CAMK_CAMK4 (Calcium/calmodulin-dependent protein kinase type IV)

Total number of chains: 3
Active chains: 2
Uniprot: KCC4_HUMAN
Kinase Domain Residues: 46 - 300
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 66.7% AF-Q16566-K1A
None None 1 33.3% 2W4OA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CAMK4 AF-Q16566-K1A Q16566 38 308 473.0 No_ligand No_ligand Active DFGin 6.8308 14.0227 BLAminus -124.46, 176.48 55.21, 77.24 -84.68, 15.91 287.09, 84.48 -62.02, -27.43 in-in in 9.0461 Saltbr-in 2.7002 HRD-in -73.53, -48.06 65.28, 7.09 in-in-in SNCiii in-in ActLoopNT-in 2.9486 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.19, 170.22 APE9-dihe-na 100.17, 171.33 APE8-dihe-in -80.42, 124.09 APE8-rot-in 304.98 APE67-dihe-in -65.57, -17.88 -39.32, -52.52 APE12-dist-in 9.1427 APE11-dist-in 11.6624 APE10-dist-in 5.9795 APE9-dist-in 3.5464 None None None AF2 -1.0 1.0 1.0 A 271.0 271.0 0 27 27 0 [[46, 300]] 1.0 AF-Q16566-K1 CAMK_CAMK4_HUMAN CAMK 2e-90 308.5 1.0 256.0 256.0 184 185 186 188 190 75 89 93 161 163 162 164.0 223 211 206 205 204 203 202 201 200 119 Calcium/calmodulin-dependent protein kinase type IV
CAMK4 AF-Q16566-K3A Q16566 38 308 473.0 No_ligand No_ligand Active DFGin 6.4074 13.9337 BLAminus -126.57, 176.47 50.26, 85.3 -89.34, 16.16 296.27, 90.91 -58.07, -37.2 in-in in 8.7656 Saltbr-in 2.6819 HRD-in -76.87, -46.3 67.64, -3.0 in-in-in SNCiii in-in ActLoopNT-in 2.8589 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.73, 178.0 APE9-dihe-na 87.53, 176.04 APE8-dihe-in -85.64, 118.83 APE8-rot-in 305.77 APE67-dihe-in -59.67, -22.63 -41.18, -50.68 APE12-dist-in 8.5969 APE11-dist-in 11.4698 APE10-dist-in 5.8268 APE9-dist-in 3.6727 None None None AF2 -1.0 1.0 1.0 A 271.0 271.0 0 27 27 0 [[46, 300]] 1.0 AF-Q16566-K3 CAMK_CAMK4_HUMAN CAMK 2e-90 308.5 1.0 256.0 256.0 184 185 186 188 190 75 89 93 161 163 162 164.0 223 211 206 205 204 203 202 201 200 119 Calcium/calmodulin-dependent protein kinase type IV
CAMK4 2W4OA Q16566 34 337 473.0 DKI:1338 Type1 Inactive None 999.0 999.0 None -105.26, 174.45 73.67, 2.86 -24.08, 999.0 999.0, 999.0 999.0, 999.0 none-none none 999.0 Saltbr-none 999.0 HRD-in -71.0, -50.24 71.4, -6.92 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -43.31 APE8-dihe-in -126.65, 64.25 APE8-rot-out 52.05 APE67-dihe-in -68.6, -13.19 -64.59, -15.06 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.3159 None None None XRAY 2.17 0.216 0.237 A 349.0 278.0 26 27 11 16 [[46, 300]] 1.0 2w4o CAMK_CAMK4_HUMAN CAMK 4.7e-90 307.9 1.0 256.0 256.0 184 185 186 188 190 75 89 93 161 163 162 164.0 223 211 206 205 204 203 202 201 200 119 Calcium/calmodulin-dependent protein kinase type IV

CAMK_CAMK4 (Calcium/calmodulin-dependent protein kinase type IV)

Total number of chains: 5
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
None None 3 60.0% 9FQREr
DFGin BLAminus 2 40.0% AF-Q16566-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CAMK4 A0A4W2D4I1_BOBOX 9FQRER A0A4W2D4I1 36 329 463.0 No_ligand No_ligand Inactive None 12.3212 16.9695 None -79.69, 53.87 -80.71, -16.44 -72.85, -33.72 50.21, 88.41 -58.87, -22.03 out-out out 19.1571 Saltbr-out 16.8429 HRD-in -117.67, -51.38 86.12, -4.78 out-out-out SNCooo out-out ActLoopNT-out 6.402 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oioo APE10-dihe-na -65.17, -19.62 APE9-dihe-na -59.8, -47.59 APE8-dihe-in -88.99, 155.34 APE8-rot-out 52.38 APE67-dihe-out 41.34, 25.56 -60.61, -62.75 APE12-dist-out 15.5006 APE11-dist-in 13.7158 APE10-dist-out 18.6028 APE9-dist-out 11.6919 None None None EM 5.0 999.0 999.0 Er 463.0 294.0 0 27 27 0 [[46, 300]] 1.0 9fqr Bos indicus CAMK_CAMK4_BOBOX CAMK 1.1e-89 306.6 1.0 256.0 256.0 184 185 186 188 190 75 89 93 161 163 162 164.0 223 211 206 205 204 203 202 201 200 119 Calcium/calmodulin-dependent protein kinase type IV
CAMK4 A0A4W2D4I1_BOBOX 9FQRG9 A0A4W2D4I1 36 329 463.0 No_ligand No_ligand Inactive None 13.3086 16.8045 None -93.56, 61.19 -78.93, -13.87 -71.72, -28.83 52.3, 79.79 -66.09, -17.82 out-out out 19.262 Saltbr-out 19.3158 HRD-in -123.1, -43.42 52.77, 45.48 out-out-out SNCooo out-out ActLoopNT-out 6.3197 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oooo APE10-dihe-na -82.64, -8.39 APE9-dihe-na -66.39, -41.85 APE8-dihe-in -85.19, 148.83 APE8-rot-out 61.48 APE67-dihe-out 41.22, 24.8 -67.83, -59.85 APE12-dist-out 16.2996 APE11-dist-out 14.6734 APE10-dist-out 19.8191 APE9-dist-out 11.995 None None None EM 5.0 999.0 999.0 G9 463.0 294.0 0 27 27 0 [[46, 300]] 1.0 9fqr Bos indicus CAMK_CAMK4_BOBOX CAMK 1.1e-89 306.6 1.0 256.0 256.0 184 185 186 188 190 75 89 93 161 163 162 164.0 223 211 206 205 204 203 202 201 200 119 Calcium/calmodulin-dependent protein kinase type IV
CAMK4 KCC4_HUMAN AF-Q16566-K1A Q16566 38 308 473.0 No_ligand No_ligand Active DFGin 6.8308 14.0227 BLAminus -124.46, 176.48 55.21, 77.24 -84.68, 15.91 287.09, 84.48 -62.02, -27.43 in-in in 9.0461 Saltbr-in 2.7002 HRD-in -73.53, -48.06 65.28, 7.09 in-in-in SNCiii in-in ActLoopNT-in 2.9486 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.19, 170.22 APE9-dihe-na 100.17, 171.33 APE8-dihe-in -80.42, 124.09 APE8-rot-in 304.98 APE67-dihe-in -65.57, -17.88 -39.32, -52.52 APE12-dist-in 9.1427 APE11-dist-in 11.6624 APE10-dist-in 5.9795 APE9-dist-in 3.5464 None None None AF2 -1.0 1.0 1.0 A 271.0 271.0 0 27 27 0 [[46, 300]] 1.0 AF-Q16566-K1 Homo sapiens CAMK_CAMK4_HUMAN CAMK 2e-90 308.5 1.0 256.0 256.0 184 185 186 188 190 75 89 93 161 163 162 164.0 223 211 206 205 204 203 202 201 200 119 Calcium/calmodulin-dependent protein kinase type IV
CAMK4 KCC4_HUMAN AF-Q16566-K3A Q16566 38 308 473.0 No_ligand No_ligand Active DFGin 6.4074 13.9337 BLAminus -126.57, 176.47 50.26, 85.3 -89.34, 16.16 296.27, 90.91 -58.07, -37.2 in-in in 8.7656 Saltbr-in 2.6819 HRD-in -76.87, -46.3 67.64, -3.0 in-in-in SNCiii in-in ActLoopNT-in 2.8589 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.73, 178.0 APE9-dihe-na 87.53, 176.04 APE8-dihe-in -85.64, 118.83 APE8-rot-in 305.77 APE67-dihe-in -59.67, -22.63 -41.18, -50.68 APE12-dist-in 8.5969 APE11-dist-in 11.4698 APE10-dist-in 5.8268 APE9-dist-in 3.6727 None None None AF2 -1.0 1.0 1.0 A 271.0 271.0 0 27 27 0 [[46, 300]] 1.0 AF-Q16566-K3 Homo sapiens CAMK_CAMK4_HUMAN CAMK 2e-90 308.5 1.0 256.0 256.0 184 185 186 188 190 75 89 93 161 163 162 164.0 223 211 206 205 204 203 202 201 200 119 Calcium/calmodulin-dependent protein kinase type IV
CAMK4 KCC4_HUMAN 2W4OA Q16566 34 337 473.0 DKI:1338 Type1 Inactive None 999.0 999.0 None -105.26, 174.45 73.67, 2.86 -24.08, 999.0 999.0, 999.0 999.0, 999.0 none-none none 999.0 Saltbr-none 999.0 HRD-in -71.0, -50.24 71.4, -6.92 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -43.31 APE8-dihe-in -126.65, 64.25 APE8-rot-out 52.05 APE67-dihe-in -68.6, -13.19 -64.59, -15.06 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.3159 None None None XRAY 2.17 0.216 0.237 A 349.0 278.0 26 27 11 16 [[46, 300]] 1.0 2w4o Homo sapiens CAMK_CAMK4_HUMAN CAMK 4.7e-90 307.9 1.0 256.0 256.0 184 185 186 188 190 75 89 93 161 163 162 164.0 223 211 206 205 204 203 202 201 200 119 Calcium/calmodulin-dependent protein kinase type IV

CAMK_CAMK4 (Calcium/calmodulin-dependent protein kinase type IV)

Total number of chains: 2
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
None None 2 100.0% 9FQREr
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CAMK4 A0A4W2D4I1_BOBOX 9FQRER A0A4W2D4I1 36 329 463.0 No_ligand No_ligand Inactive None 12.3212 16.9695 None -79.69, 53.87 -80.71, -16.44 -72.85, -33.72 50.21, 88.41 -58.87, -22.03 out-out out 19.1571 Saltbr-out 16.8429 HRD-in -117.67, -51.38 86.12, -4.78 out-out-out SNCooo out-out ActLoopNT-out 6.402 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oioo APE10-dihe-na -65.17, -19.62 APE9-dihe-na -59.8, -47.59 APE8-dihe-in -88.99, 155.34 APE8-rot-out 52.38 APE67-dihe-out 41.34, 25.56 -60.61, -62.75 APE12-dist-out 15.5006 APE11-dist-in 13.7158 APE10-dist-out 18.6028 APE9-dist-out 11.6919 None None None EM 5.0 999.0 999.0 Er 463.0 294.0 0 27 27 0 [[46, 300]] 1.0 9fqr Bos indicus CAMK_CAMK4_BOBOX CAMK 1.1e-89 306.6 1.0 256.0 256.0 184 185 186 188 190 75 89 93 161 163 162 164.0 223 211 206 205 204 203 202 201 200 119 Calcium/calmodulin-dependent protein kinase type IV
CAMK4 A0A4W2D4I1_BOBOX 9FQRG9 A0A4W2D4I1 36 329 463.0 No_ligand No_ligand Inactive None 13.3086 16.8045 None -93.56, 61.19 -78.93, -13.87 -71.72, -28.83 52.3, 79.79 -66.09, -17.82 out-out out 19.262 Saltbr-out 19.3158 HRD-in -123.1, -43.42 52.77, 45.48 out-out-out SNCooo out-out ActLoopNT-out 6.3197 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oooo APE10-dihe-na -82.64, -8.39 APE9-dihe-na -66.39, -41.85 APE8-dihe-in -85.19, 148.83 APE8-rot-out 61.48 APE67-dihe-out 41.22, 24.8 -67.83, -59.85 APE12-dist-out 16.2996 APE11-dist-out 14.6734 APE10-dist-out 19.8191 APE9-dist-out 11.995 None None None EM 5.0 999.0 999.0 G9 463.0 294.0 0 27 27 0 [[46, 300]] 1.0 9fqr Bos indicus CAMK_CAMK4_BOBOX CAMK 1.1e-89 306.6 1.0 256.0 256.0 184 185 186 188 190 75 89 93 161 163 162 164.0 223 211 206 205 204 203 202 201 200 119 Calcium/calmodulin-dependent protein kinase type IV