CMGC_CDK5 (Cyclin-dependent kinase 5)

Total number of chains: 22
Active chains: 13
Uniprot: CDK5_HUMAN
Kinase Domain Residues: 4 - 286
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 22 100.0% AF-Q00535-K1A

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Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CDK5 1H4LA Q00535 2 287 292.0 No_ligand No_ligand Active DFGin 6.6202 15.4792 BLAminus -143.56, 176.2 53.14, 75.93 -87.23, 17.57 281.42, 66.7 -52.55, -28.59 in-in in 8.8095 Saltbr-in 3.2322 HRD-in -81.11, -48.22 60.62, 20.26 in-in-in SNCiii in-in ActLoopNT-in 3.0091 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.33, 150.77 APE9-dihe-na 67.7, 126.9 APE8-dihe-in -54.75, 150.37 APE8-rot-in 308.87 APE67-dihe-in -61.52, -7.78 -40.44, -61.3 APE12-dist-in 12.9199 APE11-dist-in 9.7497 APE10-dist-in 6.6944 APE9-dist-in 3.2531 None None None XRAY 2.65 0.236 0.287 A 292.0 278.0 8 28 28 0 [[4, 286]] 1.0 1h4l CMGC_CDK5_HUMAN CMGC 7.3e-84 288.0 1.0 301.0 301.0 143 144 145 147 149 33 51 55 123 125 124 126.0 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
CDK5 1H4LB Q00535 2 287 292.0 No_ligand No_ligand Active DFGin 6.6592 15.4399 BLAminus -143.33, -179.13 52.72, 73.32 -87.36, 23.9 283.69, 63.17 -58.01, -24.27 in-in in 8.934 Saltbr-in 3.125 HRD-in -84.82, -44.08 59.2, 10.17 in-in-in SNCiii in-in ActLoopNT-in 3.013 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.96, 143.89 APE9-dihe-na 72.68, 133.7 APE8-dihe-in -61.48, 143.63 APE8-rot-in 309.63 APE67-dihe-in -61.01, -6.73 -35.26, -57.65 APE12-dist-in 12.7648 APE11-dist-in 9.5823 APE10-dist-in 6.522 APE9-dist-in 3.1447 None None None XRAY 2.65 0.236 0.287 B 292.0 278.0 8 28 28 0 [[4, 286]] 1.0 1h4l CMGC_CDK5_HUMAN CMGC 7.3e-84 288.0 1.0 301.0 301.0 143 144 145 147 149 33 51 55 123 125 124 126.0 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
CDK5 AF-Q00535-K1A Q00535 1 292 292.0 No_ligand No_ligand Active DFGin 6.8121 15.0795 BLAminus -137.71, 176.76 52.72, 65.61 -76.52, 17.03 281.04, 72.01 -63.52, -30.68 in-in in 8.8174 Saltbr-in 2.7367 HRD-in -77.47, -45.4 62.19, 14.23 in-in-in SNCiii in-in ActLoopNT-in 2.8666 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.25, 162.61 APE9-dihe-na 62.11, 128.26 APE8-dihe-in -54.35, 135.75 APE8-rot-in 298.8 APE67-dihe-in -65.0, -24.32 -44.79, -46.3 APE12-dist-in 13.2835 APE11-dist-in 10.4527 APE10-dist-in 6.8641 APE9-dist-in 3.2781 None None None AF2 -1.0 1.0 1.0 A 292.0 292.0 0 28 28 0 [[4, 286]] 1.0 AF-Q00535-K1 CMGC_CDK5_HUMAN CMGC 4e-84 288.8 1.0 301.0 301.0 143 144 145 147 149 33 51 55 123 125 124 126.0 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
CDK5 AF-Q00535-K3A Q00535 1 292 292.0 No_ligand No_ligand Active DFGin 6.7214 14.9428 BLAminus -139.19, 173.54 59.01, 63.04 -76.77, 15.26 281.96, 72.04 -59.74, -32.22 in-in in 8.9267 Saltbr-in 2.821 HRD-in -77.38, -51.01 62.6, 14.42 in-in-in SNCiii in-in ActLoopNT-in 2.8423 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.79, 159.19 APE9-dihe-na 60.88, 136.97 APE8-dihe-in -57.12, 135.78 APE8-rot-in 296.35 APE67-dihe-in -65.12, -22.17 -41.34, -44.93 APE12-dist-in 13.0008 APE11-dist-in 10.5199 APE10-dist-in 6.701 APE9-dist-in 3.61 None None None AF2 -1.0 1.0 1.0 A 292.0 292.0 0 28 28 0 [[4, 286]] 1.0 AF-Q00535-K3 CMGC_CDK5_HUMAN CMGC 4e-84 288.8 1.0 301.0 301.0 143 144 145 147 149 33 51 55 123 125 124 126.0 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
CDK5 7VDSB Q00535 3 288 292.0 No_ligand No_ligand Active DFGin 6.2538 15.0864 BLAminus -137.57, 174.05 68.25, 91.71 -107.27, 29.03 281.77, 31.22 -63.82, -33.82 in-in in 8.8344 Saltbr-in 3.0003 HRD-in -79.36, -55.2 68.82, 21.54 in-in-in SNCiii in-in ActLoopNT-in 2.8349 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.32, 150.53 APE9-dihe-na 76.98, 135.45 APE8-dihe-in -57.6, 129.9 APE8-rot-in 306.14 APE67-dihe-in -71.32, -21.13 -39.47, -39.34 APE12-dist-in 12.6886 APE11-dist-in 9.9312 APE10-dist-in 6.2877 APE9-dist-in 3.4263 None None None XRAY 3.05 0.228 0.272 B 292.0 278.0 8 28 28 0 [[4, 286]] 1.0 7vds CMGC_CDK5_HUMAN CMGC 4e-84 288.8 1.0 301.0 301.0 143 144 145 147 149 33 51 55 123 125 124 126.0 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
CDK5 1UNLB Q00535 1 292 292.0 No_ligand No_ligand Active DFGin 6.886 14.8508 BLAminus -135.82, 173.41 59.96, 81.07 -98.2, 33.32 283.07, 69.38 -75.63, -27.28 in-in in 8.4516 Saltbr-in 3.158 HRD-in -77.91, -53.06 63.81, 22.82 in-in-in SNCiii in-in ActLoopNT-in 3.0044 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.88, 159.89 APE9-dihe-na 67.72, 132.78 APE8-dihe-in -56.55, 142.64 APE8-rot-in 295.52 APE67-dihe-in -68.05, -20.23 -51.27, -43.49 APE12-dist-in 12.8777 APE11-dist-in 10.1756 APE10-dist-in 6.3904 APE9-dist-in 3.2178 D144N None None XRAY 2.2 0.216 0.219 B 292.0 292.0 0 28 28 0 [[4, 286]] 1.0 1unl CMGC_CDK5_HUMAN CMGC 8e-83 284.6 1.0 301.0 301.0 143 144 145 147 149 33 51 55 123 125 124 126.0 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
CDK5 3O0GA Q00535 1 289 292.0 No_ligand No_ligand Active DFGin 6.8294 15.2178 BLAminus -136.42, 175.77 61.32, 76.52 -94.77, 26.39 279.12, 71.78 -74.78, -15.11 in-in in 8.7244 Saltbr-in 2.5526 HRD-in -79.72, -52.16 68.31, 13.14 in-in-in SNCiii in-in ActLoopNT-in 2.9154 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.07, 157.29 APE9-dihe-na 70.83, 127.92 APE8-dihe-in -52.36, 134.76 APE8-rot-in 293.6 APE67-dihe-in -63.53, -19.46 -44.63, -48.78 APE12-dist-in 13.4692 APE11-dist-in 10.7286 APE10-dist-in 6.966 APE9-dist-in 3.2718 D144N None None XRAY 1.95 0.228 0.256 A 292.0 289.0 0 28 28 0 [[4, 286]] 1.0 3o0g CMGC_CDK5_HUMAN CMGC 8e-83 284.6 1.0 301.0 301.0 143 144 145 147 149 33 51 55 123 125 124 126.0 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
CDK5 1UNGA Q00535 1 292 292.0 ALH:1293 Type1 Active DFGin 6.8038 15.5082 BLAminus -133.26, 177.58 62.73, 72.63 -89.91, 24.29 283.27, 66.96 -66.0, -18.39 in-in in 8.9632 Saltbr-in 2.6515 HRD-in -78.57, -49.35 66.52, 4.37 in-in-in SNCiii in-in ActLoopNT-in 2.7567 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.0, 143.2 APE9-dihe-na 84.58, 125.12 APE8-dihe-in -53.58, 144.18 APE8-rot-in 305.47 APE67-dihe-in -64.4, -16.61 -47.26, -45.44 APE12-dist-in 13.7754 APE11-dist-in 10.8356 APE10-dist-in 7.0066 APE9-dist-in 3.4894 D144N None None XRAY 2.3 0.216 0.225 A 292.0 288.0 4 28 28 0 [[4, 286]] 1.0 1ung CMGC_CDK5_HUMAN CMGC 8e-83 284.6 1.0 301.0 301.0 143 144 145 147 149 33 51 55 123 125 124 126.0 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
CDK5 1UNGB Q00535 2 288 292.0 ALH:1288 Type1 Active DFGin 6.7562 15.2398 BLAminus -135.97, 174.05 60.46, 78.03 -103.9, 21.9 274.8, 75.17 -65.02, -29.35 in-in in 9.083 Saltbr-in 2.6574 HRD-in -79.66, -50.24 62.45, 11.53 in-in-in SNCiii in-in ActLoopNT-in 3.0431 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.0, 151.25 APE9-dihe-na 73.87, 134.42 APE8-dihe-in -67.73, 142.85 APE8-rot-in 304.57 APE67-dihe-in -65.69, -18.42 -33.73, -53.69 APE12-dist-in 12.9582 APE11-dist-in 9.5843 APE10-dist-in 6.5108 APE9-dist-in 3.3065 D144N None None XRAY 2.3 0.216 0.225 B 292.0 269.0 18 28 28 0 [[4, 286]] 1.0 1ung CMGC_CDK5_HUMAN CMGC 8e-83 284.6 1.0 301.0 301.0 143 144 145 147 149 33 51 55 123 125 124 126.0 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
CDK5 1UNHA Q00535 2 288 292.0 IXM:1288 Type1 Active DFGin 6.7757 15.0921 BLAminus -140.41, 176.0 60.42, 76.79 -95.69, 24.18 281.89, 69.34 -62.09, -29.91 in-in in 8.6743 Saltbr-in 2.9932 HRD-in -79.64, -52.48 66.83, 20.74 in-in-in SNCiii in-in ActLoopNT-in 2.8414 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.37, 151.6 APE9-dihe-na 72.7, 127.61 APE8-dihe-in -51.97, 137.86 APE8-rot-in 307.6 APE67-dihe-in -65.83, -14.98 -38.09, -55.48 APE12-dist-in 13.0995 APE11-dist-in 9.8991 APE10-dist-in 6.9004 APE9-dist-in 3.3457 D144N None None XRAY 2.35 0.229 0.23 A 292.0 277.0 10 28 28 0 [[4, 286]] 1.0 1unh CMGC_CDK5_HUMAN CMGC 8e-83 284.6 1.0 301.0 301.0 143 144 145 147 149 33 51 55 123 125 124 126.0 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
CDK5 1UNHB Q00535 2 288 292.0 IXM:1288 Type1 Active DFGin 6.8388 15.1453 BLAminus -141.38, 178.67 60.42, 76.27 -98.32, 21.68 277.9, 76.2 -63.97, -22.06 in-in in 8.6349 Saltbr-in 3.2558 HRD-in -75.22, -55.65 69.38, 16.95 in-in-in SNCiii in-in ActLoopNT-in 2.8267 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.18, 147.66 APE9-dihe-na 73.19, 127.24 APE8-dihe-in -46.64, 135.38 APE8-rot-in 297.76 APE67-dihe-in -66.71, -15.92 -39.6, -54.16 APE12-dist-in 13.1463 APE11-dist-in 9.9739 APE10-dist-in 7.0516 APE9-dist-in 3.3187 D144N None None XRAY 2.35 0.229 0.23 B 292.0 277.0 10 28 28 0 [[4, 286]] 1.0 1unh CMGC_CDK5_HUMAN CMGC 8e-83 284.6 1.0 301.0 301.0 143 144 145 147 149 33 51 55 123 125 124 126.0 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
CDK5 1UNLA Q00535 1 292 292.0 RRC:1293 Type1 Active DFGin 6.8293 15.2016 BLAminus -128.33, 173.21 66.87, 81.02 -97.91, 23.56 283.17, 72.64 -73.67, -20.59 in-in in 8.3091 Saltbr-in 2.8471 HRD-in -82.56, -50.74 69.72, 10.97 in-in-in SNCiii in-in ActLoopNT-in 2.9193 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.08, 156.73 APE9-dihe-na 71.89, 126.73 APE8-dihe-in -48.26, 136.09 APE8-rot-in 296.72 APE67-dihe-in -59.67, -21.67 -44.15, -47.77 APE12-dist-in 13.5586 APE11-dist-in 10.7803 APE10-dist-in 7.1047 APE9-dist-in 3.2635 D144N None None XRAY 2.2 0.216 0.219 A 292.0 292.0 0 28 28 0 [[4, 286]] 1.0 1unl CMGC_CDK5_HUMAN CMGC 8e-83 284.6 1.0 301.0 301.0 143 144 145 147 149 33 51 55 123 125 124 126.0 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
CDK5 3O0GB Q00535 6 288 292.0 3O0:293 Type1 Active DFGin 6.923 14.7947 BLAminus -129.48, 175.97 62.66, 84.26 -100.98, 30.43 284.37, 72.05 -63.02, -27.78 in-in in 8.8214 Saltbr-in 2.7631 HRD-in -83.72, -54.01 67.99, 17.3 in-in-in SNCiii in-in ActLoopNT-in 2.8557 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.49, 157.23 APE9-dihe-na 72.19, 128.42 APE8-dihe-in -53.83, 140.52 APE8-rot-in 308.29 APE67-dihe-in -61.77, -21.68 -45.86, -49.86 APE12-dist-in 12.7273 APE11-dist-in 9.9091 APE10-dist-in 6.3251 APE9-dist-in 3.248 D144N None None XRAY 1.95 0.228 0.256 B 292.0 264.0 21 28 28 0 [[4, 286]] 1.0 3o0g CMGC_CDK5_HUMAN CMGC 8e-83 284.6 1.0 301.0 301.0 143 144 145 147 149 33 51 55 123 125 124 126.0 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
CDK5 7VDPA Q00535 2 291 292.0 65L:301 Type1 Inactive DFGin 6.7648 15.3893 BLAminus -127.42, 170.52 67.24, 87.09 -100.87, 23.21 283.17, 74.31 -63.43, -25.09 in-out in 8.8533 Saltbr-out 3.7283 HRD-in -78.41, -56.12 72.29, 8.93 out-in-out SNCoio in-out ActLoopNT-in 2.8658 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -134.29, 146.94 APE9-dihe-na 69.86, 130.59 APE8-dihe-in -56.21, 145.09 APE8-rot-out 66.15 APE67-dihe-in -65.94, -20.99 -45.11, -46.74 APE12-dist-in 13.3218 APE11-dist-in 10.197 APE10-dist-in 6.9249 APE9-dist-in 3.3917 None None None XRAY 2.09 0.202 0.229 A 292.0 287.0 3 28 28 0 [[4, 286]] 1.0 7vdp CMGC_CDK5_HUMAN CMGC 4e-84 288.8 1.0 301.0 301.0 143 144 145 147 149 33 51 55 123 125 124 126.0 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
CDK5 7VDPB Q00535 3 288 292.0 65L:301 Type1 Inactive DFGin 6.7292 14.9863 BLAminus -127.65, 169.87 66.53, 89.09 -101.2, 27.01 283.91, 72.42 -67.19, -23.91 in-out in 8.8191 Saltbr-out 3.7073 HRD-in -80.8, -59.5 69.85, 17.04 out-in-out SNCoio in-out ActLoopNT-in 2.8868 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -137.89, 151.46 APE9-dihe-na 71.79, 133.86 APE8-dihe-in -61.46, 147.21 APE8-rot-out 65.8 APE67-dihe-in -67.63, -21.22 -46.93, -48.84 APE12-dist-in 12.798 APE11-dist-in 9.6021 APE10-dist-in 6.4704 APE9-dist-in 3.3707 None None None XRAY 2.09 0.202 0.229 B 292.0 279.0 7 28 28 0 [[4, 286]] 1.0 7vdp CMGC_CDK5_HUMAN CMGC 4e-84 288.8 1.0 301.0 301.0 143 144 145 147 149 33 51 55 123 125 124 126.0 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
CDK5 7VDQA Q00535 2 291 292.0 64V:301 Type1 Inactive DFGin 6.6062 15.2883 BLAminus -126.33, 172.99 66.95, 84.9 -102.8, 32.89 288.52, 70.91 -63.45, -40.23 in-in in 8.7668 Saltbr-in 2.9151 HRD-in -78.08, -59.02 67.94, 17.12 in-in-out SNCiio in-out ActLoopNT-in 2.8528 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -140.03, 142.95 APE9-dihe-na 72.97, 131.4 APE8-dihe-in -63.75, 141.79 APE8-rot-out 59.38 APE67-dihe-in -67.5, -17.15 -39.1, -48.99 APE12-dist-in 13.3265 APE11-dist-in 10.4562 APE10-dist-in 6.9809 APE9-dist-in 3.343 None None None XRAY 2.91 0.254 0.284 A 292.0 290.0 0 28 28 0 [[4, 286]] 1.0 7vdq CMGC_CDK5_HUMAN CMGC 4e-84 288.8 1.0 301.0 301.0 143 144 145 147 149 33 51 55 123 125 124 126.0 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
CDK5 7VDQB Q00535 3 288 292.0 64V:301 Type1 Inactive DFGin 6.7029 15.3713 BLAminus -126.83, 173.21 67.53, 85.45 -103.83, 35.8 289.7, 71.3 -66.2, -38.73 in-in in 8.902 Saltbr-in 2.9093 HRD-in -79.53, -57.9 70.89, 16.51 in-in-out SNCiio in-out ActLoopNT-in 2.8736 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -139.15, 143.9 APE9-dihe-na 74.88, 143.9 APE8-dihe-in -77.64, 140.07 APE8-rot-out 62.74 APE67-dihe-in -67.14, -19.69 -37.77, -52.43 APE12-dist-in 12.7444 APE11-dist-in 9.9205 APE10-dist-in 6.6672 APE9-dist-in 3.3445 None None None XRAY 2.91 0.254 0.284 B 292.0 277.0 9 28 28 0 [[4, 286]] 1.0 7vdq CMGC_CDK5_HUMAN CMGC 4e-84 288.8 1.0 301.0 301.0 143 144 145 147 149 33 51 55 123 125 124 126.0 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
CDK5 7VDRA Q00535 2 291 292.0 63I:301 Type1 Inactive DFGin 6.6266 15.74 BLAminus -129.05, 171.62 69.47, 86.46 -104.09, 25.41 283.64, 74.23 -68.34, -21.06 in-in in 8.8803 Saltbr-in 3.314 HRD-in -78.35, -59.52 73.04, 14.77 in-in-out SNCiio in-out ActLoopNT-in 2.8632 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -137.3, 138.66 APE9-dihe-na 71.75, 135.69 APE8-dihe-in -66.11, 146.84 APE8-rot-out 71.82 APE67-dihe-in -69.63, -20.89 -44.06, -44.5 APE12-dist-in 13.0087 APE11-dist-in 9.9559 APE10-dist-in 6.9609 APE9-dist-in 3.3204 None None None XRAY 2.55 0.221 0.256 A 292.0 290.0 0 28 28 0 [[4, 286]] 1.0 7vdr CMGC_CDK5_HUMAN CMGC 4e-84 288.8 1.0 301.0 301.0 143 144 145 147 149 33 51 55 123 125 124 126.0 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
CDK5 7VDRB Q00535 3 288 292.0 63I:301 Type1 Inactive DFGin 6.5755 15.3317 BLAminus -129.35, 171.52 69.7, 87.29 -105.48, 25.0 285.38, 76.15 -68.91, -20.79 in-in in 8.8894 Saltbr-in 3.2949 HRD-in -80.02, -61.31 72.56, 17.73 in-in-out SNCiio in-out ActLoopNT-in 2.8656 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -136.41, 145.43 APE9-dihe-na 74.65, 138.0 APE8-dihe-in -69.3, 148.16 APE8-rot-out 71.5 APE67-dihe-in -71.13, -20.44 -45.23, -46.82 APE12-dist-in 12.9322 APE11-dist-in 9.9297 APE10-dist-in 6.82 APE9-dist-in 3.3178 None None None XRAY 2.55 0.221 0.256 B 292.0 275.0 11 28 28 0 [[4, 286]] 1.0 7vdr CMGC_CDK5_HUMAN CMGC 4e-84 288.8 1.0 301.0 301.0 143 144 145 147 149 33 51 55 123 125 124 126.0 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
CDK5 7VDSA Q00535 2 291 292.0 61U:301 Type1 Inactive DFGin 6.5205 15.3292 BLAminus -137.7, 177.02 65.97, 88.94 -109.08, 27.6 287.56, 67.14 -63.86, -33.05 in-in in 8.6242 Saltbr-in 3.3531 HRD-in -79.29, -55.01 68.82, 18.0 in-in-out SNCiio in-out ActLoopNT-in 2.8448 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -138.28, 148.16 APE9-dihe-na 77.03, 134.42 APE8-dihe-in -61.09, 132.18 APE8-rot-out 39.92 APE67-dihe-in -70.87, -20.07 -38.56, -38.27 APE12-dist-in 13.1199 APE11-dist-in 10.3195 APE10-dist-in 6.5539 APE9-dist-in 3.394 None None None XRAY 3.05 0.228 0.272 A 292.0 290.0 0 28 28 0 [[4, 286]] 1.0 7vds CMGC_CDK5_HUMAN CMGC 4e-84 288.8 1.0 301.0 301.0 143 144 145 147 149 33 51 55 123 125 124 126.0 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
CDK5 4AU8A Q00535 2 289 292.0 Z3R:61293 Type1 Inactive DFGin 7.1122 15.1372 BLAminus -135.37, 172.87 64.95, 77.01 -97.51, 18.8 282.03, 77.47 -65.91, -19.1 in-in in 8.2084 Saltbr-in 2.6454 HRD-in -73.52, -48.92 73.07, -7.77 in-in-out SNCiio in-out ActLoopNT-in 2.9444 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -144.11, 169.24 APE9-dihe-na -57.47, 146.77 APE8-dihe-in -51.22, 149.12 APE8-rot-out 191.34 APE67-dihe-in -62.35, -21.28 -39.22, -50.79 APE12-dist-in 12.0461 APE11-dist-out 6.6974 APE10-dist-out 8.6457 APE9-dist-in 3.8759 None None None XRAY 1.9 0.197 0.234 A 296.0 274.0 14 28 26 2 [[4, 286]] 1.0 4au8 CMGC_CDK5_HUMAN CMGC 4.2e-84 288.8 1.0 301.0 301.0 143 144 145 147 149 33 51 55 123 125 124 126.0 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
CDK5 4AU8B Q00535 2 289 292.0 Z3R:61293 Type1 Inactive DFGin 7.2608 15.5319 BLAminus -136.24, 169.41 66.3, 80.09 -99.68, 21.4 281.94, 79.2 -66.25, -19.98 in-in in 8.1283 Saltbr-in 2.8349 HRD-in -70.21, -48.16 75.6, -7.91 in-in-out SNCiio in-out ActLoopNT-in 2.947 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoi APE10-dihe-na 999.0, 152.31 APE9-dihe-na -57.56, 146.64 APE8-dihe-in -53.33, 139.32 APE8-rot-out 196.17 APE67-dihe-in -60.73, -25.67 -36.04, -48.68 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.8336 APE9-dist-in 3.8301 None None None XRAY 1.9 0.197 0.234 B 296.0 277.0 11 28 22 6 [[4, 286]] 1.0 4au8 CMGC_CDK5_HUMAN CMGC 4.2e-84 288.8 1.0 301.0 301.0 143 144 145 147 149 33 51 55 123 125 124 126.0 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5

CMGC_CDK5 (Cyclin-dependent kinase 5)

Total number of chains: 22
Active chains: 13
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 22 100.0% AF-Q00535-K1A

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Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CDK5 CDK5_HUMAN 1H4LA Q00535 2 287 292.0 No_ligand No_ligand Active DFGin 6.6202 15.4792 BLAminus -143.56, 176.2 53.14, 75.93 -87.23, 17.57 281.42, 66.7 -52.55, -28.59 in-in in 8.8095 Saltbr-in 3.2322 HRD-in -81.11, -48.22 60.62, 20.26 in-in-in SNCiii in-in ActLoopNT-in 3.0091 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.33, 150.77 APE9-dihe-na 67.7, 126.9 APE8-dihe-in -54.75, 150.37 APE8-rot-in 308.87 APE67-dihe-in -61.52, -7.78 -40.44, -61.3 APE12-dist-in 12.9199 APE11-dist-in 9.7497 APE10-dist-in 6.6944 APE9-dist-in 3.2531 None None None XRAY 2.65 0.236 0.287 A 292.0 278.0 8 28 28 0 [[4, 286]] 1.0 1h4l Homo sapiens CMGC_CDK5_HUMAN CMGC 7.3e-84 288.0 1.0 301.0 301.0 143 144 145 147 149 33 51 55 123 125 124 126.0 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
CDK5 CDK5_HUMAN 1H4LB Q00535 2 287 292.0 No_ligand No_ligand Active DFGin 6.6592 15.4399 BLAminus -143.33, -179.13 52.72, 73.32 -87.36, 23.9 283.69, 63.17 -58.01, -24.27 in-in in 8.934 Saltbr-in 3.125 HRD-in -84.82, -44.08 59.2, 10.17 in-in-in SNCiii in-in ActLoopNT-in 3.013 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.96, 143.89 APE9-dihe-na 72.68, 133.7 APE8-dihe-in -61.48, 143.63 APE8-rot-in 309.63 APE67-dihe-in -61.01, -6.73 -35.26, -57.65 APE12-dist-in 12.7648 APE11-dist-in 9.5823 APE10-dist-in 6.522 APE9-dist-in 3.1447 None None None XRAY 2.65 0.236 0.287 B 292.0 278.0 8 28 28 0 [[4, 286]] 1.0 1h4l Homo sapiens CMGC_CDK5_HUMAN CMGC 7.3e-84 288.0 1.0 301.0 301.0 143 144 145 147 149 33 51 55 123 125 124 126.0 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
CDK5 CDK5_HUMAN AF-Q00535-K1A Q00535 1 292 292.0 No_ligand No_ligand Active DFGin 6.8121 15.0795 BLAminus -137.71, 176.76 52.72, 65.61 -76.52, 17.03 281.04, 72.01 -63.52, -30.68 in-in in 8.8174 Saltbr-in 2.7367 HRD-in -77.47, -45.4 62.19, 14.23 in-in-in SNCiii in-in ActLoopNT-in 2.8666 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.25, 162.61 APE9-dihe-na 62.11, 128.26 APE8-dihe-in -54.35, 135.75 APE8-rot-in 298.8 APE67-dihe-in -65.0, -24.32 -44.79, -46.3 APE12-dist-in 13.2835 APE11-dist-in 10.4527 APE10-dist-in 6.8641 APE9-dist-in 3.2781 None None None AF2 -1.0 1.0 1.0 A 292.0 292.0 0 28 28 0 [[4, 286]] 1.0 AF-Q00535-K1 Homo sapiens CMGC_CDK5_HUMAN CMGC 4e-84 288.8 1.0 301.0 301.0 143 144 145 147 149 33 51 55 123 125 124 126.0 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
CDK5 CDK5_HUMAN AF-Q00535-K3A Q00535 1 292 292.0 No_ligand No_ligand Active DFGin 6.7214 14.9428 BLAminus -139.19, 173.54 59.01, 63.04 -76.77, 15.26 281.96, 72.04 -59.74, -32.22 in-in in 8.9267 Saltbr-in 2.821 HRD-in -77.38, -51.01 62.6, 14.42 in-in-in SNCiii in-in ActLoopNT-in 2.8423 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.79, 159.19 APE9-dihe-na 60.88, 136.97 APE8-dihe-in -57.12, 135.78 APE8-rot-in 296.35 APE67-dihe-in -65.12, -22.17 -41.34, -44.93 APE12-dist-in 13.0008 APE11-dist-in 10.5199 APE10-dist-in 6.701 APE9-dist-in 3.61 None None None AF2 -1.0 1.0 1.0 A 292.0 292.0 0 28 28 0 [[4, 286]] 1.0 AF-Q00535-K3 Homo sapiens CMGC_CDK5_HUMAN CMGC 4e-84 288.8 1.0 301.0 301.0 143 144 145 147 149 33 51 55 123 125 124 126.0 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
CDK5 CDK5_HUMAN 7VDSB Q00535 3 288 292.0 No_ligand No_ligand Active DFGin 6.2538 15.0864 BLAminus -137.57, 174.05 68.25, 91.71 -107.27, 29.03 281.77, 31.22 -63.82, -33.82 in-in in 8.8344 Saltbr-in 3.0003 HRD-in -79.36, -55.2 68.82, 21.54 in-in-in SNCiii in-in ActLoopNT-in 2.8349 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.32, 150.53 APE9-dihe-na 76.98, 135.45 APE8-dihe-in -57.6, 129.9 APE8-rot-in 306.14 APE67-dihe-in -71.32, -21.13 -39.47, -39.34 APE12-dist-in 12.6886 APE11-dist-in 9.9312 APE10-dist-in 6.2877 APE9-dist-in 3.4263 None None None XRAY 3.05 0.228 0.272 B 292.0 278.0 8 28 28 0 [[4, 286]] 1.0 7vds Homo sapiens CMGC_CDK5_HUMAN CMGC 4e-84 288.8 1.0 301.0 301.0 143 144 145 147 149 33 51 55 123 125 124 126.0 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
CDK5 CDK5_HUMAN 1UNLB Q00535 1 292 292.0 No_ligand No_ligand Active DFGin 6.886 14.8508 BLAminus -135.82, 173.41 59.96, 81.07 -98.2, 33.32 283.07, 69.38 -75.63, -27.28 in-in in 8.4516 Saltbr-in 3.158 HRD-in -77.91, -53.06 63.81, 22.82 in-in-in SNCiii in-in ActLoopNT-in 3.0044 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.88, 159.89 APE9-dihe-na 67.72, 132.78 APE8-dihe-in -56.55, 142.64 APE8-rot-in 295.52 APE67-dihe-in -68.05, -20.23 -51.27, -43.49 APE12-dist-in 12.8777 APE11-dist-in 10.1756 APE10-dist-in 6.3904 APE9-dist-in 3.2178 D144N None None XRAY 2.2 0.216 0.219 B 292.0 292.0 0 28 28 0 [[4, 286]] 1.0 1unl Homo sapiens CMGC_CDK5_HUMAN CMGC 8e-83 284.6 1.0 301.0 301.0 143 144 145 147 149 33 51 55 123 125 124 126.0 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
CDK5 CDK5_HUMAN 3O0GA Q00535 1 289 292.0 No_ligand No_ligand Active DFGin 6.8294 15.2178 BLAminus -136.42, 175.77 61.32, 76.52 -94.77, 26.39 279.12, 71.78 -74.78, -15.11 in-in in 8.7244 Saltbr-in 2.5526 HRD-in -79.72, -52.16 68.31, 13.14 in-in-in SNCiii in-in ActLoopNT-in 2.9154 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.07, 157.29 APE9-dihe-na 70.83, 127.92 APE8-dihe-in -52.36, 134.76 APE8-rot-in 293.6 APE67-dihe-in -63.53, -19.46 -44.63, -48.78 APE12-dist-in 13.4692 APE11-dist-in 10.7286 APE10-dist-in 6.966 APE9-dist-in 3.2718 D144N None None XRAY 1.95 0.228 0.256 A 292.0 289.0 0 28 28 0 [[4, 286]] 1.0 3o0g Homo sapiens CMGC_CDK5_HUMAN CMGC 8e-83 284.6 1.0 301.0 301.0 143 144 145 147 149 33 51 55 123 125 124 126.0 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
CDK5 CDK5_HUMAN 1UNGA Q00535 1 292 292.0 ALH:1293 Type1 Active DFGin 6.8038 15.5082 BLAminus -133.26, 177.58 62.73, 72.63 -89.91, 24.29 283.27, 66.96 -66.0, -18.39 in-in in 8.9632 Saltbr-in 2.6515 HRD-in -78.57, -49.35 66.52, 4.37 in-in-in SNCiii in-in ActLoopNT-in 2.7567 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.0, 143.2 APE9-dihe-na 84.58, 125.12 APE8-dihe-in -53.58, 144.18 APE8-rot-in 305.47 APE67-dihe-in -64.4, -16.61 -47.26, -45.44 APE12-dist-in 13.7754 APE11-dist-in 10.8356 APE10-dist-in 7.0066 APE9-dist-in 3.4894 D144N None None XRAY 2.3 0.216 0.225 A 292.0 288.0 4 28 28 0 [[4, 286]] 1.0 1ung Homo sapiens CMGC_CDK5_HUMAN CMGC 8e-83 284.6 1.0 301.0 301.0 143 144 145 147 149 33 51 55 123 125 124 126.0 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
CDK5 CDK5_HUMAN 1UNGB Q00535 2 288 292.0 ALH:1288 Type1 Active DFGin 6.7562 15.2398 BLAminus -135.97, 174.05 60.46, 78.03 -103.9, 21.9 274.8, 75.17 -65.02, -29.35 in-in in 9.083 Saltbr-in 2.6574 HRD-in -79.66, -50.24 62.45, 11.53 in-in-in SNCiii in-in ActLoopNT-in 3.0431 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.0, 151.25 APE9-dihe-na 73.87, 134.42 APE8-dihe-in -67.73, 142.85 APE8-rot-in 304.57 APE67-dihe-in -65.69, -18.42 -33.73, -53.69 APE12-dist-in 12.9582 APE11-dist-in 9.5843 APE10-dist-in 6.5108 APE9-dist-in 3.3065 D144N None None XRAY 2.3 0.216 0.225 B 292.0 269.0 18 28 28 0 [[4, 286]] 1.0 1ung Homo sapiens CMGC_CDK5_HUMAN CMGC 8e-83 284.6 1.0 301.0 301.0 143 144 145 147 149 33 51 55 123 125 124 126.0 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
CDK5 CDK5_HUMAN 1UNHA Q00535 2 288 292.0 IXM:1288 Type1 Active DFGin 6.7757 15.0921 BLAminus -140.41, 176.0 60.42, 76.79 -95.69, 24.18 281.89, 69.34 -62.09, -29.91 in-in in 8.6743 Saltbr-in 2.9932 HRD-in -79.64, -52.48 66.83, 20.74 in-in-in SNCiii in-in ActLoopNT-in 2.8414 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.37, 151.6 APE9-dihe-na 72.7, 127.61 APE8-dihe-in -51.97, 137.86 APE8-rot-in 307.6 APE67-dihe-in -65.83, -14.98 -38.09, -55.48 APE12-dist-in 13.0995 APE11-dist-in 9.8991 APE10-dist-in 6.9004 APE9-dist-in 3.3457 D144N None None XRAY 2.35 0.229 0.23 A 292.0 277.0 10 28 28 0 [[4, 286]] 1.0 1unh Homo sapiens CMGC_CDK5_HUMAN CMGC 8e-83 284.6 1.0 301.0 301.0 143 144 145 147 149 33 51 55 123 125 124 126.0 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
CDK5 CDK5_HUMAN 1UNHB Q00535 2 288 292.0 IXM:1288 Type1 Active DFGin 6.8388 15.1453 BLAminus -141.38, 178.67 60.42, 76.27 -98.32, 21.68 277.9, 76.2 -63.97, -22.06 in-in in 8.6349 Saltbr-in 3.2558 HRD-in -75.22, -55.65 69.38, 16.95 in-in-in SNCiii in-in ActLoopNT-in 2.8267 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.18, 147.66 APE9-dihe-na 73.19, 127.24 APE8-dihe-in -46.64, 135.38 APE8-rot-in 297.76 APE67-dihe-in -66.71, -15.92 -39.6, -54.16 APE12-dist-in 13.1463 APE11-dist-in 9.9739 APE10-dist-in 7.0516 APE9-dist-in 3.3187 D144N None None XRAY 2.35 0.229 0.23 B 292.0 277.0 10 28 28 0 [[4, 286]] 1.0 1unh Homo sapiens CMGC_CDK5_HUMAN CMGC 8e-83 284.6 1.0 301.0 301.0 143 144 145 147 149 33 51 55 123 125 124 126.0 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
CDK5 CDK5_HUMAN 1UNLA Q00535 1 292 292.0 RRC:1293 Type1 Active DFGin 6.8293 15.2016 BLAminus -128.33, 173.21 66.87, 81.02 -97.91, 23.56 283.17, 72.64 -73.67, -20.59 in-in in 8.3091 Saltbr-in 2.8471 HRD-in -82.56, -50.74 69.72, 10.97 in-in-in SNCiii in-in ActLoopNT-in 2.9193 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.08, 156.73 APE9-dihe-na 71.89, 126.73 APE8-dihe-in -48.26, 136.09 APE8-rot-in 296.72 APE67-dihe-in -59.67, -21.67 -44.15, -47.77 APE12-dist-in 13.5586 APE11-dist-in 10.7803 APE10-dist-in 7.1047 APE9-dist-in 3.2635 D144N None None XRAY 2.2 0.216 0.219 A 292.0 292.0 0 28 28 0 [[4, 286]] 1.0 1unl Homo sapiens CMGC_CDK5_HUMAN CMGC 8e-83 284.6 1.0 301.0 301.0 143 144 145 147 149 33 51 55 123 125 124 126.0 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
CDK5 CDK5_HUMAN 3O0GB Q00535 6 288 292.0 3O0:293 Type1 Active DFGin 6.923 14.7947 BLAminus -129.48, 175.97 62.66, 84.26 -100.98, 30.43 284.37, 72.05 -63.02, -27.78 in-in in 8.8214 Saltbr-in 2.7631 HRD-in -83.72, -54.01 67.99, 17.3 in-in-in SNCiii in-in ActLoopNT-in 2.8557 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.49, 157.23 APE9-dihe-na 72.19, 128.42 APE8-dihe-in -53.83, 140.52 APE8-rot-in 308.29 APE67-dihe-in -61.77, -21.68 -45.86, -49.86 APE12-dist-in 12.7273 APE11-dist-in 9.9091 APE10-dist-in 6.3251 APE9-dist-in 3.248 D144N None None XRAY 1.95 0.228 0.256 B 292.0 264.0 21 28 28 0 [[4, 286]] 1.0 3o0g Homo sapiens CMGC_CDK5_HUMAN CMGC 8e-83 284.6 1.0 301.0 301.0 143 144 145 147 149 33 51 55 123 125 124 126.0 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
CDK5 CDK5_HUMAN 7VDPA Q00535 2 291 292.0 65L:301 Type1 Inactive DFGin 6.7648 15.3893 BLAminus -127.42, 170.52 67.24, 87.09 -100.87, 23.21 283.17, 74.31 -63.43, -25.09 in-out in 8.8533 Saltbr-out 3.7283 HRD-in -78.41, -56.12 72.29, 8.93 out-in-out SNCoio in-out ActLoopNT-in 2.8658 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -134.29, 146.94 APE9-dihe-na 69.86, 130.59 APE8-dihe-in -56.21, 145.09 APE8-rot-out 66.15 APE67-dihe-in -65.94, -20.99 -45.11, -46.74 APE12-dist-in 13.3218 APE11-dist-in 10.197 APE10-dist-in 6.9249 APE9-dist-in 3.3917 None None None XRAY 2.09 0.202 0.229 A 292.0 287.0 3 28 28 0 [[4, 286]] 1.0 7vdp Homo sapiens CMGC_CDK5_HUMAN CMGC 4e-84 288.8 1.0 301.0 301.0 143 144 145 147 149 33 51 55 123 125 124 126.0 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
CDK5 CDK5_HUMAN 7VDPB Q00535 3 288 292.0 65L:301 Type1 Inactive DFGin 6.7292 14.9863 BLAminus -127.65, 169.87 66.53, 89.09 -101.2, 27.01 283.91, 72.42 -67.19, -23.91 in-out in 8.8191 Saltbr-out 3.7073 HRD-in -80.8, -59.5 69.85, 17.04 out-in-out SNCoio in-out ActLoopNT-in 2.8868 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -137.89, 151.46 APE9-dihe-na 71.79, 133.86 APE8-dihe-in -61.46, 147.21 APE8-rot-out 65.8 APE67-dihe-in -67.63, -21.22 -46.93, -48.84 APE12-dist-in 12.798 APE11-dist-in 9.6021 APE10-dist-in 6.4704 APE9-dist-in 3.3707 None None None XRAY 2.09 0.202 0.229 B 292.0 279.0 7 28 28 0 [[4, 286]] 1.0 7vdp Homo sapiens CMGC_CDK5_HUMAN CMGC 4e-84 288.8 1.0 301.0 301.0 143 144 145 147 149 33 51 55 123 125 124 126.0 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
CDK5 CDK5_HUMAN 7VDQA Q00535 2 291 292.0 64V:301 Type1 Inactive DFGin 6.6062 15.2883 BLAminus -126.33, 172.99 66.95, 84.9 -102.8, 32.89 288.52, 70.91 -63.45, -40.23 in-in in 8.7668 Saltbr-in 2.9151 HRD-in -78.08, -59.02 67.94, 17.12 in-in-out SNCiio in-out ActLoopNT-in 2.8528 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -140.03, 142.95 APE9-dihe-na 72.97, 131.4 APE8-dihe-in -63.75, 141.79 APE8-rot-out 59.38 APE67-dihe-in -67.5, -17.15 -39.1, -48.99 APE12-dist-in 13.3265 APE11-dist-in 10.4562 APE10-dist-in 6.9809 APE9-dist-in 3.343 None None None XRAY 2.91 0.254 0.284 A 292.0 290.0 0 28 28 0 [[4, 286]] 1.0 7vdq Homo sapiens CMGC_CDK5_HUMAN CMGC 4e-84 288.8 1.0 301.0 301.0 143 144 145 147 149 33 51 55 123 125 124 126.0 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
CDK5 CDK5_HUMAN 7VDQB Q00535 3 288 292.0 64V:301 Type1 Inactive DFGin 6.7029 15.3713 BLAminus -126.83, 173.21 67.53, 85.45 -103.83, 35.8 289.7, 71.3 -66.2, -38.73 in-in in 8.902 Saltbr-in 2.9093 HRD-in -79.53, -57.9 70.89, 16.51 in-in-out SNCiio in-out ActLoopNT-in 2.8736 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -139.15, 143.9 APE9-dihe-na 74.88, 143.9 APE8-dihe-in -77.64, 140.07 APE8-rot-out 62.74 APE67-dihe-in -67.14, -19.69 -37.77, -52.43 APE12-dist-in 12.7444 APE11-dist-in 9.9205 APE10-dist-in 6.6672 APE9-dist-in 3.3445 None None None XRAY 2.91 0.254 0.284 B 292.0 277.0 9 28 28 0 [[4, 286]] 1.0 7vdq Homo sapiens CMGC_CDK5_HUMAN CMGC 4e-84 288.8 1.0 301.0 301.0 143 144 145 147 149 33 51 55 123 125 124 126.0 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
CDK5 CDK5_HUMAN 7VDRA Q00535 2 291 292.0 63I:301 Type1 Inactive DFGin 6.6266 15.74 BLAminus -129.05, 171.62 69.47, 86.46 -104.09, 25.41 283.64, 74.23 -68.34, -21.06 in-in in 8.8803 Saltbr-in 3.314 HRD-in -78.35, -59.52 73.04, 14.77 in-in-out SNCiio in-out ActLoopNT-in 2.8632 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -137.3, 138.66 APE9-dihe-na 71.75, 135.69 APE8-dihe-in -66.11, 146.84 APE8-rot-out 71.82 APE67-dihe-in -69.63, -20.89 -44.06, -44.5 APE12-dist-in 13.0087 APE11-dist-in 9.9559 APE10-dist-in 6.9609 APE9-dist-in 3.3204 None None None XRAY 2.55 0.221 0.256 A 292.0 290.0 0 28 28 0 [[4, 286]] 1.0 7vdr Homo sapiens CMGC_CDK5_HUMAN CMGC 4e-84 288.8 1.0 301.0 301.0 143 144 145 147 149 33 51 55 123 125 124 126.0 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
CDK5 CDK5_HUMAN 7VDRB Q00535 3 288 292.0 63I:301 Type1 Inactive DFGin 6.5755 15.3317 BLAminus -129.35, 171.52 69.7, 87.29 -105.48, 25.0 285.38, 76.15 -68.91, -20.79 in-in in 8.8894 Saltbr-in 3.2949 HRD-in -80.02, -61.31 72.56, 17.73 in-in-out SNCiio in-out ActLoopNT-in 2.8656 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -136.41, 145.43 APE9-dihe-na 74.65, 138.0 APE8-dihe-in -69.3, 148.16 APE8-rot-out 71.5 APE67-dihe-in -71.13, -20.44 -45.23, -46.82 APE12-dist-in 12.9322 APE11-dist-in 9.9297 APE10-dist-in 6.82 APE9-dist-in 3.3178 None None None XRAY 2.55 0.221 0.256 B 292.0 275.0 11 28 28 0 [[4, 286]] 1.0 7vdr Homo sapiens CMGC_CDK5_HUMAN CMGC 4e-84 288.8 1.0 301.0 301.0 143 144 145 147 149 33 51 55 123 125 124 126.0 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
CDK5 CDK5_HUMAN 7VDSA Q00535 2 291 292.0 61U:301 Type1 Inactive DFGin 6.5205 15.3292 BLAminus -137.7, 177.02 65.97, 88.94 -109.08, 27.6 287.56, 67.14 -63.86, -33.05 in-in in 8.6242 Saltbr-in 3.3531 HRD-in -79.29, -55.01 68.82, 18.0 in-in-out SNCiio in-out ActLoopNT-in 2.8448 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -138.28, 148.16 APE9-dihe-na 77.03, 134.42 APE8-dihe-in -61.09, 132.18 APE8-rot-out 39.92 APE67-dihe-in -70.87, -20.07 -38.56, -38.27 APE12-dist-in 13.1199 APE11-dist-in 10.3195 APE10-dist-in 6.5539 APE9-dist-in 3.394 None None None XRAY 3.05 0.228 0.272 A 292.0 290.0 0 28 28 0 [[4, 286]] 1.0 7vds Homo sapiens CMGC_CDK5_HUMAN CMGC 4e-84 288.8 1.0 301.0 301.0 143 144 145 147 149 33 51 55 123 125 124 126.0 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
CDK5 CDK5_HUMAN 4AU8A Q00535 2 289 292.0 Z3R:61293 Type1 Inactive DFGin 7.1122 15.1372 BLAminus -135.37, 172.87 64.95, 77.01 -97.51, 18.8 282.03, 77.47 -65.91, -19.1 in-in in 8.2084 Saltbr-in 2.6454 HRD-in -73.52, -48.92 73.07, -7.77 in-in-out SNCiio in-out ActLoopNT-in 2.9444 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -144.11, 169.24 APE9-dihe-na -57.47, 146.77 APE8-dihe-in -51.22, 149.12 APE8-rot-out 191.34 APE67-dihe-in -62.35, -21.28 -39.22, -50.79 APE12-dist-in 12.0461 APE11-dist-out 6.6974 APE10-dist-out 8.6457 APE9-dist-in 3.8759 None None None XRAY 1.9 0.197 0.234 A 296.0 274.0 14 28 26 2 [[4, 286]] 1.0 4au8 Homo sapiens CMGC_CDK5_HUMAN CMGC 4.2e-84 288.8 1.0 301.0 301.0 143 144 145 147 149 33 51 55 123 125 124 126.0 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
CDK5 CDK5_HUMAN 4AU8B Q00535 2 289 292.0 Z3R:61293 Type1 Inactive DFGin 7.2608 15.5319 BLAminus -136.24, 169.41 66.3, 80.09 -99.68, 21.4 281.94, 79.2 -66.25, -19.98 in-in in 8.1283 Saltbr-in 2.8349 HRD-in -70.21, -48.16 75.6, -7.91 in-in-out SNCiio in-out ActLoopNT-in 2.947 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoi APE10-dihe-na 999.0, 152.31 APE9-dihe-na -57.56, 146.64 APE8-dihe-in -53.33, 139.32 APE8-rot-out 196.17 APE67-dihe-in -60.73, -25.67 -36.04, -48.68 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.8336 APE9-dist-in 3.8301 None None None XRAY 1.9 0.197 0.234 B 296.0 277.0 11 28 22 6 [[4, 286]] 1.0 4au8 Homo sapiens CMGC_CDK5_HUMAN CMGC 4.2e-84 288.8 1.0 301.0 301.0 143 144 145 147 149 33 51 55 123 125 124 126.0 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5

CMGC_CDK5 (Cyclin-dependent kinase 5)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative

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Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name