CMGC_CDK5 (Cyclin-dependent kinase 5)

Total number of chains: 22
Active chains: 13
Family: CMGC
Uniprot: CDK5_HUMAN
Kinase Domain Residues: 4 - 286
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 22 100.0% AF-Q00535-K1A

Hover over column headers for tooltip help

PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
1H4LA 2 287 292.0 No_ligand No_ligand Active DFGin 6.62 15.479 BLAminus -143.56, 176.2 53.14, 75.93 -87.23, 17.57 281.42, 66.7 -52.55, -28.59 in-in in 8.809 Saltbr-in 3.232 HRD-in -81.11, -48.22 60.62, 20.26 in-in-in SNCiii in-in ActLoopNT-in 3.009 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.33, 150.77 APE9-dihe-na 67.7, 126.9 APE8-dihe-in -54.75, 150.37 APE8-rot-in 308.87 APE67-dihe-in -61.52, -7.78 -40.44, -61.3 APE12-dist-in 12.92 APE11-dist-in 9.75 APE10-dist-in 6.694 APE9-dist-in 3.253 None None None XRAY 2.65 0.236 0.287 A 292 278 8 0 0 0 [[4, 286]] 1.0 1h4l CMGC_CDK5_HUMAN CMGC 7.3e-84 288.0 1 301 301 143 144 145 147 149 33 51 55 123 125 124 126 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
1H4LB 2 287 292.0 No_ligand No_ligand Active DFGin 6.659 15.44 BLAminus -143.33, -179.13 52.72, 73.32 -87.36, 23.9 283.69, 63.17 -58.01, -24.27 in-in in 8.934 Saltbr-in 3.125 HRD-in -84.82, -44.08 59.2, 10.17 in-in-in SNCiii in-in ActLoopNT-in 3.013 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.96, 143.89 APE9-dihe-na 72.68, 133.7 APE8-dihe-in -61.48, 143.63 APE8-rot-in 309.63 APE67-dihe-in -61.01, -6.73 -35.26, -57.65 APE12-dist-in 12.765 APE11-dist-in 9.582 APE10-dist-in 6.522 APE9-dist-in 3.145 None None None XRAY 2.65 0.236 0.287 B 292 278 8 0 0 0 [[4, 286]] 1.0 1h4l CMGC_CDK5_HUMAN CMGC 7.3e-84 288.0 1 301 301 143 144 145 147 149 33 51 55 123 125 124 126 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
AF-Q00535-K1A 1 292 292.0 No_ligand No_ligand Active DFGin 6.812 15.079 BLAminus -137.71, 176.76 52.72, 65.61 -76.52, 17.03 281.04, 72.01 -63.52, -30.68 in-in in 8.817 Saltbr-in 2.737 HRD-in -77.47, -45.4 62.19, 14.23 in-in-in SNCiii in-in ActLoopNT-in 2.867 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.25, 162.61 APE9-dihe-na 62.11, 128.26 APE8-dihe-in -54.35, 135.75 APE8-rot-in 298.8 APE67-dihe-in -65.0, -24.32 -44.79, -46.3 APE12-dist-in 13.284 APE11-dist-in 10.453 APE10-dist-in 6.864 APE9-dist-in 3.278 None None None AF2 -1.0 1.0 1.0 A 292 292 0 0 0 0 [[4, 286]] 1.0 AF-Q00535-K1 CMGC_CDK5_HUMAN CMGC 4e-84 288.8 1 301 301 143 144 145 147 149 33 51 55 123 125 124 126 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
AF-Q00535-K3A 1 292 292.0 No_ligand No_ligand Active DFGin 6.721 14.943 BLAminus -139.19, 173.54 59.01, 63.04 -76.77, 15.26 281.96, 72.04 -59.74, -32.22 in-in in 8.927 Saltbr-in 2.821 HRD-in -77.38, -51.01 62.6, 14.42 in-in-in SNCiii in-in ActLoopNT-in 2.842 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.79, 159.19 APE9-dihe-na 60.88, 136.97 APE8-dihe-in -57.12, 135.78 APE8-rot-in 296.35 APE67-dihe-in -65.12, -22.17 -41.34, -44.93 APE12-dist-in 13.001 APE11-dist-in 10.52 APE10-dist-in 6.701 APE9-dist-in 3.61 None None None AF2 -1.0 1.0 1.0 A 292 292 0 0 0 0 [[4, 286]] 1.0 AF-Q00535-K3 CMGC_CDK5_HUMAN CMGC 4e-84 288.8 1 301 301 143 144 145 147 149 33 51 55 123 125 124 126 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
7VDSB 3 288 292.0 No_ligand No_ligand Active DFGin 6.254 15.086 BLAminus -137.57, 174.05 68.25, 91.71 -107.27, 29.03 281.77, 31.22 -63.82, -33.82 in-in in 8.834 Saltbr-in 3.0 HRD-in -79.36, -55.2 68.82, 21.54 in-in-in SNCiii in-in ActLoopNT-in 2.835 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.32, 150.53 APE9-dihe-na 76.98, 135.45 APE8-dihe-in -57.6, 129.9 APE8-rot-in 306.14 APE67-dihe-in -71.32, -21.13 -39.47, -39.34 APE12-dist-in 12.689 APE11-dist-in 9.931 APE10-dist-in 6.288 APE9-dist-in 3.426 None None None XRAY 3.05 0.228 0.272 B 292 278 8 0 0 0 [[4, 286]] 1.0 7vds CMGC_CDK5_HUMAN CMGC 4e-84 288.8 1 301 301 143 144 145 147 149 33 51 55 123 125 124 126 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
1UNLB 1 292 292.0 No_ligand No_ligand Active DFGin 6.886 14.851 BLAminus -135.82, 173.41 59.96, 81.07 -98.2, 33.32 283.07, 69.38 -75.63, -27.28 in-in in 8.452 Saltbr-in 3.158 HRD-in -77.91, -53.06 63.81, 22.82 in-in-in SNCiii in-in ActLoopNT-in 3.004 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.88, 159.89 APE9-dihe-na 67.72, 132.78 APE8-dihe-in -56.55, 142.64 APE8-rot-in 295.52 APE67-dihe-in -68.05, -20.23 -51.27, -43.49 APE12-dist-in 12.878 APE11-dist-in 10.176 APE10-dist-in 6.39 APE9-dist-in 3.218 D144N None None XRAY 2.2 0.216 0.219 B 292 292 0 0 0 0 [[4, 286]] 1.0 1unl CMGC_CDK5_HUMAN CMGC 8e-83 284.6 1 301 301 143 144 145 147 149 33 51 55 123 125 124 126 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
3O0GA 1 289 292.0 No_ligand No_ligand Active DFGin 6.829 15.218 BLAminus -136.42, 175.77 61.32, 76.52 -94.77, 26.39 279.12, 71.78 -74.78, -15.11 in-in in 8.724 Saltbr-in 2.553 HRD-in -79.72, -52.16 68.31, 13.14 in-in-in SNCiii in-in ActLoopNT-in 2.915 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.07, 157.29 APE9-dihe-na 70.83, 127.92 APE8-dihe-in -52.36, 134.76 APE8-rot-in 293.6 APE67-dihe-in -63.53, -19.46 -44.63, -48.78 APE12-dist-in 13.469 APE11-dist-in 10.729 APE10-dist-in 6.966 APE9-dist-in 3.272 D144N None None XRAY 1.95 0.228 0.256 A 292 289 0 0 0 0 [[4, 286]] 1.0 3o0g CMGC_CDK5_HUMAN CMGC 8e-83 284.6 1 301 301 143 144 145 147 149 33 51 55 123 125 124 126 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
1UNGA 1 292 292.0 ALH:1293 Type1 Active DFGin 6.804 15.508 BLAminus -133.26, 177.58 62.73, 72.63 -89.91, 24.29 283.27, 66.96 -66.0, -18.39 in-in in 8.963 Saltbr-in 2.651 HRD-in -78.57, -49.35 66.52, 4.37 in-in-in SNCiii in-in ActLoopNT-in 2.757 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.0, 143.2 APE9-dihe-na 84.58, 125.12 APE8-dihe-in -53.58, 144.18 APE8-rot-in 305.47 APE67-dihe-in -64.4, -16.61 -47.26, -45.44 APE12-dist-in 13.775 APE11-dist-in 10.836 APE10-dist-in 7.007 APE9-dist-in 3.489 D144N None None XRAY 2.3 0.216 0.225 A 292 288 4 0 0 0 [[4, 286]] 1.0 1ung CMGC_CDK5_HUMAN CMGC 8e-83 284.6 1 301 301 143 144 145 147 149 33 51 55 123 125 124 126 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
1UNGB 2 288 292.0 ALH:1288 Type1 Active DFGin 6.756 15.24 BLAminus -135.97, 174.05 60.46, 78.03 -103.9, 21.9 274.8, 75.17 -65.02, -29.35 in-in in 9.083 Saltbr-in 2.657 HRD-in -79.66, -50.24 62.45, 11.53 in-in-in SNCiii in-in ActLoopNT-in 3.043 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.0, 151.25 APE9-dihe-na 73.87, 134.42 APE8-dihe-in -67.73, 142.85 APE8-rot-in 304.57 APE67-dihe-in -65.69, -18.42 -33.73, -53.69 APE12-dist-in 12.958 APE11-dist-in 9.584 APE10-dist-in 6.511 APE9-dist-in 3.307 D144N None None XRAY 2.3 0.216 0.225 B 292 269 18 0 0 0 [[4, 286]] 1.0 1ung CMGC_CDK5_HUMAN CMGC 8e-83 284.6 1 301 301 143 144 145 147 149 33 51 55 123 125 124 126 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
1UNHA 2 288 292.0 IXM:1288 Type1 Active DFGin 6.776 15.092 BLAminus -140.41, 176.0 60.42, 76.79 -95.69, 24.18 281.89, 69.34 -62.09, -29.91 in-in in 8.674 Saltbr-in 2.993 HRD-in -79.64, -52.48 66.83, 20.74 in-in-in SNCiii in-in ActLoopNT-in 2.841 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.37, 151.6 APE9-dihe-na 72.7, 127.61 APE8-dihe-in -51.97, 137.86 APE8-rot-in 307.6 APE67-dihe-in -65.83, -14.98 -38.09, -55.48 APE12-dist-in 13.1 APE11-dist-in 9.899 APE10-dist-in 6.9 APE9-dist-in 3.346 D144N None None XRAY 2.35 0.229 0.23 A 292 277 10 0 0 0 [[4, 286]] 1.0 1unh CMGC_CDK5_HUMAN CMGC 8e-83 284.6 1 301 301 143 144 145 147 149 33 51 55 123 125 124 126 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
1UNHB 2 288 292.0 IXM:1288 Type1 Active DFGin 6.839 15.145 BLAminus -141.38, 178.67 60.42, 76.27 -98.32, 21.68 277.9, 76.2 -63.97, -22.06 in-in in 8.635 Saltbr-in 3.256 HRD-in -75.22, -55.65 69.38, 16.95 in-in-in SNCiii in-in ActLoopNT-in 2.827 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.18, 147.66 APE9-dihe-na 73.19, 127.24 APE8-dihe-in -46.64, 135.38 APE8-rot-in 297.76 APE67-dihe-in -66.71, -15.92 -39.6, -54.16 APE12-dist-in 13.146 APE11-dist-in 9.974 APE10-dist-in 7.052 APE9-dist-in 3.319 D144N None None XRAY 2.35 0.229 0.23 B 292 277 10 0 0 0 [[4, 286]] 1.0 1unh CMGC_CDK5_HUMAN CMGC 8e-83 284.6 1 301 301 143 144 145 147 149 33 51 55 123 125 124 126 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
1UNLA 1 292 292.0 RRC:1293 Type1 Active DFGin 6.829 15.202 BLAminus -128.33, 173.21 66.87, 81.02 -97.91, 23.56 283.17, 72.64 -73.67, -20.59 in-in in 8.309 Saltbr-in 2.847 HRD-in -82.56, -50.74 69.72, 10.97 in-in-in SNCiii in-in ActLoopNT-in 2.919 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.08, 156.73 APE9-dihe-na 71.89, 126.73 APE8-dihe-in -48.26, 136.09 APE8-rot-in 296.72 APE67-dihe-in -59.67, -21.67 -44.15, -47.77 APE12-dist-in 13.559 APE11-dist-in 10.78 APE10-dist-in 7.105 APE9-dist-in 3.264 D144N None None XRAY 2.2 0.216 0.219 A 292 292 0 0 0 0 [[4, 286]] 1.0 1unl CMGC_CDK5_HUMAN CMGC 8e-83 284.6 1 301 301 143 144 145 147 149 33 51 55 123 125 124 126 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
3O0GB 6 288 292.0 3O0:293 Type1 Active DFGin 6.923 14.795 BLAminus -129.48, 175.97 62.66, 84.26 -100.98, 30.43 284.37, 72.05 -63.02, -27.78 in-in in 8.821 Saltbr-in 2.763 HRD-in -83.72, -54.01 67.99, 17.3 in-in-in SNCiii in-in ActLoopNT-in 2.856 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.49, 157.23 APE9-dihe-na 72.19, 128.42 APE8-dihe-in -53.83, 140.52 APE8-rot-in 308.29 APE67-dihe-in -61.77, -21.68 -45.86, -49.86 APE12-dist-in 12.727 APE11-dist-in 9.909 APE10-dist-in 6.325 APE9-dist-in 3.248 D144N None None XRAY 1.95 0.228 0.256 B 292 264 21 0 0 0 [[4, 286]] 1.0 3o0g CMGC_CDK5_HUMAN CMGC 8e-83 284.6 1 301 301 143 144 145 147 149 33 51 55 123 125 124 126 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
7VDPA 2 291 292.0 65L:301 Type1 Inactive DFGin 6.765 15.389 BLAminus -127.42, 170.52 67.24, 87.09 -100.87, 23.21 283.17, 74.31 -63.43, -25.09 in-out in 8.853 Saltbr-out 3.728 HRD-in -78.41, -56.12 72.29, 8.93 out-in-out SNCoio in-out ActLoopNT-in 2.866 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -134.29, 146.94 APE9-dihe-na 69.86, 130.59 APE8-dihe-in -56.21, 145.09 APE8-rot-out 66.15 APE67-dihe-in -65.94, -20.99 -45.11, -46.74 APE12-dist-in 13.322 APE11-dist-in 10.197 APE10-dist-in 6.925 APE9-dist-in 3.392 None None None XRAY 2.09 0.202 0.229 A 292 287 3 0 0 0 [[4, 286]] 1.0 7vdp CMGC_CDK5_HUMAN CMGC 4e-84 288.8 1 301 301 143 144 145 147 149 33 51 55 123 125 124 126 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
7VDPB 3 288 292.0 65L:301 Type1 Inactive DFGin 6.729 14.986 BLAminus -127.65, 169.87 66.53, 89.09 -101.2, 27.01 283.91, 72.42 -67.19, -23.91 in-out in 8.819 Saltbr-out 3.707 HRD-in -80.8, -59.5 69.85, 17.04 out-in-out SNCoio in-out ActLoopNT-in 2.887 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -137.89, 151.46 APE9-dihe-na 71.79, 133.86 APE8-dihe-in -61.46, 147.21 APE8-rot-out 65.8 APE67-dihe-in -67.63, -21.22 -46.93, -48.84 APE12-dist-in 12.798 APE11-dist-in 9.602 APE10-dist-in 6.47 APE9-dist-in 3.371 None None None XRAY 2.09 0.202 0.229 B 292 279 7 0 0 0 [[4, 286]] 1.0 7vdp CMGC_CDK5_HUMAN CMGC 4e-84 288.8 1 301 301 143 144 145 147 149 33 51 55 123 125 124 126 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
7VDQA 2 291 292.0 64V:301 Type1 Inactive DFGin 6.606 15.288 BLAminus -126.33, 172.99 66.95, 84.9 -102.8, 32.89 288.52, 70.91 -63.45, -40.23 in-in in 8.767 Saltbr-in 2.915 HRD-in -78.08, -59.02 67.94, 17.12 in-in-out SNCiio in-out ActLoopNT-in 2.853 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -140.03, 142.95 APE9-dihe-na 72.97, 131.4 APE8-dihe-in -63.75, 141.79 APE8-rot-out 59.38 APE67-dihe-in -67.5, -17.15 -39.1, -48.99 APE12-dist-in 13.326 APE11-dist-in 10.456 APE10-dist-in 6.981 APE9-dist-in 3.343 None None None XRAY 2.91 0.254 0.284 A 292 290 0 0 0 0 [[4, 286]] 1.0 7vdq CMGC_CDK5_HUMAN CMGC 4e-84 288.8 1 301 301 143 144 145 147 149 33 51 55 123 125 124 126 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
7VDQB 3 288 292.0 64V:301 Type1 Inactive DFGin 6.703 15.371 BLAminus -126.83, 173.21 67.53, 85.45 -103.83, 35.8 289.7, 71.3 -66.2, -38.73 in-in in 8.902 Saltbr-in 2.909 HRD-in -79.53, -57.9 70.89, 16.51 in-in-out SNCiio in-out ActLoopNT-in 2.874 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -139.15, 143.9 APE9-dihe-na 74.88, 143.9 APE8-dihe-in -77.64, 140.07 APE8-rot-out 62.74 APE67-dihe-in -67.14, -19.69 -37.77, -52.43 APE12-dist-in 12.744 APE11-dist-in 9.921 APE10-dist-in 6.667 APE9-dist-in 3.345 None None None XRAY 2.91 0.254 0.284 B 292 277 9 0 0 0 [[4, 286]] 1.0 7vdq CMGC_CDK5_HUMAN CMGC 4e-84 288.8 1 301 301 143 144 145 147 149 33 51 55 123 125 124 126 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
7VDRA 2 291 292.0 63I:301 Type1 Inactive DFGin 6.627 15.74 BLAminus -129.05, 171.62 69.47, 86.46 -104.09, 25.41 283.64, 74.23 -68.34, -21.06 in-in in 8.88 Saltbr-in 3.314 HRD-in -78.35, -59.52 73.04, 14.77 in-in-out SNCiio in-out ActLoopNT-in 2.863 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -137.3, 138.66 APE9-dihe-na 71.75, 135.69 APE8-dihe-in -66.11, 146.84 APE8-rot-out 71.82 APE67-dihe-in -69.63, -20.89 -44.06, -44.5 APE12-dist-in 13.009 APE11-dist-in 9.956 APE10-dist-in 6.961 APE9-dist-in 3.32 None None None XRAY 2.55 0.221 0.256 A 292 290 0 0 0 0 [[4, 286]] 1.0 7vdr CMGC_CDK5_HUMAN CMGC 4e-84 288.8 1 301 301 143 144 145 147 149 33 51 55 123 125 124 126 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
7VDRB 3 288 292.0 63I:301 Type1 Inactive DFGin 6.575 15.332 BLAminus -129.35, 171.52 69.7, 87.29 -105.48, 25.0 285.38, 76.15 -68.91, -20.79 in-in in 8.889 Saltbr-in 3.295 HRD-in -80.02, -61.31 72.56, 17.73 in-in-out SNCiio in-out ActLoopNT-in 2.866 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -136.41, 145.43 APE9-dihe-na 74.65, 138.0 APE8-dihe-in -69.3, 148.16 APE8-rot-out 71.5 APE67-dihe-in -71.13, -20.44 -45.23, -46.82 APE12-dist-in 12.932 APE11-dist-in 9.93 APE10-dist-in 6.82 APE9-dist-in 3.318 None None None XRAY 2.55 0.221 0.256 B 292 275 11 0 0 0 [[4, 286]] 1.0 7vdr CMGC_CDK5_HUMAN CMGC 4e-84 288.8 1 301 301 143 144 145 147 149 33 51 55 123 125 124 126 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
7VDSA 2 291 292.0 61U:301 Type1 Inactive DFGin 6.521 15.329 BLAminus -137.7, 177.02 65.97, 88.94 -109.08, 27.6 287.56, 67.14 -63.86, -33.05 in-in in 8.624 Saltbr-in 3.353 HRD-in -79.29, -55.01 68.82, 18.0 in-in-out SNCiio in-out ActLoopNT-in 2.845 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -138.28, 148.16 APE9-dihe-na 77.03, 134.42 APE8-dihe-in -61.09, 132.18 APE8-rot-out 39.92 APE67-dihe-in -70.87, -20.07 -38.56, -38.27 APE12-dist-in 13.12 APE11-dist-in 10.319 APE10-dist-in 6.554 APE9-dist-in 3.394 None None None XRAY 3.05 0.228 0.272 A 292 290 0 0 0 0 [[4, 286]] 1.0 7vds CMGC_CDK5_HUMAN CMGC 4e-84 288.8 1 301 301 143 144 145 147 149 33 51 55 123 125 124 126 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
4AU8A 2 289 292.0 Z3R:61293 Type1 Inactive DFGin 7.112 15.137 BLAminus -135.37, 172.87 64.95, 77.01 -97.51, 18.8 282.03, 77.47 -65.91, -19.1 in-in in 8.208 Saltbr-in 2.645 HRD-in -73.52, -48.92 73.07, -7.77 in-in-out SNCiio in-out ActLoopNT-in 2.944 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -144.11, 169.24 APE9-dihe-na -57.47, 146.77 APE8-dihe-in -51.22, 149.12 APE8-rot-out 191.34 APE67-dihe-in -62.35, -21.28 -39.22, -50.79 APE12-dist-in 12.046 APE11-dist-out 6.697 APE10-dist-out 8.646 APE9-dist-in 3.876 None None None XRAY 1.9 0.197 0.234 A 296 274 14 0 0 2 [[4, 286]] 1.0 4au8 CMGC_CDK5_HUMAN CMGC 4.2e-84 288.8 1 301 301 143 144 145 147 149 33 51 55 123 125 124 126 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
4AU8B 2 289 292.0 Z3R:61293 Type1 Inactive DFGin 7.261 15.532 BLAminus -136.24, 169.41 66.3, 80.09 -99.68, 21.4 281.94, 79.2 -66.25, -19.98 in-in in 8.128 Saltbr-in 2.835 HRD-in -70.21, -48.16 75.6, -7.91 in-in-out SNCiio in-out ActLoopNT-in 2.947 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoi APE10-dihe-na 999.0, 152.31 APE9-dihe-na -57.56, 146.64 APE8-dihe-in -53.33, 139.32 APE8-rot-out 196.17 APE67-dihe-in -60.73, -25.67 -36.04, -48.68 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.834 APE9-dist-in 3.83 None None None XRAY 1.9 0.197 0.234 B 296 277 11 0 0 6 [[4, 286]] 1.0 4au8 CMGC_CDK5_HUMAN CMGC 4.2e-84 288.8 1 301 301 143 144 145 147 149 33 51 55 123 125 124 126 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5

CMGC_CDK5 (Cyclin-dependent kinase 5)

Total number of chains: 22
Active chains: 13
Family: CMGC
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 22 100.0% AF-Q00535-K1A

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CDK5_HUMAN 1H4LA Q00535 2 287 292.0 No_ligand No_ligand Active DFGin 6.62 15.479 BLAminus -143.56, 176.2 53.14, 75.93 -87.23, 17.57 281.42, 66.7 -52.55, -28.59 in-in in 8.809 Saltbr-in 3.232 HRD-in -81.11, -48.22 60.62, 20.26 in-in-in SNCiii in-in ActLoopNT-in 3.009 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.33, 150.77 APE9-dihe-na 67.7, 126.9 APE8-dihe-in -54.75, 150.37 APE8-rot-in 308.87 APE67-dihe-in -61.52, -7.78 -40.44, -61.3 APE12-dist-in 12.92 APE11-dist-in 9.75 APE10-dist-in 6.694 APE9-dist-in 3.253 None None None XRAY 2.65 0.236 0.287 A 292 278 8 0 0 0 [[4, 286]] 1.0 1h4l Homo sapiens CMGC_CDK5_HUMAN CMGC 7.3e-84 288.0 1 301 301 143 144 145 147 149 33 51 55 123 125 124 126 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
CDK5_HUMAN 1H4LB Q00535 2 287 292.0 No_ligand No_ligand Active DFGin 6.659 15.44 BLAminus -143.33, -179.13 52.72, 73.32 -87.36, 23.9 283.69, 63.17 -58.01, -24.27 in-in in 8.934 Saltbr-in 3.125 HRD-in -84.82, -44.08 59.2, 10.17 in-in-in SNCiii in-in ActLoopNT-in 3.013 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.96, 143.89 APE9-dihe-na 72.68, 133.7 APE8-dihe-in -61.48, 143.63 APE8-rot-in 309.63 APE67-dihe-in -61.01, -6.73 -35.26, -57.65 APE12-dist-in 12.765 APE11-dist-in 9.582 APE10-dist-in 6.522 APE9-dist-in 3.145 None None None XRAY 2.65 0.236 0.287 B 292 278 8 0 0 0 [[4, 286]] 1.0 1h4l Homo sapiens CMGC_CDK5_HUMAN CMGC 7.3e-84 288.0 1 301 301 143 144 145 147 149 33 51 55 123 125 124 126 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
CDK5_HUMAN AF-Q00535-K1A Q00535 1 292 292.0 No_ligand No_ligand Active DFGin 6.812 15.079 BLAminus -137.71, 176.76 52.72, 65.61 -76.52, 17.03 281.04, 72.01 -63.52, -30.68 in-in in 8.817 Saltbr-in 2.737 HRD-in -77.47, -45.4 62.19, 14.23 in-in-in SNCiii in-in ActLoopNT-in 2.867 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.25, 162.61 APE9-dihe-na 62.11, 128.26 APE8-dihe-in -54.35, 135.75 APE8-rot-in 298.8 APE67-dihe-in -65.0, -24.32 -44.79, -46.3 APE12-dist-in 13.284 APE11-dist-in 10.453 APE10-dist-in 6.864 APE9-dist-in 3.278 None None None AF2 -1.0 1.0 1.0 A 292 292 0 0 0 0 [[4, 286]] 1.0 AF-Q00535-K1 Homo sapiens CMGC_CDK5_HUMAN CMGC 4e-84 288.8 1 301 301 143 144 145 147 149 33 51 55 123 125 124 126 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
CDK5_HUMAN AF-Q00535-K3A Q00535 1 292 292.0 No_ligand No_ligand Active DFGin 6.721 14.943 BLAminus -139.19, 173.54 59.01, 63.04 -76.77, 15.26 281.96, 72.04 -59.74, -32.22 in-in in 8.927 Saltbr-in 2.821 HRD-in -77.38, -51.01 62.6, 14.42 in-in-in SNCiii in-in ActLoopNT-in 2.842 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.79, 159.19 APE9-dihe-na 60.88, 136.97 APE8-dihe-in -57.12, 135.78 APE8-rot-in 296.35 APE67-dihe-in -65.12, -22.17 -41.34, -44.93 APE12-dist-in 13.001 APE11-dist-in 10.52 APE10-dist-in 6.701 APE9-dist-in 3.61 None None None AF2 -1.0 1.0 1.0 A 292 292 0 0 0 0 [[4, 286]] 1.0 AF-Q00535-K3 Homo sapiens CMGC_CDK5_HUMAN CMGC 4e-84 288.8 1 301 301 143 144 145 147 149 33 51 55 123 125 124 126 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
CDK5_HUMAN 7VDSB Q00535 3 288 292.0 No_ligand No_ligand Active DFGin 6.254 15.086 BLAminus -137.57, 174.05 68.25, 91.71 -107.27, 29.03 281.77, 31.22 -63.82, -33.82 in-in in 8.834 Saltbr-in 3.0 HRD-in -79.36, -55.2 68.82, 21.54 in-in-in SNCiii in-in ActLoopNT-in 2.835 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.32, 150.53 APE9-dihe-na 76.98, 135.45 APE8-dihe-in -57.6, 129.9 APE8-rot-in 306.14 APE67-dihe-in -71.32, -21.13 -39.47, -39.34 APE12-dist-in 12.689 APE11-dist-in 9.931 APE10-dist-in 6.288 APE9-dist-in 3.426 None None None XRAY 3.05 0.228 0.272 B 292 278 8 0 0 0 [[4, 286]] 1.0 7vds Homo sapiens CMGC_CDK5_HUMAN CMGC 4e-84 288.8 1 301 301 143 144 145 147 149 33 51 55 123 125 124 126 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
CDK5_HUMAN 1UNLB Q00535 1 292 292.0 No_ligand No_ligand Active DFGin 6.886 14.851 BLAminus -135.82, 173.41 59.96, 81.07 -98.2, 33.32 283.07, 69.38 -75.63, -27.28 in-in in 8.452 Saltbr-in 3.158 HRD-in -77.91, -53.06 63.81, 22.82 in-in-in SNCiii in-in ActLoopNT-in 3.004 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.88, 159.89 APE9-dihe-na 67.72, 132.78 APE8-dihe-in -56.55, 142.64 APE8-rot-in 295.52 APE67-dihe-in -68.05, -20.23 -51.27, -43.49 APE12-dist-in 12.878 APE11-dist-in 10.176 APE10-dist-in 6.39 APE9-dist-in 3.218 D144N None None XRAY 2.2 0.216 0.219 B 292 292 0 0 0 0 [[4, 286]] 1.0 1unl Homo sapiens CMGC_CDK5_HUMAN CMGC 8e-83 284.6 1 301 301 143 144 145 147 149 33 51 55 123 125 124 126 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
CDK5_HUMAN 3O0GA Q00535 1 289 292.0 No_ligand No_ligand Active DFGin 6.829 15.218 BLAminus -136.42, 175.77 61.32, 76.52 -94.77, 26.39 279.12, 71.78 -74.78, -15.11 in-in in 8.724 Saltbr-in 2.553 HRD-in -79.72, -52.16 68.31, 13.14 in-in-in SNCiii in-in ActLoopNT-in 2.915 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.07, 157.29 APE9-dihe-na 70.83, 127.92 APE8-dihe-in -52.36, 134.76 APE8-rot-in 293.6 APE67-dihe-in -63.53, -19.46 -44.63, -48.78 APE12-dist-in 13.469 APE11-dist-in 10.729 APE10-dist-in 6.966 APE9-dist-in 3.272 D144N None None XRAY 1.95 0.228 0.256 A 292 289 0 0 0 0 [[4, 286]] 1.0 3o0g Homo sapiens CMGC_CDK5_HUMAN CMGC 8e-83 284.6 1 301 301 143 144 145 147 149 33 51 55 123 125 124 126 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
CDK5_HUMAN 1UNGA Q00535 1 292 292.0 ALH:1293 Type1 Active DFGin 6.804 15.508 BLAminus -133.26, 177.58 62.73, 72.63 -89.91, 24.29 283.27, 66.96 -66.0, -18.39 in-in in 8.963 Saltbr-in 2.651 HRD-in -78.57, -49.35 66.52, 4.37 in-in-in SNCiii in-in ActLoopNT-in 2.757 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.0, 143.2 APE9-dihe-na 84.58, 125.12 APE8-dihe-in -53.58, 144.18 APE8-rot-in 305.47 APE67-dihe-in -64.4, -16.61 -47.26, -45.44 APE12-dist-in 13.775 APE11-dist-in 10.836 APE10-dist-in 7.007 APE9-dist-in 3.489 D144N None None XRAY 2.3 0.216 0.225 A 292 288 4 0 0 0 [[4, 286]] 1.0 1ung Homo sapiens CMGC_CDK5_HUMAN CMGC 8e-83 284.6 1 301 301 143 144 145 147 149 33 51 55 123 125 124 126 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
CDK5_HUMAN 1UNGB Q00535 2 288 292.0 ALH:1288 Type1 Active DFGin 6.756 15.24 BLAminus -135.97, 174.05 60.46, 78.03 -103.9, 21.9 274.8, 75.17 -65.02, -29.35 in-in in 9.083 Saltbr-in 2.657 HRD-in -79.66, -50.24 62.45, 11.53 in-in-in SNCiii in-in ActLoopNT-in 3.043 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.0, 151.25 APE9-dihe-na 73.87, 134.42 APE8-dihe-in -67.73, 142.85 APE8-rot-in 304.57 APE67-dihe-in -65.69, -18.42 -33.73, -53.69 APE12-dist-in 12.958 APE11-dist-in 9.584 APE10-dist-in 6.511 APE9-dist-in 3.307 D144N None None XRAY 2.3 0.216 0.225 B 292 269 18 0 0 0 [[4, 286]] 1.0 1ung Homo sapiens CMGC_CDK5_HUMAN CMGC 8e-83 284.6 1 301 301 143 144 145 147 149 33 51 55 123 125 124 126 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
CDK5_HUMAN 1UNHA Q00535 2 288 292.0 IXM:1288 Type1 Active DFGin 6.776 15.092 BLAminus -140.41, 176.0 60.42, 76.79 -95.69, 24.18 281.89, 69.34 -62.09, -29.91 in-in in 8.674 Saltbr-in 2.993 HRD-in -79.64, -52.48 66.83, 20.74 in-in-in SNCiii in-in ActLoopNT-in 2.841 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.37, 151.6 APE9-dihe-na 72.7, 127.61 APE8-dihe-in -51.97, 137.86 APE8-rot-in 307.6 APE67-dihe-in -65.83, -14.98 -38.09, -55.48 APE12-dist-in 13.1 APE11-dist-in 9.899 APE10-dist-in 6.9 APE9-dist-in 3.346 D144N None None XRAY 2.35 0.229 0.23 A 292 277 10 0 0 0 [[4, 286]] 1.0 1unh Homo sapiens CMGC_CDK5_HUMAN CMGC 8e-83 284.6 1 301 301 143 144 145 147 149 33 51 55 123 125 124 126 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
CDK5_HUMAN 1UNHB Q00535 2 288 292.0 IXM:1288 Type1 Active DFGin 6.839 15.145 BLAminus -141.38, 178.67 60.42, 76.27 -98.32, 21.68 277.9, 76.2 -63.97, -22.06 in-in in 8.635 Saltbr-in 3.256 HRD-in -75.22, -55.65 69.38, 16.95 in-in-in SNCiii in-in ActLoopNT-in 2.827 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.18, 147.66 APE9-dihe-na 73.19, 127.24 APE8-dihe-in -46.64, 135.38 APE8-rot-in 297.76 APE67-dihe-in -66.71, -15.92 -39.6, -54.16 APE12-dist-in 13.146 APE11-dist-in 9.974 APE10-dist-in 7.052 APE9-dist-in 3.319 D144N None None XRAY 2.35 0.229 0.23 B 292 277 10 0 0 0 [[4, 286]] 1.0 1unh Homo sapiens CMGC_CDK5_HUMAN CMGC 8e-83 284.6 1 301 301 143 144 145 147 149 33 51 55 123 125 124 126 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
CDK5_HUMAN 1UNLA Q00535 1 292 292.0 RRC:1293 Type1 Active DFGin 6.829 15.202 BLAminus -128.33, 173.21 66.87, 81.02 -97.91, 23.56 283.17, 72.64 -73.67, -20.59 in-in in 8.309 Saltbr-in 2.847 HRD-in -82.56, -50.74 69.72, 10.97 in-in-in SNCiii in-in ActLoopNT-in 2.919 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.08, 156.73 APE9-dihe-na 71.89, 126.73 APE8-dihe-in -48.26, 136.09 APE8-rot-in 296.72 APE67-dihe-in -59.67, -21.67 -44.15, -47.77 APE12-dist-in 13.559 APE11-dist-in 10.78 APE10-dist-in 7.105 APE9-dist-in 3.264 D144N None None XRAY 2.2 0.216 0.219 A 292 292 0 0 0 0 [[4, 286]] 1.0 1unl Homo sapiens CMGC_CDK5_HUMAN CMGC 8e-83 284.6 1 301 301 143 144 145 147 149 33 51 55 123 125 124 126 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
CDK5_HUMAN 3O0GB Q00535 6 288 292.0 3O0:293 Type1 Active DFGin 6.923 14.795 BLAminus -129.48, 175.97 62.66, 84.26 -100.98, 30.43 284.37, 72.05 -63.02, -27.78 in-in in 8.821 Saltbr-in 2.763 HRD-in -83.72, -54.01 67.99, 17.3 in-in-in SNCiii in-in ActLoopNT-in 2.856 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.49, 157.23 APE9-dihe-na 72.19, 128.42 APE8-dihe-in -53.83, 140.52 APE8-rot-in 308.29 APE67-dihe-in -61.77, -21.68 -45.86, -49.86 APE12-dist-in 12.727 APE11-dist-in 9.909 APE10-dist-in 6.325 APE9-dist-in 3.248 D144N None None XRAY 1.95 0.228 0.256 B 292 264 21 0 0 0 [[4, 286]] 1.0 3o0g Homo sapiens CMGC_CDK5_HUMAN CMGC 8e-83 284.6 1 301 301 143 144 145 147 149 33 51 55 123 125 124 126 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
CDK5_HUMAN 7VDPA Q00535 2 291 292.0 65L:301 Type1 Inactive DFGin 6.765 15.389 BLAminus -127.42, 170.52 67.24, 87.09 -100.87, 23.21 283.17, 74.31 -63.43, -25.09 in-out in 8.853 Saltbr-out 3.728 HRD-in -78.41, -56.12 72.29, 8.93 out-in-out SNCoio in-out ActLoopNT-in 2.866 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -134.29, 146.94 APE9-dihe-na 69.86, 130.59 APE8-dihe-in -56.21, 145.09 APE8-rot-out 66.15 APE67-dihe-in -65.94, -20.99 -45.11, -46.74 APE12-dist-in 13.322 APE11-dist-in 10.197 APE10-dist-in 6.925 APE9-dist-in 3.392 None None None XRAY 2.09 0.202 0.229 A 292 287 3 0 0 0 [[4, 286]] 1.0 7vdp Homo sapiens CMGC_CDK5_HUMAN CMGC 4e-84 288.8 1 301 301 143 144 145 147 149 33 51 55 123 125 124 126 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
CDK5_HUMAN 7VDPB Q00535 3 288 292.0 65L:301 Type1 Inactive DFGin 6.729 14.986 BLAminus -127.65, 169.87 66.53, 89.09 -101.2, 27.01 283.91, 72.42 -67.19, -23.91 in-out in 8.819 Saltbr-out 3.707 HRD-in -80.8, -59.5 69.85, 17.04 out-in-out SNCoio in-out ActLoopNT-in 2.887 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -137.89, 151.46 APE9-dihe-na 71.79, 133.86 APE8-dihe-in -61.46, 147.21 APE8-rot-out 65.8 APE67-dihe-in -67.63, -21.22 -46.93, -48.84 APE12-dist-in 12.798 APE11-dist-in 9.602 APE10-dist-in 6.47 APE9-dist-in 3.371 None None None XRAY 2.09 0.202 0.229 B 292 279 7 0 0 0 [[4, 286]] 1.0 7vdp Homo sapiens CMGC_CDK5_HUMAN CMGC 4e-84 288.8 1 301 301 143 144 145 147 149 33 51 55 123 125 124 126 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
CDK5_HUMAN 7VDQA Q00535 2 291 292.0 64V:301 Type1 Inactive DFGin 6.606 15.288 BLAminus -126.33, 172.99 66.95, 84.9 -102.8, 32.89 288.52, 70.91 -63.45, -40.23 in-in in 8.767 Saltbr-in 2.915 HRD-in -78.08, -59.02 67.94, 17.12 in-in-out SNCiio in-out ActLoopNT-in 2.853 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -140.03, 142.95 APE9-dihe-na 72.97, 131.4 APE8-dihe-in -63.75, 141.79 APE8-rot-out 59.38 APE67-dihe-in -67.5, -17.15 -39.1, -48.99 APE12-dist-in 13.326 APE11-dist-in 10.456 APE10-dist-in 6.981 APE9-dist-in 3.343 None None None XRAY 2.91 0.254 0.284 A 292 290 0 0 0 0 [[4, 286]] 1.0 7vdq Homo sapiens CMGC_CDK5_HUMAN CMGC 4e-84 288.8 1 301 301 143 144 145 147 149 33 51 55 123 125 124 126 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
CDK5_HUMAN 7VDQB Q00535 3 288 292.0 64V:301 Type1 Inactive DFGin 6.703 15.371 BLAminus -126.83, 173.21 67.53, 85.45 -103.83, 35.8 289.7, 71.3 -66.2, -38.73 in-in in 8.902 Saltbr-in 2.909 HRD-in -79.53, -57.9 70.89, 16.51 in-in-out SNCiio in-out ActLoopNT-in 2.874 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -139.15, 143.9 APE9-dihe-na 74.88, 143.9 APE8-dihe-in -77.64, 140.07 APE8-rot-out 62.74 APE67-dihe-in -67.14, -19.69 -37.77, -52.43 APE12-dist-in 12.744 APE11-dist-in 9.921 APE10-dist-in 6.667 APE9-dist-in 3.345 None None None XRAY 2.91 0.254 0.284 B 292 277 9 0 0 0 [[4, 286]] 1.0 7vdq Homo sapiens CMGC_CDK5_HUMAN CMGC 4e-84 288.8 1 301 301 143 144 145 147 149 33 51 55 123 125 124 126 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
CDK5_HUMAN 7VDRA Q00535 2 291 292.0 63I:301 Type1 Inactive DFGin 6.627 15.74 BLAminus -129.05, 171.62 69.47, 86.46 -104.09, 25.41 283.64, 74.23 -68.34, -21.06 in-in in 8.88 Saltbr-in 3.314 HRD-in -78.35, -59.52 73.04, 14.77 in-in-out SNCiio in-out ActLoopNT-in 2.863 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -137.3, 138.66 APE9-dihe-na 71.75, 135.69 APE8-dihe-in -66.11, 146.84 APE8-rot-out 71.82 APE67-dihe-in -69.63, -20.89 -44.06, -44.5 APE12-dist-in 13.009 APE11-dist-in 9.956 APE10-dist-in 6.961 APE9-dist-in 3.32 None None None XRAY 2.55 0.221 0.256 A 292 290 0 0 0 0 [[4, 286]] 1.0 7vdr Homo sapiens CMGC_CDK5_HUMAN CMGC 4e-84 288.8 1 301 301 143 144 145 147 149 33 51 55 123 125 124 126 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
CDK5_HUMAN 7VDRB Q00535 3 288 292.0 63I:301 Type1 Inactive DFGin 6.575 15.332 BLAminus -129.35, 171.52 69.7, 87.29 -105.48, 25.0 285.38, 76.15 -68.91, -20.79 in-in in 8.889 Saltbr-in 3.295 HRD-in -80.02, -61.31 72.56, 17.73 in-in-out SNCiio in-out ActLoopNT-in 2.866 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -136.41, 145.43 APE9-dihe-na 74.65, 138.0 APE8-dihe-in -69.3, 148.16 APE8-rot-out 71.5 APE67-dihe-in -71.13, -20.44 -45.23, -46.82 APE12-dist-in 12.932 APE11-dist-in 9.93 APE10-dist-in 6.82 APE9-dist-in 3.318 None None None XRAY 2.55 0.221 0.256 B 292 275 11 0 0 0 [[4, 286]] 1.0 7vdr Homo sapiens CMGC_CDK5_HUMAN CMGC 4e-84 288.8 1 301 301 143 144 145 147 149 33 51 55 123 125 124 126 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
CDK5_HUMAN 7VDSA Q00535 2 291 292.0 61U:301 Type1 Inactive DFGin 6.521 15.329 BLAminus -137.7, 177.02 65.97, 88.94 -109.08, 27.6 287.56, 67.14 -63.86, -33.05 in-in in 8.624 Saltbr-in 3.353 HRD-in -79.29, -55.01 68.82, 18.0 in-in-out SNCiio in-out ActLoopNT-in 2.845 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -138.28, 148.16 APE9-dihe-na 77.03, 134.42 APE8-dihe-in -61.09, 132.18 APE8-rot-out 39.92 APE67-dihe-in -70.87, -20.07 -38.56, -38.27 APE12-dist-in 13.12 APE11-dist-in 10.319 APE10-dist-in 6.554 APE9-dist-in 3.394 None None None XRAY 3.05 0.228 0.272 A 292 290 0 0 0 0 [[4, 286]] 1.0 7vds Homo sapiens CMGC_CDK5_HUMAN CMGC 4e-84 288.8 1 301 301 143 144 145 147 149 33 51 55 123 125 124 126 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
CDK5_HUMAN 4AU8A Q00535 2 289 292.0 Z3R:61293 Type1 Inactive DFGin 7.112 15.137 BLAminus -135.37, 172.87 64.95, 77.01 -97.51, 18.8 282.03, 77.47 -65.91, -19.1 in-in in 8.208 Saltbr-in 2.645 HRD-in -73.52, -48.92 73.07, -7.77 in-in-out SNCiio in-out ActLoopNT-in 2.944 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -144.11, 169.24 APE9-dihe-na -57.47, 146.77 APE8-dihe-in -51.22, 149.12 APE8-rot-out 191.34 APE67-dihe-in -62.35, -21.28 -39.22, -50.79 APE12-dist-in 12.046 APE11-dist-out 6.697 APE10-dist-out 8.646 APE9-dist-in 3.876 None None None XRAY 1.9 0.197 0.234 A 296 274 14 0 0 2 [[4, 286]] 1.0 4au8 Homo sapiens CMGC_CDK5_HUMAN CMGC 4.2e-84 288.8 1 301 301 143 144 145 147 149 33 51 55 123 125 124 126 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5
CDK5_HUMAN 4AU8B Q00535 2 289 292.0 Z3R:61293 Type1 Inactive DFGin 7.261 15.532 BLAminus -136.24, 169.41 66.3, 80.09 -99.68, 21.4 281.94, 79.2 -66.25, -19.98 in-in in 8.128 Saltbr-in 2.835 HRD-in -70.21, -48.16 75.6, -7.91 in-in-out SNCiio in-out ActLoopNT-in 2.947 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoi APE10-dihe-na 999.0, 152.31 APE9-dihe-na -57.56, 146.64 APE8-dihe-in -53.33, 139.32 APE8-rot-out 196.17 APE67-dihe-in -60.73, -25.67 -36.04, -48.68 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.834 APE9-dist-in 3.83 None None None XRAY 1.9 0.197 0.234 B 296 277 11 0 0 6 [[4, 286]] 1.0 4au8 Homo sapiens CMGC_CDK5_HUMAN CMGC 4.2e-84 288.8 1 301 301 143 144 145 147 149 33 51 55 123 125 124 126 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5

CMGC_CDK5 (Cyclin-dependent kinase 5)

Total number of chains: 0
Active chains: 0
Family: CMGC
Spatial label Dihedral label Number of Chains Percent Representative

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name