CMGC_CDKL3 (Cyclin-dependent kinase-like 3)

Total number of chains: 3
Active chains: 2
Uniprot: CDKL3_HUMAN
Kinase Domain Residues: 4 - 286
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 100.0% AF-Q8IVW4-K1A

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PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AF-Q8IVW4-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 1 - 294 0 None None Cyclin-dependent kinase-like 3
AF-Q8IVW4-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 1 - 294 0 None None Cyclin-dependent kinase-like 3
3ZDUA 2.2 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaoii APEdist_iioo 38R Type1 1 - 309 0 None T158D,Y160E Cyclin-dependent kinase-like 3

CMGC_CDKL3 (Cyclin-dependent kinase-like 3)

Total number of chains: 3
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 100.0% AF-Q8IVW4-K1A

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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
CDKL3_HUMAN AF-Q8IVW4-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 1 - 294 0 None None Cyclin-dependent kinase-like 3 Homo sapiens
CDKL3_HUMAN AF-Q8IVW4-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 1 - 294 0 None None Cyclin-dependent kinase-like 3 Homo sapiens
CDKL3_HUMAN 3ZDUA 2.2 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaoii APEdist_iioo 38R Type1 1 - 309 0 None T158D,Y160E Cyclin-dependent kinase-like 3 Homo sapiens

CMGC_CDKL3 (Cyclin-dependent kinase-like 3)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative

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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism