CAMK_BRSK2 (Serine/threonine-protein kinase BRSK2)

Total number of chains: 2
Active chains: 2
Uniprot: BRSK2_HUMAN
Kinase Domain Residues: 19 - 270
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 100.0% AF-Q8IWQ3-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
BRSK2 AF-Q8IWQ3-K1A Q8IWQ3 11 278 736.0 No_ligand No_ligand Active DFGin 6.7549 15.1392 BLAminus -120.06, 176.45 55.43, 76.65 -86.23, 17.08 284.49, 75.24 -61.34, -26.15 in-in in 9.2107 Saltbr-in 2.7225 HRD-in -77.84, -45.13 64.62, 10.05 in-in-in SNCiii in-in ActLoopNT-in 2.9375 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.81, 174.5 APE9-dihe-na 96.2, 170.99 APE8-dihe-in -71.92, 131.75 APE8-rot-in 284.78 APE67-dihe-in -64.62, -25.5 -53.71, -37.53 APE12-dist-in 8.698 APE11-dist-in 11.0366 APE10-dist-in 5.404 APE9-dist-in 3.5603 None None None AF2 -1.0 1.0 1.0 A 268.0 268.0 0 27 27 0 [[19, 270]] 1.0 AF-Q8IWQ3-K1 CAMK_BRSK2_HUMAN CAMK 2.5e-90 308.2 1.0 256.0 256.0 158 159 160 162 164 48 66 70 138 140 139 141.0 198 185 180 179 178 177 176 175 174 96 Serine/threonine-protein kinase BRSK2
BRSK2 AF-Q8IWQ3-K3A Q8IWQ3 11 278 736.0 No_ligand No_ligand Active DFGin 6.6907 15.1734 BLAminus -125.49, 176.18 54.9, 67.65 -75.8, 15.73 285.69, 75.39 -60.59, -24.71 in-in in 9.0842 Saltbr-in 2.7838 HRD-in -81.88, -46.37 65.68, 11.01 in-in-in SNCiii in-in ActLoopNT-in 2.8831 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.02, -179.24 APE9-dihe-na 88.25, 169.54 APE8-dihe-in -84.0, 130.88 APE8-rot-in 303.39 APE67-dihe-in -65.92, -26.66 -51.03, -36.6 APE12-dist-in 8.393 APE11-dist-in 11.1492 APE10-dist-in 5.5643 APE9-dist-in 3.296 None None None AF2 -1.0 1.0 1.0 A 268.0 268.0 0 27 27 0 [[19, 270]] 1.0 AF-Q8IWQ3-K3 CAMK_BRSK2_HUMAN CAMK 2.5e-90 308.2 1.0 256.0 256.0 158 159 160 162 164 48 66 70 138 140 139 141.0 198 185 180 179 178 177 176 175 174 96 Serine/threonine-protein kinase BRSK2

CAMK_BRSK2 (Serine/threonine-protein kinase BRSK2)

Total number of chains: 5
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBminus 3 60.0% 4YOMB
DFGin BLAminus 2 40.0% AF-Q8IWQ3-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
BRSK2 BRSK2_HUMAN AF-Q8IWQ3-K1A Q8IWQ3 11 278 736.0 No_ligand No_ligand Active DFGin 6.7549 15.1392 BLAminus -120.06, 176.45 55.43, 76.65 -86.23, 17.08 284.49, 75.24 -61.34, -26.15 in-in in 9.2107 Saltbr-in 2.7225 HRD-in -77.84, -45.13 64.62, 10.05 in-in-in SNCiii in-in ActLoopNT-in 2.9375 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.81, 174.5 APE9-dihe-na 96.2, 170.99 APE8-dihe-in -71.92, 131.75 APE8-rot-in 284.78 APE67-dihe-in -64.62, -25.5 -53.71, -37.53 APE12-dist-in 8.698 APE11-dist-in 11.0366 APE10-dist-in 5.404 APE9-dist-in 3.5603 None None None AF2 -1.0 1.0 1.0 A 268.0 268.0 0 27 27 0 [[19, 270]] 1.0 AF-Q8IWQ3-K1 Homo sapiens CAMK_BRSK2_HUMAN CAMK 2.5e-90 308.2 1.0 256.0 256.0 158 159 160 162 164 48 66 70 138 140 139 141.0 198 185 180 179 178 177 176 175 174 96 Serine/threonine-protein kinase BRSK2
BRSK2 BRSK2_HUMAN AF-Q8IWQ3-K3A Q8IWQ3 11 278 736.0 No_ligand No_ligand Active DFGin 6.6907 15.1734 BLAminus -125.49, 176.18 54.9, 67.65 -75.8, 15.73 285.69, 75.39 -60.59, -24.71 in-in in 9.0842 Saltbr-in 2.7838 HRD-in -81.88, -46.37 65.68, 11.01 in-in-in SNCiii in-in ActLoopNT-in 2.8831 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.02, -179.24 APE9-dihe-na 88.25, 169.54 APE8-dihe-in -84.0, 130.88 APE8-rot-in 303.39 APE67-dihe-in -65.92, -26.66 -51.03, -36.6 APE12-dist-in 8.393 APE11-dist-in 11.1492 APE10-dist-in 5.5643 APE9-dist-in 3.296 None None None AF2 -1.0 1.0 1.0 A 268.0 268.0 0 27 27 0 [[19, 270]] 1.0 AF-Q8IWQ3-K3 Homo sapiens CAMK_BRSK2_HUMAN CAMK 2.5e-90 308.2 1.0 256.0 256.0 158 159 160 162 164 48 66 70 138 140 139 141.0 198 185 180 179 178 177 176 175 174 96 Serine/threonine-protein kinase BRSK2
BRSK2 BRSK2_MOUSE 4YNZA Q69Z98 15 342 735.0 No_ligand No_ligand Inactive DFGin 9.5205 16.6662 BLBminus -106.45, 164.0 68.77, 27.13 -57.31, 139.36 279.79, 94.55 86.12, -5.09 out-out out 13.5593 Saltbr-out 12.5035 HRD-in -77.11, -51.98 75.87, -6.93 out-out-none SNCoon out-none ActLoopNT-out 8.242 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 84.68 APE8-rot-in 271.57 APE67-dihe-in -57.11, -27.27 -61.14, -17.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.192 0.229 A 342.0 306.0 11 27 16 11 [[20, 271]] 1.0 4ynz Mus musculus CAMK_BRSK2_MOUSE CAMK 7.8e-90 306.7 1.0 256.0 256.0 159 160 161 163 165 49 67 71 139 141 140 142.0 199 186 181 180 179 178 177 176 175 97 Serine/threonine-protein kinase BRSK2
BRSK2 BRSK2_MOUSE 4YNZB Q69Z98 15 342 735.0 No_ligand No_ligand Inactive DFGin 10.0895 17.0576 BLBminus -99.2, 160.7 78.67, 20.51 -56.13, 125.47 268.96, 105.21 90.0, 7.34 out-out out 13.6268 Saltbr-out 13.0634 HRD-in -79.25, -56.37 79.68, -10.31 out-out-out SNCooo out-out ActLoopNT-out 8.0472 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -43.68 APE8-rot-out 41.3 APE67-dihe-in -59.0, -25.23 -59.59, -23.15 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.192 0.229 B 342.0 316.0 12 27 15 12 [[20, 271]] 1.0 4ynz Mus musculus CAMK_BRSK2_MOUSE CAMK 7.8e-90 306.7 1.0 256.0 256.0 159 160 161 163 165 49 67 71 139 141 140 142.0 199 186 181 180 179 178 177 176 175 97 Serine/threonine-protein kinase BRSK2
BRSK2 BRSK2_MOUSE 4YOMB Q69Z98 13 342 735.0 No_ligand No_ligand Inactive DFGin 9.8916 17.512 BLBminus -89.03, 148.1 88.53, 14.03 -52.65, 136.0 272.36, 105.77 73.62, 10.41 out-out out 15.1704 Saltbr-out 14.3416 HRD-in -85.98, -48.78 73.53, -13.96 out-out-out SNCooo out-out ActLoopNT-out 8.3615 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioo APE10-dihe-na -97.75, -16.67 APE9-dihe-na 97.87, 163.51 APE8-dihe-in -92.55, 118.02 APE8-rot-out 185.61 APE67-dihe-in -58.3, -32.05 -74.26, -23.05 APE12-dist-out 15.0897 APE11-dist-in 11.2315 APE10-dist-out 14.5563 APE9-dist-out 6.9395 None None None XRAY 2.49 0.199 0.236 B 350.0 320.0 0 27 27 0 [[20, 271]] 1.0 4yom Mus musculus CAMK_BRSK2_MOUSE CAMK 8.3e-90 306.6 1.0 256.0 256.0 159 160 161 163 165 49 67 71 139 141 140 142.0 199 186 181 180 179 178 177 176 175 97 Serine/threonine-protein kinase BRSK2

CAMK_BRSK2 (Serine/threonine-protein kinase BRSK2)

Total number of chains: 3
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBminus 3 100.0% 4YOMB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
BRSK2 BRSK2_MOUSE 4YNZA Q69Z98 15 342 735.0 No_ligand No_ligand Inactive DFGin 9.5205 16.6662 BLBminus -106.45, 164.0 68.77, 27.13 -57.31, 139.36 279.79, 94.55 86.12, -5.09 out-out out 13.5593 Saltbr-out 12.5035 HRD-in -77.11, -51.98 75.87, -6.93 out-out-none SNCoon out-none ActLoopNT-out 8.242 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 84.68 APE8-rot-in 271.57 APE67-dihe-in -57.11, -27.27 -61.14, -17.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.192 0.229 A 342.0 306.0 11 27 16 11 [[20, 271]] 1.0 4ynz Mus musculus CAMK_BRSK2_MOUSE CAMK 7.8e-90 306.7 1.0 256.0 256.0 159 160 161 163 165 49 67 71 139 141 140 142.0 199 186 181 180 179 178 177 176 175 97 Serine/threonine-protein kinase BRSK2
BRSK2 BRSK2_MOUSE 4YNZB Q69Z98 15 342 735.0 No_ligand No_ligand Inactive DFGin 10.0895 17.0576 BLBminus -99.2, 160.7 78.67, 20.51 -56.13, 125.47 268.96, 105.21 90.0, 7.34 out-out out 13.6268 Saltbr-out 13.0634 HRD-in -79.25, -56.37 79.68, -10.31 out-out-out SNCooo out-out ActLoopNT-out 8.0472 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -43.68 APE8-rot-out 41.3 APE67-dihe-in -59.0, -25.23 -59.59, -23.15 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.192 0.229 B 342.0 316.0 12 27 15 12 [[20, 271]] 1.0 4ynz Mus musculus CAMK_BRSK2_MOUSE CAMK 7.8e-90 306.7 1.0 256.0 256.0 159 160 161 163 165 49 67 71 139 141 140 142.0 199 186 181 180 179 178 177 176 175 97 Serine/threonine-protein kinase BRSK2
BRSK2 BRSK2_MOUSE 4YOMB Q69Z98 13 342 735.0 No_ligand No_ligand Inactive DFGin 9.8916 17.512 BLBminus -89.03, 148.1 88.53, 14.03 -52.65, 136.0 272.36, 105.77 73.62, 10.41 out-out out 15.1704 Saltbr-out 14.3416 HRD-in -85.98, -48.78 73.53, -13.96 out-out-out SNCooo out-out ActLoopNT-out 8.3615 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioo APE10-dihe-na -97.75, -16.67 APE9-dihe-na 97.87, 163.51 APE8-dihe-in -92.55, 118.02 APE8-rot-out 185.61 APE67-dihe-in -58.3, -32.05 -74.26, -23.05 APE12-dist-out 15.0897 APE11-dist-in 11.2315 APE10-dist-out 14.5563 APE9-dist-out 6.9395 None None None XRAY 2.49 0.199 0.236 B 350.0 320.0 0 27 27 0 [[20, 271]] 1.0 4yom Mus musculus CAMK_BRSK2_MOUSE CAMK 8.3e-90 306.6 1.0 256.0 256.0 159 160 161 163 165 49 67 71 139 141 140 142.0 199 186 181 180 179 178 177 176 175 97 Serine/threonine-protein kinase BRSK2