CMGC_CLK4 (Dual specificity protein kinase CLK4)

Total number of chains: 3
Active chains: 2
Uniprot: CLK4_HUMAN
Kinase Domain Residues: 159 - 475
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 100.0% AF-Q9HAZ1-K3A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CLK4 AF-Q9HAZ1-K3A Q9HAZ1 151 481 481.0 No_ligand No_ligand Active DFGin 6.9138 14.084 BLAminus -129.71, 177.08 60.46, 66.9 -80.96, 11.84 303.18, 103.72 -67.11, -11.41 in-in in 8.4256 Saltbr-in 2.7105 HRD-in -73.96, -35.9 67.8, -11.84 in-in-in SNCiii in-in ActLoopNT-in 2.94 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.92, 173.12 APE9-dihe-na 63.33, 138.04 APE8-dihe-in -54.54, 136.82 APE8-rot-in 291.66 APE67-dihe-in -72.84, -17.68 -52.16, -40.41 APE12-dist-in 13.8787 APE11-dist-in 11.4073 APE10-dist-in 7.6748 APE9-dist-in 3.0042 None None None AF2 -1.0 1.0 1.0 A 331.0 331.0 0 25 25 0 [[159, 475]] 1.0 AF-Q9HAZ1-K3 CMGC_CLK4_HUMAN CMGC 8.3e-93 316.8 1.0 301.0 301.0 322 323 324 326 328 189 204 208 283 285 284 286.0 359 347 342 341 340 339 338 337 336 240 Dual specificity protein kinase CLK4
CLK4 6FYVA Q9HAZ1 148 479 481.0 3NG:60501 Type1 Active DFGin 7.194 14.3116 BLAminus -120.78, 176.99 65.84, 75.81 -95.62, 15.62 293.79, 91.03 -57.52, -19.12 in-in in 8.7694 Saltbr-in 2.7842 HRD-in -64.07, -51.05 77.92, -13.36 in-in-in SNCiii in-in ActLoopNT-in 2.8295 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.05, 170.31 APE9-dihe-na 72.69, 148.35 APE8-dihe-in -68.0, 139.98 APE8-rot-in 290.09 APE67-dihe-in -63.52, -22.37 -39.86, -52.09 APE12-dist-in 13.2233 APE11-dist-in 11.4076 APE10-dist-in 7.3586 APE9-dist-in 3.0267 None None None XRAY 2.46 0.204 0.223 A 337.0 329.0 3 25 25 0 [[159, 475]] 1.0 6fyv CMGC_CLK4_HUMAN CMGC 8.9e-93 316.7 1.0 301.0 301.0 322 323 324 326 328 189 204 208 283 285 284 286.0 359 347 342 341 340 339 338 337 336 240 Dual specificity protein kinase CLK4
CLK4 AF-Q9HAZ1-K1A Q9HAZ1 151 481 481.0 No_ligand No_ligand Inactive DFGin 7.0579 14.1424 BLAminus -130.45, 173.3 63.68, 69.12 -83.19, 10.51 297.64, 97.66 -68.4, -11.23 in-in in 8.4401 Saltbr-in 2.7017 HRD-in -70.75, -39.46 64.75, -18.88 in-in-out SNCiio in-out ActLoopNT-in 2.9276 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -122.3, 174.53 APE9-dihe-na 65.4, 146.47 APE8-dihe-in -58.14, 136.59 APE8-rot-in 292.62 APE67-dihe-in -71.45, -17.04 -50.72, -42.61 APE12-dist-out 14.0458 APE11-dist-in 11.781 APE10-dist-in 7.5644 APE9-dist-in 2.9128 None None None AF2 -1.0 1.0 1.0 A 331.0 331.0 0 25 25 0 [[159, 475]] 1.0 AF-Q9HAZ1-K1 CMGC_CLK4_HUMAN CMGC 8.3e-93 316.8 1.0 301.0 301.0 322 323 324 326 328 189 204 208 283 285 284 286.0 359 347 342 341 340 339 338 337 336 240 Dual specificity protein kinase CLK4

CMGC_CLK4 (Dual specificity protein kinase CLK4)

Total number of chains: 3
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 100.0% AF-Q9HAZ1-K3A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CLK4 CLK4_HUMAN AF-Q9HAZ1-K3A Q9HAZ1 151 481 481.0 No_ligand No_ligand Active DFGin 6.9138 14.084 BLAminus -129.71, 177.08 60.46, 66.9 -80.96, 11.84 303.18, 103.72 -67.11, -11.41 in-in in 8.4256 Saltbr-in 2.7105 HRD-in -73.96, -35.9 67.8, -11.84 in-in-in SNCiii in-in ActLoopNT-in 2.94 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.92, 173.12 APE9-dihe-na 63.33, 138.04 APE8-dihe-in -54.54, 136.82 APE8-rot-in 291.66 APE67-dihe-in -72.84, -17.68 -52.16, -40.41 APE12-dist-in 13.8787 APE11-dist-in 11.4073 APE10-dist-in 7.6748 APE9-dist-in 3.0042 None None None AF2 -1.0 1.0 1.0 A 331.0 331.0 0 25 25 0 [[159, 475]] 1.0 AF-Q9HAZ1-K3 Homo sapiens CMGC_CLK4_HUMAN CMGC 8.3e-93 316.8 1.0 301.0 301.0 322 323 324 326 328 189 204 208 283 285 284 286.0 359 347 342 341 340 339 338 337 336 240 Dual specificity protein kinase CLK4
CLK4 CLK4_HUMAN 6FYVA Q9HAZ1 148 479 481.0 3NG:60501 Type1 Active DFGin 7.194 14.3116 BLAminus -120.78, 176.99 65.84, 75.81 -95.62, 15.62 293.79, 91.03 -57.52, -19.12 in-in in 8.7694 Saltbr-in 2.7842 HRD-in -64.07, -51.05 77.92, -13.36 in-in-in SNCiii in-in ActLoopNT-in 2.8295 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.05, 170.31 APE9-dihe-na 72.69, 148.35 APE8-dihe-in -68.0, 139.98 APE8-rot-in 290.09 APE67-dihe-in -63.52, -22.37 -39.86, -52.09 APE12-dist-in 13.2233 APE11-dist-in 11.4076 APE10-dist-in 7.3586 APE9-dist-in 3.0267 None None None XRAY 2.46 0.204 0.223 A 337.0 329.0 3 25 25 0 [[159, 475]] 1.0 6fyv Homo sapiens CMGC_CLK4_HUMAN CMGC 8.9e-93 316.7 1.0 301.0 301.0 322 323 324 326 328 189 204 208 283 285 284 286.0 359 347 342 341 340 339 338 337 336 240 Dual specificity protein kinase CLK4
CLK4 CLK4_HUMAN AF-Q9HAZ1-K1A Q9HAZ1 151 481 481.0 No_ligand No_ligand Inactive DFGin 7.0579 14.1424 BLAminus -130.45, 173.3 63.68, 69.12 -83.19, 10.51 297.64, 97.66 -68.4, -11.23 in-in in 8.4401 Saltbr-in 2.7017 HRD-in -70.75, -39.46 64.75, -18.88 in-in-out SNCiio in-out ActLoopNT-in 2.9276 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -122.3, 174.53 APE9-dihe-na 65.4, 146.47 APE8-dihe-in -58.14, 136.59 APE8-rot-in 292.62 APE67-dihe-in -71.45, -17.04 -50.72, -42.61 APE12-dist-out 14.0458 APE11-dist-in 11.781 APE10-dist-in 7.5644 APE9-dist-in 2.9128 None None None AF2 -1.0 1.0 1.0 A 331.0 331.0 0 25 25 0 [[159, 475]] 1.0 AF-Q9HAZ1-K1 Homo sapiens CMGC_CLK4_HUMAN CMGC 8.3e-93 316.8 1.0 301.0 301.0 322 323 324 326 328 189 204 208 283 285 284 286.0 359 347 342 341 340 339 338 337 336 240 Dual specificity protein kinase CLK4

CMGC_CLK4 (Dual specificity protein kinase CLK4)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name