CMGC_CLK4 (Dual specificity protein kinase CLK4)

Total number of chains: 3
Active chains: 2
Family: CMGC
Uniprot: CLK4_HUMAN
Kinase Domain Residues: 159 - 475
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 100.0% AF-Q9HAZ1-K3A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AF-Q9HAZ1-K3A 151 481 481.0 No_ligand No_ligand Active DFGin 6.914 14.084 BLAminus -129.71, 177.08 60.46, 66.9 -80.96, 11.84 303.18, 103.72 -67.11, -11.41 in-in in 8.426 Saltbr-in 2.711 HRD-in -73.96, -35.9 67.8, -11.84 in-in-in SNCiii in-in ActLoopNT-in 2.94 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.92, 173.12 APE9-dihe-na 63.33, 138.04 APE8-dihe-in -54.54, 136.82 APE8-rot-in 291.66 APE67-dihe-in -72.84, -17.68 -52.16, -40.41 APE12-dist-in 13.879 APE11-dist-in 11.407 APE10-dist-in 7.675 APE9-dist-in 3.004 None None None AF2 -1.0 1.0 1.0 A 331 331 0 0 0 0 [[159, 475]] 1.0 AF-Q9HAZ1-K3 CMGC_CLK4_HUMAN CMGC 8.3e-93 316.8 1 301 301 322 323 324 326 328 189 204 208 283 285 284 286 359 347 342 341 340 339 338 337 336 240 Dual specificity protein kinase CLK4
6FYVA 148 479 481.0 3NG:60501 Type1 Active DFGin 7.194 14.312 BLAminus -120.78, 176.99 65.84, 75.81 -95.62, 15.62 293.79, 91.03 -57.52, -19.12 in-in in 8.769 Saltbr-in 2.784 HRD-in -64.07, -51.05 77.92, -13.36 in-in-in SNCiii in-in ActLoopNT-in 2.829 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.05, 170.31 APE9-dihe-na 72.69, 148.35 APE8-dihe-in -68.0, 139.98 APE8-rot-in 290.09 APE67-dihe-in -63.52, -22.37 -39.86, -52.09 APE12-dist-in 13.223 APE11-dist-in 11.408 APE10-dist-in 7.359 APE9-dist-in 3.027 None None None XRAY 2.46 0.204 0.223 A 337 329 3 0 0 0 [[159, 475]] 1.0 6fyv CMGC_CLK4_HUMAN CMGC 8.9e-93 316.7 1 301 301 322 323 324 326 328 189 204 208 283 285 284 286 359 347 342 341 340 339 338 337 336 240 Dual specificity protein kinase CLK4
AF-Q9HAZ1-K1A 151 481 481.0 No_ligand No_ligand Inactive DFGin 7.058 14.142 BLAminus -130.45, 173.3 63.68, 69.12 -83.19, 10.51 297.64, 97.66 -68.4, -11.23 in-in in 8.44 Saltbr-in 2.702 HRD-in -70.75, -39.46 64.75, -18.88 in-in-out SNCiio in-out ActLoopNT-in 2.928 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -122.3, 174.53 APE9-dihe-na 65.4, 146.47 APE8-dihe-in -58.14, 136.59 APE8-rot-in 292.62 APE67-dihe-in -71.45, -17.04 -50.72, -42.61 APE12-dist-out 14.046 APE11-dist-in 11.781 APE10-dist-in 7.564 APE9-dist-in 2.913 None None None AF2 -1.0 1.0 1.0 A 331 331 0 0 0 0 [[159, 475]] 1.0 AF-Q9HAZ1-K1 CMGC_CLK4_HUMAN CMGC 8.3e-93 316.8 1 301 301 322 323 324 326 328 189 204 208 283 285 284 286 359 347 342 341 340 339 338 337 336 240 Dual specificity protein kinase CLK4

CMGC_CLK4 (Dual specificity protein kinase CLK4)

Total number of chains: 3
Active chains: 2
Family: CMGC
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 100.0% AF-Q9HAZ1-K3A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CLK4_HUMAN AF-Q9HAZ1-K3A Q9HAZ1 151 481 481.0 No_ligand No_ligand Active DFGin 6.914 14.084 BLAminus -129.71, 177.08 60.46, 66.9 -80.96, 11.84 303.18, 103.72 -67.11, -11.41 in-in in 8.426 Saltbr-in 2.711 HRD-in -73.96, -35.9 67.8, -11.84 in-in-in SNCiii in-in ActLoopNT-in 2.94 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.92, 173.12 APE9-dihe-na 63.33, 138.04 APE8-dihe-in -54.54, 136.82 APE8-rot-in 291.66 APE67-dihe-in -72.84, -17.68 -52.16, -40.41 APE12-dist-in 13.879 APE11-dist-in 11.407 APE10-dist-in 7.675 APE9-dist-in 3.004 None None None AF2 -1.0 1.0 1.0 A 331 331 0 0 0 0 [[159, 475]] 1.0 AF-Q9HAZ1-K3 Homo sapiens CMGC_CLK4_HUMAN CMGC 8.3e-93 316.8 1 301 301 322 323 324 326 328 189 204 208 283 285 284 286 359 347 342 341 340 339 338 337 336 240 Dual specificity protein kinase CLK4
CLK4_HUMAN 6FYVA Q9HAZ1 148 479 481.0 3NG:60501 Type1 Active DFGin 7.194 14.312 BLAminus -120.78, 176.99 65.84, 75.81 -95.62, 15.62 293.79, 91.03 -57.52, -19.12 in-in in 8.769 Saltbr-in 2.784 HRD-in -64.07, -51.05 77.92, -13.36 in-in-in SNCiii in-in ActLoopNT-in 2.829 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.05, 170.31 APE9-dihe-na 72.69, 148.35 APE8-dihe-in -68.0, 139.98 APE8-rot-in 290.09 APE67-dihe-in -63.52, -22.37 -39.86, -52.09 APE12-dist-in 13.223 APE11-dist-in 11.408 APE10-dist-in 7.359 APE9-dist-in 3.027 None None None XRAY 2.46 0.204 0.223 A 337 329 3 0 0 0 [[159, 475]] 1.0 6fyv Homo sapiens CMGC_CLK4_HUMAN CMGC 8.9e-93 316.7 1 301 301 322 323 324 326 328 189 204 208 283 285 284 286 359 347 342 341 340 339 338 337 336 240 Dual specificity protein kinase CLK4
CLK4_HUMAN AF-Q9HAZ1-K1A Q9HAZ1 151 481 481.0 No_ligand No_ligand Inactive DFGin 7.058 14.142 BLAminus -130.45, 173.3 63.68, 69.12 -83.19, 10.51 297.64, 97.66 -68.4, -11.23 in-in in 8.44 Saltbr-in 2.702 HRD-in -70.75, -39.46 64.75, -18.88 in-in-out SNCiio in-out ActLoopNT-in 2.928 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -122.3, 174.53 APE9-dihe-na 65.4, 146.47 APE8-dihe-in -58.14, 136.59 APE8-rot-in 292.62 APE67-dihe-in -71.45, -17.04 -50.72, -42.61 APE12-dist-out 14.046 APE11-dist-in 11.781 APE10-dist-in 7.564 APE9-dist-in 2.913 None None None AF2 -1.0 1.0 1.0 A 331 331 0 0 0 0 [[159, 475]] 1.0 AF-Q9HAZ1-K1 Homo sapiens CMGC_CLK4_HUMAN CMGC 8.3e-93 316.8 1 301 301 322 323 324 326 328 189 204 208 283 285 284 286 359 347 342 341 340 339 338 337 336 240 Dual specificity protein kinase CLK4

CMGC_CLK4 (Dual specificity protein kinase CLK4)

Total number of chains: 0
Active chains: 0
Family: CMGC
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name