 176.23 APE9-dihe-na 94.17, -174.52 APE8-dihe-in -93.98, 123.12 APE8-rot-in 292.41 APE67-dihe-in -50.15, -33.97 -47.47, -45.23 APE12-dist-in 9.062 APE11-dist-in 11.878 APE10-dist-in 6.596 APE9-dist-in 4.938 W315S,S318A None None XRAY 3.0 0.219 0.238 A 321 304 0 0 0 0 [[23, 285]] 1.0 2a27 CAMK_DAPK2_HUMAN CAMK 3.8e-93 317.5 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
2A27B 12 314 370.0 No_ligand No_ligand Active DFGin 6.612 14.361 BLAminus -128.8, 178.95 63.13, 92.86 -105.98, 25.61 284.03, 68.57 -62.5, -24.47 in-in in 9.6 Saltbr-in 2.83 HRD-in -73.11, -45.22 65.39, 7.83 in-in-in SNCiii in-in ActLoopNT-in 2.949 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -162.32, -179.49 APE9-dihe-na 92.47, -174.21 APE8-dihe-in -101.26, 116.5 APE8-rot-in 291.51 APE67-dihe-in -51.34, -36.73 -43.33, -43.36 APE12-dist-in 8.9 APE11-dist-in 11.847 APE10-dist-in 6.499 APE9-dist-in 4.93 W315S,S318A None None XRAY 3.0 0.219 0.238 B 321 303 0 0 0 0 [[23, 285]] 1.0 2a27 CAMK_DAPK2_HUMAN CAMK 3.8e-93 317.5 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
2A27C 12 314 370.0 No_ligand No_ligand Active DFGin 6.535 14.276 BLAminus -119.58, 179.43 60.32, 93.21 -105.66, 28.61 288.37, 70.21 -56.82, -32.17 in-in in 9.415 Saltbr-in 2.747 HRD-in -64.58, -43.31 62.91, 12.23 in-in-in SNCiii in-in ActLoopNT-in 2.945 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -166.57, -173.49 APE9-dihe-na 88.28, -179.86 APE8-dihe-in -91.76, 125.02 APE8-rot-in 294.66 APE67-dihe-in -57.69, -26.01 -51.43, -37.95 APE12-dist-in 8.974 APE11-dist-in 11.934 APE10-dist-in 6.661 APE9-dist-in 5.004 W315S,S318A None None XRAY 3.0 0.219 0.238 C 321 303 0 0 0 0 [[23, 285]] 1.0 2a27 CAMK_DAPK2_HUMAN CAMK 3.8e-93 317.5 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
2A27D 12 315 370.0 No_ligand No_ligand Active DFGin 6.614 14.274 BLAminus -128.72, 173.8 64.24, 85.67 -99.62, 29.31 288.35, 73.41 -61.92, -24.01 in-in in 9.509 Saltbr-in 2.967 HRD-in -61.88, -44.12 64.48, 16.31 in-in-in SNCiii in-in ActLoopNT-in 3.03 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -164.97, 174.44 APE9-dihe-na 97.7, -173.91 APE8-dihe-in -95.63, 120.09 APE8-rot-in 295.75 APE67-dihe-in -52.82, -41.33 -48.68, -38.8 APE12-dist-in 8.983 APE11-dist-in 11.901 APE10-dist-in 6.604 APE9-dist-in 5.056 W315S,S318A None None XRAY 3.0 0.219 0.238 D 321 304 0 0 0 0 [[23, 285]] 1.0 2a27 CAMK_DAPK2_HUMAN CAMK 3.8e-93 317.5 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
2A27E 12 314 370.0 No_ligand No_ligand Active DFGin 6.59 14.278 BLAminus -127.77, 177.54 62.34, 86.62 -102.34, 30.02 287.41, 74.52 -63.41, -26.85 in-in in 9.495 Saltbr-in 2.971 HRD-in -59.4, -40.6 59.41, 13.5 in-in-in SNCiii in-in ActLoopNT-in 3.059 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -164.68, 177.19 APE9-dihe-na 98.73, -172.63 APE8-dihe-in -97.09, 127.42 APE8-rot-in 291.88 APE67-dihe-in -54.69, -35.47 -51.42, -39.37 APE12-dist-in 9.007 APE11-dist-in 11.831 APE10-dist-in 6.497 APE9-dist-in 5.032 W315S,S318A None None XRAY 3.0 0.219 0.238 E 321 303 0 0 0 0 [[23, 285]] 1.0 2a27 CAMK_DAPK2_HUMAN CAMK 3.8e-93 317.5 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
2A27F 12 314 370.0 No_ligand No_ligand Active DFGin 6.562 14.329 BLAminus -127.03, 174.44 65.54, 88.72 -104.86, 29.67 286.18, 74.61 -65.35, -24.05 in-in in 9.517 Saltbr-in 3.024 HRD-in -60.92, -43.54 63.95, 5.76 in-in-in SNCiii in-in ActLoopNT-in 3.056 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -164.14, 177.97 APE9-dihe-na 93.1, -173.27 APE8-dihe-in -95.16, 126.31 APE8-rot-in 293.95 APE67-dihe-in -51.6, -34.66 -49.35, -43.58 APE12-dist-in 8.92 APE11-dist-in 11.823 APE10-dist-in 6.493 APE9-dist-in 4.989 W315S,S318A None None XRAY 3.0 0.219 0.238 F 321 303 0 0 0 0 [[23, 285]] 1.0 2a27 CAMK_DAPK2_HUMAN CAMK 3.8e-93 317.5 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
2A27G 12 314 370.0 No_ligand No_ligand Active DFGin 6.607 14.297 BLAminus -124.09, 178.3 60.6, 89.92 -103.61, 28.71 285.69, 73.55 -60.18, -29.0 in-in in 9.425 Saltbr-in 2.683 HRD-in -71.81, -39.91 60.98, 9.67 in-in-in SNCiii in-in ActLoopNT-in 3.057 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -166.99, 177.16 APE9-dihe-na 93.34, -171.63 APE8-dihe-in -96.64, 123.77 APE8-rot-in 295.97 APE67-dihe-in -51.99, -38.48 -50.28, -42.77 APE12-dist-in 8.978 APE11-dist-in 11.913 APE10-dist-in 6.584 APE9-dist-in 4.991 W315S,S318A None None XRAY 3.0 0.219 0.238 G 321 303 0 0 0 0 [[23, 285]] 1.0 2a27 CAMK_DAPK2_HUMAN CAMK 3.8e-93 317.5 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
2A27H 12 315 370.0 No_ligand No_ligand Active DFGin 6.647 14.323 BLAminus -123.58, 174.89 63.39, 89.9 -102.17, 30.06 285.48, 73.38 -65.43, -21.82 in-in in 9.448 Saltbr-in 3.19 HRD-in -66.67, -41.82 64.99, 1.08 in-in-in SNCiii in-in ActLoopNT-in 2.965 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -163.98, -179.93 APE9-dihe-na 94.89, -170.15 APE8-dihe-in -97.76, 127.58 APE8-rot-in 296.2 APE67-dihe-in -52.93, -38.07 -50.7, -43.43 APE12-dist-in 9.044 APE11-dist-in 11.909 APE10-dist-in 6.583 APE9-dist-in 5.025 W315S,S318A None None XRAY 3.0 0.219 0.238 H 321 304 0 0 0 0 [[23, 285]] 1.0 2a27 CAMK_DAPK2_HUMAN CAMK 3.8e-93 317.5 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
6PAWA 14 329 370.0 No_ligand No_ligand Active DFGin 6.442 14.454 BLAminus -122.03, -177.25 57.16, 81.82 -97.53, 30.83 278.66, 75.16 -67.2, -22.6 in-in in 9.418 Saltbr-in 2.627 HRD-in -76.69, -48.31 67.06, 8.69 in-in-in SNCiii in-in ActLoopNT-in 3.109 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.75, -176.65 APE9-dihe-na 82.4, 175.05 APE8-dihe-in -80.56, 124.94 APE8-rot-in 304.27 APE67-dihe-in -61.86, -22.31 -57.54, -31.53 APE12-dist-in 9.008 APE11-dist-in 11.822 APE10-dist-in 6.428 APE9-dist-in 4.793 S318A None None XRAY 2.953 0.251 0.288 A 323 316 0 0 0 0 [[23, 285]] 1.0 6paw CAMK_DAPK2_HUMAN CAMK 3.4e-93 317.7 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
6PAWB 14 329 370.0 No_ligand No_ligand Active DFGin 6.268 14.391 BLAminus -124.88, 179.75 58.62, 84.44 -98.1, 27.06 285.38, 66.39 -72.13, -22.89 in-in in 9.696 Saltbr-in 3.39 HRD-in -76.63, -42.55 65.57, 8.55 in-in-in SNCiii in-in ActLoopNT-in 3.284 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.24, -175.02 APE9-dihe-na 83.62, 169.09 APE8-dihe-in -76.77, 128.15 APE8-rot-in 299.79 APE67-dihe-in -59.93, -21.65 -53.61, -36.04 APE12-dist-in 8.841 APE11-dist-in 11.493 APE10-dist-in 6.117 APE9-dist-in 4.821 S318A None None XRAY 2.953 0.251 0.288 B 323 316 0 0 0 0 [[23, 285]] 1.0 6paw CAMK_DAPK2_HUMAN CAMK 3.4e-93 317.7 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
6PAWE 14 318 370.0 No_ligand No_ligand Active DFGin 6.466 14.572 BLAminus -116.08, 179.4 58.57, 83.74 -98.92, 25.78 280.98, 73.39 -66.81, -17.19 in-in in 9.605 Saltbr-in 2.825 HRD-in -83.63, -43.25 64.29, 15.45 in-in-in SNCiii in-in ActLoopNT-in 3.233 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.5, -175.51 APE9-dihe-na 83.99, 168.94 APE8-dihe-in -78.08, 128.41 APE8-rot-in 292.6 APE67-dihe-in -60.21, -23.76 -55.3, -35.49 APE12-dist-in 9.018 APE11-dist-in 11.914 APE10-dist-in 6.56 APE9-dist-in 4.899 S318A None None XRAY 2.953 0.251 0.288 E 323 305 0 0 0 0 [[23, 285]] 1.0 6paw CAMK_DAPK2_HUMAN CAMK 3.4e-93 317.7 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
2CKEA 11 311 370.0 IQU:61302 Type1 Active DFGin 6.687 14.291 BLAminus -129.73, 173.26 58.67, 84.81 -97.03, 34.61 290.28, 75.18 -67.91, -24.67 in-in in 9.473 Saltbr-in 3.072 HRD-in -81.88, -47.07 66.79, 11.32 in-in-in SNCiii in-in ActLoopNT-in 3.043 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.73, -175.93 APE9-dihe-na 82.66, 179.11 APE8-dihe-in -92.9, 115.05 APE8-rot-in 304.67 APE67-dihe-in -49.56, -32.91 -37.98, -48.12 APE12-dist-in 8.904 APE11-dist-in 11.732 APE10-dist-in 6.352 APE9-dist-in 4.83 None None None XRAY 2.8 0.206 0.261 A 321 301 0 0 0 0 [[23, 285]] 1.0 2cke CAMK_DAPK2_HUMAN CAMK 3.3e-93 317.7 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
2CKEB 12 311 370.0 IQU:61302 Type1 Active DFGin 6.665 14.187 BLAminus -129.39, 175.97 58.22, 89.64 -106.74, 41.11 290.87, 75.34 -78.74, -13.64 in-in in 9.531 Saltbr-in 2.987 HRD-in -79.93, -46.41 62.29, 15.38 in-in-in SNCiii in-in ActLoopNT-in 2.968 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.79, 172.99 APE9-dihe-na 95.73, 174.88 APE8-dihe-in -90.25, 115.25 APE8-rot-in 312.17 APE67-dihe-in -52.78, -31.46 -41.53, -38.53 APE12-dist-in 8.726 APE11-dist-in 11.712 APE10-dist-in 6.407 APE9-dist-in 5.041 None None None XRAY 2.8 0.206 0.261 B 321 300 0 0 0 0 [[23, 285]] 1.0 2cke CAMK_DAPK2_HUMAN CAMK 3.3e-93 317.7 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
2CKEC 12 311 370.0 IQU:61302 Type1 Active DFGin 6.62 14.19 BLAminus -124.69, 173.31 66.47, 87.12 -105.4, 35.82 287.2, 74.68 -74.65, -17.2 in-in in 9.397 Saltbr-in 3.245 HRD-in -80.55, -43.97 65.13, 16.98 in-in-in SNCiii in-in ActLoopNT-in 2.939 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.99, 174.7 APE9-dihe-na 88.24, 173.59 APE8-dihe-in -80.52, 122.26 APE8-rot-in 299.81 APE67-dihe-in -51.42, -30.04 -42.33, -47.48 APE12-dist-in 8.922 APE11-dist-in 11.761 APE10-dist-in 6.395 APE9-dist-in 4.982 None None None XRAY 2.8 0.206 0.261 C 321 300 0 0 0 0 [[23, 285]] 1.0 2cke CAMK_DAPK2_HUMAN CAMK 3.3e-93 317.7 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
2CKED 12 311 370.0 IQU:61302 Type1 Active DFGin 6.654 14.203 BLAminus -124.44, -179.32 54.35, 92.57 -105.67, 31.58 285.28, 75.86 -69.96, -19.93 in-in in 9.238 Saltbr-in 2.624 HRD-in -86.03, -41.35 62.45, 5.47 in-in-in SNCiii in-in ActLoopNT-in 3.043 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.25, -177.67 APE9-dihe-na 85.99, 174.33 APE8-dihe-in -91.52, 115.64 APE8-rot-in 307.04 APE67-dihe-in -50.72, -29.31 -39.85, -44.61 APE12-dist-in 8.878 APE11-dist-in 11.768 APE10-dist-in 6.342 APE9-dist-in 4.801 None None None XRAY 2.8 0.206 0.261 D 321 300 0 0 0 0 [[23, 285]] 1.0 2cke CAMK_DAPK2_HUMAN CAMK 3.3e-93 317.7 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
1WMKA 12 314 370.0 No_ligand No_ligand Inactive DFGin 6.984 14.703 BLAminus -124.47, 176.97 56.77, 75.04 -90.1, 20.67 279.62, 81.9 -56.56, -39.4 in-in in 9.708 Saltbr-in 3.035 HRD-out -81.83, 99.17 -76.56, -22.78 in-in-out SNCiio in-out ActLoopNT-in 3.314 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iiio APE10-dihe-na -118.44, -145.98 APE9-dihe-na -77.2, -107.64 APE8-dihe-in -90.83, 131.29 APE8-rot-in 307.68 APE67-dihe-in -69.41, -57.35 -38.46, -47.18 APE12-dist-in 9.438 APE11-dist-in 12.335 APE10-dist-in 7.585 APE9-dist-out 6.458 S318D None None XRAY 3.6 0.277 0.296 A 321 303 0 0 0 0 [[23, 285]] 1.0 1wmk CAMK_DAPK2_HUMAN CAMK 3.8e-93 317.5 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
1WMKB 12 325 370.0 No_ligand No_ligand Inactive DFGin 6.99 14.677 BLAminus -123.83, 175.0 57.65, 77.26 -91.95, 20.12 278.43, 81.15 -55.48, -38.85 in-in in 9.668 Saltbr-in 3.012 HRD-out -85.49, 99.42 -75.23, -24.88 in-in-out SNCiio in-out ActLoopNT-in 3.238 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iiio APE10-dihe-na -118.73, -149.61 APE9-dihe-na -72.52, -105.23 APE8-dihe-in -93.74, 127.9 APE8-rot-in 307.19 APE67-dihe-in -70.37, -56.91 -37.3, -46.02 APE12-dist-in 9.481 APE11-dist-in 12.349 APE10-dist-in 7.596 APE9-dist-out 6.645 S318D None None XRAY 3.6 0.277 0.296 B 321 314 0 0 0 0 [[23, 285]] 1.0 1wmk CAMK_DAPK2_HUMAN CAMK 3.8e-93 317.5 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
1WMKC 12 314 370.0 No_ligand No_ligand Inactive DFGin 7.057 14.684 BLAminus -121.36, -179.76 54.36, 74.95 -92.16, 24.36 279.03, 80.29 -58.74, -38.93 in-in in 9.698 Saltbr-in 3.123 HRD-out -83.19, 102.02 -77.56, -23.26 in-in-out SNCiio in-out ActLoopNT-in 3.242 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iiio APE10-dihe-na -121.25, -147.48 APE9-dihe-na -75.69, -109.56 APE8-dihe-in -89.56, 130.83 APE8-rot-in 306.98 APE67-dihe-in -70.96, -52.35 -38.17, -47.31 APE12-dist-in 9.486 APE11-dist-in 12.28 APE10-dist-in 7.548 APE9-dist-out 6.432 S318D None None XRAY 3.6 0.277 0.296 C 321 303 0 0 0 0 [[23, 285]] 1.0 1wmk CAMK_DAPK2_HUMAN CAMK 3.8e-93 317.5 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
1WMKD 12 325 370.0 No_ligand No_ligand Inactive DFGin 7.001 14.651 BLAminus -122.99, 177.67 55.34, 77.64 -92.85, 23.78 279.97, 81.51 -58.97, -38.43 in-in in 9.684 Saltbr-in 3.1 HRD-out -82.59, 100.46 -75.61, -25.16 in-in-out SNCiio in-out ActLoopNT-in 3.308 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iiio APE10-dihe-na -122.63, -146.39 APE9-dihe-na -76.34, -110.66 APE8-dihe-in -89.22, 130.23 APE8-rot-in 307.35 APE67-dihe-in -71.07, -54.68 -38.28, -45.89 APE12-dist-in 9.515 APE11-dist-in 12.321 APE10-dist-in 7.571 APE9-dist-out 6.514 S318D None None XRAY 3.6 0.277 0.296 D 321 314 0 0 0 0 [[23, 285]] 1.0 1wmk CAMK_DAPK2_HUMAN CAMK 3.8e-93 317.5 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
1WMKE 12 324 370.0 No_ligand No_ligand Inactive DFGin 7.034 14.713 BLAminus -122.63, 176.75 57.9, 76.85 -91.62, 22.21 279.08, 80.7 -58.67, -36.65 in-in in 9.658 Saltbr-in 2.99 HRD-out -83.03, 100.48 -75.84, -26.0 in-in-out SNCiio in-out ActLoopNT-in 3.231 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iiio APE10-dihe-na -121.4, -147.38 APE9-dihe-na -75.59, -108.6 APE8-dihe-in -90.66, 130.02 APE8-rot-in 307.25 APE67-dihe-in -70.2, -55.58 -37.75, -46.5 APE12-dist-in 9.479 APE11-dist-in 12.302 APE10-dist-in 7.545 APE9-dist-out 6.528 S318D None None XRAY 3.6 0.277 0.296 E 321 313 0 0 0 0 [[23, 285]] 1.0 1wmk CAMK_DAPK2_HUMAN CAMK 3.8e-93 317.5 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
1WMKF 12 314 370.0 No_ligand No_ligand Inactive DFGin 6.982 14.693 BLAminus -126.68, 176.14 57.52, 77.59 -92.99, 21.95 279.27, 80.61 -57.44, -37.75 in-in in 9.684 Saltbr-in 3.188 HRD-out -81.04, 99.48 -74.82, -27.97 in-in-out SNCiio in-out ActLoopNT-in 3.307 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iiio APE10-dihe-na -120.39, -148.32 APE9-dihe-na -75.39, -109.1 APE8-dihe-in -88.31, 128.97 APE8-rot-in 308.6 APE67-dihe-in -69.23, -54.73 -37.16, -48.06 APE12-dist-in 9.479 APE11-dist-in 12.321 APE10-dist-in 7.59 APE9-dist-out 6.668 S318D None None XRAY 3.6 0.277 0.296 F 321 303 0 0 0 0 [[23, 285]] 1.0 1wmk CAMK_DAPK2_HUMAN CAMK 3.8e-93 317.5 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
1WMKG 12 324 370.0 No_ligand No_ligand Inactive DFGin 7.093 14.729 BLAminus -124.0, 175.72 58.44, 75.32 -91.76, 23.15 279.28, 81.16 -58.05, -37.93 in-in in 9.688 Saltbr-in 3.142 HRD-out -83.09, 99.29 -74.35, -25.54 in-in-out SNCiio in-out ActLoopNT-in 3.239 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iiio APE10-dihe-na -121.7, -149.21 APE9-dihe-na -74.19, -106.96 APE8-dihe-in -92.26, 130.14 APE8-rot-in 309.38 APE67-dihe-in -70.96, -54.55 -38.4, -46.33 APE12-dist-in 9.431 APE11-dist-in 12.31 APE10-dist-in 7.587 APE9-dist-out 6.587 S318D None None XRAY 3.6 0.277 0.296 G 321 313 0 0 0 0 [[23, 285]] 1.0 1wmk CAMK_DAPK2_HUMAN CAMK 3.8e-93 317.5 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
1WMKH 12 315 370.0 No_ligand No_ligand Inactive DFGin 7.04 14.686 BLAminus -123.98, 176.46 56.06, 75.96 -91.13, 20.76 280.08, 81.64 -56.3, -38.2 in-in in 9.685 Saltbr-in 3.098 HRD-out -84.95, 99.36 -74.02, -26.27 in-in-out SNCiio in-out ActLoopNT-in 3.224 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iiio APE10-dihe-na -121.81, -147.77 APE9-dihe-na -74.13, -104.79 APE8-dihe-in -93.68, 131.1 APE8-rot-in 306.9 APE67-dihe-in -69.72, -53.51 -39.34, -46.87 APE12-dist-in 9.435 APE11-dist-in 12.318 APE10-dist-in 7.565 APE9-dist-out 6.677 S318D None None XRAY 3.6 0.277 0.296 H 321 304 0 0 0 0 [[23, 285]] 1.0 1wmk CAMK_DAPK2_HUMAN CAMK 3.8e-93 317.5 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
6PAWF 14 327 370.0 No_ligand No_ligand Inactive DFGin 6.666 14.632 BLAminus -119.76, 179.77 55.32, 81.97 -94.59, 20.41 282.99, 78.85 -62.11, -22.64 in-in in 9.758 Saltbr-in 3.487 HRD-in -73.07, -44.77 67.02, 0.39 in-in-out SNCiio in-out ActLoopNT-in 3.092 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -159.56, -173.7 APE9-dihe-na 80.6, 170.36 APE8-dihe-in -77.13, 128.44 APE8-rot-out 43.23 APE67-dihe-in -57.57, -21.72 -55.55, -36.48 APE12-dist-in 9.097 APE11-dist-in 11.95 APE10-dist-in 6.566 APE9-dist-in 4.912 S318A None None XRAY 2.953 0.251 0.288 F 323 314 0 0 0 0 [[23, 285]] 1.0 6paw CAMK_DAPK2_HUMAN CAMK 3.4e-93 317.7 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2

CAMK_DAPK2 (Death-associated protein kinase 2)

Total number of chains: 47
Active chains: 36
Family: CAMK
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 47 100.0% AF-Q9UIK4-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
DAPK2_HUMAN AF-Q9UIK4-K1A Q9UIK4 15 293 370.0 No_ligand No_ligand Active DFGin 6.737 14.239 BLAminus -125.32, 174.59 58.75, 76.17 -83.05, 18.0 284.14, 75.43 -59.61, -33.51 in-in in 9.135 Saltbr-in 2.714 HRD-in -75.9, -40.25 62.39, -2.72 in-in-in SNCiii in-in ActLoopNT-in 2.865 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.72, -178.17 APE9-dihe-na 84.15, 175.65 APE8-dihe-in -84.33, 122.57 APE8-rot-in 300.43 APE67-dihe-in -62.19, -26.76 -48.87, -35.92 APE12-dist-in 9.14 APE11-dist-in 11.981 APE10-dist-in 6.411 APE9-dist-in 4.841 None None None AF2 -1.0 1.0 1.0 A 279 279 0 0 0 0 [[23, 285]] 1.0 AF-Q9UIK4-K1 Homo sapiens CAMK_DAPK2_HUMAN CAMK 2.3e-93 318.1 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
DAPK2_HUMAN AF-Q9UIK4-K3A Q9UIK4 15 293 370.0 No_ligand No_ligand Active DFGin 6.792 14.164 BLAminus -129.71, 178.32 56.42, 68.87 -80.44, 15.54 285.17, 79.99 -60.17, -30.61 in-in in 9.185 Saltbr-in 2.677 HRD-in -81.54, -39.53 61.7, 6.77 in-in-in SNCiii in-in ActLoopNT-in 2.874 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.83, -174.16 APE9-dihe-na 83.87, 170.68 APE8-dihe-in -76.0, 126.83 APE8-rot-in 296.82 APE67-dihe-in -76.45, -22.52 -53.19, -25.87 APE12-dist-in 8.65 APE11-dist-in 11.681 APE10-dist-in 6.104 APE9-dist-in 4.249 None None None AF2 -1.0 1.0 1.0 A 279 279 0 0 0 0 [[23, 285]] 1.0 AF-Q9UIK4-K3 Homo sapiens CAMK_DAPK2_HUMAN CAMK 2.3e-93 318.1 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
DAPK2_HUMAN 1ZWSA Q9UIK4 12 289 370.0 No_ligand No_ligand Active DFGin 6.576 14.283 BLAminus -132.15, -167.45 56.41, 94.99 -115.1, 28.9 282.7, 67.14 -71.51, -40.03 in-in in 9.278 Saltbr-in 2.788 HRD-in -64.12, -34.32 52.39, 5.5 in-in-in SNCiii in-in ActLoopNT-in 3.003 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.54, 176.58 APE9-dihe-na 83.2, 172.18 APE8-dihe-in -70.67, 133.8 APE8-rot-in 287.45 APE67-dihe-in -61.47, -41.51 -48.38, -43.38 APE12-dist-in 9.394 APE11-dist-in 11.901 APE10-dist-in 6.479 APE9-dist-in 5.166 None None None XRAY 2.9 0.22 0.258 A 288 278 0 0 0 0 [[23, 285]] 1.0 1zws Homo sapiens CAMK_DAPK2_HUMAN CAMK 2.2e-93 318.2 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
DAPK2_HUMAN 1ZWSB Q9UIK4 12 289 370.0 No_ligand No_ligand Active DFGin 6.36 13.912 BLAminus -137.19, -168.37 55.98, 91.07 -111.53, 32.85 283.82, 65.98 -73.55, -40.26 in-in in 9.232 Saltbr-in 2.567 HRD-in -63.39, -39.72 55.12, 8.12 in-in-in SNCiii in-in ActLoopNT-in 2.967 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.71, 173.58 APE9-dihe-na 82.9, 175.15 APE8-dihe-in -68.55, 129.72 APE8-rot-in 290.27 APE67-dihe-in -61.35, -40.7 -46.71, -44.32 APE12-dist-in 9.395 APE11-dist-in 11.866 APE10-dist-in 6.463 APE9-dist-in 5.311 None None None XRAY 2.9 0.22 0.258 B 288 278 0 0 0 0 [[23, 285]] 1.0 1zws Homo sapiens CAMK_DAPK2_HUMAN CAMK 2.2e-93 318.2 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
DAPK2_HUMAN 1ZWSC Q9UIK4 12 289 370.0 No_ligand No_ligand Active DFGin 6.319 13.862 BLAminus -132.5, -167.2 53.15, 90.88 -112.82, 31.85 284.73, 65.04 -73.27, -38.01 in-in in 9.284 Saltbr-in 2.688 HRD-in -68.16, -32.65 50.21, 8.96 in-in-in SNCiii in-in ActLoopNT-in 2.891 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.56, 174.55 APE9-dihe-na 83.13, 169.1 APE8-dihe-in -67.01, 134.85 APE8-rot-in 292.8 APE67-dihe-in -59.52, -42.93 -50.35, -45.83 APE12-dist-in 9.371 APE11-dist-in 11.85 APE10-dist-in 6.423 APE9-dist-in 5.142 None None None XRAY 2.9 0.22 0.258 C 288 278 0 0 0 0 [[23, 285]] 1.0 1zws Homo sapiens CAMK_DAPK2_HUMAN CAMK 2.2e-93 318.2 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
DAPK2_HUMAN 1ZWSD Q9UIK4 12 289 370.0 No_ligand No_ligand Active DFGin 6.814 14.156 BLAminus -134.17, -169.15 57.65, 90.27 -112.42, 30.44 284.65, 67.8 -71.85, -40.65 in-in in 9.282 Saltbr-in 2.871 HRD-in -67.33, -33.5 50.97, 9.13 in-in-in SNCiii in-in ActLoopNT-in 2.941 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.48, 173.83 APE9-dihe-na 84.93, 170.2 APE8-dihe-in -68.1, 133.86 APE8-rot-in 288.9 APE67-dihe-in -62.51, -41.81 -51.68, -40.28 APE12-dist-in 9.373 APE11-dist-in 11.857 APE10-dist-in 6.479 APE9-dist-in 5.155 None None None XRAY 2.9 0.22 0.258 D 288 278 0 0 0 0 [[23, 285]] 1.0 1zws Homo sapiens CAMK_DAPK2_HUMAN CAMK 2.2e-93 318.2 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
DAPK2_HUMAN 1ZWSE Q9UIK4 12 289 370.0 No_ligand No_ligand Active DFGin 6.505 14.264 BLAminus -135.58, -169.39 57.54, 90.45 -111.37, 28.44 284.97, 67.41 -69.3, -41.51 in-in in 9.274 Saltbr-in 2.623 HRD-in -64.71, -33.2 48.39, 10.72 in-in-in SNCiii in-in ActLoopNT-in 2.941 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.29, 176.06 APE9-dihe-na 80.99, 170.16 APE8-dihe-in -67.96, 130.54 APE8-rot-in 286.66 APE67-dihe-in -60.14, -42.3 -46.67, -45.24 APE12-dist-in 9.454 APE11-dist-in 11.901 APE10-dist-in 6.481 APE9-dist-in 5.143 None None None XRAY 2.9 0.22 0.258 E 288 278 0 0 0 0 [[23, 285]] 1.0 1zws Homo sapiens CAMK_DAPK2_HUMAN CAMK 2.2e-93 318.2 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
DAPK2_HUMAN 1ZWSF Q9UIK4 12 289 370.0 No_ligand No_ligand Active DFGin 6.616 14.119 BLAminus -134.89, -171.11 59.13, 90.4 -111.83, 30.75 284.9, 68.52 -70.77, -42.22 in-in in 9.252 Saltbr-in 2.717 HRD-in -68.15, -31.91 48.69, 8.26 in-in-in SNCiii in-in ActLoopNT-in 2.924 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.01, 175.17 APE9-dihe-na 83.79, 172.67 APE8-dihe-in -69.6, 133.37 APE8-rot-in 288.79 APE67-dihe-in -55.11, -42.77 -48.58, -49.06 APE12-dist-in 9.345 APE11-dist-in 11.879 APE10-dist-in 6.468 APE9-dist-in 5.182 None None None XRAY 2.9 0.22 0.258 F 288 278 0 0 0 0 [[23, 285]] 1.0 1zws Homo sapiens CAMK_DAPK2_HUMAN CAMK 2.2e-93 318.2 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
DAPK2_HUMAN 1ZWSG Q9UIK4 12 289 370.0 No_ligand No_ligand Active DFGin 6.494 14.314 BLAminus -135.82, -167.53 53.97, 90.48 -113.32, 35.99 285.56, 66.11 -76.17, -40.16 in-in in 9.308 Saltbr-in 2.761 HRD-in -70.16, -30.04 48.89, 6.41 in-in-in SNCiii in-in ActLoopNT-in 3.012 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.82, 170.5 APE9-dihe-na 87.99, 169.2 APE8-dihe-in -66.17, 133.35 APE8-rot-in 288.2 APE67-dihe-in -59.33, -41.0 -48.7, -47.09 APE12-dist-in 9.465 APE11-dist-in 11.898 APE10-dist-in 6.496 APE9-dist-in 5.212 None None None XRAY 2.9 0.22 0.258 G 288 278 0 0 0 0 [[23, 285]] 1.0 1zws Homo sapiens CAMK_DAPK2_HUMAN CAMK 2.2e-93 318.2 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
DAPK2_HUMAN 1ZWSH Q9UIK4 12 289 370.0 No_ligand No_ligand Active DFGin 6.27 14.197 BLAminus -133.4, -170.17 58.61, 87.07 -108.85, 31.49 285.83, 66.74 -71.93, -40.32 in-in in 9.277 Saltbr-in 2.741 HRD-in -64.8, -35.37 53.61, 6.34 in-in-in SNCiii in-in ActLoopNT-in 3.009 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.03, 173.5 APE9-dihe-na 82.53, 171.84 APE8-dihe-in -65.87, 135.25 APE8-rot-in 288.98 APE67-dihe-in -60.79, -46.0 -54.44, -40.56 APE12-dist-in 9.404 APE11-dist-in 11.849 APE10-dist-in 6.494 APE9-dist-in 5.251 None None None XRAY 2.9 0.22 0.258 H 288 278 0 0 0 0 [[23, 285]] 1.0 1zws Homo sapiens CAMK_DAPK2_HUMAN CAMK 2.2e-93 318.2 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
DAPK2_HUMAN 1Z9XA Q9UIK4 12 314 370.0 No_ligand No_ligand Active DFGin 6.816 14.366 BLAminus -122.37, 177.57 56.53, 86.55 -100.47, 35.14 283.04, 77.57 -68.13, -25.45 in-in in 9.056 Saltbr-in 2.769 HRD-in -75.07, -45.14 67.51, 4.68 in-in-in SNCiii in-in ActLoopNT-in 2.993 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.7, -179.11 APE9-dihe-na 83.76, 179.39 APE8-dihe-in -86.47, 121.49 APE8-rot-in 309.23 APE67-dihe-in -48.81, -31.88 -43.95, -49.24 APE12-dist-in 8.92 APE11-dist-in 11.918 APE10-dist-in 6.415 APE9-dist-in 4.86 W315S,S318A None None XRAY 3.93 0.33 0.351 A 321 303 0 0 0 0 [[23, 285]] 1.0 1z9x Homo sapiens CAMK_DAPK2_HUMAN CAMK 3.3e-93 317.7 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
DAPK2_HUMAN 1Z9XB Q9UIK4 12 314 370.0 No_ligand No_ligand Active DFGin 6.806 14.377 BLAminus -121.42, 177.63 56.47, 86.85 -100.52, 34.69 283.29, 77.46 -67.57, -26.04 in-in in 9.067 Saltbr-in 2.764 HRD-in -74.83, -45.4 68.23, 4.11 in-in-in SNCiii in-in ActLoopNT-in 2.983 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.57, -178.94 APE9-dihe-na 83.9, 179.12 APE8-dihe-in -86.59, 121.31 APE8-rot-in 309.2 APE67-dihe-in -49.13, -32.19 -43.92, -48.8 APE12-dist-in 8.924 APE11-dist-in 11.92 APE10-dist-in 6.411 APE9-dist-in 4.858 W315S,S318A None None XRAY 3.93 0.33 0.351 B 321 303 0 0 0 0 [[23, 285]] 1.0 1z9x Homo sapiens CAMK_DAPK2_HUMAN CAMK 3.3e-93 317.7 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
DAPK2_HUMAN 1Z9XC Q9UIK4 12 314 370.0 No_ligand No_ligand Active DFGin 7.547 15.118 BLAminus -121.58, 177.96 56.36, 86.72 -100.47, 34.43 282.81, 77.57 -67.06, -26.01 in-in in 9.066 Saltbr-in 2.763 HRD-in -75.38, -45.42 68.46, 3.57 in-in-in SNCiii in-in ActLoopNT-in 3.0 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.2, -179.43 APE9-dihe-na 84.44, 179.57 APE8-dihe-in -86.83, 121.87 APE8-rot-in 309.46 APE67-dihe-in -47.91, -32.76 -44.6, -49.36 APE12-dist-in 8.906 APE11-dist-in 11.912 APE10-dist-in 6.407 APE9-dist-in 4.844 W315S,S318A None None XRAY 3.93 0.33 0.351 C 321 303 0 0 0 0 [[23, 285]] 1.0 1z9x Homo sapiens CAMK_DAPK2_HUMAN CAMK 3.3e-93 317.7 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
DAPK2_HUMAN 2A2AA Q9UIK4 11 314 370.0 No_ligand No_ligand Active DFGin 6.684 14.383 BLAminus -119.69, 176.81 61.75, 81.41 -93.47, 23.98 279.88, 74.53 -64.03, -23.6 in-in in 9.123 Saltbr-in 2.683 HRD-in -79.25, -46.58 67.96, 6.69 in-in-in SNCiii in-in ActLoopNT-in 2.962 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -162.47, 174.87 APE9-dihe-na 87.2, -175.68 APE8-dihe-in -94.34, 118.35 APE8-rot-in 300.79 APE67-dihe-in -42.19, -35.19 -47.04, -45.86 APE12-dist-in 9.043 APE11-dist-in 11.952 APE10-dist-in 6.521 APE9-dist-in 5.011 None None None XRAY 1.47 0.15 0.207 A 321 304 0 0 0 0 [[23, 285]] 1.0 2a2a Homo sapiens CAMK_DAPK2_HUMAN CAMK 3.3e-93 317.7 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
DAPK2_HUMAN 2A2AB Q9UIK4 12 314 370.0 No_ligand No_ligand Active DFGin 6.744 14.433 BLAminus -122.21, 176.05 67.68, 77.6 -93.12, 25.58 282.77, 69.19 -68.39, -22.13 in-in in 9.205 Saltbr-in 2.677 HRD-in -72.99, -49.0 70.27, 4.72 in-in-in SNCiii in-in ActLoopNT-in 2.916 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -162.25, 174.69 APE9-dihe-na 93.45, -177.28 APE8-dihe-in -94.41, 118.68 APE8-rot-in 298.27 APE67-dihe-in -43.8, -34.91 -44.15, -50.24 APE12-dist-in 9.252 APE11-dist-in 12.047 APE10-dist-in 6.554 APE9-dist-in 4.958 None None None XRAY 1.47 0.15 0.207 B 321 303 0 0 0 0 [[23, 285]] 1.0 2a2a Homo sapiens CAMK_DAPK2_HUMAN CAMK 3.3e-93 317.7 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
DAPK2_HUMAN 2A2AC Q9UIK4 12 314 370.0 No_ligand No_ligand Active DFGin 6.674 14.357 BLAminus -119.2, 175.64 65.74, 81.62 -92.41, 23.02 284.57, 71.19 -59.72, -25.65 in-in in 9.154 Saltbr-in 2.768 HRD-in -71.23, -46.84 64.68, 10.26 in-in-in SNCiii in-in ActLoopNT-in 2.973 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -162.68, 178.36 APE9-dihe-na 94.02, -175.35 APE8-dihe-in -101.38, 118.1 APE8-rot-in 296.46 APE67-dihe-in -47.95, -31.42 -44.91, -46.17 APE12-dist-in 9.26 APE11-dist-in 11.995 APE10-dist-in 6.54 APE9-dist-in 4.91 None None None XRAY 1.47 0.15 0.207 C 321 303 0 0 0 0 [[23, 285]] 1.0 2a2a Homo sapiens CAMK_DAPK2_HUMAN CAMK 3.3e-93 317.7 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
DAPK2_HUMAN 2A2AD Q9UIK4 12 314 370.0 No_ligand No_ligand Active DFGin 6.736 14.315 BLAminus -119.82, 176.82 65.08, 80.61 -93.47, 23.05 280.52, 72.68 -60.48, -25.95 in-in in 9.057 Saltbr-in 2.602 HRD-in -77.29, -46.94 69.67, 10.05 in-in-in SNCiii in-in ActLoopNT-in 2.909 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -166.96, 171.02 APE9-dihe-na 99.63, -176.16 APE8-dihe-in -99.77, 118.11 APE8-rot-in 296.93 APE67-dihe-in -46.19, -31.96 -45.17, -49.15 APE12-dist-in 9.188 APE11-dist-in 11.973 APE10-dist-in 6.51 APE9-dist-in 4.815 None None None XRAY 1.47 0.15 0.207 D 321 303 0 0 0 0 [[23, 285]] 1.0 2a2a Homo sapiens CAMK_DAPK2_HUMAN CAMK 3.3e-93 317.7 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
DAPK2_HUMAN 2A27A Q9UIK4 12 315 370.0 No_ligand No_ligand Active DFGin 6.681 14.248 BLAminus -127.78, 179.29 58.65, 91.35 -105.91, 29.68 286.17, 76.56 -61.63, -31.63 in-in in 9.384 Saltbr-in 2.881 HRD-in -69.88, -45.14 64.75, 7.97 in-in-in SNCiii in-in ActLoopNT-in 2.996 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -171.1, 176.23 APE9-dihe-na 94.17, -174.52 APE8-dihe-in -93.98, 123.12 APE8-rot-in 292.41 APE67-dihe-in -50.15, -33.97 -47.47, -45.23 APE12-dist-in 9.062 APE11-dist-in 11.878 APE10-dist-in 6.596 APE9-dist-in 4.938 W315S,S318A None None XRAY 3.0 0.219 0.238 A 321 304 0 0 0 0 [[23, 285]] 1.0 2a27 Homo sapiens CAMK_DAPK2_HUMAN CAMK 3.8e-93 317.5 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
DAPK2_HUMAN 2A27B Q9UIK4 12 314 370.0 No_ligand No_ligand Active DFGin 6.612 14.361 BLAminus -128.8, 178.95 63.13, 92.86 -105.98, 25.61 284.03, 68.57 -62.5, -24.47 in-in in 9.6 Saltbr-in 2.83 HRD-in -73.11, -45.22 65.39, 7.83 in-in-in SNCiii in-in ActLoopNT-in 2.949 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -162.32, -179.49 APE9-dihe-na 92.47, -174.21 APE8-dihe-in -101.26, 116.5 APE8-rot-in 291.51 APE67-dihe-in -51.34, -36.73 -43.33, -43.36 APE12-dist-in 8.9 APE11-dist-in 11.847 APE10-dist-in 6.499 APE9-dist-in 4.93 W315S,S318A None None XRAY 3.0 0.219 0.238 B 321 303 0 0 0 0 [[23, 285]] 1.0 2a27 Homo sapiens CAMK_DAPK2_HUMAN CAMK 3.8e-93 317.5 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
DAPK2_HUMAN 2A27C Q9UIK4 12 314 370.0 No_ligand No_ligand Active DFGin 6.535 14.276 BLAminus -119.58, 179.43 60.32, 93.21 -105.66, 28.61 288.37, 70.21 -56.82, -32.17 in-in in 9.415 Saltbr-in 2.747 HRD-in -64.58, -43.31 62.91, 12.23 in-in-in SNCiii in-in ActLoopNT-in 2.945 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -166.57, -173.49 APE9-dihe-na 88.28, -179.86 APE8-dihe-in -91.76, 125.02 APE8-rot-in 294.66 APE67-dihe-in -57.69, -26.01 -51.43, -37.95 APE12-dist-in 8.974 APE11-dist-in 11.934 APE10-dist-in 6.661 APE9-dist-in 5.004 W315S,S318A None None XRAY 3.0 0.219 0.238 C 321 303 0 0 0 0 [[23, 285]] 1.0 2a27 Homo sapiens CAMK_DAPK2_HUMAN CAMK 3.8e-93 317.5 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
DAPK2_HUMAN 2A27D Q9UIK4 12 315 370.0 No_ligand No_ligand Active DFGin 6.614 14.274 BLAminus -128.72, 173.8 64.24, 85.67 -99.62, 29.31 288.35, 73.41 -61.92, -24.01 in-in in 9.509 Saltbr-in 2.967 HRD-in -61.88, -44.12 64.48, 16.31 in-in-in SNCiii in-in ActLoopNT-in 3.03 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -164.97, 174.44 APE9-dihe-na 97.7, -173.91 APE8-dihe-in -95.63, 120.09 APE8-rot-in 295.75 APE67-dihe-in -52.82, -41.33 -48.68, -38.8 APE12-dist-in 8.983 APE11-dist-in 11.901 APE10-dist-in 6.604 APE9-dist-in 5.056 W315S,S318A None None XRAY 3.0 0.219 0.238 D 321 304 0 0 0 0 [[23, 285]] 1.0 2a27 Homo sapiens CAMK_DAPK2_HUMAN CAMK 3.8e-93 317.5 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
DAPK2_HUMAN 2A27E Q9UIK4 12 314 370.0 No_ligand No_ligand Active DFGin 6.59 14.278 BLAminus -127.77, 177.54 62.34, 86.62 -102.34, 30.02 287.41, 74.52 -63.41, -26.85 in-in in 9.495 Saltbr-in 2.971 HRD-in -59.4, -40.6 59.41, 13.5 in-in-in SNCiii in-in ActLoopNT-in 3.059 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -164.68, 177.19 APE9-dihe-na 98.73, -172.63 APE8-dihe-in -97.09, 127.42 APE8-rot-in 291.88 APE67-dihe-in -54.69, -35.47 -51.42, -39.37 APE12-dist-in 9.007 APE11-dist-in 11.831 APE10-dist-in 6.497 APE9-dist-in 5.032 W315S,S318A None None XRAY 3.0 0.219 0.238 E 321 303 0 0 0 0 [[23, 285]] 1.0 2a27 Homo sapiens CAMK_DAPK2_HUMAN CAMK 3.8e-93 317.5 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
DAPK2_HUMAN 2A27F Q9UIK4 12 314 370.0 No_ligand No_ligand Active DFGin 6.562 14.329 BLAminus -127.03, 174.44 65.54, 88.72 -104.86, 29.67 286.18, 74.61 -65.35, -24.05 in-in in 9.517 Saltbr-in 3.024 HRD-in -60.92, -43.54 63.95, 5.76 in-in-in SNCiii in-in ActLoopNT-in 3.056 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -164.14, 177.97 APE9-dihe-na 93.1, -173.27 APE8-dihe-in -95.16, 126.31 APE8-rot-in 293.95 APE67-dihe-in -51.6, -34.66 -49.35, -43.58 APE12-dist-in 8.92 APE11-dist-in 11.823 APE10-dist-in 6.493 APE9-dist-in 4.989 W315S,S318A None None XRAY 3.0 0.219 0.238 F 321 303 0 0 0 0 [[23, 285]] 1.0 2a27 Homo sapiens CAMK_DAPK2_HUMAN CAMK 3.8e-93 317.5 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
DAPK2_HUMAN 2A27G Q9UIK4 12 314 370.0 No_ligand No_ligand Active DFGin 6.607 14.297 BLAminus -124.09, 178.3 60.6, 89.92 -103.61, 28.71 285.69, 73.55 -60.18, -29.0 in-in in 9.425 Saltbr-in 2.683 HRD-in -71.81, -39.91 60.98, 9.67 in-in-in SNCiii in-in ActLoopNT-in 3.057 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -166.99, 177.16 APE9-dihe-na 93.34, -171.63 APE8-dihe-in -96.64, 123.77 APE8-rot-in 295.97 APE67-dihe-in -51.99, -38.48 -50.28, -42.77 APE12-dist-in 8.978 APE11-dist-in 11.913 APE10-dist-in 6.584 APE9-dist-in 4.991 W315S,S318A None None XRAY 3.0 0.219 0.238 G 321 303 0 0 0 0 [[23, 285]] 1.0 2a27 Homo sapiens CAMK_DAPK2_HUMAN CAMK 3.8e-93 317.5 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
DAPK2_HUMAN 2A27H Q9UIK4 12 315 370.0 No_ligand No_ligand Active DFGin 6.647 14.323 BLAminus -123.58, 174.89 63.39, 89.9 -102.17, 30.06 285.48, 73.38 -65.43, -21.82 in-in in 9.448 Saltbr-in 3.19 HRD-in -66.67, -41.82 64.99, 1.08 in-in-in SNCiii in-in ActLoopNT-in 2.965 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -163.98, -179.93 APE9-dihe-na 94.89, -170.15 APE8-dihe-in -97.76, 127.58 APE8-rot-in 296.2 APE67-dihe-in -52.93, -38.07 -50.7, -43.43 APE12-dist-in 9.044 APE11-dist-in 11.909 APE10-dist-in 6.583 APE9-dist-in 5.025 W315S,S318A None None XRAY 3.0 0.219 0.238 H 321 304 0 0 0 0 [[23, 285]] 1.0 2a27 Homo sapiens CAMK_DAPK2_HUMAN CAMK 3.8e-93 317.5 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
DAPK2_HUMAN 6PAWA Q9UIK4 14 329 370.0 No_ligand No_ligand Active DFGin 6.442 14.454 BLAminus -122.03, -177.25 57.16, 81.82 -97.53, 30.83 278.66, 75.16 -67.2, -22.6 in-in in 9.418 Saltbr-in 2.627 HRD-in -76.69, -48.31 67.06, 8.69 in-in-in SNCiii in-in ActLoopNT-in 3.109 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.75, -176.65 APE9-dihe-na 82.4, 175.05 APE8-dihe-in -80.56, 124.94 APE8-rot-in 304.27 APE67-dihe-in -61.86, -22.31 -57.54, -31.53 APE12-dist-in 9.008 APE11-dist-in 11.822 APE10-dist-in 6.428 APE9-dist-in 4.793 S318A None None XRAY 2.953 0.251 0.288 A 323 316 0 0 0 0 [[23, 285]] 1.0 6paw Homo sapiens CAMK_DAPK2_HUMAN CAMK 3.4e-93 317.7 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
DAPK2_HUMAN 6PAWB Q9UIK4 14 329 370.0 No_ligand No_ligand Active DFGin 6.268 14.391 BLAminus -124.88, 179.75 58.62, 84.44 -98.1, 27.06 285.38, 66.39 -72.13, -22.89 in-in in 9.696 Saltbr-in 3.39 HRD-in -76.63, -42.55 65.57, 8.55 in-in-in SNCiii in-in ActLoopNT-in 3.284 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.24, -175.02 APE9-dihe-na 83.62, 169.09 APE8-dihe-in -76.77, 128.15 APE8-rot-in 299.79 APE67-dihe-in -59.93, -21.65 -53.61, -36.04 APE12-dist-in 8.841 APE11-dist-in 11.493 APE10-dist-in 6.117 APE9-dist-in 4.821 S318A None None XRAY 2.953 0.251 0.288 B 323 316 0 0 0 0 [[23, 285]] 1.0 6paw Homo sapiens CAMK_DAPK2_HUMAN CAMK 3.4e-93 317.7 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
DAPK2_HUMAN 6PAWE Q9UIK4 14 318 370.0 No_ligand No_ligand Active DFGin 6.466 14.572 BLAminus -116.08, 179.4 58.57, 83.74 -98.92, 25.78 280.98, 73.39 -66.81, -17.19 in-in in 9.605 Saltbr-in 2.825 HRD-in -83.63, -43.25 64.29, 15.45 in-in-in SNCiii in-in ActLoopNT-in 3.233 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.5, -175.51 APE9-dihe-na 83.99, 168.94 APE8-dihe-in -78.08, 128.41 APE8-rot-in 292.6 APE67-dihe-in -60.21, -23.76 -55.3, -35.49 APE12-dist-in 9.018 APE11-dist-in 11.914 APE10-dist-in 6.56 APE9-dist-in 4.899 S318A None None XRAY 2.953 0.251 0.288 E 323 305 0 0 0 0 [[23, 285]] 1.0 6paw Homo sapiens CAMK_DAPK2_HUMAN CAMK 3.4e-93 317.7 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
DAPK2_HUMAN 2CKEA Q9UIK4 11 311 370.0 IQU:61302 Type1 Active DFGin 6.687 14.291 BLAminus -129.73, 173.26 58.67, 84.81 -97.03, 34.61 290.28, 75.18 -67.91, -24.67 in-in in 9.473 Saltbr-in 3.072 HRD-in -81.88, -47.07 66.79, 11.32 in-in-in SNCiii in-in ActLoopNT-in 3.043 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.73, -175.93 APE9-dihe-na 82.66, 179.11 APE8-dihe-in -92.9, 115.05 APE8-rot-in 304.67 APE67-dihe-in -49.56, -32.91 -37.98, -48.12 APE12-dist-in 8.904 APE11-dist-in 11.732 APE10-dist-in 6.352 APE9-dist-in 4.83 None None None XRAY 2.8 0.206 0.261 A 321 301 0 0 0 0 [[23, 285]] 1.0 2cke Homo sapiens CAMK_DAPK2_HUMAN CAMK 3.3e-93 317.7 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
DAPK2_HUMAN 2CKEB Q9UIK4 12 311 370.0 IQU:61302 Type1 Active DFGin 6.665 14.187 BLAminus -129.39, 175.97 58.22, 89.64 -106.74, 41.11 290.87, 75.34 -78.74, -13.64 in-in in 9.531 Saltbr-in 2.987 HRD-in -79.93, -46.41 62.29, 15.38 in-in-in SNCiii in-in ActLoopNT-in 2.968 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.79, 172.99 APE9-dihe-na 95.73, 174.88 APE8-dihe-in -90.25, 115.25 APE8-rot-in 312.17 APE67-dihe-in -52.78, -31.46 -41.53, -38.53 APE12-dist-in 8.726 APE11-dist-in 11.712 APE10-dist-in 6.407 APE9-dist-in 5.041 None None None XRAY 2.8 0.206 0.261 B 321 300 0 0 0 0 [[23, 285]] 1.0 2cke Homo sapiens CAMK_DAPK2_HUMAN CAMK 3.3e-93 317.7 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
DAPK2_HUMAN 2CKEC Q9UIK4 12 311 370.0 IQU:61302 Type1 Active DFGin 6.62 14.19 BLAminus -124.69, 173.31 66.47, 87.12 -105.4, 35.82 287.2, 74.68 -74.65, -17.2 in-in in 9.397 Saltbr-in 3.245 HRD-in -80.55, -43.97 65.13, 16.98 in-in-in SNCiii in-in ActLoopNT-in 2.939 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.99, 174.7 APE9-dihe-na 88.24, 173.59 APE8-dihe-in -80.52, 122.26 APE8-rot-in 299.81 APE67-dihe-in -51.42, -30.04 -42.33, -47.48 APE12-dist-in 8.922 APE11-dist-in 11.761 APE10-dist-in 6.395 APE9-dist-in 4.982 None None None XRAY 2.8 0.206 0.261 C 321 300 0 0 0 0 [[23, 285]] 1.0 2cke Homo sapiens CAMK_DAPK2_HUMAN CAMK 3.3e-93 317.7 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
DAPK2_HUMAN 2CKED Q9UIK4 12 311 370.0 IQU:61302 Type1 Active DFGin 6.654 14.203 BLAminus -124.44, -179.32 54.35, 92.57 -105.67, 31.58 285.28, 75.86 -69.96, -19.93 in-in in 9.238 Saltbr-in 2.624 HRD-in -86.03, -41.35 62.45, 5.47 in-in-in SNCiii in-in ActLoopNT-in 3.043 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.25, -177.67 APE9-dihe-na 85.99, 174.33 APE8-dihe-in -91.52, 115.64 APE8-rot-in 307.04 APE67-dihe-in -50.72, -29.31 -39.85, -44.61 APE12-dist-in 8.878 APE11-dist-in 11.768 APE10-dist-in 6.342 APE9-dist-in 4.801 None None None XRAY 2.8 0.206 0.261 D 321 300 0 0 0 0 [[23, 285]] 1.0 2cke Homo sapiens CAMK_DAPK2_HUMAN CAMK 3.3e-93 317.7 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
DAPK2_HUMAN 1WMKA Q9UIK4 12 314 370.0 No_ligand No_ligand Inactive DFGin 6.984 14.703 BLAminus -124.47, 176.97 56.77, 75.04 -90.1, 20.67 279.62, 81.9 -56.56, -39.4 in-in in 9.708 Saltbr-in 3.035 HRD-out -81.83, 99.17 -76.56, -22.78 in-in-out SNCiio in-out ActLoopNT-in 3.314 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iiio APE10-dihe-na -118.44, -145.98 APE9-dihe-na -77.2, -107.64 APE8-dihe-in -90.83, 131.29 APE8-rot-in 307.68 APE67-dihe-in -69.41, -57.35 -38.46, -47.18 APE12-dist-in 9.438 APE11-dist-in 12.335 APE10-dist-in 7.585 APE9-dist-out 6.458 S318D None None XRAY 3.6 0.277 0.296 A 321 303 0 0 0 0 [[23, 285]] 1.0 1wmk Homo sapiens CAMK_DAPK2_HUMAN CAMK 3.8e-93 317.5 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
DAPK2_HUMAN 1WMKB Q9UIK4 12 325 370.0 No_ligand No_ligand Inactive DFGin 6.99 14.677 BLAminus -123.83, 175.0 57.65, 77.26 -91.95, 20.12 278.43, 81.15 -55.48, -38.85 in-in in 9.668 Saltbr-in 3.012 HRD-out -85.49, 99.42 -75.23, -24.88 in-in-out SNCiio in-out ActLoopNT-in 3.238 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iiio APE10-dihe-na -118.73, -149.61 APE9-dihe-na -72.52, -105.23 APE8-dihe-in -93.74, 127.9 APE8-rot-in 307.19 APE67-dihe-in -70.37, -56.91 -37.3, -46.02 APE12-dist-in 9.481 APE11-dist-in 12.349 APE10-dist-in 7.596 APE9-dist-out 6.645 S318D None None XRAY 3.6 0.277 0.296 B 321 314 0 0 0 0 [[23, 285]] 1.0 1wmk Homo sapiens CAMK_DAPK2_HUMAN CAMK 3.8e-93 317.5 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
DAPK2_HUMAN 1WMKC Q9UIK4 12 314 370.0 No_ligand No_ligand Inactive DFGin 7.057 14.684 BLAminus -121.36, -179.76 54.36, 74.95 -92.16, 24.36 279.03, 80.29 -58.74, -38.93 in-in in 9.698 Saltbr-in 3.123 HRD-out -83.19, 102.02 -77.56, -23.26 in-in-out SNCiio in-out ActLoopNT-in 3.242 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iiio APE10-dihe-na -121.25, -147.48 APE9-dihe-na -75.69, -109.56 APE8-dihe-in -89.56, 130.83 APE8-rot-in 306.98 APE67-dihe-in -70.96, -52.35 -38.17, -47.31 APE12-dist-in 9.486 APE11-dist-in 12.28 APE10-dist-in 7.548 APE9-dist-out 6.432 S318D None None XRAY 3.6 0.277 0.296 C 321 303 0 0 0 0 [[23, 285]] 1.0 1wmk Homo sapiens CAMK_DAPK2_HUMAN CAMK 3.8e-93 317.5 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
DAPK2_HUMAN 1WMKD Q9UIK4 12 325 370.0 No_ligand No_ligand Inactive DFGin 7.001 14.651 BLAminus -122.99, 177.67 55.34, 77.64 -92.85, 23.78 279.97, 81.51 -58.97, -38.43 in-in in 9.684 Saltbr-in 3.1 HRD-out -82.59, 100.46 -75.61, -25.16 in-in-out SNCiio in-out ActLoopNT-in 3.308 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iiio APE10-dihe-na -122.63, -146.39 APE9-dihe-na -76.34, -110.66 APE8-dihe-in -89.22, 130.23 APE8-rot-in 307.35 APE67-dihe-in -71.07, -54.68 -38.28, -45.89 APE12-dist-in 9.515 APE11-dist-in 12.321 APE10-dist-in 7.571 APE9-dist-out 6.514 S318D None None XRAY 3.6 0.277 0.296 D 321 314 0 0 0 0 [[23, 285]] 1.0 1wmk Homo sapiens CAMK_DAPK2_HUMAN CAMK 3.8e-93 317.5 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
DAPK2_HUMAN 1WMKE Q9UIK4 12 324 370.0 No_ligand No_ligand Inactive DFGin 7.034 14.713 BLAminus -122.63, 176.75 57.9, 76.85 -91.62, 22.21 279.08, 80.7 -58.67, -36.65 in-in in 9.658 Saltbr-in 2.99 HRD-out -83.03, 100.48 -75.84, -26.0 in-in-out SNCiio in-out ActLoopNT-in 3.231 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iiio APE10-dihe-na -121.4, -147.38 APE9-dihe-na -75.59, -108.6 APE8-dihe-in -90.66, 130.02 APE8-rot-in 307.25 APE67-dihe-in -70.2, -55.58 -37.75, -46.5 APE12-dist-in 9.479 APE11-dist-in 12.302 APE10-dist-in 7.545 APE9-dist-out 6.528 S318D None None XRAY 3.6 0.277 0.296 E 321 313 0 0 0 0 [[23, 285]] 1.0 1wmk Homo sapiens CAMK_DAPK2_HUMAN CAMK 3.8e-93 317.5 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
DAPK2_HUMAN 1WMKF Q9UIK4 12 314 370.0 No_ligand No_ligand Inactive DFGin 6.982 14.693 BLAminus -126.68, 176.14 57.52, 77.59 -92.99, 21.95 279.27, 80.61 -57.44, -37.75 in-in in 9.684 Saltbr-in 3.188 HRD-out -81.04, 99.48 -74.82, -27.97 in-in-out SNCiio in-out ActLoopNT-in 3.307 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iiio APE10-dihe-na -120.39, -148.32 APE9-dihe-na -75.39, -109.1 APE8-dihe-in -88.31, 128.97 APE8-rot-in 308.6 APE67-dihe-in -69.23, -54.73 -37.16, -48.06 APE12-dist-in 9.479 APE11-dist-in 12.321 APE10-dist-in 7.59 APE9-dist-out 6.668 S318D None None XRAY 3.6 0.277 0.296 F 321 303 0 0 0 0 [[23, 285]] 1.0 1wmk Homo sapiens CAMK_DAPK2_HUMAN CAMK 3.8e-93 317.5 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
DAPK2_HUMAN 1WMKG Q9UIK4 12 324 370.0 No_ligand No_ligand Inactive DFGin 7.093 14.729 BLAminus -124.0, 175.72 58.44, 75.32 -91.76, 23.15 279.28, 81.16 -58.05, -37.93 in-in in 9.688 Saltbr-in 3.142 HRD-out -83.09, 99.29 -74.35, -25.54 in-in-out SNCiio in-out ActLoopNT-in 3.239 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iiio APE10-dihe-na -121.7, -149.21 APE9-dihe-na -74.19, -106.96 APE8-dihe-in -92.26, 130.14 APE8-rot-in 309.38 APE67-dihe-in -70.96, -54.55 -38.4, -46.33 APE12-dist-in 9.431 APE11-dist-in 12.31 APE10-dist-in 7.587 APE9-dist-out 6.587 S318D None None XRAY 3.6 0.277 0.296 G 321 313 0 0 0 0 [[23, 285]] 1.0 1wmk Homo sapiens CAMK_DAPK2_HUMAN CAMK 3.8e-93 317.5 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
DAPK2_HUMAN 1WMKH Q9UIK4 12 315 370.0 No_ligand No_ligand Inactive DFGin 7.04 14.686 BLAminus -123.98, 176.46 56.06, 75.96 -91.13, 20.76 280.08, 81.64 -56.3, -38.2 in-in in 9.685 Saltbr-in 3.098 HRD-out -84.95, 99.36 -74.02, -26.27 in-in-out SNCiio in-out ActLoopNT-in 3.224 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iiio APE10-dihe-na -121.81, -147.77 APE9-dihe-na -74.13, -104.79 APE8-dihe-in -93.68, 131.1 APE8-rot-in 306.9 APE67-dihe-in -69.72, -53.51 -39.34, -46.87 APE12-dist-in 9.435 APE11-dist-in 12.318 APE10-dist-in 7.565 APE9-dist-out 6.677 S318D None None XRAY 3.6 0.277 0.296 H 321 304 0 0 0 0 [[23, 285]] 1.0 1wmk Homo sapiens CAMK_DAPK2_HUMAN CAMK 3.8e-93 317.5 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
DAPK2_HUMAN 6PAWF Q9UIK4 14 327 370.0 No_ligand No_ligand Inactive DFGin 6.666 14.632 BLAminus -119.76, 179.77 55.32, 81.97 -94.59, 20.41 282.99, 78.85 -62.11, -22.64 in-in in 9.758 Saltbr-in 3.487 HRD-in -73.07, -44.77 67.02, 0.39 in-in-out SNCiio in-out ActLoopNT-in 3.092 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -159.56, -173.7 APE9-dihe-na 80.6, 170.36 APE8-dihe-in -77.13, 128.44 APE8-rot-out 43.23 APE67-dihe-in -57.57, -21.72 -55.55, -36.48 APE12-dist-in 9.097 APE11-dist-in 11.95 APE10-dist-in 6.566 APE9-dist-in 4.912 S318A None None XRAY 2.953 0.251 0.288 F 323 314 0 0 0 0 [[23, 285]] 1.0 6paw Homo sapiens CAMK_DAPK2_HUMAN CAMK 3.4e-93 317.7 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
DAPK2_MOUSE 2YAAA Q8VDF3 12 311 370.0 ATP:61302 ATPlike Active DFGin 6.531 14.282 BLAminus -119.44, -173.75 61.63, 82.55 -100.44, 26.82 279.23, 73.82 -61.71, -30.38 in-in in 9.437 Saltbr-in 2.945 HRD-in -69.91, -51.35 70.12, 4.4 in-in-in SNCiii in-in ActLoopNT-in 2.83 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -164.66, 179.02 APE9-dihe-na 88.17, 165.82 APE8-dihe-in -83.03, 124.75 APE8-rot-in 307.34 APE67-dihe-in -54.24, -28.42 -45.93, -43.89 APE12-dist-in 8.679 APE11-dist-in 11.592 APE10-dist-in 6.391 APE9-dist-in 4.926 None None None XRAY 2.3 0.219 0.271 A 361 300 0 0 0 0 [[23, 285]] 1.0 2yaa Mus musculus CAMK_DAPK2_MOUSE CAMK 1.1e-93 319.4 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
DAPK2_MOUSE 2YABA Q8VDF3 13 311 370.0 AMP:61302 ATPlike Active DFGin 6.504 14.098 BLAminus -124.73, -175.5 61.61, 83.44 -98.66, 29.53 280.86, 70.25 -68.26, -23.3 in-in in 9.084 Saltbr-in 2.894 HRD-in -75.19, -47.84 69.74, 6.94 in-in-in SNCiii in-in ActLoopNT-in 2.881 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -162.38, -177.82 APE9-dihe-na 87.95, 171.12 APE8-dihe-in -92.08, 123.94 APE8-rot-in 301.03 APE67-dihe-in -53.06, -29.06 -44.13, -47.2 APE12-dist-in 8.535 APE11-dist-in 11.604 APE10-dist-in 6.372 APE9-dist-in 4.88 None None None XRAY 1.9 0.174 0.215 A 361 299 0 0 0 0 [[23, 285]] 1.0 2yab Mus musculus CAMK_DAPK2_MOUSE CAMK 1.1e-93 319.4 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
DAPK2_MOUSE 2YA9A Q8VDF3 13 311 370.0 D1D:61302 Allosteric Active DFGin 6.673 14.535 BLAminus -116.77, -178.18 56.87, 83.27 -93.45, 27.21 282.36, 70.25 -56.74, -30.08 in-in in 9.404 Saltbr-in 2.819 HRD-in -75.13, -48.3 71.1, 3.32 in-in-in SNCiii in-in ActLoopNT-in 2.773 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -175.45, 171.23 APE9-dihe-na 100.59, 172.3 APE8-dihe-in -84.52, 118.09 APE8-rot-in 308.2 APE67-dihe-in -49.56, -33.46 -39.32, -48.06 APE12-dist-in 9.013 APE11-dist-in 11.864 APE10-dist-in 6.661 APE9-dist-in 5.0 None None None XRAY 2.3 0.209 0.261 A 361 299 0 0 0 0 [[23, 285]] 1.0 2ya9 Mus musculus CAMK_DAPK2_MOUSE CAMK 1.1e-93 319.4 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
DAPK2_MOUSE 2YA9B Q8VDF3 13 311 370.0 D1D:61302 Allosteric Active DFGin 6.635 14.583 BLAminus -118.69, 179.73 62.43, 83.62 -94.95, 25.09 288.82, 65.83 -53.12, -29.16 in-in in 9.647 Saltbr-in 3.014 HRD-in -72.05, -50.32 71.39, 12.46 in-in-in SNCiii in-in ActLoopNT-in 2.821 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -171.11, 177.47 APE9-dihe-na 89.54, 178.67 APE8-dihe-in -91.55, 120.58 APE8-rot-in 302.08 APE67-dihe-in -51.6, -31.38 -44.65, -44.42 APE12-dist-in 9.064 APE11-dist-in 11.942 APE10-dist-in 6.675 APE9-dist-in 4.967 None None None XRAY 2.3 0.209 0.261 B 361 299 0 0 0 0 [[23, 285]] 1.0 2ya9 Mus musculus CAMK_DAPK2_MOUSE CAMK 1.1e-93 319.4 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
DAPK2_MOUSE 2YAAB Q8VDF3 13 311 370.0 ATP:61302 ATPlike Inactive DFGin 6.584 14.289 BLAminus -119.54, -178.65 66.98, 88.67 -108.71, 24.01 280.41, 69.43 -62.37, -28.55 out-out out 10.171 Saltbr-out 5.377 HRD-in -72.87, -55.45 75.11, 6.49 out-in-in SNCoii in-in ActLoopNT-in 2.911 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -174.59, 179.36 APE9-dihe-na 81.98, 166.79 APE8-dihe-in -83.03, 125.4 APE8-rot-in 303.87 APE67-dihe-in -54.18, -26.93 -45.18, -48.55 APE12-dist-in 8.764 APE11-dist-in 11.596 APE10-dist-in 6.43 APE9-dist-in 4.828 None None None XRAY 2.3 0.219 0.271 B 361 299 0 0 0 0 [[23, 285]] 1.0 2yaa Mus musculus CAMK_DAPK2_MOUSE CAMK 1.1e-93 319.4 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
DAPK2_MOUSE 2YABB Q8VDF3 13 311 370.0 AMP:61302 ATPlike Inactive DFGin 6.468 14.474 BLAminus -120.72, 178.3 68.63, 85.28 -101.56, 30.58 281.66, 69.64 -64.58, -26.78 in-out in 9.898 Saltbr-out 4.586 HRD-in -74.81, -49.22 70.61, 7.92 out-in-in SNCoii in-in ActLoopNT-in 2.9 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -164.8, 177.85 APE9-dihe-na 92.04, 167.03 APE8-dihe-in -90.83, 122.42 APE8-rot-in 298.95 APE67-dihe-in -52.33, -27.71 -45.36, -46.31 APE12-dist-in 8.647 APE11-dist-in 11.618 APE10-dist-in 6.351 APE9-dist-in 4.931 None None None XRAY 1.9 0.174 0.215 B 361 299 0 0 0 0 [[23, 285]] 1.0 2yab Mus musculus CAMK_DAPK2_MOUSE CAMK 1.1e-93 319.4 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2

CAMK_DAPK2 (Death-associated protein kinase 2)

Total number of chains: 6
Active chains: 4
Family: CAMK
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 6 100.0% 2YABA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
DAPK2_MOUSE 2YAAA Q8VDF3 12 311 370.0 ATP:61302 ATPlike Active DFGin 6.531 14.282 BLAminus -119.44, -173.75 61.63, 82.55 -100.44, 26.82 279.23, 73.82 -61.71, -30.38 in-in in 9.437 Saltbr-in 2.945 HRD-in -69.91, -51.35 70.12, 4.4 in-in-in SNCiii in-in ActLoopNT-in 2.83 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -164.66, 179.02 APE9-dihe-na 88.17, 165.82 APE8-dihe-in -83.03, 124.75 APE8-rot-in 307.34 APE67-dihe-in -54.24, -28.42 -45.93, -43.89 APE12-dist-in 8.679 APE11-dist-in 11.592 APE10-dist-in 6.391 APE9-dist-in 4.926 None None None XRAY 2.3 0.219 0.271 A 361 300 0 0 0 0 [[23, 285]] 1.0 2yaa Mus musculus CAMK_DAPK2_MOUSE CAMK 1.1e-93 319.4 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
DAPK2_MOUSE 2YABA Q8VDF3 13 311 370.0 AMP:61302 ATPlike Active DFGin 6.504 14.098 BLAminus -124.73, -175.5 61.61, 83.44 -98.66, 29.53 280.86, 70.25 -68.26, -23.3 in-in in 9.084 Saltbr-in 2.894 HRD-in -75.19, -47.84 69.74, 6.94 in-in-in SNCiii in-in ActLoopNT-in 2.881 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -162.38, -177.82 APE9-dihe-na 87.95, 171.12 APE8-dihe-in -92.08, 123.94 APE8-rot-in 301.03 APE67-dihe-in -53.06, -29.06 -44.13, -47.2 APE12-dist-in 8.535 APE11-dist-in 11.604 APE10-dist-in 6.372 APE9-dist-in 4.88 None None None XRAY 1.9 0.174 0.215 A 361 299 0 0 0 0 [[23, 285]] 1.0 2yab Mus musculus CAMK_DAPK2_MOUSE CAMK 1.1e-93 319.4 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
DAPK2_MOUSE 2YA9A Q8VDF3 13 311 370.0 D1D:61302 Allosteric Active DFGin 6.673 14.535 BLAminus -116.77, -178.18 56.87, 83.27 -93.45, 27.21 282.36, 70.25 -56.74, -30.08 in-in in 9.404 Saltbr-in 2.819 HRD-in -75.13, -48.3 71.1, 3.32 in-in-in SNCiii in-in ActLoopNT-in 2.773 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -175.45, 171.23 APE9-dihe-na 100.59, 172.3 APE8-dihe-in -84.52, 118.09 APE8-rot-in 308.2 APE67-dihe-in -49.56, -33.46 -39.32, -48.06 APE12-dist-in 9.013 APE11-dist-in 11.864 APE10-dist-in 6.661 APE9-dist-in 5.0 None None None XRAY 2.3 0.209 0.261 A 361 299 0 0 0 0 [[23, 285]] 1.0 2ya9 Mus musculus CAMK_DAPK2_MOUSE CAMK 1.1e-93 319.4 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
DAPK2_MOUSE 2YA9B Q8VDF3 13 311 370.0 D1D:61302 Allosteric Active DFGin 6.635 14.583 BLAminus -118.69, 179.73 62.43, 83.62 -94.95, 25.09 288.82, 65.83 -53.12, -29.16 in-in in 9.647 Saltbr-in 3.014 HRD-in -72.05, -50.32 71.39, 12.46 in-in-in SNCiii in-in ActLoopNT-in 2.821 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -171.11, 177.47 APE9-dihe-na 89.54, 178.67 APE8-dihe-in -91.55, 120.58 APE8-rot-in 302.08 APE67-dihe-in -51.6, -31.38 -44.65, -44.42 APE12-dist-in 9.064 APE11-dist-in 11.942 APE10-dist-in 6.675 APE9-dist-in 4.967 None None None XRAY 2.3 0.209 0.261 B 361 299 0 0 0 0 [[23, 285]] 1.0 2ya9 Mus musculus CAMK_DAPK2_MOUSE CAMK 1.1e-93 319.4 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
DAPK2_MOUSE 2YAAB Q8VDF3 13 311 370.0 ATP:61302 ATPlike Inactive DFGin 6.584 14.289 BLAminus -119.54, -178.65 66.98, 88.67 -108.71, 24.01 280.41, 69.43 -62.37, -28.55 out-out out 10.171 Saltbr-out 5.377 HRD-in -72.87, -55.45 75.11, 6.49 out-in-in SNCoii in-in ActLoopNT-in 2.911 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -174.59, 179.36 APE9-dihe-na 81.98, 166.79 APE8-dihe-in -83.03, 125.4 APE8-rot-in 303.87 APE67-dihe-in -54.18, -26.93 -45.18, -48.55 APE12-dist-in 8.764 APE11-dist-in 11.596 APE10-dist-in 6.43 APE9-dist-in 4.828 None None None XRAY 2.3 0.219 0.271 B 361 299 0 0 0 0 [[23, 285]] 1.0 2yaa Mus musculus CAMK_DAPK2_MOUSE CAMK 1.1e-93 319.4 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
DAPK2_MOUSE 2YABB Q8VDF3 13 311 370.0 AMP:61302 ATPlike Inactive DFGin 6.468 14.474 BLAminus -120.72, 178.3 68.63, 85.28 -101.56, 30.58 281.66, 69.64 -64.58, -26.78 in-out in 9.898 Saltbr-out 4.586 HRD-in -74.81, -49.22 70.61, 7.92 out-in-in SNCoii in-in ActLoopNT-in 2.9 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -164.8, 177.85 APE9-dihe-na 92.04, 167.03 APE8-dihe-in -90.83, 122.42 APE8-rot-in 298.95 APE67-dihe-in -52.33, -27.71 -45.36, -46.31 APE12-dist-in 8.647 APE11-dist-in 11.618 APE10-dist-in 6.351 APE9-dist-in 4.931 None None None XRAY 1.9 0.174 0.215 B 361 299 0 0 0 0 [[23, 285]] 1.0 2yab Mus musculus CAMK_DAPK2_MOUSE CAMK 1.1e-93 319.4 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2